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Grant L. Iverson - One of the best experts on this subject based on the ideXlab platform.
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examining Test reTest reliability and reliable change for cognition endpoints for the center tbi Neuropsychological Test Battery
Frontiers in Neurology, 2020Co-Authors: Jonas Stenberg, Justin E Karr, Toril Skandsen, Noah D Silverberg, Rune Hatlestad Karlsen, Grant L. IversonAbstract:Objective: Seven candidate cognition composite scores have been developed and evaluated as part of a research program designed to validate a cognition endpoint for traumatic brain injury (TBI) research and clinical trials, but these composites have yet to be examined longitudinally. This study examined Test-reTest reliability and methods for determining reliable change for these seven candidate composite scores, using the Neuropsychological Test Battery from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI). Methods: Participants (18-59 years-old) with mild TBI (n = 124), orthopedic trauma without head injury (n = 67), and healthy community controls (n = 63) from the Trondheim MTBI follow-up study completed the CENTER-TBI Neuropsychological Test Battery at 2 weeks and 3 months after injury. The Battery included both traditional paper-and-pencil Tests and computerized Tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Seven composite scores were calculated for the paper-and-pencil Tests, the CANTAB Tests, and all Tests combined (i.e., 21 composites in total on each assessment): the overall Test Battery mean (OTBM); global deficit score (GDS); Neuropsychological deficit score-weighted (NDS-W); low score composite (LSC); and the number of scores ≤5th percentile, ≤16th percentile, or <50th percentile. The OTBM was calculated by averaging T scores for all Tests. The other composite scores were deficit-based scores, assigning different weights to low scores. Results: All composites revealed better cognitive performance at the 3-month assessment compared to the 2-week assessment and the magnitude of improvement was similar across groups. Differences, in terms of effect sizes, were largest on the OTBMs. In the combined composites, the Test-reTest correlation was highest for the OTBM (Spearman's rho = 0.87, in the community control group) and lowest for the number of scores ≤5th percentile (rho = 0.41). Conclusion: The high Test-reTest reliability of the OTBM appears to favor its use in TBI research; however, future studies are needed to examine these candidate composite scores in participants with more severe TBIs and cognitive deficits and the association of the composites with functional outcomes.
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developing cognition endpoints for the center tbi Neuropsychological Test Battery
Frontiers in Neurology, 2020Co-Authors: Jonas Stenberg, Justin E Karr, Douglas P Terry, Simen B Saksvik, Toril Skandsen, Noah D Silverberg, Grant L. IversonAbstract:Background: Measuring cognitive functioning is common in traumatic brain injury (TBI) research, but no universally accepted method for combining several Neuropsychological Test scores into composite, or summary, scores exists. This study examined several possible composite scores for the Test Battery used in the large-scale study Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI). Methods: Participants with mild traumatic brain injury (MTBI; n = 140), orthopedic trauma (n = 72), and healthy community controls (n = 70) from the Trondheim MTBI follow-up study completed the CENTER-TBI Test Battery at 2 weeks after injury, which includes both traditional paper-and-pencil Tests and Tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Seven composite scores were calculated for the paper and pencil Tests, the CANTAB Tests, and all Tests combined (i.e., 21 composites): the overall Test Battery mean (OTBM); global deficit score (GDS); Neuropsychological deficit score-weighted (NDS-W); low score composite (LSC); and the number of scores ≤5th percentile, ≤16th percentile, or <50th percentile. Results: The OTBM and the number of scores <50th percentile composites had distributional characteristics approaching a normal distribution. The other composites were in general highly skewed and zero-inflated. When the MTBI group, the trauma control group, and the community control group were compared, effect sizes were negligible to small for all composites. Subgroups with vs. without loss of consciousness at the time of injury did not differ on the composite scores and neither did subgroups with complicated vs. uncomplicated MTBIs. Intercorrelations were high within the paper-and-pencil composites, the CANTAB composites, and the combined composites and lower between the paper-and-pencil composites and the CANTAB composites. Conclusion: None of the composites revealed significant differences between participants with MTBI and the two control groups. Some of the composite scores were highly correlated and may be redundant. Additional research on patients with moderate to severe TBIs is needed to determine which scores are most appropriate for TBI clinical trials.
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validity of impact for measuring processing speed following sports related concussion
Journal of Clinical and Experimental Neuropsychology, 2005Co-Authors: Grant L. Iverson, Mark R Lovell, Michael W CollinsAbstract:The purpose of this study was to examine the validity of ImPACT (Immediate Post-Concussion Assessment and Cognitive Testing), a computerized Neuropsychological Test Battery, for measuring attention and processing speed in athletes with concussions. This was accomplished by comparing the computerized Testing to a traditional Neuropsychological measure, the Symbol Digit Modalities Test (SDMT). Participants were 72 amateur athletes who were seen within 21 days of sustaining a sports-related concussion (Mean = 9.4, SD = 5.4 days). As predicted, the SDMT correlated more highly with the Processing Speed and Reaction Time composites than the Verbal Memory and Visual Memory Composites from ImPACT. The composite scores from ImPACT and the SDMT were subjected to exploratory factor analysis, revealing a two-factor solution interpreted as Speed/Reaction Time and Memory. It appears as if the Processing Speed Composite, Reaction Time Composite, and SDMT are measuring a similar underlying construct in this sample of con...
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cumulative effects of concussion in amateur athletes
Brain Injury, 2004Co-Authors: Grant L. Iverson, Mark R Lovell, Michael Gaetz, Michael W CollinsAbstract:Primary objective: To examine the possibility that athletes with multiple concussions show cumulative effects of injury. Methods and procedures: Amateur athletes with a history of three or more concussions were carefully matched (gender, age, education and sport) with athletes with no prior concussions. All completed a computerized Neuropsychological Test Battery at preseason (ImPACT) and then within 5 days of sustaining a concussion (mean = 1.7 days). Main outcomes and results: There were differences between groups in symptom reporting and memory performance. At baseline (i.e. preseason), athletes with multiple concussions reported more symptoms than athletes with no history of concussion. At approximately 2 days post-injury, athletes with multiple concussions scored significantly lower on memory Testing than athletes with a single concussion. Athletes with multiple concussions were 7.7 times more likely to demonstrate a major drop in memory performance than athletes with no previous concussions. Conclus...
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relationship between postconcussion headache and Neuropsychological Test performance in high school athletes
American Journal of Sports Medicine, 2003Co-Authors: Michael W Collins, Melvin Field, Mark R Lovell, Joseph C. Maroon, Karen M. Johnston, Grant L. Iverson, Freddie H FuAbstract:Background: The relevance of headache to outcome after sports-related concussion is poorly understood.Hypotheses: High school athletes reporting headache approximately 1 week after injury will have significantly more other concussion symptoms and will perform more poorly on Neuropsychological Tests than athletes not experiencing headache.Study Design: Prospective cohort study.Methods: Study participants included 109 high school athletes who had sustained concussion and who were divided into two groups: those reporting headache 7 days after injury and those reporting no headaches. The two groups were compared regarding on-field markers of concussion severity at the time of injury and symptoms and neurocognitive Test results collected via ImPACT, a computerized Neuropsychological Test Battery and postconcussion symptom scale, at a mean of 6.8 days after injury.Results: Athletes reporting posttraumatic headache demonstrated significantly worse performance on reaction time and memory ImPACT neurocognitive com...
Asta Haberg - One of the best experts on this subject based on the ideXlab platform.
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examining the subacute effects of mild traumatic brain injury with the center tbi Neuropsychological Test Battery
Journal of Neurotrauma, 2021Co-Authors: Rune Hatlestad Karlsen, Jonas Stenberg, Simen B Saksvik, Astri J Lundervold, Alexander Olsen, Ida Valikangas Rautio, Line Folvik, Asta Haberg, Anne Vik, Justin E KarrAbstract:This study investigates subacute cognitive effects of mild traumatic brain injury (MTBI) in the Trondheim Mild TBI Study, as measured, in part, by the Neuropsychological Test Battery of the Collabo...
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initial assessment of reliability of a self administered web based Neuropsychological Test Battery
Computers in Human Behavior, 2016Co-Authors: Tor Ivar Hansen, Hanne Lehn, Hallvard Roe Evensmoen, Asta HabergAbstract:IntroductionWeb-based Neuropsychological Testing can be an important tool in meeting the increasing demands for Neuropsychological assessment in the clinic and in large research studies. The primary aim of this study was to investigate practice effects and reliability of self-administered web-based Neuropsychological Tests in Memoro. Due to lack of consistent analysis and reporting of reliability in the literature, especially intraclass correlation coefficients (ICC), we highlight how using different ICC measures results in different estimates of reliability. Method61 (31 females) participants (mean age 53.3 years) completed the Memoro Tests twice with a median of 14 days between Testing. ResultsPractice effects were detected for all cognitive measures (dź=ź0.32-0.61), most pronounced for memory measures. Reliability estimated using two-way random effects single measure absolute agreement ICC(2,1) were between 0.55 and 0.74. Two-way mixed effects average measure consistency ICC(3,2), ranged from 0.79 to 0.89. Reliability was highest for the processing speed task and lower for the memory tasks. ConclusionsMemoro Tests had Test-reTest reliability similar to that of traditional, computerized and web-based Test batteries used clinically and in research. It is important to carefully choose and specify the ICC implemented, as ICC(2,1) and ICC(3,2) give different results and reflect reliability of different measures. Web-based Tests showed reliability comparable to traditional and computerized Tests.Processing speed had higher reliability estimates than memory measures.A two week reTest interval produced significant practice effects on all Tests.Practice effects were more pronounced on the memory measures.
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initial validation of a web based self administered Neuropsychological Test Battery for older adults and seniors
Journal of Clinical and Experimental Neuropsychology, 2015Co-Authors: Tor Ivar Hansen, Elise Christina D Haferstrom, Jan Ferenc Brunner, Hanne Lehn, Asta HabergAbstract:Introduction: Computerized Neuropsychological Tests are effective in assessing different cognitive domains, but are often limited by the need of proprietary hardware and technical staff. Web-based Tests can be more accessible and flexible. We aimed to investigate validity, effects of computer familiarity, education, and age, and the feasibility of a new web-based self-administered Neuropsychological Test Battery (Memoro) in older adults and seniors. Method: A total of 62 (37 female) participants (mean age 60.7 years) completed the Memoro web-based Neuropsychological Test Battery and a traditional Battery composed of similar Tests intended to measure the same cognitive constructs. Participants were assessed on computer familiarity and how they experienced the two batteries. To properly Test the factor structure of Memoro, an additional factor analysis in 218 individuals from the HUNT population was performed. Results: Comparing Memoro to traditional Tests, we observed good concurrent validity (r = .49–.63)...
Justin E Karr - One of the best experts on this subject based on the ideXlab platform.
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examining the subacute effects of mild traumatic brain injury with the center tbi Neuropsychological Test Battery
Journal of Neurotrauma, 2021Co-Authors: Rune Hatlestad Karlsen, Jonas Stenberg, Simen B Saksvik, Astri J Lundervold, Alexander Olsen, Ida Valikangas Rautio, Line Folvik, Asta Haberg, Anne Vik, Justin E KarrAbstract:This study investigates subacute cognitive effects of mild traumatic brain injury (MTBI) in the Trondheim Mild TBI Study, as measured, in part, by the Neuropsychological Test Battery of the Collabo...
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examining Test reTest reliability and reliable change for cognition endpoints for the center tbi Neuropsychological Test Battery
Frontiers in Neurology, 2020Co-Authors: Jonas Stenberg, Justin E Karr, Toril Skandsen, Noah D Silverberg, Rune Hatlestad Karlsen, Grant L. IversonAbstract:Objective: Seven candidate cognition composite scores have been developed and evaluated as part of a research program designed to validate a cognition endpoint for traumatic brain injury (TBI) research and clinical trials, but these composites have yet to be examined longitudinally. This study examined Test-reTest reliability and methods for determining reliable change for these seven candidate composite scores, using the Neuropsychological Test Battery from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI). Methods: Participants (18-59 years-old) with mild TBI (n = 124), orthopedic trauma without head injury (n = 67), and healthy community controls (n = 63) from the Trondheim MTBI follow-up study completed the CENTER-TBI Neuropsychological Test Battery at 2 weeks and 3 months after injury. The Battery included both traditional paper-and-pencil Tests and computerized Tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Seven composite scores were calculated for the paper-and-pencil Tests, the CANTAB Tests, and all Tests combined (i.e., 21 composites in total on each assessment): the overall Test Battery mean (OTBM); global deficit score (GDS); Neuropsychological deficit score-weighted (NDS-W); low score composite (LSC); and the number of scores ≤5th percentile, ≤16th percentile, or <50th percentile. The OTBM was calculated by averaging T scores for all Tests. The other composite scores were deficit-based scores, assigning different weights to low scores. Results: All composites revealed better cognitive performance at the 3-month assessment compared to the 2-week assessment and the magnitude of improvement was similar across groups. Differences, in terms of effect sizes, were largest on the OTBMs. In the combined composites, the Test-reTest correlation was highest for the OTBM (Spearman's rho = 0.87, in the community control group) and lowest for the number of scores ≤5th percentile (rho = 0.41). Conclusion: The high Test-reTest reliability of the OTBM appears to favor its use in TBI research; however, future studies are needed to examine these candidate composite scores in participants with more severe TBIs and cognitive deficits and the association of the composites with functional outcomes.
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developing cognition endpoints for the center tbi Neuropsychological Test Battery
Frontiers in Neurology, 2020Co-Authors: Jonas Stenberg, Justin E Karr, Douglas P Terry, Simen B Saksvik, Toril Skandsen, Noah D Silverberg, Grant L. IversonAbstract:Background: Measuring cognitive functioning is common in traumatic brain injury (TBI) research, but no universally accepted method for combining several Neuropsychological Test scores into composite, or summary, scores exists. This study examined several possible composite scores for the Test Battery used in the large-scale study Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI). Methods: Participants with mild traumatic brain injury (MTBI; n = 140), orthopedic trauma (n = 72), and healthy community controls (n = 70) from the Trondheim MTBI follow-up study completed the CENTER-TBI Test Battery at 2 weeks after injury, which includes both traditional paper-and-pencil Tests and Tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Seven composite scores were calculated for the paper and pencil Tests, the CANTAB Tests, and all Tests combined (i.e., 21 composites): the overall Test Battery mean (OTBM); global deficit score (GDS); Neuropsychological deficit score-weighted (NDS-W); low score composite (LSC); and the number of scores ≤5th percentile, ≤16th percentile, or <50th percentile. Results: The OTBM and the number of scores <50th percentile composites had distributional characteristics approaching a normal distribution. The other composites were in general highly skewed and zero-inflated. When the MTBI group, the trauma control group, and the community control group were compared, effect sizes were negligible to small for all composites. Subgroups with vs. without loss of consciousness at the time of injury did not differ on the composite scores and neither did subgroups with complicated vs. uncomplicated MTBIs. Intercorrelations were high within the paper-and-pencil composites, the CANTAB composites, and the combined composites and lower between the paper-and-pencil composites and the CANTAB composites. Conclusion: None of the composites revealed significant differences between participants with MTBI and the two control groups. Some of the composite scores were highly correlated and may be redundant. Additional research on patients with moderate to severe TBIs is needed to determine which scores are most appropriate for TBI clinical trials.
Felicia C Goldstein - One of the best experts on this subject based on the ideXlab platform.
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expanded demographic norms for version 3 of the alzheimer disease centers Neuropsychological Test Battery in the uniform data set
Alzheimer Disease & Associated Disorders, 2020Co-Authors: Bonnie C Sachs, Sandra Weintraub, Hiroko H Dodge, Lisa L Barnes, Timothy M Hughes, Kyle Steenland, Liping Zhao, Suzanne Craft, Monica L Parker, Felicia C GoldsteinAbstract:BACKGROUND Norms for the Uniform Data Set Version 3 Neuropsychological Battery are available for cognitively normal individuals based on age, education, and sex; however, these norms do not include race. We provide expanded norms for African Americans and whites. METHODS Data from 32 Alzheimer's Disease Centers (ADCs) and ADC affiliated cohorts with global Clinical Dementia Rating Scale (CDR) Dementia Staging Instrument scores of 0 were included. Descriptive statistics for each Test were calculated by age, sex, race, and education. Multiple linear regressions were conducted to estimate the effect of each demographic variable; squared semipartial correlation coefficients measured the relative importance of variables. RESULTS There were 8313 participants (16% African American) with complete demographic information, ranging from 6600 to 7885 depending on the Test. Lower scores were found for older and less educated groups, and African Americans versus whites. Education was the strongest predictor for most Tests, followed in order by age, race, and sex. Quadratic terms were significant for age and education, indicating some nonlinearity, but did not substantially increase R. CONCLUSIONS Although race-based norms represent incomplete proxies for other sociocultural variables, the appropriate application of these norms is important given the potential to improve diagnostic accuracy and to reduce misclassification bias in cognitive disorders of aging such as Alzheimer disease.
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differentiating among stages of cognitive impairment in aging version 3 of the uniform data set uds Neuropsychological Test Battery and moca index scores
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2020Co-Authors: Hiroko H Dodge, Kwun Chuen Gary Chan, Merilee Teylan, Walter A Kukull, Felicia C Goldstein, Nicole I Wakim, Tamar Gefen, Lisa L Barnes, Bruno Giordani, Timothy M HughesAbstract:Introduction Federally funded Alzheimer's Disease Centers in the United States have been using a standardized Neuropsychological Test Battery as part of the National Alzheimer's Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the UDS replaced the previous version (V2) in 2015. We compared V2 and V3 Neuropsychological Tests with respect to their ability to distinguish among the Clinical Dementia Rating (CDR) global scores of 0, 0.5, and 1. Methods First, we matched participants receiving V2 Tests (V2 cohort) and V3 Tests (V3 cohort) in their cognitive functions using Tests common to both versions. Then, we compared receiver-operating characteristic (ROC) area under the curve in differentiating CDRs for the remaining Tests. Results Some V3 Tests performed better than V2 Tests in differentiating between CDR 0.5 and 0, but the improvement was limited to Caucasian participants. Discussion Further efforts to improve the ability for early identification of cognitive decline among diverse racial groups are required.
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version 3 of the alzheimer disease centers Neuropsychological Test Battery in the uniform data set uds
Alzheimer Disease & Associated Disorders, 2017Co-Authors: Sandra Weintraub, Merilee Teylan, Hiroko H Dodge, Felicia C Goldstein, Bruno Giordani, Lilah M Besser, Steven H Ferris, Joel H Kramer, David A Loewenstein, Daniel C MarsonAbstract:Introduction The Neuropsychological Battery of the Uniform Data Set (UDSNB) was implemented in 2005 by the National Institute on Aging (NIA) Alzheimer Disease Centers program to measure cognitive performance in dementia and mild cognitive impairment due to Alzheimer Disease. This paper describes a revision, the UDSNB 3.0. Methods The Neuropsychology Work Group of the NIA Clinical Task Force recommended revisions through a process of due diligence to address shortcomings of the original Battery. The UDSNB 3.0 covers episodic memory, processing speed, executive function, language, and constructional ability. Data from 3602 cognitively normal participants in the National Alzheimer Coordinating Center database were analyzed. Results Descriptive statistics are presented. Multivariable linear regression analyses demonstrated score differences by age, sex, and education and were also used to create a normative calculator available online. Discussion The UDSNB 3.0 Neuropsychological Battery provides a valuable non proprietary resource for conducting research on cognitive aging and dementia.
Hiroko H Dodge - One of the best experts on this subject based on the ideXlab platform.
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expanded demographic norms for version 3 of the alzheimer disease centers Neuropsychological Test Battery in the uniform data set
Alzheimer Disease & Associated Disorders, 2020Co-Authors: Bonnie C Sachs, Sandra Weintraub, Hiroko H Dodge, Lisa L Barnes, Timothy M Hughes, Kyle Steenland, Liping Zhao, Suzanne Craft, Monica L Parker, Felicia C GoldsteinAbstract:BACKGROUND Norms for the Uniform Data Set Version 3 Neuropsychological Battery are available for cognitively normal individuals based on age, education, and sex; however, these norms do not include race. We provide expanded norms for African Americans and whites. METHODS Data from 32 Alzheimer's Disease Centers (ADCs) and ADC affiliated cohorts with global Clinical Dementia Rating Scale (CDR) Dementia Staging Instrument scores of 0 were included. Descriptive statistics for each Test were calculated by age, sex, race, and education. Multiple linear regressions were conducted to estimate the effect of each demographic variable; squared semipartial correlation coefficients measured the relative importance of variables. RESULTS There were 8313 participants (16% African American) with complete demographic information, ranging from 6600 to 7885 depending on the Test. Lower scores were found for older and less educated groups, and African Americans versus whites. Education was the strongest predictor for most Tests, followed in order by age, race, and sex. Quadratic terms were significant for age and education, indicating some nonlinearity, but did not substantially increase R. CONCLUSIONS Although race-based norms represent incomplete proxies for other sociocultural variables, the appropriate application of these norms is important given the potential to improve diagnostic accuracy and to reduce misclassification bias in cognitive disorders of aging such as Alzheimer disease.
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differentiating among stages of cognitive impairment in aging version 3 of the uniform data set uds Neuropsychological Test Battery and moca index scores
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2020Co-Authors: Hiroko H Dodge, Kwun Chuen Gary Chan, Merilee Teylan, Walter A Kukull, Felicia C Goldstein, Nicole I Wakim, Tamar Gefen, Lisa L Barnes, Bruno Giordani, Timothy M HughesAbstract:Introduction Federally funded Alzheimer's Disease Centers in the United States have been using a standardized Neuropsychological Test Battery as part of the National Alzheimer's Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the UDS replaced the previous version (V2) in 2015. We compared V2 and V3 Neuropsychological Tests with respect to their ability to distinguish among the Clinical Dementia Rating (CDR) global scores of 0, 0.5, and 1. Methods First, we matched participants receiving V2 Tests (V2 cohort) and V3 Tests (V3 cohort) in their cognitive functions using Tests common to both versions. Then, we compared receiver-operating characteristic (ROC) area under the curve in differentiating CDRs for the remaining Tests. Results Some V3 Tests performed better than V2 Tests in differentiating between CDR 0.5 and 0, but the improvement was limited to Caucasian participants. Discussion Further efforts to improve the ability for early identification of cognitive decline among diverse racial groups are required.
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version 3 of the alzheimer disease centers Neuropsychological Test Battery in the uniform data set uds
Alzheimer Disease & Associated Disorders, 2017Co-Authors: Sandra Weintraub, Merilee Teylan, Hiroko H Dodge, Felicia C Goldstein, Bruno Giordani, Lilah M Besser, Steven H Ferris, Joel H Kramer, David A Loewenstein, Daniel C MarsonAbstract:Introduction The Neuropsychological Battery of the Uniform Data Set (UDSNB) was implemented in 2005 by the National Institute on Aging (NIA) Alzheimer Disease Centers program to measure cognitive performance in dementia and mild cognitive impairment due to Alzheimer Disease. This paper describes a revision, the UDSNB 3.0. Methods The Neuropsychology Work Group of the NIA Clinical Task Force recommended revisions through a process of due diligence to address shortcomings of the original Battery. The UDSNB 3.0 covers episodic memory, processing speed, executive function, language, and constructional ability. Data from 3602 cognitively normal participants in the National Alzheimer Coordinating Center database were analyzed. Results Descriptive statistics are presented. Multivariable linear regression analyses demonstrated score differences by age, sex, and education and were also used to create a normative calculator available online. Discussion The UDSNB 3.0 Neuropsychological Battery provides a valuable non proprietary resource for conducting research on cognitive aging and dementia.