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Hyoung Suk Kim - One of the best experts on this subject based on the ideXlab platform.

  • Reply: multiple large cysts arising from Nevus comedonicus.
    Archives of plastic surgery, 2012
    Co-Authors: Hii Sun Jeong, Hye Kyung Lee, Seung-hyun Lee, Hyoung Suk Kim
    Abstract:

    We appreciate Dr. Yu Jin Kim for her insightful commentary on our recent article [1]. The additional masses that are mentioned in Dr. Yujin Kim's commentary were attached to the two masses shown on the left side of the gross specimen figure, each with its own epidermal layer [1,2]. The epidermal cyst in the center of the coronal computed tomography image is that which had the foreign body reaction noted by histology (Figs. 1, ​,2).2). Likewise, this same cyst is the one that was found to be mildly warm during pre-operative clinical examination. Fig. 1 Magnetic resonance imaging findings (T1 fat suppression image) of five epidermal cysts. Fig. 2 Histopathological findings of the central epidermal cyst showed a foreign body reaction with multiple giant cells (H&E, ×20). Our statement that cites Reference 7 was intended to describe skin appendage tumors as having pathologic findings of Nevus comedonicus [1-3]. We agree with the opinion that your article should have been more appropriately referenced in the discussion about direct pathologic findings and surgical treatments. Your advice is acknowledged and appreciated. In the present case report, we tried to present the possibility that Nevus comedonicus in the shallow epidermal layer can progress to a subcutaneous giant epidermal cyst as a late complication. In other words, Nevus comedonicus should be considered in the differential diagnosis of other deep subcutaneous tumors. Conservative treatments are aimed at reducing the formation of comedones and/or controlling infection. Considering surgical treatment, ordinary excision can be performed on localized lesions, including small pits [3,4]. In the case of an extensive lesion, wide excision and tissue expander reconstruction may be used [5]. In the present case, the dilated comedone was large enough to be explored by a probe. During exploration, the comedones seemed to have pits up to 1 cm in size, thus a wide excision with a 1 cm margin was selected in our case. Finally, we believe that the treatment modality chosen should be based on the level of the patient's discomfort, in addition to aesthetic concerns, scar formation, abscesses, and epidermal inclusion cysts.

  • Multiple large cysts arising from Nevus comedonicus.
    Archives of plastic surgery, 2012
    Co-Authors: Hii Sun Jeong, Hye Kyung Lee, Seung-hyun Lee, Hyoung Suk Kim
    Abstract:

    Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of the mesodermal part of the pilosebaceous gland. In most cases of Nevus comedonicus, an acne-like skin condition develops. Repeated inflammation can cause a morphological change to the cyst, papule, to abscess. We experienced a case of congenital Nevus comedonicus, which led to the formation of large multiple cysts. A 50-year-old man was referred with a 12.5×10 cm lobulated mass on the posterior neck and upper back. The patient had a widespread presence of Nevus comedonicus in the region ranging from the right superior chest to the posterior neck. The patient had a 30-year history of six prior excisions. A magnetic resonance imaging review led to a diagnosis of Nevus comedonicus. Surgical treatment consisted of excision of the mass and wide excision for the patch type of Nevus comedonicus around the neck. On histopathology, multiple masses were diagnosed as typical cysts containing keratinized tissue. The diffuse comedone lesions were diagnosed as Nevus comedonicus. This case shows that large, multiple cysts can occur as a long-term complication of Nevus comedonicus, and also highlights the importance of radical resection to prevent its further invagination.

  • Multiple Large Cysts Arising from Nevus
    Korean Society of Plastic and Reconstructive Surgeons, 2012
    Co-Authors: Hyoung Suk Kim, Seung-hyun Lee, Hye Kyung Lee, Hii Sun Jeong
    Abstract:

    Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of themesodermal part of the pilosebaceous gland. In most cases of Nevus comedonicus, an acnelikeskin condition develops. Repeated inflammation can cause a morphological change to thecyst, papule, to abscess. We experienced a case of congenital Nevus comedonicus, which ledto the formation of large multiple cysts. A 50-year-old man was referred with a 12.5×10 cmlobulated mass on the posterior neck and upper back. The patient had a widespread presenceof Nevus comedonicus in the region ranging from the right superior chest to the posteriorneck. The patient had a 30-year history of six prior excisions. A magnetic resonance imagingreview led to a diagnosis of Nevus comedonicus. Surgical treatment consisted of excision ofthe mass and wide excision for the patch type of Nevus comedonicus around the neck. Onhistopathology, multiple masses were diagnosed as typical cysts containing keratinized tissue.The diffuse comedone lesions were diagnosed as Nevus comedonicus. This case shows thatlarge, multiple cysts can occur as a long-term complication of Nevus comedonicus, and alsohighlights the importance of radical resection to prevent its further invagination

Hii Sun Jeong - One of the best experts on this subject based on the ideXlab platform.

  • Reply: multiple large cysts arising from Nevus comedonicus.
    Archives of plastic surgery, 2012
    Co-Authors: Hii Sun Jeong, Hye Kyung Lee, Seung-hyun Lee, Hyoung Suk Kim
    Abstract:

    We appreciate Dr. Yu Jin Kim for her insightful commentary on our recent article [1]. The additional masses that are mentioned in Dr. Yujin Kim's commentary were attached to the two masses shown on the left side of the gross specimen figure, each with its own epidermal layer [1,2]. The epidermal cyst in the center of the coronal computed tomography image is that which had the foreign body reaction noted by histology (Figs. 1, ​,2).2). Likewise, this same cyst is the one that was found to be mildly warm during pre-operative clinical examination. Fig. 1 Magnetic resonance imaging findings (T1 fat suppression image) of five epidermal cysts. Fig. 2 Histopathological findings of the central epidermal cyst showed a foreign body reaction with multiple giant cells (H&E, ×20). Our statement that cites Reference 7 was intended to describe skin appendage tumors as having pathologic findings of Nevus comedonicus [1-3]. We agree with the opinion that your article should have been more appropriately referenced in the discussion about direct pathologic findings and surgical treatments. Your advice is acknowledged and appreciated. In the present case report, we tried to present the possibility that Nevus comedonicus in the shallow epidermal layer can progress to a subcutaneous giant epidermal cyst as a late complication. In other words, Nevus comedonicus should be considered in the differential diagnosis of other deep subcutaneous tumors. Conservative treatments are aimed at reducing the formation of comedones and/or controlling infection. Considering surgical treatment, ordinary excision can be performed on localized lesions, including small pits [3,4]. In the case of an extensive lesion, wide excision and tissue expander reconstruction may be used [5]. In the present case, the dilated comedone was large enough to be explored by a probe. During exploration, the comedones seemed to have pits up to 1 cm in size, thus a wide excision with a 1 cm margin was selected in our case. Finally, we believe that the treatment modality chosen should be based on the level of the patient's discomfort, in addition to aesthetic concerns, scar formation, abscesses, and epidermal inclusion cysts.

  • Multiple large cysts arising from Nevus comedonicus.
    Archives of plastic surgery, 2012
    Co-Authors: Hii Sun Jeong, Hye Kyung Lee, Seung-hyun Lee, Hyoung Suk Kim
    Abstract:

    Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of the mesodermal part of the pilosebaceous gland. In most cases of Nevus comedonicus, an acne-like skin condition develops. Repeated inflammation can cause a morphological change to the cyst, papule, to abscess. We experienced a case of congenital Nevus comedonicus, which led to the formation of large multiple cysts. A 50-year-old man was referred with a 12.5×10 cm lobulated mass on the posterior neck and upper back. The patient had a widespread presence of Nevus comedonicus in the region ranging from the right superior chest to the posterior neck. The patient had a 30-year history of six prior excisions. A magnetic resonance imaging review led to a diagnosis of Nevus comedonicus. Surgical treatment consisted of excision of the mass and wide excision for the patch type of Nevus comedonicus around the neck. On histopathology, multiple masses were diagnosed as typical cysts containing keratinized tissue. The diffuse comedone lesions were diagnosed as Nevus comedonicus. This case shows that large, multiple cysts can occur as a long-term complication of Nevus comedonicus, and also highlights the importance of radical resection to prevent its further invagination.

  • Multiple Large Cysts Arising from Nevus
    Korean Society of Plastic and Reconstructive Surgeons, 2012
    Co-Authors: Hyoung Suk Kim, Seung-hyun Lee, Hye Kyung Lee, Hii Sun Jeong
    Abstract:

    Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of themesodermal part of the pilosebaceous gland. In most cases of Nevus comedonicus, an acnelikeskin condition develops. Repeated inflammation can cause a morphological change to thecyst, papule, to abscess. We experienced a case of congenital Nevus comedonicus, which ledto the formation of large multiple cysts. A 50-year-old man was referred with a 12.5×10 cmlobulated mass on the posterior neck and upper back. The patient had a widespread presenceof Nevus comedonicus in the region ranging from the right superior chest to the posteriorneck. The patient had a 30-year history of six prior excisions. A magnetic resonance imagingreview led to a diagnosis of Nevus comedonicus. Surgical treatment consisted of excision ofthe mass and wide excision for the patch type of Nevus comedonicus around the neck. Onhistopathology, multiple masses were diagnosed as typical cysts containing keratinized tissue.The diffuse comedone lesions were diagnosed as Nevus comedonicus. This case shows thatlarge, multiple cysts can occur as a long-term complication of Nevus comedonicus, and alsohighlights the importance of radical resection to prevent its further invagination

Hye Kyung Lee - One of the best experts on this subject based on the ideXlab platform.

  • Reply: multiple large cysts arising from Nevus comedonicus.
    Archives of plastic surgery, 2012
    Co-Authors: Hii Sun Jeong, Hye Kyung Lee, Seung-hyun Lee, Hyoung Suk Kim
    Abstract:

    We appreciate Dr. Yu Jin Kim for her insightful commentary on our recent article [1]. The additional masses that are mentioned in Dr. Yujin Kim's commentary were attached to the two masses shown on the left side of the gross specimen figure, each with its own epidermal layer [1,2]. The epidermal cyst in the center of the coronal computed tomography image is that which had the foreign body reaction noted by histology (Figs. 1, ​,2).2). Likewise, this same cyst is the one that was found to be mildly warm during pre-operative clinical examination. Fig. 1 Magnetic resonance imaging findings (T1 fat suppression image) of five epidermal cysts. Fig. 2 Histopathological findings of the central epidermal cyst showed a foreign body reaction with multiple giant cells (H&E, ×20). Our statement that cites Reference 7 was intended to describe skin appendage tumors as having pathologic findings of Nevus comedonicus [1-3]. We agree with the opinion that your article should have been more appropriately referenced in the discussion about direct pathologic findings and surgical treatments. Your advice is acknowledged and appreciated. In the present case report, we tried to present the possibility that Nevus comedonicus in the shallow epidermal layer can progress to a subcutaneous giant epidermal cyst as a late complication. In other words, Nevus comedonicus should be considered in the differential diagnosis of other deep subcutaneous tumors. Conservative treatments are aimed at reducing the formation of comedones and/or controlling infection. Considering surgical treatment, ordinary excision can be performed on localized lesions, including small pits [3,4]. In the case of an extensive lesion, wide excision and tissue expander reconstruction may be used [5]. In the present case, the dilated comedone was large enough to be explored by a probe. During exploration, the comedones seemed to have pits up to 1 cm in size, thus a wide excision with a 1 cm margin was selected in our case. Finally, we believe that the treatment modality chosen should be based on the level of the patient's discomfort, in addition to aesthetic concerns, scar formation, abscesses, and epidermal inclusion cysts.

  • Multiple large cysts arising from Nevus comedonicus.
    Archives of plastic surgery, 2012
    Co-Authors: Hii Sun Jeong, Hye Kyung Lee, Seung-hyun Lee, Hyoung Suk Kim
    Abstract:

    Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of the mesodermal part of the pilosebaceous gland. In most cases of Nevus comedonicus, an acne-like skin condition develops. Repeated inflammation can cause a morphological change to the cyst, papule, to abscess. We experienced a case of congenital Nevus comedonicus, which led to the formation of large multiple cysts. A 50-year-old man was referred with a 12.5×10 cm lobulated mass on the posterior neck and upper back. The patient had a widespread presence of Nevus comedonicus in the region ranging from the right superior chest to the posterior neck. The patient had a 30-year history of six prior excisions. A magnetic resonance imaging review led to a diagnosis of Nevus comedonicus. Surgical treatment consisted of excision of the mass and wide excision for the patch type of Nevus comedonicus around the neck. On histopathology, multiple masses were diagnosed as typical cysts containing keratinized tissue. The diffuse comedone lesions were diagnosed as Nevus comedonicus. This case shows that large, multiple cysts can occur as a long-term complication of Nevus comedonicus, and also highlights the importance of radical resection to prevent its further invagination.

  • Multiple Large Cysts Arising from Nevus
    Korean Society of Plastic and Reconstructive Surgeons, 2012
    Co-Authors: Hyoung Suk Kim, Seung-hyun Lee, Hye Kyung Lee, Hii Sun Jeong
    Abstract:

    Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of themesodermal part of the pilosebaceous gland. In most cases of Nevus comedonicus, an acnelikeskin condition develops. Repeated inflammation can cause a morphological change to thecyst, papule, to abscess. We experienced a case of congenital Nevus comedonicus, which ledto the formation of large multiple cysts. A 50-year-old man was referred with a 12.5×10 cmlobulated mass on the posterior neck and upper back. The patient had a widespread presenceof Nevus comedonicus in the region ranging from the right superior chest to the posteriorneck. The patient had a 30-year history of six prior excisions. A magnetic resonance imagingreview led to a diagnosis of Nevus comedonicus. Surgical treatment consisted of excision ofthe mass and wide excision for the patch type of Nevus comedonicus around the neck. Onhistopathology, multiple masses were diagnosed as typical cysts containing keratinized tissue.The diffuse comedone lesions were diagnosed as Nevus comedonicus. This case shows thatlarge, multiple cysts can occur as a long-term complication of Nevus comedonicus, and alsohighlights the importance of radical resection to prevent its further invagination

Seung-hyun Lee - One of the best experts on this subject based on the ideXlab platform.

  • Reply: multiple large cysts arising from Nevus comedonicus.
    Archives of plastic surgery, 2012
    Co-Authors: Hii Sun Jeong, Hye Kyung Lee, Seung-hyun Lee, Hyoung Suk Kim
    Abstract:

    We appreciate Dr. Yu Jin Kim for her insightful commentary on our recent article [1]. The additional masses that are mentioned in Dr. Yujin Kim's commentary were attached to the two masses shown on the left side of the gross specimen figure, each with its own epidermal layer [1,2]. The epidermal cyst in the center of the coronal computed tomography image is that which had the foreign body reaction noted by histology (Figs. 1, ​,2).2). Likewise, this same cyst is the one that was found to be mildly warm during pre-operative clinical examination. Fig. 1 Magnetic resonance imaging findings (T1 fat suppression image) of five epidermal cysts. Fig. 2 Histopathological findings of the central epidermal cyst showed a foreign body reaction with multiple giant cells (H&E, ×20). Our statement that cites Reference 7 was intended to describe skin appendage tumors as having pathologic findings of Nevus comedonicus [1-3]. We agree with the opinion that your article should have been more appropriately referenced in the discussion about direct pathologic findings and surgical treatments. Your advice is acknowledged and appreciated. In the present case report, we tried to present the possibility that Nevus comedonicus in the shallow epidermal layer can progress to a subcutaneous giant epidermal cyst as a late complication. In other words, Nevus comedonicus should be considered in the differential diagnosis of other deep subcutaneous tumors. Conservative treatments are aimed at reducing the formation of comedones and/or controlling infection. Considering surgical treatment, ordinary excision can be performed on localized lesions, including small pits [3,4]. In the case of an extensive lesion, wide excision and tissue expander reconstruction may be used [5]. In the present case, the dilated comedone was large enough to be explored by a probe. During exploration, the comedones seemed to have pits up to 1 cm in size, thus a wide excision with a 1 cm margin was selected in our case. Finally, we believe that the treatment modality chosen should be based on the level of the patient's discomfort, in addition to aesthetic concerns, scar formation, abscesses, and epidermal inclusion cysts.

  • Multiple large cysts arising from Nevus comedonicus.
    Archives of plastic surgery, 2012
    Co-Authors: Hii Sun Jeong, Hye Kyung Lee, Seung-hyun Lee, Hyoung Suk Kim
    Abstract:

    Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of the mesodermal part of the pilosebaceous gland. In most cases of Nevus comedonicus, an acne-like skin condition develops. Repeated inflammation can cause a morphological change to the cyst, papule, to abscess. We experienced a case of congenital Nevus comedonicus, which led to the formation of large multiple cysts. A 50-year-old man was referred with a 12.5×10 cm lobulated mass on the posterior neck and upper back. The patient had a widespread presence of Nevus comedonicus in the region ranging from the right superior chest to the posterior neck. The patient had a 30-year history of six prior excisions. A magnetic resonance imaging review led to a diagnosis of Nevus comedonicus. Surgical treatment consisted of excision of the mass and wide excision for the patch type of Nevus comedonicus around the neck. On histopathology, multiple masses were diagnosed as typical cysts containing keratinized tissue. The diffuse comedone lesions were diagnosed as Nevus comedonicus. This case shows that large, multiple cysts can occur as a long-term complication of Nevus comedonicus, and also highlights the importance of radical resection to prevent its further invagination.

  • Multiple Large Cysts Arising from Nevus
    Korean Society of Plastic and Reconstructive Surgeons, 2012
    Co-Authors: Hyoung Suk Kim, Seung-hyun Lee, Hye Kyung Lee, Hii Sun Jeong
    Abstract:

    Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of themesodermal part of the pilosebaceous gland. In most cases of Nevus comedonicus, an acnelikeskin condition develops. Repeated inflammation can cause a morphological change to thecyst, papule, to abscess. We experienced a case of congenital Nevus comedonicus, which ledto the formation of large multiple cysts. A 50-year-old man was referred with a 12.5×10 cmlobulated mass on the posterior neck and upper back. The patient had a widespread presenceof Nevus comedonicus in the region ranging from the right superior chest to the posteriorneck. The patient had a 30-year history of six prior excisions. A magnetic resonance imagingreview led to a diagnosis of Nevus comedonicus. Surgical treatment consisted of excision ofthe mass and wide excision for the patch type of Nevus comedonicus around the neck. Onhistopathology, multiple masses were diagnosed as typical cysts containing keratinized tissue.The diffuse comedone lesions were diagnosed as Nevus comedonicus. This case shows thatlarge, multiple cysts can occur as a long-term complication of Nevus comedonicus, and alsohighlights the importance of radical resection to prevent its further invagination

Rudolf Happle - One of the best experts on this subject based on the ideXlab platform.

  • Trichilemmal cyst Nevus: a new complex organoid epidermal Nevus.
    Journal of The American Academy of Dermatology, 2007
    Co-Authors: Iliana Tantcheva-poór, Katja Reinhold, Thomas Krieg, Rudolf Happle
    Abstract:

    A 31-year-old woman had an organoid Nevus characterized by multiple trichilemmal cysts arranged in a bandlike pattern. The involved streaks followed Blaschko's lines and were covered, in addition, by multiple filiform hyperkeratoses and comedo-like plugs. Some histopathologic features of this complex Nevus were reminiscent of those of well-established organoid nevi such as Nevus comedonicus, porokeratotic eccrine Nevus, or hair follicle Nevus, but the presence of multiple large trichilemmal cysts was a conspicuously distinctive abnormality. Consequently, we propose for this new organoid Nevus the names " trichilemmal cyst Nevus" or "Nevus trichilemmocysticus."

  • Epidermal Nevus syndromes.
    Seminars in Dermatology, 1995
    Co-Authors: Rudolf Happle
    Abstract:

    A clinical entity called "the epidermal Nevus syndrome" does not exist. Rather, there are various epidermal Nevus syndromes that can be distinguished by clinical, histopathological, and genetic criteria. In this review, five distinct epidermal Nevus syndromes, recognizable by different types of associated epithelial nevi, are described. The Schimmelpenning syndrome is characterized by a sebaceous Nevus associated with cerebral anomalies, coloboma, and lipodermoid of the conjunctiva. By contrast, cataracts are a prominent feature of the Nevus comedonicus syndrome. The pigmented hairy epidermal Nevus syndrome includes Becker Nevus, ipsilateral hypoplasia of the breast, and skeletal defects such as scoliosis. In the Proteus syndrome, the associated epidermal Nevus is of a flat, velvety, nonorganoid type. The CHILD syndrome occurs almost exclusively in girls. The associated CHILD Nevus shows unique features such as a diffuse form of lateralization, ptychotropism, and microscopic changes of verruciform xanthoma. The five epidermal Nevus syndromes differ in their genetic basis. The Schimmelpenning and Nevus comedonicus syndromes are most likely nonhereditary traits. By contrast, the pigmented hairy epidermal Nevus syndrome and the Proteus syndrome may be explained by paradominant inheritance. The CHILD syndrome is caused by an X-linked dominant mutation exerting a lethal effect on male embryos. A correct diagnosis of these phenotypes is important for both recognition and treatment of associated anomalies as well as for genetic counseling.