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Mosaad A Abdelwahhab - One of the best experts on this subject based on the ideXlab platform.
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antioxidant property of Nigella sativa black cumin and syzygium aromaticum clove in rats during aflatoxicosis
Journal of Applied Toxicology, 2005Co-Authors: Mosaad A AbdelwahhabAbstract:Aflatoxins, a group of closely related, extremely toxic mycotoxins produced by Aspergillus flavus and A. parasiticus, can occur as natural contaminants of foods and feeds. Aflatoxins have been shown to be hepatotoxic, carcinogenic, mutagenic and teratogenic to different animal species. Nigella sativa (black cumin) and Syzygium aromaticum (clove) oil are used for the treatment of inflammatory diseases and have antioxidant properties. The aim of this study was to investigate the ability of these volatile oils to scavenge free radicals generated during aflatoxicosis. Sixty male rats were divided into six treatment groups, including a control group, and the groups were treated for 30 days with Nigella sativa and Syzygium aromaticum oils with or without aflatoxin. Blood samples were collected at the end of the experimental period for haematological and biochemical analysis. The results indicated that exposure to aflatoxins resulted in haematological and biochemical changes typical for aflatoxicosis. Treatment with Nigella sativa and Syzygium aromaticum oil of rats fed an aflatoxin-contaminated diet resulted in significant protection against aflatoxicosis. Moreover, Nigella sativa oil was found to be more effective than Syzygium aromaticum oil in restoring the parameters that were altered by aflatoxin in rats. Copyright © 2005 John Wiley & Sons, Ltd.
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antioxidant property of Nigella sativa black cumin and syzygium aromaticum clove in rats during aflatoxicosis
Journal of Applied Toxicology, 2005Co-Authors: Mosaad A Abdelwahhab, Soher E AlyAbstract:Aflatoxins, a group of closely related, extremely toxic mycotoxins produced by Aspergillus flavus and A. parasiticus, can occur as natural contaminants of foods and feeds. Aflatoxins have been shown to be hepatotoxic, carcinogenic, mutagenic and teratogenic to different animal species. Nigella sativa (black cumin) and Syzygium aromaticum (clove) oil are used for the treatment of inflammatory diseases and have antioxidant properties. The aim of this study was to investigate the ability of these volatile oils to scavenge free radicals generated during aflatoxicosis. Sixty male rats were divided into six treatment groups, including a control group, and the groups were treated for 30 days with Nigella sativa and Syzygium aromaticum oils with or without aflatoxin. Blood samples were collected at the end of the experimental period for haematological and biochemical analysis. The results indicated that exposure to aflatoxins resulted in haematological and biochemical changes typical for aflatoxicosis. Treatment with Nigella sativa and Syzygium aromaticum oil of rats fed an aflatoxin-contaminated diet resulted in significant protection against aflatoxicosis. Moreover, Nigella sativa oil was found to be more effective than Syzygium aromaticum oil in restoring the parameters that were altered by aflatoxin in rats.
Soher E Aly - One of the best experts on this subject based on the ideXlab platform.
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antioxidant property of Nigella sativa black cumin and syzygium aromaticum clove in rats during aflatoxicosis
Journal of Applied Toxicology, 2005Co-Authors: Mosaad A Abdelwahhab, Soher E AlyAbstract:Aflatoxins, a group of closely related, extremely toxic mycotoxins produced by Aspergillus flavus and A. parasiticus, can occur as natural contaminants of foods and feeds. Aflatoxins have been shown to be hepatotoxic, carcinogenic, mutagenic and teratogenic to different animal species. Nigella sativa (black cumin) and Syzygium aromaticum (clove) oil are used for the treatment of inflammatory diseases and have antioxidant properties. The aim of this study was to investigate the ability of these volatile oils to scavenge free radicals generated during aflatoxicosis. Sixty male rats were divided into six treatment groups, including a control group, and the groups were treated for 30 days with Nigella sativa and Syzygium aromaticum oils with or without aflatoxin. Blood samples were collected at the end of the experimental period for haematological and biochemical analysis. The results indicated that exposure to aflatoxins resulted in haematological and biochemical changes typical for aflatoxicosis. Treatment with Nigella sativa and Syzygium aromaticum oil of rats fed an aflatoxin-contaminated diet resulted in significant protection against aflatoxicosis. Moreover, Nigella sativa oil was found to be more effective than Syzygium aromaticum oil in restoring the parameters that were altered by aflatoxin in rats.
Pierre S Haddad - One of the best experts on this subject based on the ideXlab platform.
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Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats.
Journal of Ethnopharmacology, 2009Co-Authors: Bouchra Meddah, Yahia Cherrah, Robert Ducroc, Moulay El Abbes Faouzi, Bruno Eto, Lahcen Mahraoui, Ali Benhaddou-andaloussi, Louis C. Martineau, Pierre S HaddadAbstract:Abstract Aim of the study Nigella sativa L. (Ranunculaceae) seeds have been used traditionally for centuries, notably for treating diabetes. Materials and methods We studied the effects of the crude aqueous extract of Nigella sativa seeds on intestinal glucose absorption in vitro using a short-circuit current technique and in vivo using an oral glucose tolerance test. Results The aqueous extract of Nigella sativa (0.1 pg/ml to 100 ng/ml) exerted dose-dependent inhibition of sodium-dependent glucose transport across isolated rat jejunum. Maximal inhibition exceeded 80% and IC50 was close to 10 pg/ml. An oral glucose tolerance test was carried out in rats after the initial dose and after a 6-week treatment of Nigella sativa (2 g/(kg day)), and compared to metformin (300 mg/(kg day)). Chronic Nigella sativa treatment improved glucose tolerance as efficiently as metformin. Nigella sativa and metformin also reduced body weight without any toxic effect. Conclusions To our knowledge, this is the first demonstration that Nigella sativa directly inhibits the electrogenic intestinal absorption of glucose in vitro. Together with the observed improvement of glucose tolerance and body weight in rats after chronic oral administration in vivo, these effects further validate the traditional use of Nigella sativa seeds against diabetes.
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the petroleum ether extract of Nigella sativa exerts lipid lowering and insulin sensitizing actions in the rat
Journal of Ethnopharmacology, 2004Co-Authors: Phuong Mai Le, Ali Benhaddouandaloussi, A Settaf, Pierre S Haddad, Aziz Elimadi, Yahia CherrahAbstract:Abstract We studied the effect of a 4-week intragastric gavage with a petroleum ether extract of Nigella sativa seeds on blood glucose, insulin and lipids in the normal rat. Petroleum ether extract caused a 25% reduction in food intake that translated into a transient weight loss. No sign of toxicity of the plant could be seen in vivo or in vitro. Fasting plasma glucose remained stable throughout Nigella sativa treatment. At the end of the 4-week treatment, Nigella sativa -treated rats had lower fasting plasma levels of insulin and triglycerides, and higher HDL-cholesterol as compared to pair-fed controls. Response to insulin was evaluated in hepatocytes isolated from animals of all groups by Western blot analysis of phosphorylated MAPK p44/42erk and PKB. In vivo Nigella sativa treatment resulted in greater dose-dependent activation of MAPK and PKB in response to insulin. These results suggest that the petroleum ether extract of Nigella sativa has a slight anorexic effect, and that it contains the hypolipidemic activity previously obtained with the plant. More significantly, our data demonstrate that in vivo treatment with the petroleum ether extract exerts an insulin-sensitizing action by enhancing the activity of the two major intracellular signal transduction pathways of the hormone’s receptor.
M. Akram Khan - One of the best experts on this subject based on the ideXlab platform.
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Chemical composition and medicinal properties of Nigella sativa Linn.
InflammoPharmacology, 1999Co-Authors: M. Akram KhanAbstract:The black cumin or Nigella sativa L. seeds have many acclaimed medicinal properties such as bronchodilatory, hypotensive, antibacterial, antifungal, analgesic, anti-inflammatory and immunopotentiating and are universally accepted as a panacea. This review article has surveyed the relevant literature on Nigella sativa from 1960-1998 and examines the scientific evidence for these medicinal claims and highlights areas in need of research.
Wang Yan - One of the best experts on this subject based on the ideXlab platform.
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Chemical Components of Xinjiang Uyghur Medicine Nigella Glandulifera Seed
Shanghai Journal of Traditional Chinese Medicine, 2008Co-Authors: Wang YanAbstract:Objective To study the chemical constituents of Nigella glandulifera seed, a Xinjiang traditional Uyghur Medicine. Methods The Nigella glandulifera seed was chemically separated by NMR and structural identification by GC-MS. Results Ten compounds were isolated from Nigella glandulifera seed. Conclusion They were Kaempferol 3-o-[β-D -glucopyranosyl-(1→2)- β-D-galactopyranosyl-(1→2)-glucopy ranosyl], Daucosterol, Rutin, Campesterol, Fuzitine, Hexadecanoicacid, Nigellamose, Nigeglanoside, Cholesterol, Stigmasterol.
