The Experts below are selected from a list of 666 Experts worldwide ranked by ideXlab platform
Mantang Liu - One of the best experts on this subject based on the ideXlab platform.
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efficacy of bipap ventilator combined with Nikethamide in the treatment of chronic obstructive pulmonary disease complicated by type ii respiratory failure
国际医药卫生导报, 2017Co-Authors: Mantang LiuAbstract:Objective To observe the efficacy of non-invasive bi-level positive airway pressure (BiPAP) ventilator combined with Nikethamide in the treatment of chronic obstructive pulmonary disease (COPD) complicated by type Ⅱ respiratory failure. Methods 82 patients with COPD complicated by type Ⅱ respiratory failure were randomly divided into two groups, 41 cases in each group. Two groups received conventional treatment, control group was treated with Nikethamide, and observation group was treated with BiPAP ventilator on the basis of control group. The blood gas analysis results and efficacy of two groups were compared. Results After 72 h of treatment, the levels of PaO2, SaO2, PaCO2 of observation group significantly improved compared with control group (P<0.05). The curative effect of observation group significantly increased compared with control group (P<0.05). Conclusion BiPAP ventilator combined with Nikethamide for treating COPD complicated by type Ⅱ respiratory failure can improve curative effect, improve blood gas analysis, and promote patients’ recovery. Key words: BiPAP ventilator; Nikethamide; Chronic obstructive pulmonary disease; Type Ⅱ respiratory failure
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Efficacy of BiPAP ventilator combined with Nikethamide in the treatment of chronic obstructive pulmonary disease complicated by type II respiratory failure
2017Co-Authors: Mantang LiuAbstract:Objective To observe the efficacy of non-invasive bi-level positive airway pressure (BiPAP) ventilator combined with Nikethamide in the treatment of chronic obstructive pulmonary disease (COPD) complicated by type Ⅱ respiratory failure. Methods 82 patients with COPD complicated by type Ⅱ respiratory failure were randomly divided into two groups, 41 cases in each group. Two groups received conventional treatment, control group was treated with Nikethamide, and observation group was treated with BiPAP ventilator on the basis of control group. The blood gas analysis results and efficacy of two groups were compared. Results After 72 h of treatment, the levels of PaO2, SaO2, PaCO2 of observation group significantly improved compared with control group (P
Yulan Chai - One of the best experts on this subject based on the ideXlab platform.
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Efficacy and safety of BiPAP ventilator combined with Nikethamide for the chronic obstructive pulmonary disease complicated with type II respiratory failure
Chinese Journal of Primary Medicine and Pharmacy, 2015Co-Authors: Yulan ChaiAbstract:Objective To observe the efficacy and safety of BiPAP ventilator combined with Nikethamide for the chronic obstructive pulmonary disease (COPD) complicated with type II respiratory failure. Methods 76 COPD patients complicated with type II respiratory failure were selected as the research subjects, they were randomly divided into two groups by single blind and randomized method, 38 cases in each group.The control group was treated with Nikethamide therapy, while the observation group used BiPAP combined with mechanical ventilation therapy.The clinical therapeutic effect and adverse reactions were analyzed and compared in the two groups. Results The total effective rate in the observation group was 92.11%, which was significantly higher than 68.42% in the control group (χ2=10.54, P 0.05). Conclusion BiPAP ventilator combined with Nikethamide meters has remarkable curative effect and high safety in treatment of COPD patients complicated with type II respiratory failure, which is worthy of clinical reference and popularization. Key words: Ventilator; Nikethamide; Respiratory failure
Yuxian Zhang - One of the best experts on this subject based on the ideXlab platform.
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Effect of quercetin-3-O-sambubioside isolated from Eucommia ulmoides male flowers on spontaneous activity and convulsion rate in mice.
Planta medica, 2014Co-Authors: Lipeng Yang, Shaoyang Liu, Dong-qing Fei, Min Zhang, Yuxian ZhangAbstract:The purpose of this study was to evaluate the effects of quercetin-3-O-sambubioside on the neural system. Quercetin-3-O-sambubioside is a monomeric compound found in Eucommia ulmoides male flowers from which it was extracted using a system solvent method. In the experiments, spontaneous activity and convulsion rate in mice were recorded, and quercetin-3-O-sambubioside shows eminent effects similar to Nikethamide on increasing spontaneous activity and stimulating the nerve center to enhance excitement. These findings are indicative of the powerful ability of quercetin-3-O-sambubioside to promote the stimulation of the nerve center.
Anant R Kapdi - One of the best experts on this subject based on the ideXlab platform.
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Pd/PTABS: An Efficient Catalytic System for the Aminocarbonylation of a Sugar-Protected Nucleoside
Synthesis, 2019Co-Authors: Shatrughn Bhilare, Vinayak V. Gaikwad, Gaurav R. Gupta, Jagrut Shah, Yogesh S. Sanghvi, Bhalchandra M. Bhanage, Anant R KapdiAbstract:A highly efficient and mild protocol for the aminocarbonylation of a nucleoside is developed by employing palladium/(1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate (Pd/PTABS) as the catalytic system. The developed aminocarbonylation methodology employs CO gas at a relatively low temperature of 60 °C and is suitable for a wide range of amines, including (heteroaryl)benzylic, aliphatic acyclic, alicyclic and secondary amines. This protocol is also utilized for the synthesis of a sangivamycin precursor by carrying out the Pd-catalyzed amination and aminocarbonylation simultaneously. The utility of this protocol is further demonstrated by the synthesis of the drugs moclobemide and Nikethamide.
Zhi-bin Qian - One of the best experts on this subject based on the ideXlab platform.
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Role of 5-HT(2A) receptor in increase in respiratory-related rhythmic discharge activity by Nikethamide in neonatal rat transverse medullary slices
Sheng li xue bao : [Acta physiologica Sinica], 2008Co-Authors: Zhi-bin QianAbstract:To investigate the effects of Nikethamide on the generation and modulation of rhythmic respiration of neonatal rats and the role of 5-HT(2A) receptor in this course, experiments were performed on the transverse medullary slices of neonatal rats (both sexes, 1-3 d) in vitro. The slices containing the medial region of the nucleus retrofacialis (mNRF) with the hypoglossal nerve rootlets were prepared in which the respiratory-related rhythmic discharge activity (RRDA) was recorded from the hypoglossal nerve rootlets by suction electrode. The possible role of Nikethamide on RRDA was investigated by administration of an agonist of 5-HT(2A) receptor, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), and an antagonist of 5-HT(2A) receptor, ketanserine, dissolved in modified Krebos solution (MKS). Thirty slices were randomly divided into five groups: Group 1: the slices were perfused with different concentrations of Nikethamide (0.5, 1, 3, 5, 7, 10 μg/mL), and the most effective concentration was selected; Group 2: the slices were perfused with DOI (40 μmol/L); Group 3: the slices were perfused with ketanserine (40 μmol/L); Group 4: the slices were perfused with ketanserine + DOI; Group 5: the slices were perfused with Nikethamide, then perfused with Nikethamide + ketanserine after washout of Nikethamide. Nikethamide increased RRDA in transverse medullary slices at 0.5-7 μg/mL, and 5 μg/mL was the most effective concentration. DOI increased RRDA with prolonged inspiratory time (TI), increased integral amplitude (IA), and shortened respiratory cycle (RC). Ketanserine decreased RRDA with shortened TI, decreased IA and prolonged RC. Ketanserine + DOI had no significant effects on RRDA. The effects of Nikethamide on RC and IA were totally and partially reversed by additional application of ketanserine, but the effect of Nikethamide on TI was not influenced by ketanserine. It is proposed that Nikethamide increases RRDA partly via 5-HT(2A) receptors.
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GABA A receptor participates in respiratory enhancement induced by Nikethamide in neonatal rats
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2008Co-Authors: Zhi-bin QianAbstract:OBJECTIVE To investigate the role of GABA A receptor in Nikethamide-induced respiratory enhancement in the medullary slices of neonatal rats. METHODS Ex vivo medullary slices of neonatal rats (1 to 3 days old) containing the medial region of the nucleus retrofacialis with the hypoglossal nerve rootlets were prepared and perfused with modified Kreb's solution to record respiration-related rhythmic discharge activity (RRDA) from the hypoglossal nerve rootlets using suction electrodes. Thirty RRDA-positive slices were randomized into 5 equal groups and perfused with Nikethamide (at concentrations of 0.5, 1, 3, 5, 7, and 10 microg/ml with the optimal Nikethamide concentration determined), GABA (at 10, 20, 40, and 60 micromol/ to determine the optimal concentration), 10 micromol/ bicuculline, 10 micromol/ bicuculline plus 40 micromol/L GABA, and 5 microg/ml Nikethamide followed by 5 microg/ml Nikethamide plus 10 micromol/ bicuculline after wash out, respectively. RESULTS Nikethamide increased RRDA at the concentrations of 0.5-7 microg/ml, and 5 microg/ml Nikethamide showed the most distinct effect on the inspiratory time (TI), integral amplitude (IA), and respiratory cycle (RC). GABA at 40 micromol/ showed the most effective inhibition of RRDA in terms of TI, IA, and RC. Bicuculline at 10 micromol/ could increase the IA, TI and RC, but the combination of 10 micromol/ bicuculline and 40 micromol/ GABA had no significant effects on RRDA. Compared with Nikethamide used alone, Nikethamide plus bicuculline significantly increased TI and IA without affecting RC. CONCLUSION Nikethamide can enhance RRDA of the hypoglossal nerve rootlets in the medullary slices of neonatal rats, and the effect can be partially mediated by the GABA A receptor.