The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform

Serge Chiron - One of the best experts on this subject based on the ideXlab platform.

  • Sulfate radical anion oxidation of diclofenac and sulfamethoxazole for water decontamination
    Chemical Engineering Journal, 2012
    Co-Authors: Moussa Mahdi Ahmed, Stéphane Barbati, Pierre Doumenq, Serge Chiron
    Abstract:

    Abstract This study aimed at investigating the reactivity of aniline-based pharmaceuticals with sulfate radical anion generated by the peroxymonosulfate (PMS)/Cobalt(II) system and by taking sulfamethoxazole and diclofenac as probe compounds. Transformation pathways were proposed for both pharmaceuticals relying on the identification of the main reaction intermediate products using liquid chromatography coupled to time of flight mass spectrometry. For diclofenac, the major transformation pathway led to the formation of a quinone imine Derivative while for sulfamethoxazole a Nitro Derivative was obtained as the major intermediate. However, in both cases, oxidative reactions started with the formation of a N-centered radical probably through an one-electron transfer from the pharmaceutical to sulfate radical anion. This was followed by further multistep degradation involving decarboxylation, hydroxylation and bond cleavage reactions in route to mineralization. From a kinetic point of view, aniline-based pharmaceuticals quickly reacted with sulfate radical anion with second order kinetic rate constants in the 9–10 × 10 9  M −1  s −1 range. Sulfate radical-based technologies show promising results for the removal of these particular pharmaceuticals from wastewater treatment plant effluents mainly because of the higher selectivity of sulfate radical anion over hydroxyl radical, limiting radical scavenging by natural organic matter and allowing for higher abatement and mineralization rates.

  • Sulfate radical anion oxidation of diclofenac and sulfamethoxazole for water decontamination
    Chemical Engineering Journal, 2012
    Co-Authors: Moussa Mahdi Ahmed, Stéphane Barbati, Pierre Doumenq, Serge Chiron
    Abstract:

    This study aimed at investigating the reactivity of aniline-based pharmaceuticals with sulfate radical anion generated by the peroxymonosulfate (PMS)/Cobalt(II) system and by taking sulfamethoxazole and diclofenac as probe compounds. Transformation pathways were proposed for both pharmaceuticals relying on the identification of the main reaction intermediate products using liquid chromatography coupled to time of flight mass spectrometry. For diclofenac, the major transformation pathway led to the formation of a quinone imine Derivative while for sulfamethoxazole a Nitro Derivative was obtained as the major intermediate. However, in both cases, oxidative reactions started with the formation of a N-centered radical probably through an one-electron transfer from the pharmaceutical to sulfate radical anion. This was followed by further multistep degradation involving decarboxylation, hydroxylation and bond cleavage reactions in route to mineralization. From a kinetic point of view, aniline-based pharmaceuticals quickly reacted with sulfate radical anion with second order kinetic rate constants in the 9-10 x 10(9) M-1 s(-1) Sulfate radical-based technologies show promising results for the removal of these particular pharmaceuticals from wastewater treatment plant effluents mainly because of the higher selectivity of sulfate radical anion over hydroxyl radical, limiting radical scavenging by natural organic matter and allowing for higher abatement and mineralization rates. (C) 2012 Elsevier B.V. All rights reserved.

Moussa Mahdi Ahmed - One of the best experts on this subject based on the ideXlab platform.

  • Sulfate radical anion oxidation of diclofenac and sulfamethoxazole for water decontamination
    Chemical Engineering Journal, 2012
    Co-Authors: Moussa Mahdi Ahmed, Stéphane Barbati, Pierre Doumenq, Serge Chiron
    Abstract:

    Abstract This study aimed at investigating the reactivity of aniline-based pharmaceuticals with sulfate radical anion generated by the peroxymonosulfate (PMS)/Cobalt(II) system and by taking sulfamethoxazole and diclofenac as probe compounds. Transformation pathways were proposed for both pharmaceuticals relying on the identification of the main reaction intermediate products using liquid chromatography coupled to time of flight mass spectrometry. For diclofenac, the major transformation pathway led to the formation of a quinone imine Derivative while for sulfamethoxazole a Nitro Derivative was obtained as the major intermediate. However, in both cases, oxidative reactions started with the formation of a N-centered radical probably through an one-electron transfer from the pharmaceutical to sulfate radical anion. This was followed by further multistep degradation involving decarboxylation, hydroxylation and bond cleavage reactions in route to mineralization. From a kinetic point of view, aniline-based pharmaceuticals quickly reacted with sulfate radical anion with second order kinetic rate constants in the 9–10 × 10 9  M −1  s −1 range. Sulfate radical-based technologies show promising results for the removal of these particular pharmaceuticals from wastewater treatment plant effluents mainly because of the higher selectivity of sulfate radical anion over hydroxyl radical, limiting radical scavenging by natural organic matter and allowing for higher abatement and mineralization rates.

  • Sulfate radical anion oxidation of diclofenac and sulfamethoxazole for water decontamination
    Chemical Engineering Journal, 2012
    Co-Authors: Moussa Mahdi Ahmed, Stéphane Barbati, Pierre Doumenq, Serge Chiron
    Abstract:

    This study aimed at investigating the reactivity of aniline-based pharmaceuticals with sulfate radical anion generated by the peroxymonosulfate (PMS)/Cobalt(II) system and by taking sulfamethoxazole and diclofenac as probe compounds. Transformation pathways were proposed for both pharmaceuticals relying on the identification of the main reaction intermediate products using liquid chromatography coupled to time of flight mass spectrometry. For diclofenac, the major transformation pathway led to the formation of a quinone imine Derivative while for sulfamethoxazole a Nitro Derivative was obtained as the major intermediate. However, in both cases, oxidative reactions started with the formation of a N-centered radical probably through an one-electron transfer from the pharmaceutical to sulfate radical anion. This was followed by further multistep degradation involving decarboxylation, hydroxylation and bond cleavage reactions in route to mineralization. From a kinetic point of view, aniline-based pharmaceuticals quickly reacted with sulfate radical anion with second order kinetic rate constants in the 9-10 x 10(9) M-1 s(-1) Sulfate radical-based technologies show promising results for the removal of these particular pharmaceuticals from wastewater treatment plant effluents mainly because of the higher selectivity of sulfate radical anion over hydroxyl radical, limiting radical scavenging by natural organic matter and allowing for higher abatement and mineralization rates. (C) 2012 Elsevier B.V. All rights reserved.

Philippe Tréchot - One of the best experts on this subject based on the ideXlab platform.

  • A case of nicorandil-induced unilateral corneal ulceration.
    International wound journal, 2013
    Co-Authors: F Trechot, Nadine Petitpain, Benjamine Batta, Marie C Bazard, Karine Angioi, Philippe Tréchot
    Abstract:

    Nicorandil, a second-generation Nitro Derivative, has been reported to induce single or multiple ulcerations in many locations, including oral, anal, perianal, vulvovaginal, perivulval, penile, gastrointestinal, colic, peristomal and skin locations. Ocular locations are now highly suspected. Herein, we report the case of a 78-year-old woman who experienced corneal ulceration at second cataract surgery (right eye) while being treated with nicorandil for 3 years. Four years before, she had had an uneventful first cataract surgery (left eye). The ulcers healed within 6 weeks after simple withdrawal of nicorandil, an expected delay for this type of chemical ulcer. The substitution of nicorandil with classic nitric oxide donors has already been done without complication. Surgical intervention is unnecessary and inappropriate. Case reports of ocular side effects induced by nicorandil are rare and probably underestimated.

  • Nicorandil and ulceration: how to dig the furrow
    European journal of dermatology : EJD, 2013
    Co-Authors: Philippe Tréchot, Nadine Petitpain, Jean-françois Cuny, Catherine Laurain, Nicolas Gambier, Annick Barbaud, Jean-luc Schmutz
    Abstract:

    Nicorandil (Adancor®, Ikorel®, etc) is an original vasodilator, used to control angina by decreasing cardiac pre-load and afterload. Nicorandil is an association of nitrates and potassium channel activators (nicotinamide) and is considered a second-generation Nitro-Derivative. The nicotinamide moiety is also present in its metabolites [1]. Initially introduced in Japan (1984) and later in Europe, Asia (1994), nicorandil was found to be involved in the induction of ulcers in 1997 [2].Subsequent [...]

F. Rodríguez-caabeiro - One of the best experts on this subject based on the ideXlab platform.

  • Ultrastructural alterations induced by nifurtimox and another Nitro Derivative on epimastigotes of Trypanosoma cruzi
    Parasitology Research, 2002
    Co-Authors: S. Muelas-serrano, J. Pérez-serrano, A. Gómez-barrio, V. Arán, F. Rodríguez-caabeiro
    Abstract:

    We report the ultrastructural alterations induced on epimastigotes by nifurtimox and 5-Nitro-2-thienyl-malononitrile (5NO_2TM), a novel compound with anti- Trypanosoma cruzi activity. Parasites treated with concentrations of nifurtimox lower than usually employed for this kind of study showed vacuolisation, alterations of the mitochondria, the nucleus and the ribosomes. 5NO_2TM caused the same kind of damage, but to a greater degree. This result correlates with the fact that cultures treated with this compound experienced a greater loss of viability.

Pierre Doumenq - One of the best experts on this subject based on the ideXlab platform.

  • Sulfate radical anion oxidation of diclofenac and sulfamethoxazole for water decontamination
    Chemical Engineering Journal, 2012
    Co-Authors: Moussa Mahdi Ahmed, Stéphane Barbati, Pierre Doumenq, Serge Chiron
    Abstract:

    Abstract This study aimed at investigating the reactivity of aniline-based pharmaceuticals with sulfate radical anion generated by the peroxymonosulfate (PMS)/Cobalt(II) system and by taking sulfamethoxazole and diclofenac as probe compounds. Transformation pathways were proposed for both pharmaceuticals relying on the identification of the main reaction intermediate products using liquid chromatography coupled to time of flight mass spectrometry. For diclofenac, the major transformation pathway led to the formation of a quinone imine Derivative while for sulfamethoxazole a Nitro Derivative was obtained as the major intermediate. However, in both cases, oxidative reactions started with the formation of a N-centered radical probably through an one-electron transfer from the pharmaceutical to sulfate radical anion. This was followed by further multistep degradation involving decarboxylation, hydroxylation and bond cleavage reactions in route to mineralization. From a kinetic point of view, aniline-based pharmaceuticals quickly reacted with sulfate radical anion with second order kinetic rate constants in the 9–10 × 10 9  M −1  s −1 range. Sulfate radical-based technologies show promising results for the removal of these particular pharmaceuticals from wastewater treatment plant effluents mainly because of the higher selectivity of sulfate radical anion over hydroxyl radical, limiting radical scavenging by natural organic matter and allowing for higher abatement and mineralization rates.

  • Sulfate radical anion oxidation of diclofenac and sulfamethoxazole for water decontamination
    Chemical Engineering Journal, 2012
    Co-Authors: Moussa Mahdi Ahmed, Stéphane Barbati, Pierre Doumenq, Serge Chiron
    Abstract:

    This study aimed at investigating the reactivity of aniline-based pharmaceuticals with sulfate radical anion generated by the peroxymonosulfate (PMS)/Cobalt(II) system and by taking sulfamethoxazole and diclofenac as probe compounds. Transformation pathways were proposed for both pharmaceuticals relying on the identification of the main reaction intermediate products using liquid chromatography coupled to time of flight mass spectrometry. For diclofenac, the major transformation pathway led to the formation of a quinone imine Derivative while for sulfamethoxazole a Nitro Derivative was obtained as the major intermediate. However, in both cases, oxidative reactions started with the formation of a N-centered radical probably through an one-electron transfer from the pharmaceutical to sulfate radical anion. This was followed by further multistep degradation involving decarboxylation, hydroxylation and bond cleavage reactions in route to mineralization. From a kinetic point of view, aniline-based pharmaceuticals quickly reacted with sulfate radical anion with second order kinetic rate constants in the 9-10 x 10(9) M-1 s(-1) Sulfate radical-based technologies show promising results for the removal of these particular pharmaceuticals from wastewater treatment plant effluents mainly because of the higher selectivity of sulfate radical anion over hydroxyl radical, limiting radical scavenging by natural organic matter and allowing for higher abatement and mineralization rates. (C) 2012 Elsevier B.V. All rights reserved.