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Joseph Kim - One of the best experts on this subject based on the ideXlab platform.

  • Race and Correlations Between Lymph Node Number and Survival for Patients with Gastric Cancer
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2013
    Co-Authors: Rebecca A. Nelson, Joseph Kim, Amanda K. Arrington, Wendy Lee, Julio Garcia-aguilar
    Abstract:

    There is ongoing debate whether extended lymphadenectomy improves survival in gastric cancer patients who undergo surgical resection. We previously observed that Korean-American patients had the highest overall survival in Los Angeles County. Our objective was to assess lymph Node (LN) Number and its impact on survival for Korean-American gastric cancer patients. We utilized the National Cancer Institute's Surveillance, Epidemiology, and End Results registry to identify Korean-Americans with gastric adenocarcinoma treated with curative-intent gastrectomy between 1988 and 2008. We grouped patients according to examined LN Number (1-15 and 16+) and compared characteristics. We performed similar analysis for white patients. Out of 982 Korean-American patients with gastric adenocarcinoma, most patients had 1-15 examined LNs (60 %). When we compared LN groups, we observed higher overall survival in the 1-15 group than the 16+ group (5-year survival, 59 % vs 52 %, respectively; p = 0.04). However, LN Number was not prognostic of overall survival on stepwise Cox proportional hazards analysis. In contrast, LN Number was prognostic for white patients. Although examined LN Number may impact survival for white patients, outcomes of Korean-American gastric cancer patients were independent of LN Number. Our data suggest that survival of Korean-American gastric cancer patients are comparable with outcomes from East Asian hospitals and may be independent of surgical technique.

  • the impact of lymph Node Number on survival in patients with lymph Node negative pancreatic cancer
    Pancreas, 2008
    Co-Authors: Minia Hellan, Can-lan Sun, Avo Artinyan, Smita Bhatia, Joshua D. I. Ellenhorn, Pablo Mojicamanosa, Joseph Kim
    Abstract:

    Objectives:The role of lymph Node (LN) dissection for pancreatic cancer remains uncertain, and guidelines for a minimum LN Number have not been established. We hypothesized that LN Number in Node-negative (N0) pancreatic cancer influences survival.Methods:The Surveillance, Epidemiology, and End Resu

  • The impact of lymph Node Number on survival in patients with lymph Node-negative pancreatic cancer.
    Pancreas, 2008
    Co-Authors: Minia Hellan, Can-lan Sun, Avo Artinyan, Pablo Mojica-manosa, Smita Bhatia, Joshua D. I. Ellenhorn, Joseph Kim
    Abstract:

    The role of lymph Node (LN) dissection for pancreatic cancer remains uncertain, and guidelines for a minimum LN Number have not been established. We hypothesized that LN Number in Node-negative (N0) pancreatic cancer influences survival. The Surveillance, Epidemiology, and End Results database was queried for patients undergoing resection for N0 pancreatic adenocarcinoma between 1988 and 2003. Lymph Node Number was categorized as 1-10, 11-20, and >20. In a cohort of 1915 patients, the median LN Number was 7 (range 1-57); 1365 (71%) patients had <11 LN. Survival was significantly better in the 11 to 20 compared with the 1-10 group (median, 20 vs 15 months, respectively, P < 0.0001); no difference was observed between the 11-20 and >20 groups (median, 20 vs 23 months, respectively, P = 0.14). Multivariate analysis demonstrated the prognostic significance of LN Number for determining overall survival (hazard ratio 0.98, 95% confidence interval: 0.97-0.99; P<0.0001). Pancreatic cancer lymphadenectomy with examination of >10 LN is associated with improved survival in N0 disease and should be considered a benchmark for adequacy of surgery and/or pathology. Currently, only a minority of patients are assessed by this measure. The variation in LN Number may be indicative of diverse surgical technique and/or pathologic analysis and warrants further investigation.

Bruce H. Haughey - One of the best experts on this subject based on the ideXlab platform.

  • high metastatic Node Number not extracapsular spread or n classification is a Node related prognosticator in transorally resected neck dissected p16 positive oropharynx cancer
    Oral Oncology, 2015
    Co-Authors: Parul Sinha, Dorina Kallogjeri, Wade L. Thorstad, James S. Lewis, Rebecca D. Chernock, Brian Nussenbaum, Bruce H. Haughey
    Abstract:

    Summary Background Due to unique biology and prognosis, precise identification of predictive parameters is critical for p16+ oropharyngeal squamous cell carcinoma (OPSCC). Prior studies showing absence of prognostication from extracapsular spread (ECS) and/or high N-classification in surgically-treated p16+ OPSCC necessitate new, evidence-based prognosticators. Methods A prospectively assembled cohort of 220, transoral surgery + neck dissection ± adjuvant therapy-treated, p16+ OPSCC patients was analyzed. Disease recurrence and disease-specific survival (DSS) were primary endpoints. Results Median follow-up was 59 (12–189) months. Distribution of metastatic Node Numbers was: 0 in 9.5% (n = 21), 1 in 33.6% (n = 74), 2 in 17% (n = 38), 3 in 14.5% (n = 32), 4 in 8.2% (n = 18), and ⩾ 5 in 17% (n = 37). ECS was recorded in 80% (n = 159), and N2c–N3 in 17% (n = 38). Adjuvant radiotherapy and chemoradiotherapy was administered in 44% and 34%. Recurrence developed in 22 patients (10%); 4 local, 5 regional, 2 regional and distant, and 11 distant. The 3- and 5-year DSS estimates were 94.6% and 93%. Multivariable logistic regression identified ⩾ 5 Nodes and T3–T4 classification as predictors for recurrence. In multivariable Cox analyses, ⩾ 5 Nodes, T3–T4 classification and margins were prognostic for DSS. ECS, N2c–N3 classification and smoking were not prognostic. Conclusions Metastatic Node Number, not ECS or high N-classification is an independent nodal predictor of outcomes in surgically-treated p16+ OPSCC patients. Despite high DSS (~80%), closer surveillance for recurrence is recommended for patients with ⩾ 5 metastatic Nodes.

  • High metastatic Node Number, not extracapsular spread or N-classification is a Node-related prognosticator in transorally-resected, neck-dissected p16-positive oropharynx cancer.
    Oral oncology, 2015
    Co-Authors: Parul Sinha, Dorina Kallogjeri, Wade L. Thorstad, James S. Lewis, Rebecca D. Chernock, Brian Nussenbaum, Bruce H. Haughey
    Abstract:

    Due to unique biology and prognosis, precise identification of predictive parameters is critical for p16+ oropharyngeal squamous cell carcinoma (OPSCC). Prior studies showing absence of prognostication from extracapsular spread (ECS) and/or high N-classification in surgically-treated p16+ OPSCC necessitate new, evidence-based prognosticators. A prospectively assembled cohort of 220, transoral surgery+neck dissection±adjuvant therapy-treated, p16+ OPSCC patients was analyzed. Disease recurrence and disease-specific survival (DSS) were primary endpoints. Median follow-up was 59 (12-189) months. Distribution of metastatic Node Numbers was: 0 in 9.5% (n=21), 1 in 33.6% (n=74), 2 in 17% (n=38), 3 in 14.5% (n=32), 4 in 8.2% (n=18), and ⩾5 in 17% (n=37). ECS was recorded in 80% (n=159), and N2c-N3 in 17% (n=38). Adjuvant radiotherapy and chemoradiotherapy was administered in 44% and 34%. Recurrence developed in 22 patients (10%); 4 local, 5 regional, 2 regional and distant, and 11 distant. The 3- and 5-year DSS estimates were 94.6% and 93%. Multivariable logistic regression identified ⩾5 Nodes and T3-T4 classification as predictors for recurrence. In multivariable Cox analyses, ⩾5 Nodes, T3-T4 classification and margins were prognostic for DSS. ECS, N2c-N3 classification and smoking were not prognostic. Metastatic Node Number, not ECS or high N-classification is an independent nodal predictor of outcomes in surgically-treated p16+ OPSCC patients. Despite high DSS (~80%), closer surveillance for recurrence is recommended for patients with ⩾5 metastatic Nodes. Copyright © 2015 Elsevier Ltd. All rights reserved.

Fanjiang Kong - One of the best experts on this subject based on the ideXlab platform.

  • soybean ap1 homologs control flowering time and plant height
    Journal of Integrative Plant Biology, 2020
    Co-Authors: Liyu Chen, Haiyang Nan, Lingping Kong, Lin Yue, Hui Yang, Qingsong Zhao, Chao Fang, Qun Cheng, Fanjiang Kong
    Abstract:

    Flowering time and plant height are key agronomic traits that directly affect soybean (Glycine max) yield. APETALA1 (AP1) functions as a class A gene in the ABCE model for floral organ development, helping to specify carpel, stamen, petal, and sepal identities. There are four AP1 homologs in soybean, all of which are mainly expressed in the shoot apex. Here, we used clustered regularly interspaced short palindromic repeats (CRISPR) - CRISPR-associated protein 9 technology to generate a homozygous quadruple mutant, gmap1, with loss-of-function mutations in all four GmAP1 genes. Under short-day (SD) conditions, the gmap1 quadruple mutant exhibited delayed flowering, changes in flower morphology, and increased Node Number and interNode length, resulting in plants that were taller than the wild type. Conversely, overexpression of GmAP1a resulted in early flowering and reduced plant height compared to the wild type under SD conditions. The gmap1 mutant and the overexpression lines also exhibited altered expression of several genes related to flowering and gibberellic acid metabolism, thereby providing insight into the role of GmAP1 in the regulatory networks controlling flowering time and plant height in soybean. Increased Node Number is the trait with the most promise for enhancing soybean pod Number and grain yield. Therefore, the mutant alleles of the four AP1 homologs described here will be invaluable for molecular breeding of improved soybean yield.

David R. Urbach - One of the best experts on this subject based on the ideXlab platform.

  • An evaluation of the relationship between lymph Node Number and staging in pT3 colon cancer using population-based data.
    Diseases of the colon and rectum, 2010
    Co-Authors: Nancy N. Baxter, Rocco Ricciardi, Marko Simunovic, David R. Urbach, Beth A Virnig
    Abstract:

    PURPOSE: The Number of lymph Nodes examined has been proposed as a quality benchmark for colon cancer surgery, although it is unknown whether this strategy reduces understaging. METHODS: We identified 11,044 patients who underwent surgery for colon cancer with pT3 wall penetration between 1988 and 2003 from the Surveillance, Epidemiology and End Results cancer registry. We determined the proportion of patients who were Node positive for each Node count. We used logistic regression to predict the odds of being Node positive by Node count after adjusting for confounders. We used joinpoint analysis to determine whether there was a consistent relationship between Node count and the odds of being Node positive. RESULTS: The proportion of patients found to be Node positive increased with Node count at low counts (≤5–6 Nodes), but patients with 7 Nodes identified were as likely to be Node positive as patients with 30 or more Nodes (odds ratio = 0.97; 95% CI = 0.90–1.05). Joinpoint analysis demonstrated a dramatic increase in odds of Node positivity with increasing Node count to 5 Nodes (slope = 0.2; P CONCLUSIONS: Staging of pT3 colon cancer improves with increasing Node count, but only when the Node count is low (

  • Factors affecting the Number of lymph Nodes retrieved in colorectal cancer specimens
    Surgical Endoscopy, 2007
    Co-Authors: Michelle A. Ostadi, Julie L. Harnish, Stacey Stegienko, David R. Urbach
    Abstract:

    Background Staging of colorectal cancer is dependent on the Number of lymph Nodes in a surgical specimen that are positive for metastatic cancer. It is generally recommended that a minimum of 12 lymph Nodes be examined to ensure adequate staging. It is unclear which factors specifically contribute to variation in the Number of lymph Nodes retrieved from surgical specimens. This study aims to understand the factors affecting the Number of lymph Nodes identified in surgical colorectal cancer specimens. Methods A total of 264 retrospectively collected cases of colorectal cancer surgically treated at the University Health Network in Toronto from 2004 to 2006 were analyzed. We used univariate analyses of variance (ANOVA), and univariate and multivariable linear and logistic regression analyses to study variation in the lymph Node Number associated with a variety of explanatory variables. Results The average Number of lymph Nodes retrieved per case was 18.1, with 70 (26.5%) cases containing fewer than 12. Variation in the lymph Node Number was greatest between different pathology assistants (p =  

Jun Zhu - One of the best experts on this subject based on the ideXlab platform.

  • Dissecting Genetic Network of Fruit Branch Traits in Upland Cotton by Association Mapping Using SSR Markers.
    PloS one, 2017
    Co-Authors: Yongjun Mei, Angli Xue, Shuli Fan, Meizhen Song, Chaoyou Pang, Wenfeng Pei, Jun Zhu
    Abstract:

    Genetic architecture of branch traits has large influences on the morphological structure, photosynthetic capacity, planting density, and yield of Upland cotton (Gossypium hirsutum L.). This research aims to reveal the genetic effects of six branch traits, including bottom fruit branch Node Number (BFBNN), bottom fruit branch length (BFBL), middle fruit branch Node Number (MFBNN), middle fruit branch length (MFBL), upper fruit branch Node Number (UFBNN), and upper fruit branch length (UFBL). Association mapping was conducted for these traits of 39 lines and their 178 F-1 hybrids in three environments. There were 20 highly significant Quantitative Trait SSRs (QTSs) detected by mixed linear model approach analyzing a full genetic model with genetic effects of additive, dominance, epistasis and their environment interaction. The phenotypic variation explained by genetic effects ranged from 32.64 similar to 91.61%, suggesting these branch traits largely influenced by genetic factors.