The Experts below are selected from a list of 1707 Experts worldwide ranked by ideXlab platform
Martin Bech - One of the best experts on this subject based on the ideXlab platform.
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three dimensional architecture of human diabetic peripheral nerves revealed by x ray phase contrast holographic nanotomography
Scientific Reports, 2020Co-Authors: Lars B Dahlin, Vedrana Andersen Dahl, Kristian R Rix, Anders Bjorholm Dahl, Janus Nortoft Jensen, Peter Cloetens, Alexandra Pacureanu, Simin Mohseni, Niels O B Thomsen, Martin BechAbstract:A deeper knowledge of the architecture of the peripheral nerve with three-dimensional (3D) imaging of the nerve tissue at the sub-cellular scale may contribute to unravel the pathophysiology of neuropathy. Here we demonstrate the feasibility of X-ray phase contrast holographic nanotomography to enable 3D imaging of nerves at high resolution, while covering a relatively large tissue volume. We show various subcomponents of human peripheral nerves in biopsies from patients with type 1 and 2 diabetes and in a healthy subject. Together with well-organized, parallel myelinated nerve fibres we show regenerative clusters with twisted nerve fibres, a sprouted axon from a Node of Ranvier and other specific details. A novel 3D construction (with movie created) of a Node of Ranvier with end segment of a degenerated axon and sprout of a regenerated one is captured. Many of these architectural elements are not described in the literature. Thus, X-ray phase contrast holographic nanotomography enables identifying specific morphological structures in 3D in peripheral nerve biopsies from a healthy subject and from patients with type 1 and 2 diabetes.
Lars B Dahlin - One of the best experts on this subject based on the ideXlab platform.
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three dimensional architecture of human diabetic peripheral nerves revealed by x ray phase contrast holographic nanotomography
Scientific Reports, 2020Co-Authors: Lars B Dahlin, Vedrana Andersen Dahl, Kristian R Rix, Anders Bjorholm Dahl, Janus Nortoft Jensen, Peter Cloetens, Alexandra Pacureanu, Simin Mohseni, Niels O B Thomsen, Martin BechAbstract:A deeper knowledge of the architecture of the peripheral nerve with three-dimensional (3D) imaging of the nerve tissue at the sub-cellular scale may contribute to unravel the pathophysiology of neuropathy. Here we demonstrate the feasibility of X-ray phase contrast holographic nanotomography to enable 3D imaging of nerves at high resolution, while covering a relatively large tissue volume. We show various subcomponents of human peripheral nerves in biopsies from patients with type 1 and 2 diabetes and in a healthy subject. Together with well-organized, parallel myelinated nerve fibres we show regenerative clusters with twisted nerve fibres, a sprouted axon from a Node of Ranvier and other specific details. A novel 3D construction (with movie created) of a Node of Ranvier with end segment of a degenerated axon and sprout of a regenerated one is captured. Many of these architectural elements are not described in the literature. Thus, X-ray phase contrast holographic nanotomography enables identifying specific morphological structures in 3D in peripheral nerve biopsies from a healthy subject and from patients with type 1 and 2 diabetes.
Cecile Cauquil - One of the best experts on this subject based on the ideXlab platform.
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electrophysiological features of chronic inflammatory demyelinating polyradiculoneuropathy associated with igg4 antibodies targeting neurofascin 155 or contactin 1 glycoproteins
Clinical Neurophysiology, 2020Co-Authors: Ludivine Kouton, Jose Boucraut, Jerome Devaux, Yusuf A Rajabally, David H Adams, Jean Christophe Antoine, Frederic Bourdain, Alexandre Brodovitch, Jeanphilippe Camdessanche, Cecile CauquilAbstract:Abstract Objective Chronic inflammatory demyelinating polyradiculoneuropathies (CIDP) with antibodies against neurofascin 155 (Nfasc155) or contactin-1 (CNTN1) have distinctive clinical features. Knowledge on their electrophysiological characteristics is still scarce. In this study, we are investigating whether these patients have specific electrophysiological characteristics. Methods The electrophysiological data from 13 patients with anti-Nfasc155 IgG4 antibodies, 9 with anti-CNTN1 IgG4 antibodies were compared with those of 40 consecutive CIDP patients without antibodies. Results All the patients with antibodies against Nfasc155 or CNTN1 fulfilled the EFNS/PNS electrodiagnostic criteria for definite CIDP. There was no electrophysiological difference between patients with anti-CNTN1 and anti-Nfasc155 antibodies. Nerve conduction abnormalities were heterogeneously distributed along nerves trunks and roots. They were more pronounced than in CIDP without antibodies. Motor conduction velocity on median nerve 7.4 ms were predictive of positive antibodies against the Node of Ranvier with a sensitivity of 59% and a specificity of 93%. Conclusions Marked conduction abnormalities may suggest the presence of positive antibodies against the Node of Ranvier. Significance Anti-Nfasc155 and anti-CNTN1 antibodies target the the paranodal axo-glial domain but are associated with nerve conduction abnormalities mimicking a “demyelinating” neuropathy.
Kristian R Rix - One of the best experts on this subject based on the ideXlab platform.
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three dimensional architecture of human diabetic peripheral nerves revealed by x ray phase contrast holographic nanotomography
Scientific Reports, 2020Co-Authors: Lars B Dahlin, Vedrana Andersen Dahl, Kristian R Rix, Anders Bjorholm Dahl, Janus Nortoft Jensen, Peter Cloetens, Alexandra Pacureanu, Simin Mohseni, Niels O B Thomsen, Martin BechAbstract:A deeper knowledge of the architecture of the peripheral nerve with three-dimensional (3D) imaging of the nerve tissue at the sub-cellular scale may contribute to unravel the pathophysiology of neuropathy. Here we demonstrate the feasibility of X-ray phase contrast holographic nanotomography to enable 3D imaging of nerves at high resolution, while covering a relatively large tissue volume. We show various subcomponents of human peripheral nerves in biopsies from patients with type 1 and 2 diabetes and in a healthy subject. Together with well-organized, parallel myelinated nerve fibres we show regenerative clusters with twisted nerve fibres, a sprouted axon from a Node of Ranvier and other specific details. A novel 3D construction (with movie created) of a Node of Ranvier with end segment of a degenerated axon and sprout of a regenerated one is captured. Many of these architectural elements are not described in the literature. Thus, X-ray phase contrast holographic nanotomography enables identifying specific morphological structures in 3D in peripheral nerve biopsies from a healthy subject and from patients with type 1 and 2 diabetes.
Anders Bjorholm Dahl - One of the best experts on this subject based on the ideXlab platform.
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three dimensional architecture of human diabetic peripheral nerves revealed by x ray phase contrast holographic nanotomography
Scientific Reports, 2020Co-Authors: Lars B Dahlin, Vedrana Andersen Dahl, Kristian R Rix, Anders Bjorholm Dahl, Janus Nortoft Jensen, Peter Cloetens, Alexandra Pacureanu, Simin Mohseni, Niels O B Thomsen, Martin BechAbstract:A deeper knowledge of the architecture of the peripheral nerve with three-dimensional (3D) imaging of the nerve tissue at the sub-cellular scale may contribute to unravel the pathophysiology of neuropathy. Here we demonstrate the feasibility of X-ray phase contrast holographic nanotomography to enable 3D imaging of nerves at high resolution, while covering a relatively large tissue volume. We show various subcomponents of human peripheral nerves in biopsies from patients with type 1 and 2 diabetes and in a healthy subject. Together with well-organized, parallel myelinated nerve fibres we show regenerative clusters with twisted nerve fibres, a sprouted axon from a Node of Ranvier and other specific details. A novel 3D construction (with movie created) of a Node of Ranvier with end segment of a degenerated axon and sprout of a regenerated one is captured. Many of these architectural elements are not described in the literature. Thus, X-ray phase contrast holographic nanotomography enables identifying specific morphological structures in 3D in peripheral nerve biopsies from a healthy subject and from patients with type 1 and 2 diabetes.