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Paddy J Horner - One of the best experts on this subject based on the ideXlab platform.

  • Treatment regimens in Non-Gonococcal Urethritis
    Sexually Transmitted Infections, 2015
    Co-Authors: Naomi Carter, Paddy J Horner
    Abstract:

    A letter in response to: ‘ Suboptimal adherence to doxycycline and treatment outcomes among men with Non-Gonococcal Urethritis: a prospective cohort study ’ and ‘ Empiric NSU treatment needs updating ’.1 ,2 The effect of suboptimal adherence to a 7-day 100 mg twice daily doxycycline regimen on treatment failure in men with Non-Gonococcal Urethritis (NGU) was assessed by Khosropour et al .1 The authors conclude that suboptimal adherence to doxycycline, defined as missing one or more doses, is associated with microbiological failure in chlamydial NGU in men.1 We …

  • Chlamydia trachomatis and Non-Gonococcal Urethritis
    Medicine, 2005
    Co-Authors: Lindsey Harryman, Karla Blee, Paddy J Horner
    Abstract:

    Chlamydia is a common sexually transmitted infection (STI) in young people. It is often asymptomatic, but untreated infection can have significant long-term complications that may present to non-sexual health specialities. These include pelvic inflammatory disease (PID) and infertility in women. Current diagnostic techniques are sensitive and highly specific and are approved for patient-taken samples. This means non-specialist settings are well placed to diagnose and treat chlamydia in individuals from high-risk groups who may not access hospital-based healthcare services. The English National Chlamydia Screening Programme (NCSP) aims for all sexually active young men and women under the age of 25 to be aware of chlamydia and its effects, and have access to services providing screening, prevention and treatment, but there remains debate about its cost-effectiveness. Testing for chlamydia should be used as an opportunity to screen for other STIs including gonorrhoea, HIV and syphilis where indicated and also as a chance to offer advice for those engaging in high-risk sexual behaviour. Non-Gonococcal Urethritis is an important cause of urethral discharge and dysuria in men and is usually sexually transmitted. However, it can occur in stable relationships and in 30% no micro-organism is detected. Diagnosis and treatment are best undertaken in a specialist sexual health centre, although management is possible in a community setting. There is debate about the efficacy of current recommended treatments and national guidelines should be consulted for up-to-date antibiotic regimens.

  • Urinary tract infection in patients with acute Non-Gonococcal Urethritis.
    International Journal of Std & Aids, 2003
    Co-Authors: Andrew Leung, Shaw Taylor, Angela Smith, Robert C. Spencer, Paddy J Horner
    Abstract:

    In young sexually active male patients, clinical differentiation between Non-Gonococcal Urethritis (NGU) and urinary tract infection (UTI) can be difficult. UTI as a cause of NGU has been suggested before, but the prevalence of UTI among acute NGU patients has not been evaluated. We conducted a prospective cross-sectional study of 156 male patients with clinical features of acute Urethritis. The prevalence of UTI among acute NGU patients was 6.4% (CI: 1.5–11.3%). There was a possible association between UTI and NGU but this was not statistically significant. The sensitivity and specificity for combining leucocyte esterase and nitrite tests were 83.3% and 89.8% respectively, with a negative predictive value of 98.8%. We conclude that a mid-stream urine specimen should routinely be collected in patients with symptoms of Urethritis. This should be analysed by dipsticks incorporating nitrite and leucocyte esterase tests. Those with a positive dipstick should then be confirmed by culture.

Wang Pei-tu - One of the best experts on this subject based on the ideXlab platform.

  • Clinical Observation of Berberine in Treatment of Non-Gonococcal Urethritis and Cervicitis Due to Chlamydia Trachomatis
    Chinese Archives of Traditional Chinese Medicine, 2008
    Co-Authors: Wang Pei-tu
    Abstract:

    Objective:To observation the efficacy and safety of berberine in treating Non-Gonococcal Urethritis and cervicitis due to chlamydia trachomatis.Methods:86 patients with Non-Gonococcal Urethritis and cervicitis were randomized into treatment Group(n=44)and control Group(n=42).Treatment group was treated oral berberine 0.4g,tid for 14 days.Control group was treated oral doxycycline 0.1g,bid for 14 days.The efficacy and safety of all patients were observed before and after the treatment.Results:The overall efficacy rates of berberine and doxycycline were 65.9% and 73.8%,Bacteria elimination rates were 65.9% and 73.8%,and the side effect rates wore 18.2% and 14.3% respectively.No significant differences were observed between the two groups.Conclusion:Berberine is effective and safe in treating Non-Gonococcal Urethritis and cervicitis due to chlamydia trachomatis.

  • Comparative study of minocycline and fleroxacin in the treatment of Non-Gonococcal Urethritis and cervicitis
    2005
    Co-Authors: Wang Pei-tu
    Abstract:

    Objective:To study the efficacy and safety of minocycline and fleroxacin in the treatment of Non-Gonococcal Urethritis and cervicitis.Methods:216 cases with Non-Gonococcal Urethritis and cervicitis were randomly divided into two groups.Minocycline group(n=108) was treated with minocycline 100mg,po,bid for 14d,fleroxacin group(n=108)was treated with fleroxacin 0.4g,iv drip,qd for 14d.Results:The total effective rates of minocycline and fleroxacin were 92.6% and 90.7% respectively.Pathogens elimination rates were 92.6% and 90.7% respectively.The adverse rates were 9.3% and 8.3%,respectively.No significant differences were observed between the two groups.The sensitivity rates of Chlamydia trachomatis to minocycline and fleroxacin were 96.9% and 98.5%,respectively.The sensitivity rates of Ureaplasma urealyticum to minocycline and fleroxacin were 89.4% and 87.5%,respectively.No significant differences were observed between the two groups.Conclusion:Minocycline is effective and safe in the treatment of Non-Gonococcal Urethritis and cervicitis.

Kreaurat M - One of the best experts on this subject based on the ideXlab platform.

  • Azithromycin in Non-Gonococcal Urethritis.
    Journal of the Medical Association of Thailand Chotmaihet thangphaet, 1997
    Co-Authors: Charoenwatanachokchai A, Chitwarakorn A, Palanuvej T, Pakdeewong S, Khumhaeng M, Kreaurat M
    Abstract:

    The efficacy and safety of a single 1 g oral dose of azithromycin was evaluated in 100 male patients with Non-Gonococcal Urethritis (NGU). Enrolled were men with > or = 5 polymorphonuclear leukocytes (PMNL)/high power field (HPF) (x 1000 magnification) in a Gram-stained smear of urethral discharge with or without symptoms and signs of NGU. Of the 66 evaluable patients, Chlamydia trachomatis was isolated from 18 cases (27.3%) and Ureaplasma urealyticum from 12 cases (18.2%). After treatment, signs and symptoms disappeared from 59 cases (89.4%). Forty-four cases (66.7%) showed reduced PMNL/HPF. C. trachomatis was eradicated in 18 cases (100%) and U. urealyticum in 12 cases (83.3%). One patient complained of mild dizziness, moderate nausea, and palpitations. Single 1 g oral dose of azithromycin appears to be effective and safe for treating chlamydial, non-chlamydial, and ureaplasmal NGU. In addition, its ease of use encourages patient compliance.

Wen Yunxiang - One of the best experts on this subject based on the ideXlab platform.

Edgar Perea - One of the best experts on this subject based on the ideXlab platform.