The Experts below are selected from a list of 480 Experts worldwide ranked by ideXlab platform
Paolo Cavarzere - One of the best experts on this subject based on the ideXlab platform.
-
A novel de novo partial xq duplication in a girl with short stature, Nonverbal Learning Disability and diminished ovarian reserve - effect of growth hormone treatment and fertility preservation strategies: a case report and up-to-date review
International Journal of Pediatric Endocrinology, 2020Co-Authors: Francesca Parissone, Mairi Pucci, Emanuela Meneghelli, Orsetta Zuffardi, Rossana Di Paola, Stefano Zaffagnini, Massimo Franchi, Elisabetta Santangelo, Gaetano Cantalupo, Paolo CavarzereAbstract:Background Xq duplication is a rare condition with a very variable phenotype, which could mimic other genetic syndromes involving the long arm of chromosome X. Sometimes short stature and diminished ovarian reserve (DOR) may be present. Treatments with rGH (Recombinant growth Hormon) or with fertility preservation strategies have not been previously described. Case presentation We present the case of a female with a novel de novo Xq partial duplication (karyotype: 46,Xder(X)(qter→q21.31::pter→qter) confirmed by array-CGH analysis. She presented with short stature, Nonverbal Learning Disability, developmental delay during childhood, severe scoliosis, spontaneous onset of menarche and irregular menstrual cycles. AMH (Anti-Müllerian Hormone) allowed detection of a preserved but severely diminished ovarian reserve with a POI (Premature Ovarian insufficiency) onset risk. She was effectively subjected to fertility preservation strategies and rGH therapy. We also reviewed other published cases with Xq duplication, reporting the main clinics characteristics and any adopted treatment. Conclusions rGH treatment and cryopreservation in a multidisciplinary approach are good therapeutic strategies for Xq duplication syndrome with short stature and premature ovarian failure.
-
a novel de novo partial xq duplication in a girl with short stature Nonverbal Learning Disability and diminished ovarian reserve effect of growth hormone treatment and fertility preservation strategies a case report and up to date review
International Journal of Pediatric Endocrinology, 2020Co-Authors: Francesca Parissone, Mairi Pucci, Emanuela Meneghelli, Orsetta Zuffardi, Rossana Di Paola, Stefano Zaffagnini, Massimo Franchi, Elisabetta Santangelo, Gaetano Cantalupo, Paolo CavarzereAbstract:Xq duplication is a rare condition with a very variable phenotype, which could mimic other genetic syndromes involving the long arm of chromosome X. Sometimes short stature and diminished ovarian reserve (DOR) may be present. Treatments with rGH (Recombinant growth Hormon) or with fertility preservation strategies have not been previously described. We present the case of a female with a novel de novo Xq partial duplication (karyotype: 46,Xder(X)(qter→q21.31::pter→qter) confirmed by array-CGH analysis. She presented with short stature, Nonverbal Learning Disability, developmental delay during childhood, severe scoliosis, spontaneous onset of menarche and irregular menstrual cycles. AMH (Anti-Mullerian Hormone) allowed detection of a preserved but severely diminished ovarian reserve with a POI (Premature Ovarian insufficiency) onset risk. She was effectively subjected to fertility preservation strategies and rGH therapy. We also reviewed other published cases with Xq duplication, reporting the main clinics characteristics and any adopted treatment. rGH treatment and cryopreservation in a multidisciplinary approach are good therapeutic strategies for Xq duplication syndrome with short stature and premature ovarian failure.
Margaret Semrudclikeman - One of the best experts on this subject based on the ideXlab platform.
-
social functioning using direct and indirect measures with children with high functioning autism Nonverbal Learning Disability and typically developing children
Child Neuropsychology, 2016Co-Authors: Margaret Semrudclikeman, Jodene Goldenring Fine, Jesse C BledsoeAbstract:Social perception is an important underlying foundation for emotional development and overall adaptation. The majority of studies with children with High Functioning Autism (HFA) or Nonverbal Learning disabilities (NLD) evaluating social functioning have used measures of parent and/or teacher ratings. The present study utilized parent and teacher ratings of behavior as well as executive functioning in addition to direct measures of social perception. Three groups participated in this study (control [n = 38] HFA [n = 36], NLD [n = 31]). Results indicated that the HFA group experienced the most difficulty understanding emotional cues on the direct measure while both the HFA and NLD groups experienced difficulty with Nonverbal cues. Significant difficulties were reported on the parent rating scale for sadness and social withdrawal for both clinical groups. Executive functioning was found to be particularly problematic for the clinical groups. The direct social perception measure was highly correlated with the measures of executive functioning and reflects the contribution that executive functions have on social functioning. These findings suggest that the clinical presentation on behavior rating scales may be very similar for children with HFA and NLD. Moreover, it appears that measures of executive functioning are sensitive to the clinical difficulties these groups experience. The findings also suggest there is a commonality in these disorders that warrants further investigation.
-
smaller splenium in children with Nonverbal Learning Disability compared to controls high functioning autism and adhd
Child Neuropsychology, 2014Co-Authors: Jodene Goldenring Fine, Kayla A Musielak, Margaret SemrudclikemanAbstract:The current study investigated morphological differences in the corpus callosum in children ages 8 to 18 years old with Nonverbal Learning Disability (NLD; n = 19), high-functioning autism (HFA; n = 23), predominantly inattentive ADHD (ADHD:PI; n = 23), and combined type ADHD (ADHD:C; n = 25), as well as those demonstrating typical development (n = 57). Midsagittal area of the corpus callosum and five midsagittal anterior-to-posterior corpus callosum segments were examined using magnetic resonance imaging. Controlling for midsagittal brain area and age, no group differences were found for total corpus callosum area. This finding indicates that higher functioning children on the autistic spectrum do not have smaller corpus callosi as has been found in previous research with heterogeneous samples. Following segmentation of the corpus callosum, the NLD group was observed to have significantly smaller splenia compared to all other groups. Smaller splenia in the NLD group was associated with lower WASI PIQ sco...
-
magnetic resonance imaging volumetric findings in children with asperger syndrome Nonverbal Learning Disability or healthy controls
Journal of Clinical and Experimental Neuropsychology, 2013Co-Authors: Margaret Semrudclikeman, Jodene Goldenring Fine, Jesse Bledsoe, David C ZhuAbstract:Background: The purpose of the present study was to evaluate selected regions of interest in children and adolescents with Nonverbal Learning disabilities (NVLD), Asperger syndrome (AS), and age-matched healthy controls using magnetic resonance imaging (MRI). It was hypothesized that children with AS would show larger volumes of the amygdala and hippocampal regions than the other groups. It was also hypothesized that both clinical groups would show differences in the caudate and anterior cingulate cortex (ACC). Method: There were a total of 89 children in the final sample (31 controls, 29 NVLD, 29 AS). Each child completed a MRI scan as well as basic cognitive screening measures. High-resolution T1-weighted MR volumetric images were acquired. The volume of gray matter, white matter, cerebrospinal fluid (CSF), amygdala, hippocampus, and anterior cingulate cortex (ACC) was obtained. Results: The hypothesis that the AS group would show larger hippocampal and amygdala volumes than the other groups was confirm...
-
social competence intervention program scip a pilot study of a creative drama program for youth with social difficulties
Arts in Psychotherapy, 2013Co-Authors: Laura A Guli, Margaret Semrudclikeman, Matthew D Lerner, Noah BrittonAbstract:Abstract This study explored the effects of participation in the Social Competence Intervention Program (SCIP), an innovative creative drama-based group intervention, of children diagnosed with autism spectrum disorder (ASD), Nonverbal Learning Disability (NLD) and/or attention deficit hyperactivity disorder (ADHD). Eighteen participants in SCIP were compared to a clinical control group of 16 on changes in measures of social perception, social competence, and naturalistic observed social behavior. Hierarchical multiple regression model was used for all primary quantitative analyses. Interviews were conducted post-treatment to provide qualitative data. The treatment group showed significant improvement in key domains of observed social behavior in a natural setting compared to the clinical control group. Parents and children in the SCIP condition reported multiple positive changes in social functioning. These findings provide preliminary support for the use of a creative drama program for children with social competence deficits related to social perception problems.
-
direct and indirect measures of social perception behavior and emotional functioning in children with asperger s disorder Nonverbal Learning Disability or adhd
Journal of Abnormal Child Psychology, 2010Co-Authors: Margaret Semrudclikeman, Jenifer Walkowiak, Alison Wilkinson, Elizabeth Portman MinneAbstract:Understanding social interactions is crucial for development of social competence. The present study was one of the first to utilize direct and indirect measures of social perception to explore possible differences among children with Nonverbal Learning Disability (NLD), Asperger’s Syndrome (AS), Attention Deficit Hyperactivity Disorder-Combined (ADHD-C), Attention Deficit Hyperactivity Disorder-Predominately Inattentive (ADHD-PI), and controls (N = 342). Multiple informants provided ratings of the child’s behavioral and social functioning. Results indicated that the NLD and AS groups experienced the most difficulty understanding emotional and Nonverbal cues on the direct measure. In addition, children with AS or NLD showed significant signs of sadness and social withdrawal compared to the other groups. Attentional skills, while related to social perception, did not predict social perception difficulties to the same degree as number of AS symptoms.
Irene C. Mammarella - One of the best experts on this subject based on the ideXlab platform.
-
editorial time to recognize Nonverbal Learning Disability to foster advances in its research
Journal of the American Academy of Child and Adolescent Psychiatry, 2021Co-Authors: Irene C. MammarellaAbstract:The definitions of most of the currently recognized neurodevelopmental disorders and the criteria used to identify them have seen important changes since their inclusion in diagnostic classification systems (see, for instance, how the definitions of specific Learning disorders and autism spectrum disorder (ASD) have been revised in successive versions of DSM). As is the case with many other mental conditions, our understanding of neurodevelopmental disorders is continuously being updated in the light of new research findings. However, this has not been the case for Nonverbal Learning Disability. More than 50 years since it was first described,1 there is still no consensus on the merits of identifying it as a separate disorder or using a clear and acknowledged diagnostic label. Instead of trying to establish why Nonverbal Learning Disability has yet to be included in the diagnostic manuals, this editorial examines why recognized criteria for the condition would improve research in this field and avoid the negative consequences of continuing to conduct research without adopting shared criteria.
-
a comparison of local global visuospatial processing in autism spectrum disorder Nonverbal Learning Disability adhd and typical development
Research in Developmental Disabilities, 2020Co-Authors: Ramona Cardillo, Claudio Vio, Irene C. MammarellaAbstract:Abstract Background Research on visuospatial functioning has revealed cognitive challenges for children with autism spectrum disorder (ASD), Nonverbal Learning Disability (NLD) and attention deficit hyperactivity disorder (ADHD). These disorders are characterized by some overlapping symptoms, making their diagnosis a challenge. Aims The study aims to clarify the role of visuospatial abilities in their neuropsychological profiles by investigating different visuospatial domains and their interplay with the local-global processing. Method and procedures Participants (N = 150) with ASD, NLD, or ADHD were compared with typically-developing (TD) children on visuospatial processing speed, visuo-perceptual abilities, visuo-constructive abilities, and visuospatial working memory. Generalized mixed-effects models were performed and receiver operating characteristic curves were estimated to express the usefulness of a local-global processing index in discriminating groups. Outcomes and results The NLD group was impaired in all domains; children with ADHD revealed a heterogeneous profile, with greater impairments in visuospatial processing speed; ASD and TD groups were comparable. The local-global processing index had predictive power in discriminating among groups in visuo-constructive task. Conclusions and implications The study of visuospatial abilities of children with ASD, NLD and ADHD might help to understand strengths and weaknesses in their neuropsychological profile and to differentiate between them. Clinical implications of these findings are discussed.
-
Nonverbal Learning Disability developmental visuospatial disorder
Handbook of Clinical Neurology, 2020Co-Authors: Irene C. Mammarella, Cesare CornoldiAbstract:Nonverbal Learning Disability is a neurodevelopmental disorder with a core deficit in visuospatial processing with possibly associated problems in attention, motor, academic, and social skills, but without associated neurologic or genetic syndromes. The present chapter, after a brief historic overview of this disorder, will present fresh evidence that clearly shows neuropsychologic and neuroanatomical distinctions between children with Nonverbal Learning Disability and those with other neurodevelopmental disorders. It ends with an attempt to find shared and valid diagnostic criteria. Acknowledging this disorder as a distinct diagnostic category will open up new research avenues with important scientific and clinical implications.
-
differences in visuospatial processing in individuals with Nonverbal Learning Disability or autism spectrum disorder without intellectual Disability
Neuropsychology (journal), 2019Co-Authors: Irene C. Mammarella, Ramona Cardillo, Leonardo ZoccanteAbstract:Objective Although previous reports produced converging empirical evidence of a core deficit on visuospatial processing in children with a Nonverbal Learning Disability (NLD), few studies compared the visuospatial profile of individuals with an autism spectrum disorder (ASD) or NLD in visuoconstructive and visuospatial working memory tasks. Nor did any of these studies investigate the role of the local bias, typically observed in ASD, when comparing these clinical groups. The present study aimed to analyze whether NLD and ASD share any characteristics. Method A group of participants with NLD (n = 17) was compared with another group who had ASD (n = 17) without intellectual Disability (ID), and without a peak in visuospatial intelligence, and with a control group (n = 17). Participants aged from 8 to 18 years performed a visuoconstructive and a visuospatial working memory task in which global-local processing styles were manipulated. Results The analysis of their visuospatial processing clearly distinguished between the neuropsychological profiles of the group with ASD without ID and the group with NLD: the latter performed less well than the former in all domains. The participants with ASD without ID had a more heterogeneous visuospatial profile, showing a diminished sensitivity to perceptual cohesiveness only in the visuoconstructive task. Conclusions Examining different visuospatial domains and manipulating the cohesiveness of the stimuli might be useful for better discriminating between NLD and ASD without ID. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
-
local and global processing in block design tasks in children with dyslexia or Nonverbal Learning Disability
Research in Developmental Disabilities, 2017Co-Authors: Ramona Cardillo, Irene C. Mammarella, Ricardo Basso Garcia, Cesare CornoldiAbstract:Visuo-constructive and perceptual abilities have been poorly investigated in children with Learning disabilities. The present study focused on local or global visuospatial processing in children with Nonverbal Learning Disability (NLD) and dyslexia compared with typically-developing (TD) controls. Participants were presented with a modified block design task (BDT), in both a typical visuo-constructive version that involves reconstructing figures from blocks, and a perceptual version in which respondents must rapidly match unfragmented figures with a corresponding fragmented target figure. The figures used in the tasks were devised by manipulating two variables: the perceptual cohesiveness and the task uncertainty, stimulating global or local processes. Our results confirmed that children with NLD had more problems with the visuo-constructive version of the task, whereas those with dyslexia showed only a slight difficulty with the visuo-constructive version, but were in greater difficulty with the perceptual version, especially in terms of response times. These findings are interpreted in relation to the slower visual processing speed of children with dyslexia, and to the visuo-constructive problems and difficulty in using flexibly-experienced global vs local processes of children with NLD. The clinical and educational implications of these findings are discussed.
Francesca Parissone - One of the best experts on this subject based on the ideXlab platform.
-
A novel de novo partial xq duplication in a girl with short stature, Nonverbal Learning Disability and diminished ovarian reserve - effect of growth hormone treatment and fertility preservation strategies: a case report and up-to-date review
International Journal of Pediatric Endocrinology, 2020Co-Authors: Francesca Parissone, Mairi Pucci, Emanuela Meneghelli, Orsetta Zuffardi, Rossana Di Paola, Stefano Zaffagnini, Massimo Franchi, Elisabetta Santangelo, Gaetano Cantalupo, Paolo CavarzereAbstract:Background Xq duplication is a rare condition with a very variable phenotype, which could mimic other genetic syndromes involving the long arm of chromosome X. Sometimes short stature and diminished ovarian reserve (DOR) may be present. Treatments with rGH (Recombinant growth Hormon) or with fertility preservation strategies have not been previously described. Case presentation We present the case of a female with a novel de novo Xq partial duplication (karyotype: 46,Xder(X)(qter→q21.31::pter→qter) confirmed by array-CGH analysis. She presented with short stature, Nonverbal Learning Disability, developmental delay during childhood, severe scoliosis, spontaneous onset of menarche and irregular menstrual cycles. AMH (Anti-Müllerian Hormone) allowed detection of a preserved but severely diminished ovarian reserve with a POI (Premature Ovarian insufficiency) onset risk. She was effectively subjected to fertility preservation strategies and rGH therapy. We also reviewed other published cases with Xq duplication, reporting the main clinics characteristics and any adopted treatment. Conclusions rGH treatment and cryopreservation in a multidisciplinary approach are good therapeutic strategies for Xq duplication syndrome with short stature and premature ovarian failure.
-
a novel de novo partial xq duplication in a girl with short stature Nonverbal Learning Disability and diminished ovarian reserve effect of growth hormone treatment and fertility preservation strategies a case report and up to date review
International Journal of Pediatric Endocrinology, 2020Co-Authors: Francesca Parissone, Mairi Pucci, Emanuela Meneghelli, Orsetta Zuffardi, Rossana Di Paola, Stefano Zaffagnini, Massimo Franchi, Elisabetta Santangelo, Gaetano Cantalupo, Paolo CavarzereAbstract:Xq duplication is a rare condition with a very variable phenotype, which could mimic other genetic syndromes involving the long arm of chromosome X. Sometimes short stature and diminished ovarian reserve (DOR) may be present. Treatments with rGH (Recombinant growth Hormon) or with fertility preservation strategies have not been previously described. We present the case of a female with a novel de novo Xq partial duplication (karyotype: 46,Xder(X)(qter→q21.31::pter→qter) confirmed by array-CGH analysis. She presented with short stature, Nonverbal Learning Disability, developmental delay during childhood, severe scoliosis, spontaneous onset of menarche and irregular menstrual cycles. AMH (Anti-Mullerian Hormone) allowed detection of a preserved but severely diminished ovarian reserve with a POI (Premature Ovarian insufficiency) onset risk. She was effectively subjected to fertility preservation strategies and rGH therapy. We also reviewed other published cases with Xq duplication, reporting the main clinics characteristics and any adopted treatment. rGH treatment and cryopreservation in a multidisciplinary approach are good therapeutic strategies for Xq duplication syndrome with short stature and premature ovarian failure.
Jodene Goldenring Fine - One of the best experts on this subject based on the ideXlab platform.
-
social functioning using direct and indirect measures with children with high functioning autism Nonverbal Learning Disability and typically developing children
Child Neuropsychology, 2016Co-Authors: Margaret Semrudclikeman, Jodene Goldenring Fine, Jesse C BledsoeAbstract:Social perception is an important underlying foundation for emotional development and overall adaptation. The majority of studies with children with High Functioning Autism (HFA) or Nonverbal Learning disabilities (NLD) evaluating social functioning have used measures of parent and/or teacher ratings. The present study utilized parent and teacher ratings of behavior as well as executive functioning in addition to direct measures of social perception. Three groups participated in this study (control [n = 38] HFA [n = 36], NLD [n = 31]). Results indicated that the HFA group experienced the most difficulty understanding emotional cues on the direct measure while both the HFA and NLD groups experienced difficulty with Nonverbal cues. Significant difficulties were reported on the parent rating scale for sadness and social withdrawal for both clinical groups. Executive functioning was found to be particularly problematic for the clinical groups. The direct social perception measure was highly correlated with the measures of executive functioning and reflects the contribution that executive functions have on social functioning. These findings suggest that the clinical presentation on behavior rating scales may be very similar for children with HFA and NLD. Moreover, it appears that measures of executive functioning are sensitive to the clinical difficulties these groups experience. The findings also suggest there is a commonality in these disorders that warrants further investigation.
-
smaller splenium in children with Nonverbal Learning Disability compared to controls high functioning autism and adhd
Child Neuropsychology, 2014Co-Authors: Jodene Goldenring Fine, Kayla A Musielak, Margaret SemrudclikemanAbstract:The current study investigated morphological differences in the corpus callosum in children ages 8 to 18 years old with Nonverbal Learning Disability (NLD; n = 19), high-functioning autism (HFA; n = 23), predominantly inattentive ADHD (ADHD:PI; n = 23), and combined type ADHD (ADHD:C; n = 25), as well as those demonstrating typical development (n = 57). Midsagittal area of the corpus callosum and five midsagittal anterior-to-posterior corpus callosum segments were examined using magnetic resonance imaging. Controlling for midsagittal brain area and age, no group differences were found for total corpus callosum area. This finding indicates that higher functioning children on the autistic spectrum do not have smaller corpus callosi as has been found in previous research with heterogeneous samples. Following segmentation of the corpus callosum, the NLD group was observed to have significantly smaller splenia compared to all other groups. Smaller splenia in the NLD group was associated with lower WASI PIQ sco...
-
magnetic resonance imaging volumetric findings in children with asperger syndrome Nonverbal Learning Disability or healthy controls
Journal of Clinical and Experimental Neuropsychology, 2013Co-Authors: Margaret Semrudclikeman, Jodene Goldenring Fine, Jesse Bledsoe, David C ZhuAbstract:Background: The purpose of the present study was to evaluate selected regions of interest in children and adolescents with Nonverbal Learning disabilities (NVLD), Asperger syndrome (AS), and age-matched healthy controls using magnetic resonance imaging (MRI). It was hypothesized that children with AS would show larger volumes of the amygdala and hippocampal regions than the other groups. It was also hypothesized that both clinical groups would show differences in the caudate and anterior cingulate cortex (ACC). Method: There were a total of 89 children in the final sample (31 controls, 29 NVLD, 29 AS). Each child completed a MRI scan as well as basic cognitive screening measures. High-resolution T1-weighted MR volumetric images were acquired. The volume of gray matter, white matter, cerebrospinal fluid (CSF), amygdala, hippocampus, and anterior cingulate cortex (ACC) was obtained. Results: The hypothesis that the AS group would show larger hippocampal and amygdala volumes than the other groups was confirm...
