The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Abhishek Singh - One of the best experts on this subject based on the ideXlab platform.
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rem sleep loss increases brain excitability role of Noradrenalin and its mechanism of action
Sleep Medicine Reviews, 2011Co-Authors: Birendra Nath Mallick, Abhishek SinghAbstract:Summary Ever since the discovery of rapid eye movement sleep (REMS), studies have been undertaken to understand its necessity, function and mechanism of action on normal physiological processes as well as in pathological conditions. In this review, first, we briefly surveyed the literature which led us to hypothesise REMS maintains brain excitability. Thereafter, we present evidence from in vivo and in vitro studies tracing behavioural to cellular to molecular pathways showing REMS deprivation (REMSD) increases Noradrenalin Level in the brain, which stimulates neuronal Na–K ATPase, the key factor for maintaining neuronal excitability, the fundamental property of a neuron for executing brain functions; we also show for the first time the role of glia in maintaining ionic homeostasis in the brain. As REMSD exerts a global effect on most of the physiological processes regulated by the brain, we propose that REMS possibly serves a housekeeping function in the brain. Finally, subject to confirmation from clinical studies, based on the results reviewed here, it is being proposed that the subjects suffering from REMS loss may be effectively treated by reducing either Noradrenalin Level or Na–K ATPase activity in the brain.
Birendra Nath Mallick - One of the best experts on this subject based on the ideXlab platform.
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rem sleep loss increases brain excitability role of Noradrenalin and its mechanism of action
Sleep Medicine Reviews, 2011Co-Authors: Birendra Nath Mallick, Abhishek SinghAbstract:Summary Ever since the discovery of rapid eye movement sleep (REMS), studies have been undertaken to understand its necessity, function and mechanism of action on normal physiological processes as well as in pathological conditions. In this review, first, we briefly surveyed the literature which led us to hypothesise REMS maintains brain excitability. Thereafter, we present evidence from in vivo and in vitro studies tracing behavioural to cellular to molecular pathways showing REMS deprivation (REMSD) increases Noradrenalin Level in the brain, which stimulates neuronal Na–K ATPase, the key factor for maintaining neuronal excitability, the fundamental property of a neuron for executing brain functions; we also show for the first time the role of glia in maintaining ionic homeostasis in the brain. As REMSD exerts a global effect on most of the physiological processes regulated by the brain, we propose that REMS possibly serves a housekeeping function in the brain. Finally, subject to confirmation from clinical studies, based on the results reviewed here, it is being proposed that the subjects suffering from REMS loss may be effectively treated by reducing either Noradrenalin Level or Na–K ATPase activity in the brain.
Shin-ichi Momomura - One of the best experts on this subject based on the ideXlab platform.
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effects of submaximal exercise on blood rheology and sympathetic nerve activity
Circulation, 2010Co-Authors: Nahoko Ikeda, Ken Tsuboi, Kenshiro Arao, Tomio Umemoto, Masanobu Kawakami, Takanori Yasu, Yoshitaka Sugawara, Norifumi Kubo, Shin-ichi MomomuraAbstract:Background: To explore the acute effects of submaximal exercise on blood rheology and sympathetic nerve activity. Methods and Results: The effects of exercise (20 or 80 Watts (W)) on blood rheology and sympathetic nerve activity were assessed in 10 healthy Japanese men. Blood sampling and heart rate variability (HRV) recording were performed during 20-min supine rest and standing ergometric exercise (20 W for 10 min, 80 W for 10 min) and recovery. Blood passage time across the microchannels (diameter, 7 μm) as a parameter of blood rheology, and the number of adhesive leukocytes on microchannel terraces as a parameter of leukocyte activation were measured. Sympathetic nerve activity was evaluated by plasma Noradrenalin Levels and the ratio of low-frequency (LF)/high-frequency (HF) by spectral analysis of HRV. Compared with values while supine at rest, significant increases in hematocrit, leukocyte count, Noradrenalin Level and blood passage time were seen after strenuous ergometer exercise at 80 W (P<0.01 each). The LF/HF ratio and nitric oxide metabolites tended to be increased with 80 W exercise. Conclusions: Strenuous exercise dynamically alters blood rheological parameters, probably by changes in hematocrit and sympathetic nerve activity. (Circ J 2010; 74: 730-734)
Takanori Yasu - One of the best experts on this subject based on the ideXlab platform.
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effects of submaximal exercise on blood rheology and sympathetic nerve activity
Circulation, 2010Co-Authors: Nahoko Ikeda, Ken Tsuboi, Kenshiro Arao, Tomio Umemoto, Masanobu Kawakami, Takanori Yasu, Yoshitaka Sugawara, Norifumi Kubo, Shin-ichi MomomuraAbstract:Background: To explore the acute effects of submaximal exercise on blood rheology and sympathetic nerve activity. Methods and Results: The effects of exercise (20 or 80 Watts (W)) on blood rheology and sympathetic nerve activity were assessed in 10 healthy Japanese men. Blood sampling and heart rate variability (HRV) recording were performed during 20-min supine rest and standing ergometric exercise (20 W for 10 min, 80 W for 10 min) and recovery. Blood passage time across the microchannels (diameter, 7 μm) as a parameter of blood rheology, and the number of adhesive leukocytes on microchannel terraces as a parameter of leukocyte activation were measured. Sympathetic nerve activity was evaluated by plasma Noradrenalin Levels and the ratio of low-frequency (LF)/high-frequency (HF) by spectral analysis of HRV. Compared with values while supine at rest, significant increases in hematocrit, leukocyte count, Noradrenalin Level and blood passage time were seen after strenuous ergometer exercise at 80 W (P<0.01 each). The LF/HF ratio and nitric oxide metabolites tended to be increased with 80 W exercise. Conclusions: Strenuous exercise dynamically alters blood rheological parameters, probably by changes in hematocrit and sympathetic nerve activity. (Circ J 2010; 74: 730-734)
Zhang Benyan - One of the best experts on this subject based on the ideXlab platform.
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effect of welding operation on Noradrenalin Level and acetylcholinesterase activity in serum of workers
Chinese Journal of Industrial Medicine, 2006Co-Authors: Zhang BenyanAbstract:Sixty-five welders and 49 non-welding workers were selected as exposed group and control group,respectively.The serum Noradrenalin(NE)Level was determined by ELISA method,the serum acetylcholinesterase(AChE)activity was determined by spectrometric method.Additionally,the blood manganese content,air manganese Levels in working places were also determined by graphite stove atomic absorption method.The result showed that the serum NE Level[(266.69±211.63) pg/ml]and AChE activity[(72.35±13.61) U/ml]in welding workers were significantly higher than that of the controls[(164.68±130.45) pg/ml]and[(60.50±13.00) U/ml]respectively(P0.01).The blood manganese content in welding workers[(0.778±0.389) μmol/L]was also significantly higher than that in the control[(0.546±0.321) μmol/L](P0.01).It is suggested that welding work may induce blood manganese content rising,serum NE Level increasing and AChE activity enhancing.
