The Experts below are selected from a list of 114 Experts worldwide ranked by ideXlab platform
Amadeo J Pesce - One of the best experts on this subject based on the ideXlab platform.
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an evaluation of the diagnostic accuracy of liquid chromatography tandem mass spectrometry versus immunoassay drug testing in pain patients
Pain Physician, 2010Co-Authors: Amadeo J Pesce, Bridgit Crews, Charles Mikel, Robert West, M Rosenthal, Cameron West, Perla Almazan, Sergey LatyshevAbstract:Urine samples from 4,200 pain patients were tested by immunoassay and LC-MS/MS for the following drugs and metabolites: Amphetamine, Methamphetamine, Alpha-hydroxyalprazolam, Lorazepam, Nordiazepam, Oxazepam, Temazepam, Cannabinoids, Cocaine, Methadone, Methadone Metabolite, Codeine, Hydrocodone, Hydromorphone, Morphine, Propoxyphene, and Norpropoxyphene.
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unstable propoxyphene metabolite excreted in human urine is detected by liquid chromatography tandem mass spectrometry
Journal of Analytical Toxicology, 2009Co-Authors: Bridgit Crews, Charles Mikel, Sergey Latyshev, Robert West, Amadeo J PesceAbstract:A "dilute and shoot" method for measuring Norpropoxyphene in human urine using liquid chromatography-tandem mass spectrometry distinguishes two different metabolites of propoxyphene, Norpropoxyphene (m/z 326) and a dehydrated rearrangement product (m/z 308). The metabolite formed from the rearrangement and dehydration of Norpropoxyphene is excreted in human urine and also may be formed from the chemical degradation of Norpropoxyphene. Previously, these two metabolites were indistinguishable by gas chromatography- mass spectrometry methods that use an alkaline extraction that converts Norpropoxyphene into its rearrangement product. The degradation of Norpropoxyphene presents a challenge for its analytical quantitation, and methods for circumventing these issues are presented.
Sergey Latyshev - One of the best experts on this subject based on the ideXlab platform.
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an evaluation of the diagnostic accuracy of liquid chromatography tandem mass spectrometry versus immunoassay drug testing in pain patients
Pain Physician, 2010Co-Authors: Amadeo J Pesce, Bridgit Crews, Charles Mikel, Robert West, M Rosenthal, Cameron West, Perla Almazan, Sergey LatyshevAbstract:Urine samples from 4,200 pain patients were tested by immunoassay and LC-MS/MS for the following drugs and metabolites: Amphetamine, Methamphetamine, Alpha-hydroxyalprazolam, Lorazepam, Nordiazepam, Oxazepam, Temazepam, Cannabinoids, Cocaine, Methadone, Methadone Metabolite, Codeine, Hydrocodone, Hydromorphone, Morphine, Propoxyphene, and Norpropoxyphene.
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unstable propoxyphene metabolite excreted in human urine is detected by liquid chromatography tandem mass spectrometry
Journal of Analytical Toxicology, 2009Co-Authors: Bridgit Crews, Charles Mikel, Sergey Latyshev, Robert West, Amadeo J PesceAbstract:A "dilute and shoot" method for measuring Norpropoxyphene in human urine using liquid chromatography-tandem mass spectrometry distinguishes two different metabolites of propoxyphene, Norpropoxyphene (m/z 326) and a dehydrated rearrangement product (m/z 308). The metabolite formed from the rearrangement and dehydration of Norpropoxyphene is excreted in human urine and also may be formed from the chemical degradation of Norpropoxyphene. Previously, these two metabolites were indistinguishable by gas chromatography- mass spectrometry methods that use an alkaline extraction that converts Norpropoxyphene into its rearrangement product. The degradation of Norpropoxyphene presents a challenge for its analytical quantitation, and methods for circumventing these issues are presented.
Bridgit Crews - One of the best experts on this subject based on the ideXlab platform.
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an evaluation of the diagnostic accuracy of liquid chromatography tandem mass spectrometry versus immunoassay drug testing in pain patients
Pain Physician, 2010Co-Authors: Amadeo J Pesce, Bridgit Crews, Charles Mikel, Robert West, M Rosenthal, Cameron West, Perla Almazan, Sergey LatyshevAbstract:Urine samples from 4,200 pain patients were tested by immunoassay and LC-MS/MS for the following drugs and metabolites: Amphetamine, Methamphetamine, Alpha-hydroxyalprazolam, Lorazepam, Nordiazepam, Oxazepam, Temazepam, Cannabinoids, Cocaine, Methadone, Methadone Metabolite, Codeine, Hydrocodone, Hydromorphone, Morphine, Propoxyphene, and Norpropoxyphene.
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unstable propoxyphene metabolite excreted in human urine is detected by liquid chromatography tandem mass spectrometry
Journal of Analytical Toxicology, 2009Co-Authors: Bridgit Crews, Charles Mikel, Sergey Latyshev, Robert West, Amadeo J PesceAbstract:A "dilute and shoot" method for measuring Norpropoxyphene in human urine using liquid chromatography-tandem mass spectrometry distinguishes two different metabolites of propoxyphene, Norpropoxyphene (m/z 326) and a dehydrated rearrangement product (m/z 308). The metabolite formed from the rearrangement and dehydration of Norpropoxyphene is excreted in human urine and also may be formed from the chemical degradation of Norpropoxyphene. Previously, these two metabolites were indistinguishable by gas chromatography- mass spectrometry methods that use an alkaline extraction that converts Norpropoxyphene into its rearrangement product. The degradation of Norpropoxyphene presents a challenge for its analytical quantitation, and methods for circumventing these issues are presented.
Andrew C. Robinson - One of the best experts on this subject based on the ideXlab platform.
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An Unusual Multiple Drug Intoxication Case Involving
2016Co-Authors: Robert J. Konrad, Robert M Brissie, Robert W. Hardy, Andrew C. Robinson, Citalopram Hbr [(_+)-l-(-dimethylaminopropyl)-lAbstract:[ Abstract J A 47-year-old male with a history of drug abuse and suicide attempts was found dead at home. The death scene investigation showed evidence of cocaine abuse and multiple drug ingestion. Citralopram, a new selective serotonin reuptake inhibitor, cocaine, oxycodone, promethazine, propoxyphene, and Norpropoxyphene were identified and quantitated in the postmortem samples by gas chromatography-mass spectrometry. The concentration of citalopram in the femoral blood was 0.88 mg/L. The heart blood concentration was 1.16 mg/t. Femoral blood concentrations of the other drugs were as follows: cocaine, 0.03 rag/L; oxycodone, 0.06 rag/L; promethazine, 0.02 rag/t; propoxyphene, 0.02 rag/L; and Norpropoxyphene, 0.07 mg/L. Other tissue samples were also analyzed. The concentrations of cocaine, oxycodone, promethazine, and propoxyphene in the blood, liver, brain, and gastric contents did not suggest an intentional overdose. However, the possibility of multiple drug interactions including citalopram was evident. In this case, the citalopram concentrations were consistent with those reported in fatal cases involving multiple drug use. Citalopram was present in urine at a concentration of 0.9 mg/L
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an unusual multiple drug intoxication case involving citalopram
Journal of Analytical Toxicology, 2000Co-Authors: Robert J. Konrad, Robert M Brissie, Robert W. Hardy, Andrew C. RobinsonAbstract:A 47-year-old male with a history of drug abuse and suicide attempts was found dead at home. The death scene investigation showed evidence of cocaine abuse and multiple drug ingestion. Citralopram, a new selective serotonin reuptake inhibitor, cocaine, oxycodone, promethazine, propoxyphene, and Norpropoxyphene were identified and quantitated in the postmortem samples by gas chromatography-mass spectrometry. The concentration of citalopram in the femoral blood was 0.88 mg/L. The heart blood concentration was 1.16 mg/L. Femoral blood concentrations of the other drugs were as follows: cocaine, 0.03 mg/L; oxycodone, 0.06 mg/L; promethazine, 0.02 mg/L; propoxyphene, 0.02 mg/L; and Norpropoxyphene, 0.07 mg/L. Other tissue samples were also analyzed. The concentrations of cocaine, oxycodone, promethazine, and propoxyphene in the blood, liver, brain, and gastric contents did not suggest an intentional overdose. However, the possibility of multiple drug interactions including citalopram was evident. In this case, the citalopram concentrations were consistent with those reported in fatal cases involving multiple drug use. Citalopram was present in urine at a concentration of 0.9 mg/L.
Robert West - One of the best experts on this subject based on the ideXlab platform.
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an evaluation of the diagnostic accuracy of liquid chromatography tandem mass spectrometry versus immunoassay drug testing in pain patients
Pain Physician, 2010Co-Authors: Amadeo J Pesce, Bridgit Crews, Charles Mikel, Robert West, M Rosenthal, Cameron West, Perla Almazan, Sergey LatyshevAbstract:Urine samples from 4,200 pain patients were tested by immunoassay and LC-MS/MS for the following drugs and metabolites: Amphetamine, Methamphetamine, Alpha-hydroxyalprazolam, Lorazepam, Nordiazepam, Oxazepam, Temazepam, Cannabinoids, Cocaine, Methadone, Methadone Metabolite, Codeine, Hydrocodone, Hydromorphone, Morphine, Propoxyphene, and Norpropoxyphene.
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unstable propoxyphene metabolite excreted in human urine is detected by liquid chromatography tandem mass spectrometry
Journal of Analytical Toxicology, 2009Co-Authors: Bridgit Crews, Charles Mikel, Sergey Latyshev, Robert West, Amadeo J PesceAbstract:A "dilute and shoot" method for measuring Norpropoxyphene in human urine using liquid chromatography-tandem mass spectrometry distinguishes two different metabolites of propoxyphene, Norpropoxyphene (m/z 326) and a dehydrated rearrangement product (m/z 308). The metabolite formed from the rearrangement and dehydration of Norpropoxyphene is excreted in human urine and also may be formed from the chemical degradation of Norpropoxyphene. Previously, these two metabolites were indistinguishable by gas chromatography- mass spectrometry methods that use an alkaline extraction that converts Norpropoxyphene into its rearrangement product. The degradation of Norpropoxyphene presents a challenge for its analytical quantitation, and methods for circumventing these issues are presented.