The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform
Hehe Lv - One of the best experts on this subject based on the ideXlab platform.
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InPrNa: A Tool for Insight Into Protein–Nucleic Acids Interaction Information
IEEE Access, 2019Co-Authors: Wei Wang, Yuan Zhao, Hongjun Zhang, Shiguang Zhang, Keliang Li, Hehe LvAbstract:Protein-Nucleic Acids bindings play key roles in many biological processes. However, the biological mechanisms underlying these interactions are not fully understood. Understanding the interface features between protein and Nucleic Acids may offer insights into how proteins are coupled with Nucleic Acids. There is a lack of tools that insight into the features of interface in a protein at present. In this work, we developed the InPrNa tool, a graphical tool for protein-Nucleic Acids complexes that works seamlessly within the PyMOL and gives quick results including 3D visualization for the residue's structure. InPrNa provides three distinct visualization modes to highlight interface, detecting interface residues with different distance between protein and Nucleic acid, marking physicochemical properties of the interface residues, and displaying three spatial structures of the interface residues. We also demonstrate the effectiveness of InPrNa's algorithm by contrast DNA binding proteins (DBPs) and RNA binding proteins (RBPs). These results show that DBPs and RBPs have significant differences in amino Acids distribution and structural distribution. InPrNa may help for analysis the interface characteristics of proteins-Nucleic Acids in PyMOL, and can be particularly useful in rapidly pinpointing the interaction mode of proteins-Nucleic Acids interface. Availability: Freely available at https://github.com/HNUBioinformatics.
Wei Wang - One of the best experts on this subject based on the ideXlab platform.
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InPrNa: A Tool for Insight Into Protein–Nucleic Acids Interaction Information
IEEE Access, 2019Co-Authors: Wei Wang, Yuan Zhao, Hongjun Zhang, Shiguang Zhang, Keliang Li, Hehe LvAbstract:Protein-Nucleic Acids bindings play key roles in many biological processes. However, the biological mechanisms underlying these interactions are not fully understood. Understanding the interface features between protein and Nucleic Acids may offer insights into how proteins are coupled with Nucleic Acids. There is a lack of tools that insight into the features of interface in a protein at present. In this work, we developed the InPrNa tool, a graphical tool for protein-Nucleic Acids complexes that works seamlessly within the PyMOL and gives quick results including 3D visualization for the residue's structure. InPrNa provides three distinct visualization modes to highlight interface, detecting interface residues with different distance between protein and Nucleic acid, marking physicochemical properties of the interface residues, and displaying three spatial structures of the interface residues. We also demonstrate the effectiveness of InPrNa's algorithm by contrast DNA binding proteins (DBPs) and RNA binding proteins (RBPs). These results show that DBPs and RBPs have significant differences in amino Acids distribution and structural distribution. InPrNa may help for analysis the interface characteristics of proteins-Nucleic Acids in PyMOL, and can be particularly useful in rapidly pinpointing the interaction mode of proteins-Nucleic Acids interface. Availability: Freely available at https://github.com/HNUBioinformatics.
Zhijian J Chen - One of the best experts on this subject based on the ideXlab platform.
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innate immune sensing and signaling of cytosolic Nucleic Acids
Annual Review of Immunology, 2014Co-Authors: Jiaxi Wu, Zhijian J ChenAbstract:The innate immune system utilizes pattern-recognition receptors (PRRs) to detect the invasion of pathogens and initiate host antimicrobial responses such as the production of type I interferons and proinflammatory cytokines. Nucleic Acids, which are essential genetic information carriers for all living organisms including viral, bacterial, and eukaryotic pathogens, are major structures detected by the innate immune system. However, inappropriate detection of self Nucleic Acids can result in autoimmune diseases. PRRs that recognize Nucleic Acids in cells include several endosomal members of the Toll-like receptor family and several cytosolic sensors for DNA and RNA. Here, we review the recent advances in understanding the mechanism of Nucleic acid sensing and signaling in the cytosol of mammalian cells as well as the emerging role of cytosolic Nucleic Acids in autoimmunity.
B Schmidt - One of the best experts on this subject based on the ideXlab platform.
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circulating Nucleic Acids cnas and cancer a survey
Biochimica et Biophysica Acta, 2007Co-Authors: M Fleischhacker, B SchmidtAbstract:It has been known for decades that it is possible to detect small amounts of extracellular Nucleic Acids in plasma and serum of healthy and diseased human beings. The unequivocal proof that part of these circulating Nucleic Acids (CNAs) is of tumor origin, initiated a surge of studies which confirmed and extended the original observations. In the past few years many experiments showed that tumor-associated alterations can be detected at the DNA and RNA level. At the DNA level the detection of point mutations, microsatellite alterations, chromosomal alterations, i.e. inversion and deletion, and hypermethylation of promoter sequences were demonstrated. At the RNA level the overexpression of tumor-associated genes was shown. These observations laid the foundation for the development of assays for an early detection of cancer as well as for other clinical means.
Keliang Li - One of the best experts on this subject based on the ideXlab platform.
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InPrNa: A Tool for Insight Into Protein–Nucleic Acids Interaction Information
IEEE Access, 2019Co-Authors: Wei Wang, Yuan Zhao, Hongjun Zhang, Shiguang Zhang, Keliang Li, Hehe LvAbstract:Protein-Nucleic Acids bindings play key roles in many biological processes. However, the biological mechanisms underlying these interactions are not fully understood. Understanding the interface features between protein and Nucleic Acids may offer insights into how proteins are coupled with Nucleic Acids. There is a lack of tools that insight into the features of interface in a protein at present. In this work, we developed the InPrNa tool, a graphical tool for protein-Nucleic Acids complexes that works seamlessly within the PyMOL and gives quick results including 3D visualization for the residue's structure. InPrNa provides three distinct visualization modes to highlight interface, detecting interface residues with different distance between protein and Nucleic acid, marking physicochemical properties of the interface residues, and displaying three spatial structures of the interface residues. We also demonstrate the effectiveness of InPrNa's algorithm by contrast DNA binding proteins (DBPs) and RNA binding proteins (RBPs). These results show that DBPs and RBPs have significant differences in amino Acids distribution and structural distribution. InPrNa may help for analysis the interface characteristics of proteins-Nucleic Acids in PyMOL, and can be particularly useful in rapidly pinpointing the interaction mode of proteins-Nucleic Acids interface. Availability: Freely available at https://github.com/HNUBioinformatics.
