The Experts below are selected from a list of 165657 Experts worldwide ranked by ideXlab platform
Martin Lotz - One of the best experts on this subject based on the ideXlab platform.
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cd137 a member of the tumor necrosis factor Receptor Family is located on chromosome 1p36 in a cluster of related genes and colocalizes with several malignancies
Biochemical and Biophysical Research Communications, 1997Co-Authors: Herbert Schwarz, Karen C Arden, Martin LotzAbstract:CD137 (ILA/4-1BB) is a member of the tumor-necrosis-factor Receptor Family. Members of this Receptor Family and their structurally related ligands are important regulators of a wide variety of physiological processes and play an especially important role in the regulation of immune responses. CD137 regulates cell proliferation and survival of T-lymphocytes. Using Southern blot analysis and polymerase chain reaction, we localized the CD137 gene to chromosome 1p36. This chromosomal region harbors the genes of several other members of this Receptor Family and is associated with deletions and rearrangements in several malignancies.
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The nerve growth factor/tumor necrosis factor Receptor Family.
Journal of leukocyte biology, 1996Co-Authors: Martin Lotz, M Setareh, J Von Kempis, Herbert SchwarzAbstract:Receptors in the nerve growth factor/tu- mor necrosis factor Receptor Family are charac- terized by the presence of cysteme-rich motifs of �4O amino acids in the extracellular domain. The ligands are type II transmembrane proteins with n-strands that form a jelly-roll n-sandwich. The re- ceptors recognize soluble or cell-surface-bound II- gands and mediate diverse cellular responses. Activation of intracellular signals is mediated at least in part by the association of proteins with a RING finger motif or a death domain to the cytoplasmic domains of the Receptors. In addition to cell-mem- brane-bound Receptors soluble forms have been de- scrihed for most of the Receptors. Activation of intracellular signals not only occurs through ligand binding to the Receptors but cross-linking of at least some members of the ligand Family can regulate cell functions. J. Leukoc. Biol. 60: 1-7; 1996.
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A Receptor induced by lymphocyte activation (ILA) : a new member of the human nerve-growth-factor/tumor-necrosis-factor Receptor Family
Gene, 1993Co-Authors: Herbert Schwarz, Julia Tuckwell, Martin LotzAbstract:A 1.4-kb full-length cDNA was isolated from a library constructed from activated human T-cell leukemia virus type 1-transformed human T-lymphocytes. Sequence analysis identified this cDNA as a new member of the human nerve-growth-factor Receptor/tumor-necrosis-factor Receptor Family and as the potential human homologue of the murine sequence, 4-1BB. The gene encodes three cysteine-rich motifs in the extracellular domain which are characteristic of this Receptor Family, a transmembrane region and a short N-terminal cytoplasmic portion which contains potential phosphorylation sites.
Herbert Schwarz - One of the best experts on this subject based on the ideXlab platform.
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cd137 a member of the tumor necrosis factor Receptor Family is located on chromosome 1p36 in a cluster of related genes and colocalizes with several malignancies
Biochemical and Biophysical Research Communications, 1997Co-Authors: Herbert Schwarz, Karen C Arden, Martin LotzAbstract:CD137 (ILA/4-1BB) is a member of the tumor-necrosis-factor Receptor Family. Members of this Receptor Family and their structurally related ligands are important regulators of a wide variety of physiological processes and play an especially important role in the regulation of immune responses. CD137 regulates cell proliferation and survival of T-lymphocytes. Using Southern blot analysis and polymerase chain reaction, we localized the CD137 gene to chromosome 1p36. This chromosomal region harbors the genes of several other members of this Receptor Family and is associated with deletions and rearrangements in several malignancies.
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The nerve growth factor/tumor necrosis factor Receptor Family.
Journal of leukocyte biology, 1996Co-Authors: Martin Lotz, M Setareh, J Von Kempis, Herbert SchwarzAbstract:Receptors in the nerve growth factor/tu- mor necrosis factor Receptor Family are charac- terized by the presence of cysteme-rich motifs of �4O amino acids in the extracellular domain. The ligands are type II transmembrane proteins with n-strands that form a jelly-roll n-sandwich. The re- ceptors recognize soluble or cell-surface-bound II- gands and mediate diverse cellular responses. Activation of intracellular signals is mediated at least in part by the association of proteins with a RING finger motif or a death domain to the cytoplasmic domains of the Receptors. In addition to cell-mem- brane-bound Receptors soluble forms have been de- scrihed for most of the Receptors. Activation of intracellular signals not only occurs through ligand binding to the Receptors but cross-linking of at least some members of the ligand Family can regulate cell functions. J. Leukoc. Biol. 60: 1-7; 1996.
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A Receptor induced by lymphocyte activation (ILA) : a new member of the human nerve-growth-factor/tumor-necrosis-factor Receptor Family
Gene, 1993Co-Authors: Herbert Schwarz, Julia Tuckwell, Martin LotzAbstract:A 1.4-kb full-length cDNA was isolated from a library constructed from activated human T-cell leukemia virus type 1-transformed human T-lymphocytes. Sequence analysis identified this cDNA as a new member of the human nerve-growth-factor Receptor/tumor-necrosis-factor Receptor Family and as the potential human homologue of the murine sequence, 4-1BB. The gene encodes three cysteine-rich motifs in the extracellular domain which are characteristic of this Receptor Family, a transmembrane region and a short N-terminal cytoplasmic portion which contains potential phosphorylation sites.
Jannie Borst - One of the best experts on this subject based on the ideXlab platform.
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Tumor necrosis factor Receptor Family members in the immune system
Seminars in immunology, 1998Co-Authors: Loes A. Gravestein, Jannie BorstAbstract:Abstract The tumor necrosis factor (TNF) Receptor Family contains death Receptors, which have a cytoplasmic death domain and can induce apoptosis, as well as Receptors with no apparent homology in the cytoplasmic tail. This second group of Receptors binds TNF Receptor–associated factors (TRAFs), which are implicated in gene regulation and anti–apoptotic signaling. A bewildering variety of TNF Receptor Family members and their ligands are expressed on cells of the immune system. Based on the pattern of expression of Receptors and ligands and based on the phenotype of available knock out mice, we summarize at which stages in lymphoid development and/or the peripheral immune response the various TNF Receptor Family members may play a role.
Carlo Riccardi - One of the best experts on this subject based on the ideXlab platform.
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a new member of the tumor necrosis factor nerve growth factor Receptor Family inhibits t cell Receptor induced apoptosis
Proceedings of the National Academy of Sciences of the United States of America, 1997Co-Authors: Giuseppe Nocentini, L. Giunchi, S. Ronchetti, L. T. Krausz, Graziella Migliorati, Rosalba Moraca, Andrea Bartoli, Carlo RiccardiAbstract:By comparing untreated and dexamethasone-treated murine T cell hybridoma (3DO) cells by the differential display technique, we have cloned a new gene, GITR (glucocorticoid-induced tumor necrosis factor Receptor Family-related gene) encoding a new member of the tumor necrosis factor/nerve growth factor Receptor Family. GITR is a 228-amino acids type I transmembrane protein characterized by three cysteine pseudorepeats in the extracellular domain and similar to CD27 and 4-1BB in the intracellular domain. GITR resulted to be expressed in normal T lymphocytes from thymus, spleen, and lymph nodes, although no expression was detected in other nonlymphoid tissues, including brain, kidney, and liver. Furthermore, GITR expression was induced in T lymphocytes upon activation by anti-CD3 mAb, Con A, or phorbol 12-myristate 13-acetate plus Ca-ionophore treatment. The constitutive expression of a transfected GITR gene induced resistance to anti-CD3 mAb-induced apoptosis, whereas antisense GITR mRNA expression lead to increased sensitivity. The protection toward T cell Receptor-induced apoptosis was specific, because other apoptotic signals (Fas triggering, dexamethasone treatment, or UV irradiation) were not modulated by GITR transfection. Thus, GITR is a new member of tumor necrosis factor/nerve growth factor Receptor Family involved in the regulation of T cell Receptor-mediated cell death.
E. Yvonne Jones - One of the best experts on this subject based on the ideXlab platform.
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The tumour necrosis factor Receptor Family: life or death choices.
Current opinion in structural biology, 2000Co-Authors: E. Yvonne JonesAbstract:Abstract The past twelve months have seen a renewal of interest in the therapeutic potential of members of the tumour necrosis factor Receptor Family and their cytokine ligands. This biomedical interest has spawned a number of structural studies, which have significantly deepened our understanding of the molecular basis for the function of these cell-surface signalling systems. The fresh data have revealed unexpected mechanisms conferring ligand–Receptor specificity and have highlighted the structural requirements for the initiation of intracellular signalling.
