The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Hang Xiao - One of the best experts on this subject based on the ideXlab platform.
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the nutraceutical bioavailability classification scheme classifying Nutraceuticals according to factors limiting their oral bioavailability
Annual Review of Food Science and Technology - (new in 2010), 2015Co-Authors: David Julian Mcclements, Fang Li, Hang XiaoAbstract:The oral bioavailability of a health-promoting dietary component (nutraceutical) may be limited by various physicochemical and physiological phenomena: liberation from food matrices, solubility in gastrointestinal fluids, interaction with gastrointestinal components, chemical degradation or metabolism, and epithelium cell permeability. Nutraceutical bioavailability can therefore be improved by designing food matrices that control their bioaccessibility (B*), absorption (A*), and transformation (T*) within the gastrointestinal tract (GIT). This article reviews the major factors influencing the gastrointestinal fate of Nutraceuticals, and then uses this information to develop a new scheme to classify the major factors limiting nutraceutical bioavailability: the nutraceutical bioavailability classification scheme (NuBACS). This new scheme is analogous to the biopharmaceutical classification scheme (BCS) used by the pharmaceutical industry to classify drug bioavailability, but it contains additional factors i...
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the nutraceutical bioavailability classification scheme classifying Nutraceuticals according to factors limiting their oral bioavailability
Annual Review of Food Science and Technology - (new in 2010), 2015Co-Authors: David Julian Mcclements, Hang XiaoAbstract:The oral bioavailability of a health-promoting dietary component (nutraceutical) may be limited by various physicochemical and physiological phenomena: liberation from food matrices, solubility in gastrointestinal fluids, interaction with gastrointestinal components, chemical degradation or metabolism, and epithelium cell permeability. Nutraceutical bioavailability can therefore be improved by designing food matrices that control their bioaccessibility (B*), absorption (A*), and transformation (T*) within the gastrointestinal tract (GIT). This article reviews the major factors influencing the gastrointestinal fate of Nutraceuticals, and then uses this information to develop a new scheme to classify the major factors limiting nutraceutical bioavailability: the nutraceutical bioavailability classification scheme (NuBACS). This new scheme is analogous to the biopharmaceutical classification scheme (BCS) used by the pharmaceutical industry to classify drug bioavailability, but it contains additional factors important for understanding nutraceutical bioavailability in foods. The article also highlights potential strategies for increasing the oral bioavailability of Nutraceuticals based on their NuBACS designation (B*A*T*).
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improving oral bioavailability of Nutraceuticals by engineered nanoparticle based delivery systems
Current opinion in food science, 2015Co-Authors: Mingfei Yao, David Julian Mcclements, Hang XiaoAbstract:Many important Nutraceuticals have poor oral bioavailability, which greatly lowers their efficacy as health-promoting agents. Engineered nanoparticles (ENs) can be used to fabricate delivery systems that improve oral bioavailability through a number of mechanisms: increasing nutraceutical stability in foods and the gastrointestinal tract (GIT); enhancing nutraceutical solubility in intestinal fluids; facilitating nutraceutical absorption by GIT; and decreasing first-pass metabolism in the gut and liver. This review depicts the mode of actions of different food-grade ENs in improving oral bioavailability of Nutraceuticals.
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droplet size and composition of nutraceutical nanoemulsions influences bioavailability of long chain fatty acids and coenzyme q10
Food Chemistry, 2014Co-Authors: Laura Salviatrujillo, Yooheon Park, Hang Xiao, David Julian McclementsAbstract:Abstract The influence of droplet size ( d 32 = 0.21, 0.70 or 2.2 μm) and oil digestibility (corn oil versus mineral oil) on the bioavailability of a model long chain fatty acid (heptadecanoic acid) and lipophilic nutraceutical (Coenzyme Q10) was investigated using a rat feeding study. Initially, we showed that small droplets were digested more rapidly than large droplets using a simulated small intestinal model (pH stat), which was attributed to the greater surface area of lipid exposed to intestinal juices. The pH stat model also confirmed that emulsified corn oil was digestible, whereas emulsified mineral oil was indigestible. A rat feeding study showed that the bioavailability of the fatty acid and lipophilic nutraceutical in small intestinal tissues was highest when they were encapsulated within digestible oil droplets with the smallest size. This study provides important information for development of nanoemulsion-based delivery systems that increase oral bioavailability of lipophilic Nutraceuticals.
David Julian Mcclements - One of the best experts on this subject based on the ideXlab platform.
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recent progress in hydrogel delivery systems for improving nutraceutical bioavailability
Food Hydrocolloids, 2017Co-Authors: David Julian McclementsAbstract:Nutraceuticals are bioactive molecules found in foods that may improve human performance, wellbeing, or health. The potential health benefits of many Nutraceuticals are not fully realized because they are chemically degraded during storage or within the gastrointestinal tract. Consequently, there is a need to develop food-grade delivery systems to encapsulate and protect Nutraceuticals until they reach an appropriate location within the human body, e.g., mouth, stomach, small intestine, or colon. Hydrogel beads (“microgels”) assembled from proteins and/or polysaccharides can improve nutraceutical performance by protecting them from chemical degradation. These beads can be fabricated using simple and inexpensive processing operations that typically involve two steps: (i) formation of biopolymer-enriched particles; (ii) cross-linking of the biopolymers. Hydrophilic Nutraceuticals are usually mixed directly with the biopolymer solution prior to formation of the hydrogel beads, whereas hydrophobic Nutraceuticals are typically incorporated into lipid droplets (emulsions or nanoemulsions) prior to mixing with the biopolymer solution. Common particle-formation methods include injection, shearing, templating, and phase separation, whereas common cross-linking methods include changes in solvent quality, counter-ion addition, enzyme addition, heating, and cooling. This article provides an overview of recent progress in the design and fabrication of food-grade hydrogel beads to encapsulate and protect Nutraceuticals, including some examples of their potential applications.
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the nutraceutical bioavailability classification scheme classifying Nutraceuticals according to factors limiting their oral bioavailability
Annual Review of Food Science and Technology - (new in 2010), 2015Co-Authors: David Julian Mcclements, Fang Li, Hang XiaoAbstract:The oral bioavailability of a health-promoting dietary component (nutraceutical) may be limited by various physicochemical and physiological phenomena: liberation from food matrices, solubility in gastrointestinal fluids, interaction with gastrointestinal components, chemical degradation or metabolism, and epithelium cell permeability. Nutraceutical bioavailability can therefore be improved by designing food matrices that control their bioaccessibility (B*), absorption (A*), and transformation (T*) within the gastrointestinal tract (GIT). This article reviews the major factors influencing the gastrointestinal fate of Nutraceuticals, and then uses this information to develop a new scheme to classify the major factors limiting nutraceutical bioavailability: the nutraceutical bioavailability classification scheme (NuBACS). This new scheme is analogous to the biopharmaceutical classification scheme (BCS) used by the pharmaceutical industry to classify drug bioavailability, but it contains additional factors i...
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the nutraceutical bioavailability classification scheme classifying Nutraceuticals according to factors limiting their oral bioavailability
Annual Review of Food Science and Technology - (new in 2010), 2015Co-Authors: David Julian Mcclements, Hang XiaoAbstract:The oral bioavailability of a health-promoting dietary component (nutraceutical) may be limited by various physicochemical and physiological phenomena: liberation from food matrices, solubility in gastrointestinal fluids, interaction with gastrointestinal components, chemical degradation or metabolism, and epithelium cell permeability. Nutraceutical bioavailability can therefore be improved by designing food matrices that control their bioaccessibility (B*), absorption (A*), and transformation (T*) within the gastrointestinal tract (GIT). This article reviews the major factors influencing the gastrointestinal fate of Nutraceuticals, and then uses this information to develop a new scheme to classify the major factors limiting nutraceutical bioavailability: the nutraceutical bioavailability classification scheme (NuBACS). This new scheme is analogous to the biopharmaceutical classification scheme (BCS) used by the pharmaceutical industry to classify drug bioavailability, but it contains additional factors important for understanding nutraceutical bioavailability in foods. The article also highlights potential strategies for increasing the oral bioavailability of Nutraceuticals based on their NuBACS designation (B*A*T*).
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improving oral bioavailability of Nutraceuticals by engineered nanoparticle based delivery systems
Current opinion in food science, 2015Co-Authors: Mingfei Yao, David Julian Mcclements, Hang XiaoAbstract:Many important Nutraceuticals have poor oral bioavailability, which greatly lowers their efficacy as health-promoting agents. Engineered nanoparticles (ENs) can be used to fabricate delivery systems that improve oral bioavailability through a number of mechanisms: increasing nutraceutical stability in foods and the gastrointestinal tract (GIT); enhancing nutraceutical solubility in intestinal fluids; facilitating nutraceutical absorption by GIT; and decreasing first-pass metabolism in the gut and liver. This review depicts the mode of actions of different food-grade ENs in improving oral bioavailability of Nutraceuticals.
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droplet size and composition of nutraceutical nanoemulsions influences bioavailability of long chain fatty acids and coenzyme q10
Food Chemistry, 2014Co-Authors: Laura Salviatrujillo, Yooheon Park, Hang Xiao, David Julian McclementsAbstract:Abstract The influence of droplet size ( d 32 = 0.21, 0.70 or 2.2 μm) and oil digestibility (corn oil versus mineral oil) on the bioavailability of a model long chain fatty acid (heptadecanoic acid) and lipophilic nutraceutical (Coenzyme Q10) was investigated using a rat feeding study. Initially, we showed that small droplets were digested more rapidly than large droplets using a simulated small intestinal model (pH stat), which was attributed to the greater surface area of lipid exposed to intestinal juices. The pH stat model also confirmed that emulsified corn oil was digestible, whereas emulsified mineral oil was indigestible. A rat feeding study showed that the bioavailability of the fatty acid and lipophilic nutraceutical in small intestinal tissues was highest when they were encapsulated within digestible oil droplets with the smallest size. This study provides important information for development of nanoemulsion-based delivery systems that increase oral bioavailability of lipophilic Nutraceuticals.
Hongshan Liang - One of the best experts on this subject based on the ideXlab platform.
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plant exine capsules based encapsulation strategy a high loading and long term effective delivery system for nobiletin
Food Research International, 2020Co-Authors: Youyan Liang, Hongshan Liang, Di Wu, Bin LiAbstract:Abstract The properties of high loading capacity and long-term absorption are of great significance in the field of Nutraceuticals or drugs delivery. Herein, we developed an innovative method to achieve these expected effects using plant exine capsules, a kind of natural pollen grains, which could provide large internal cavities for loading and robust exine against harsh conditions. In our work, we firstly made a soluble mixture of glycerol monostearate (GM) and nobiletin (NOB) inside the cavities of plant exine capsules by ultrasound with high temperature to obtain a supersaturated state of NOB, which could be characterized by XRD, DSC and FTIR. After that, the loaded capsules were cooled to room temperature. Alginate hydrogels were then selected for encapsulating and further controlling NOB release in simulated gastric and intestinal conditions. As a result, it demonstrated that our approach was able to reach an extremely high NOB loading capacity of 770 ± 40 mg/g using sunflower pollen grains (SPGs). Meanwhile, the existence of GM, SPGs and alginate hydrogels all retarded the release of the NOB synergistically, thus taking a slow release effect in the stomach while a long-term effective absorption in the intestine. Taken together, our processing method of encapsulating hydrophobic Nutraceuticals provides an important insight for broadening the applications of nutraceutical or drug encapsulation and delivery.
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leveraging plant exine capsules as ph responsive delivery vehicles for hydrophobic nutraceutical encapsulation
Food & Function, 2018Co-Authors: Di Wu, Youyan Liang, Xinyi Jing, Kai Huang, Bin Li, Hongshan LiangAbstract:Plant exine capsules are natural microscale capsules that are highly physically robust and chemically resilient. They are extracted from pollen grains and plant spores, and can be used as renewable and safe microcapsules for encapsulation applications. Herein, we report the successful evacuation of natural sunflower pollen grains (SPGs) and Lycopodiastrum casuarinoides spore exine capsules (SECs) and investigated the effects of different loading methods on the encapsulation and release of nobiletin, a model hydrophobic nutraceutical. The compositional and morphological characterizations of SPGs and SECs obtained by the developed extraction protocol confirmed that the inside contents had been removed and hollow pollen cavities were obtained successfully. In addition, coumarin-6, a hydrophobic fluorescent probe, was encapsulated into SPGs and SECs, which proved the possibility of using them to encapsulate hydrophobic Nutraceuticals. Furthermore, controlled release in simulated digestive fluids (SDF) was achieved by coating calcium alginate onto the outside of the SPGs and SECs. Looking forward, this may provide an effective and potential delivery model to protect loads from degradation in the stomach and achieve pH-responsive delivery of hydrophobic Nutraceuticals after oral administration.
Di Wu - One of the best experts on this subject based on the ideXlab platform.
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plant exine capsules based encapsulation strategy a high loading and long term effective delivery system for nobiletin
Food Research International, 2020Co-Authors: Youyan Liang, Hongshan Liang, Di Wu, Bin LiAbstract:Abstract The properties of high loading capacity and long-term absorption are of great significance in the field of Nutraceuticals or drugs delivery. Herein, we developed an innovative method to achieve these expected effects using plant exine capsules, a kind of natural pollen grains, which could provide large internal cavities for loading and robust exine against harsh conditions. In our work, we firstly made a soluble mixture of glycerol monostearate (GM) and nobiletin (NOB) inside the cavities of plant exine capsules by ultrasound with high temperature to obtain a supersaturated state of NOB, which could be characterized by XRD, DSC and FTIR. After that, the loaded capsules were cooled to room temperature. Alginate hydrogels were then selected for encapsulating and further controlling NOB release in simulated gastric and intestinal conditions. As a result, it demonstrated that our approach was able to reach an extremely high NOB loading capacity of 770 ± 40 mg/g using sunflower pollen grains (SPGs). Meanwhile, the existence of GM, SPGs and alginate hydrogels all retarded the release of the NOB synergistically, thus taking a slow release effect in the stomach while a long-term effective absorption in the intestine. Taken together, our processing method of encapsulating hydrophobic Nutraceuticals provides an important insight for broadening the applications of nutraceutical or drug encapsulation and delivery.
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leveraging plant exine capsules as ph responsive delivery vehicles for hydrophobic nutraceutical encapsulation
Food & Function, 2018Co-Authors: Di Wu, Youyan Liang, Xinyi Jing, Kai Huang, Bin Li, Hongshan LiangAbstract:Plant exine capsules are natural microscale capsules that are highly physically robust and chemically resilient. They are extracted from pollen grains and plant spores, and can be used as renewable and safe microcapsules for encapsulation applications. Herein, we report the successful evacuation of natural sunflower pollen grains (SPGs) and Lycopodiastrum casuarinoides spore exine capsules (SECs) and investigated the effects of different loading methods on the encapsulation and release of nobiletin, a model hydrophobic nutraceutical. The compositional and morphological characterizations of SPGs and SECs obtained by the developed extraction protocol confirmed that the inside contents had been removed and hollow pollen cavities were obtained successfully. In addition, coumarin-6, a hydrophobic fluorescent probe, was encapsulated into SPGs and SECs, which proved the possibility of using them to encapsulate hydrophobic Nutraceuticals. Furthermore, controlled release in simulated digestive fluids (SDF) was achieved by coating calcium alginate onto the outside of the SPGs and SECs. Looking forward, this may provide an effective and potential delivery model to protect loads from degradation in the stomach and achieve pH-responsive delivery of hydrophobic Nutraceuticals after oral administration.
Fang Li - One of the best experts on this subject based on the ideXlab platform.
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the nutraceutical bioavailability classification scheme classifying Nutraceuticals according to factors limiting their oral bioavailability
Annual Review of Food Science and Technology - (new in 2010), 2015Co-Authors: David Julian Mcclements, Fang Li, Hang XiaoAbstract:The oral bioavailability of a health-promoting dietary component (nutraceutical) may be limited by various physicochemical and physiological phenomena: liberation from food matrices, solubility in gastrointestinal fluids, interaction with gastrointestinal components, chemical degradation or metabolism, and epithelium cell permeability. Nutraceutical bioavailability can therefore be improved by designing food matrices that control their bioaccessibility (B*), absorption (A*), and transformation (T*) within the gastrointestinal tract (GIT). This article reviews the major factors influencing the gastrointestinal fate of Nutraceuticals, and then uses this information to develop a new scheme to classify the major factors limiting nutraceutical bioavailability: the nutraceutical bioavailability classification scheme (NuBACS). This new scheme is analogous to the biopharmaceutical classification scheme (BCS) used by the pharmaceutical industry to classify drug bioavailability, but it contains additional factors i...
