The Experts below are selected from a list of 7839 Experts worldwide ranked by ideXlab platform
Jacqueline A E Langius - One of the best experts on this subject based on the ideXlab platform.
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the effect of Nutritional Counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy a randomized controlled trial
Clinical Nutrition, 2020Co-Authors: Anne Van Der Werf, Jacqueline A E Langius, Johannes Berkhof, Aart Beeker, A Ten J Tije, A Vulink, A Haringhuizen, H J Van Der Vliet, Henk M W VerheulAbstract:Summary Background & aims A low muscle mass before start of treatment and loss of muscle mass during chemotherapy is related to adverse outcomes in patients with cancer. In this randomized controlled trial, the effect of Nutritional Counseling on change in muscle mass and treatment outcome in patients with metastatic colorectal cancer during first-line chemotherapy was studied. Methods Patients scheduled for first-line chemotherapy (n = 107) were randomly assigned to individualized Nutritional Counseling by a dietitian (NC) or usual care (UC). NC was aimed at sufficient protein- and energy intake, supported by oral supplements or enteral feeding if indicated. Furthermore, physical activity was encouraged. Outcomes were assessed at baseline (T0) and the time of the first (T1) and second (T2) regular follow-up computed tomography scans. The proportion of patients with a clinically relevant decrease in skeletal muscle area of ≥6.0 cm2, measured by computed tomography, was the primary outcome. Secondary outcomes included body weight, quality of life, treatment toxicity and progression free and overall survival. Results A total of 107 patients were enrolled (mean age, 65 years (SD, 11 years), 63% male). Mean change in skeletal muscle area from T0 till T1 was −2.5 (SD, 9.5) cm2, with no difference between NC versus UC (p = 0.891). The proportion of patients with a clinically relevant decrease in skeletal muscle area of ≥6.0 cm2 did not differ (NC 30% versus UC 31%, p = 0.467). NC compared with UC had a significant positive effect on body weight (B coefficient 1.7, p = 0.045), progression free survival (p = 0.039) and overall survival (p = 0.046). Conclusions NC of patients undergoing chemotherapy for metastatic colorectal cancer had no effect on muscle mass. However, we found that NC may increase body weight and improve progression free survival and overall survival compared to UC in this group of patients. These findings need further evaluation in future clinical trials. Clinical trial information ClinicalTrials.gov NCT01998152; Netherlands Trial Register NTR4223.
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the effect of individualized Nutritional Counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy a randomized controlled trial protocol
BMC Cancer, 2015Co-Authors: Anne Van Der Werf, Susanne Blauwhoffbuskermolen, Jacqueline A E Langius, Johannes Berkhof, Henk M W Verheul, Marian A E De Van Der SchuerenAbstract:Background A low muscle mass is prevalent in patients with metastatic colorectal cancer (mCRC) and has been associated with poor treatment outcome. Chemotherapeutic treatment has an additional unfavorable effect on muscle mass. Sufficient protein intake and physical activity are known to induce muscle protein anabolism in healthy individuals, however it is unclear whether optimal nutrition is effective to preserve muscle mass in patients with mCRC during first-line chemotherapy as well. We hypothesize that individual Nutritional Counseling by a trained dietitian during first-line chemotherapy is effective in preserving muscle mass and may improve clinical outcomes in patients with mCRC.
Marian A E De Van Der Schueren - One of the best experts on this subject based on the ideXlab platform.
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the effect of individualized Nutritional Counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy a randomized controlled trial protocol
BMC Cancer, 2015Co-Authors: Anne Van Der Werf, Susanne Blauwhoffbuskermolen, Jacqueline A E Langius, Johannes Berkhof, Henk M W Verheul, Marian A E De Van Der SchuerenAbstract:Background A low muscle mass is prevalent in patients with metastatic colorectal cancer (mCRC) and has been associated with poor treatment outcome. Chemotherapeutic treatment has an additional unfavorable effect on muscle mass. Sufficient protein intake and physical activity are known to induce muscle protein anabolism in healthy individuals, however it is unclear whether optimal nutrition is effective to preserve muscle mass in patients with mCRC during first-line chemotherapy as well. We hypothesize that individual Nutritional Counseling by a trained dietitian during first-line chemotherapy is effective in preserving muscle mass and may improve clinical outcomes in patients with mCRC.
Marco Benazzo - One of the best experts on this subject based on the ideXlab platform.
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Nutritional Counseling with or without systematic use of oral Nutritional supplements in head and neck cancer patients undergoing radiotherapy
Radiotherapy and Oncology, 2017Co-Authors: Emanuele Cereda, Silvia Cappello, Sara Colombo, Catherine Klersy, Ilaria Imarisio, Annalisa Turri, Marilisa Caraccia, Valeria Borioli, T Monaco, Marco BenazzoAbstract:Abstract Background To evaluate the benefit of oral Nutritional supplements (ONS) in addition to Nutritional Counseling in head and neck cancer (HNC) patients undergoing radiotherapy (RT). Methods In a single-center, randomized, pragmatic, parallel-group controlled trial (ClinicalTrials.gov: NCT02055833; February 2014–August 2016), 159 newly diagnosed HNC patients suitable for to RT regardless of previous surgery and induction chemotherapy were randomly assigned to Nutritional Counseling in combination with ONS (N = 78) or without ONS (N = 81) from the start of RT and continuing for up to 3 months after its end. Primary endpoint was the change in body weight at the end of RT. Secondary endpoints included changes in protein-calorie intake, muscle strength, phase angle and quality of life and anti-cancer treatment tolerance. Results In patients with the primary endpoint assessed (modified intention-to-treat population), Counseling plus ONS (N = 67) resulted in smaller loss of body weight than Nutritional Counseling alone (N = 69; mean difference, 1.6 kg [95%CI, 0.5–2.7]; P = 0.006). Imputation of missing outcomes provided consistent findings. In the ONS-supplemented group, higher protein-calorie intake and improvement in quality of life over time were also observed (P Conclusion In HNC patients undergoing RT or RT plus systemic treatment, and receiving Nutritional Counseling, the use of ONS resulted in better weight maintenance, increased protein-calorie intake, improved quality of life and was associated with better anti-cancer treatment tolerance.
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Nutritional Counseling with or without systematic use of oral Nutritional supplements in head and neck cancer patients undergoing radiotherapy
Journal of Clinical Oncology, 2017Co-Authors: Paolo Pedrazzoli, Emanuele Cereda, Silvia Cappello, Sara Colombo, Catherine Klersy, Ilaria Imarisio, Annalisa Turri, Marilisa Caraccia, Alberto Verlicchi, Marco BenazzoAbstract:10098Background: The benefit of systematic use of oral Nutritional supplements (ONS) in addition to Nutritional Counseling in head and neck cancer (HNC) patients undergoing radiotherapy (RT) has no...
Henk M W Verheul - One of the best experts on this subject based on the ideXlab platform.
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the effect of Nutritional Counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy a randomized controlled trial
Clinical Nutrition, 2020Co-Authors: Anne Van Der Werf, Jacqueline A E Langius, Johannes Berkhof, Aart Beeker, A Ten J Tije, A Vulink, A Haringhuizen, H J Van Der Vliet, Henk M W VerheulAbstract:Summary Background & aims A low muscle mass before start of treatment and loss of muscle mass during chemotherapy is related to adverse outcomes in patients with cancer. In this randomized controlled trial, the effect of Nutritional Counseling on change in muscle mass and treatment outcome in patients with metastatic colorectal cancer during first-line chemotherapy was studied. Methods Patients scheduled for first-line chemotherapy (n = 107) were randomly assigned to individualized Nutritional Counseling by a dietitian (NC) or usual care (UC). NC was aimed at sufficient protein- and energy intake, supported by oral supplements or enteral feeding if indicated. Furthermore, physical activity was encouraged. Outcomes were assessed at baseline (T0) and the time of the first (T1) and second (T2) regular follow-up computed tomography scans. The proportion of patients with a clinically relevant decrease in skeletal muscle area of ≥6.0 cm2, measured by computed tomography, was the primary outcome. Secondary outcomes included body weight, quality of life, treatment toxicity and progression free and overall survival. Results A total of 107 patients were enrolled (mean age, 65 years (SD, 11 years), 63% male). Mean change in skeletal muscle area from T0 till T1 was −2.5 (SD, 9.5) cm2, with no difference between NC versus UC (p = 0.891). The proportion of patients with a clinically relevant decrease in skeletal muscle area of ≥6.0 cm2 did not differ (NC 30% versus UC 31%, p = 0.467). NC compared with UC had a significant positive effect on body weight (B coefficient 1.7, p = 0.045), progression free survival (p = 0.039) and overall survival (p = 0.046). Conclusions NC of patients undergoing chemotherapy for metastatic colorectal cancer had no effect on muscle mass. However, we found that NC may increase body weight and improve progression free survival and overall survival compared to UC in this group of patients. These findings need further evaluation in future clinical trials. Clinical trial information ClinicalTrials.gov NCT01998152; Netherlands Trial Register NTR4223.
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the effect of individualized Nutritional Counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy a randomized controlled trial protocol
BMC Cancer, 2015Co-Authors: Anne Van Der Werf, Susanne Blauwhoffbuskermolen, Jacqueline A E Langius, Johannes Berkhof, Henk M W Verheul, Marian A E De Van Der SchuerenAbstract:Background A low muscle mass is prevalent in patients with metastatic colorectal cancer (mCRC) and has been associated with poor treatment outcome. Chemotherapeutic treatment has an additional unfavorable effect on muscle mass. Sufficient protein intake and physical activity are known to induce muscle protein anabolism in healthy individuals, however it is unclear whether optimal nutrition is effective to preserve muscle mass in patients with mCRC during first-line chemotherapy as well. We hypothesize that individual Nutritional Counseling by a trained dietitian during first-line chemotherapy is effective in preserving muscle mass and may improve clinical outcomes in patients with mCRC.
Anne Van Der Werf - One of the best experts on this subject based on the ideXlab platform.
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the effect of Nutritional Counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy a randomized controlled trial
Clinical Nutrition, 2020Co-Authors: Anne Van Der Werf, Jacqueline A E Langius, Johannes Berkhof, Aart Beeker, A Ten J Tije, A Vulink, A Haringhuizen, H J Van Der Vliet, Henk M W VerheulAbstract:Summary Background & aims A low muscle mass before start of treatment and loss of muscle mass during chemotherapy is related to adverse outcomes in patients with cancer. In this randomized controlled trial, the effect of Nutritional Counseling on change in muscle mass and treatment outcome in patients with metastatic colorectal cancer during first-line chemotherapy was studied. Methods Patients scheduled for first-line chemotherapy (n = 107) were randomly assigned to individualized Nutritional Counseling by a dietitian (NC) or usual care (UC). NC was aimed at sufficient protein- and energy intake, supported by oral supplements or enteral feeding if indicated. Furthermore, physical activity was encouraged. Outcomes were assessed at baseline (T0) and the time of the first (T1) and second (T2) regular follow-up computed tomography scans. The proportion of patients with a clinically relevant decrease in skeletal muscle area of ≥6.0 cm2, measured by computed tomography, was the primary outcome. Secondary outcomes included body weight, quality of life, treatment toxicity and progression free and overall survival. Results A total of 107 patients were enrolled (mean age, 65 years (SD, 11 years), 63% male). Mean change in skeletal muscle area from T0 till T1 was −2.5 (SD, 9.5) cm2, with no difference between NC versus UC (p = 0.891). The proportion of patients with a clinically relevant decrease in skeletal muscle area of ≥6.0 cm2 did not differ (NC 30% versus UC 31%, p = 0.467). NC compared with UC had a significant positive effect on body weight (B coefficient 1.7, p = 0.045), progression free survival (p = 0.039) and overall survival (p = 0.046). Conclusions NC of patients undergoing chemotherapy for metastatic colorectal cancer had no effect on muscle mass. However, we found that NC may increase body weight and improve progression free survival and overall survival compared to UC in this group of patients. These findings need further evaluation in future clinical trials. Clinical trial information ClinicalTrials.gov NCT01998152; Netherlands Trial Register NTR4223.
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the effect of individualized Nutritional Counseling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy a randomized controlled trial protocol
BMC Cancer, 2015Co-Authors: Anne Van Der Werf, Susanne Blauwhoffbuskermolen, Jacqueline A E Langius, Johannes Berkhof, Henk M W Verheul, Marian A E De Van Der SchuerenAbstract:Background A low muscle mass is prevalent in patients with metastatic colorectal cancer (mCRC) and has been associated with poor treatment outcome. Chemotherapeutic treatment has an additional unfavorable effect on muscle mass. Sufficient protein intake and physical activity are known to induce muscle protein anabolism in healthy individuals, however it is unclear whether optimal nutrition is effective to preserve muscle mass in patients with mCRC during first-line chemotherapy as well. We hypothesize that individual Nutritional Counseling by a trained dietitian during first-line chemotherapy is effective in preserving muscle mass and may improve clinical outcomes in patients with mCRC.
