The Experts below are selected from a list of 417228 Experts worldwide ranked by ideXlab platform
Griffin M. Weber - One of the best experts on this subject based on the ideXlab platform.
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biases in electronic health record data due to processes within the healthcare system retrospective Observational Study
BMJ, 2018Co-Authors: Denis Agniel, Griffin M. Weber, Isaac S. KohaneAbstract:Abstract Objective To evaluate on a large scale, across 272 common types of laboratory tests, the impact of healthcare processes on the predictive value of electronic health record (EHR) data. Design Retrospective Observational Study. Setting Two large hospitals in Boston, Massachusetts, with inpatient, emergency, and ambulatory care. Participants All 669 452 patients treated at the two hospitals over one year between 2005 and 2006. Main outcome measures The relative predictive accuracy of each laboratory test for three year survival, using the time of the day, day of the week, and ordering frequency of the test, compared to the value of the test result. Results The presence of a laboratory test order, regardless of any other information about the test result, has a significant association (P Conclusions Healthcare processes must be addressed and accounted for in analysis of Observational health data. Without careful consideration to context, EHR data are unsuitable for many research questions. However, if explicitly modeled, the same processes that make EHR data complex can be leveraged to gain insight into patients’ state of health.
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Biases in electronic health record data due to processes within the healthcare system: Retrospective Observational Study
BMJ (Online), 2018Co-Authors: Denis Agniel, Isaac S. Kohane, Griffin M. WeberAbstract:Objective To evaluate on a large scale, across 272 common types of laboratory tests, the impact of healthcare processes on the predictive value of electronic health record (EHR) data. Design Retrospective Observational Study. Setting Two large hospitals in Boston, Massachusetts, with inpatient, emergency, and ambulatory care. Participants All 669 452 patients treated at the two hospitals over one year between 2005 and 2006. Main outcome measures The relative predictive accuracy of each laboratory test for three year survival, using the time of the day, day of the week, and ordering frequency of the test, compared to the value of the test result. Results The presence of a laboratory test order, regardless of any other information about the test result, has a significant association (P
Dennis D Gagnon - One of the best experts on this subject based on the ideXlab platform.
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premature ejaculation results from a five country european Observational Study
European Urology, 2008Co-Authors: Francois Giuliano, Dennis D Gagnon, Donald L Patrick, Hartmut Porst, Giuseppe La Pera, Andrzej Kokoszka, Sanjay Merchant, Margaret Rothman, Elena PolverejanAbstract:Abstract Objectives To characterize premature ejaculation (PE) in five European countries using intravaginal ejaculatory latency time (IELT) and the Premature Ejaculation Profile (PEP). Methods This 8-wk, multicenter, Observational Study enrolled men ≥18 yr of age and their female partners. Clinicians diagnosed PE using the DSM-IV-TR criteria and at least moderate, subject-reported, ejaculation-related personal distress or interpersonal difficulty. The PEP was administered at baseline and weeks 4 and 8. Partners measured IELT; the average stopwatch-measured IELT for each 4-wk period was calculated and compared with the man's screening-estimated IELT. Relationships between individual PEP measures and IELT were assessed with path analysis. Results PE was diagnosed in 201 of 1115 men. Findings were similar to those in a similarly conducted US Study. Mean IELT was lower in the PE versus the non-PE group (3.3 vs. 10.0min, respectively), but substantial overlap was observed. Men with PE and their partners reported significantly worse control over ejaculation, ejaculation-related personal distress, satisfaction with sexual intercourse, and ejaculation-related interpersonal difficulty than men without PE and their partners. Path analysis showed that perceived control over ejaculation had a significant effect on ejaculation-related personal distress and satisfaction with sexual intercourse; IELT had an effect on control over ejaculation, no direct effect on satisfaction with sexual intercourse, and a small direct effect on ejaculation-related personal distress. Conclusions No major cultural differences existed between EU and US men with and without PE and their female partners. These results emphasize the importance of the PEP measures, especially perceived control over ejaculation, in characterizing PE.
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correlates to the clinical diagnosis of premature ejaculation results from a large Observational Study of men and their partners
The Journal of Urology, 2007Co-Authors: Raymond C Rosen, Chris G Mcmahon, Craig Niederberger, Gregory A Broderick, Carol Jamieson, Dennis D GagnonAbstract:Purpose: A recent Observational Study characterized intravaginal ejaculatory latency time and single item patient reported outcome measures in a large population of males with and without premature ejaculation, as well as their female partners. In the current analysis we assessed the relative influence of those measures in identifying premature ejaculation as diagnosed by the clinician.Materials and Methods: Data were from a 4-week, multicenter, Observational Study of men with (207) and without (1,380) premature ejaculation (diagnosed using The Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision criteria), as well as their female partners. Estimated and measured intravaginal ejaculatory latency time, age, and responses to single item (control over ejaculation, personal distress, satisfaction with sexual intercourse and interpersonal difficulty) and multiple item (male and female Golombok-Rust Inventory of Sexual Satisfaction, male Self-Esteem and Relationship questionnaire, a...
Elena Polverejan - One of the best experts on this subject based on the ideXlab platform.
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premature ejaculation results from a five country european Observational Study
European Urology, 2008Co-Authors: Francois Giuliano, Dennis D Gagnon, Donald L Patrick, Hartmut Porst, Giuseppe La Pera, Andrzej Kokoszka, Sanjay Merchant, Margaret Rothman, Elena PolverejanAbstract:Abstract Objectives To characterize premature ejaculation (PE) in five European countries using intravaginal ejaculatory latency time (IELT) and the Premature Ejaculation Profile (PEP). Methods This 8-wk, multicenter, Observational Study enrolled men ≥18 yr of age and their female partners. Clinicians diagnosed PE using the DSM-IV-TR criteria and at least moderate, subject-reported, ejaculation-related personal distress or interpersonal difficulty. The PEP was administered at baseline and weeks 4 and 8. Partners measured IELT; the average stopwatch-measured IELT for each 4-wk period was calculated and compared with the man's screening-estimated IELT. Relationships between individual PEP measures and IELT were assessed with path analysis. Results PE was diagnosed in 201 of 1115 men. Findings were similar to those in a similarly conducted US Study. Mean IELT was lower in the PE versus the non-PE group (3.3 vs. 10.0min, respectively), but substantial overlap was observed. Men with PE and their partners reported significantly worse control over ejaculation, ejaculation-related personal distress, satisfaction with sexual intercourse, and ejaculation-related interpersonal difficulty than men without PE and their partners. Path analysis showed that perceived control over ejaculation had a significant effect on ejaculation-related personal distress and satisfaction with sexual intercourse; IELT had an effect on control over ejaculation, no direct effect on satisfaction with sexual intercourse, and a small direct effect on ejaculation-related personal distress. Conclusions No major cultural differences existed between EU and US men with and without PE and their female partners. These results emphasize the importance of the PEP measures, especially perceived control over ejaculation, in characterizing PE.
I. M Stratton - One of the best experts on this subject based on the ideXlab platform.
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Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective Observational Study
BMJ, 2000Co-Authors: I. M StrattonAbstract:Objective: To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes. Design: Prospective Observational Study. Setting: 23 hospital based clinics in England, Scotland, and Northern Ireland. Participants: 4585 white, Asian Indian, and Afro-Caribbean UKPDS patients, whether randomised or not to treatment, were included in analyses of incidence; of these, 3642 were included in analyses of relative risk. Outcome measures: Primary predefined aggregate clinical outcomes: any end point or deaths related to diabetes and all cause mortality. Secondary aggregate outcomes: myocardial infarction, stroke, amputation (including death from peripheral vascular disease), and microvascular disease (predominantly retinal photo-coagulation). Single end points: non-fatal heart failure and cataract extraction. Risk reduction associated with a 1% reduction in updated mean HbA1c adjusted for possible confounders at diagnosis of diabetes. Results: The incidence of clinical complications was significantly associated with glycaemia. Each 1% reduction in updated mean HbA1c was associated with reductions in risk of 21% for any end point related to diabetes (95% confidence interval 17% to 24%, P
Donald L Patrick - One of the best experts on this subject based on the ideXlab platform.
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premature ejaculation results from a five country european Observational Study
European Urology, 2008Co-Authors: Francois Giuliano, Dennis D Gagnon, Donald L Patrick, Hartmut Porst, Giuseppe La Pera, Andrzej Kokoszka, Sanjay Merchant, Margaret Rothman, Elena PolverejanAbstract:Abstract Objectives To characterize premature ejaculation (PE) in five European countries using intravaginal ejaculatory latency time (IELT) and the Premature Ejaculation Profile (PEP). Methods This 8-wk, multicenter, Observational Study enrolled men ≥18 yr of age and their female partners. Clinicians diagnosed PE using the DSM-IV-TR criteria and at least moderate, subject-reported, ejaculation-related personal distress or interpersonal difficulty. The PEP was administered at baseline and weeks 4 and 8. Partners measured IELT; the average stopwatch-measured IELT for each 4-wk period was calculated and compared with the man's screening-estimated IELT. Relationships between individual PEP measures and IELT were assessed with path analysis. Results PE was diagnosed in 201 of 1115 men. Findings were similar to those in a similarly conducted US Study. Mean IELT was lower in the PE versus the non-PE group (3.3 vs. 10.0min, respectively), but substantial overlap was observed. Men with PE and their partners reported significantly worse control over ejaculation, ejaculation-related personal distress, satisfaction with sexual intercourse, and ejaculation-related interpersonal difficulty than men without PE and their partners. Path analysis showed that perceived control over ejaculation had a significant effect on ejaculation-related personal distress and satisfaction with sexual intercourse; IELT had an effect on control over ejaculation, no direct effect on satisfaction with sexual intercourse, and a small direct effect on ejaculation-related personal distress. Conclusions No major cultural differences existed between EU and US men with and without PE and their female partners. These results emphasize the importance of the PEP measures, especially perceived control over ejaculation, in characterizing PE.
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premature ejaculation an Observational Study of men and their partners
The Journal of Sexual Medicine, 2005Co-Authors: Donald L Patrick, Raymond C Rosen, Margaret Rothman, Stanley E Althof, Jon L Pryor, David L Rowland, Kai Fai Ho, Pauline Mcnulty, Carol JamiesonAbstract:Introduction. Premature ejaculation (PE) is the most common male sexual dysfunction affecting men and their partners. Lack of community-based data describing this condition limits understand- ing of PE and its outcomes. Aim. To characterize PE in a large population of men with and without PE using patient-reported outcome (PRO) measures elicited from men and their partners. Methods. 4-week, multicenter, Observational Study of males ( ≥ 18 years) and their female partners in monogamous relationships ( ≥ 6 months). Screening, baseline, and follow-up visits scheduled at 2-week intervals. Clinicians diagnosed PE utilizing DSM-IV-TR criteria. Intravaginal ejaculatory latency time (IELT), measured by a stopwatch held by the partner, was recorded for each sexual intercourse experience. Subject and partner independently assessed PROs: control over ejaculation and satisfaction with sexual intercourse (0 = very poor to 4 = very good), personal distress and interper- sonal difficulty (0 = not at all to 4 = extremely), and severity of PE (0 = none to 3 = severe). Results. Of the total Study population (N = 1,587), 207 subjects were diagnosed with PE and 1,380 were assigned to the non-PE group. Median IELT (min) was 1.8 (range, 0-41) for PE and 7.3 (range, 0-53) for non-PE subjects ( P < 0.0001). More PE vs. non-PE subjects gave ratings of "very poor" or "poor" for control over ejaculation (72% vs. 5%; P < 0.0001) and satisfaction with sexual intercourse (31% vs. 1%; P < 0.0001). More subjects in the PE vs. non-PE group gave ratings of "quite a bit" or "extremely" for personal distress (64% vs. 4%; P < 0.0001) and interpersonal difficulty (31% vs. 1%; P < 0.0001). Subject and partner assessments showed similar patterns and correlated moderately (0.36-0.57). Conclusions. PE subjects reported significantly shorter IELT. Overlap in IELT distributions was observed between the PE and non-PE groups, indicating the need for additional PRO measures to characterize PE. Shorter IELT was significantly associated with reduced ejaculatory control and sexual satisfaction and increased distress and interpersonal difficulty.
