The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
H.harlan Stone - One of the best experts on this subject based on the ideXlab platform.
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Obstructive Jaundice due to Coccidioides immitis.
Gastrointestinal endoscopy, 1996Co-Authors: Francisco C. Ramirez, George J. Walker, Robert A. Sanowski, Rao K. Manne, H.harlan StoneAbstract:Compared with malignancy, benign conditions causing porta hepatis lymphadenopathy and r esulting in Obstructive Jaundice may be either overlooked or ignored in the differential diagnosis because of their relative infrequency. We report for the first time a patient presenting with Obstructive Jaundice and eosinophilia and in whom extensive lymphadenopathy encasing the extrahepatic biliary system was secondary to a relatively frequent benign condition: coccidioidomycosis. Antifungal therapy resulted in complete resolution of the biliary obstruction.
Subhash Giri - One of the best experts on this subject based on the ideXlab platform.
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Tubercular Lymphadenitis: As a Rare Cause of Obstructive Jaundice
2016Co-Authors: Rajat Jhamb, Abhishek Juneja, S. V. Madhu, Subhash GiriAbstract:Obstructive Jaundice is an extremely rare presentation of abdominal tubercular lymphadenitis. We hereby report a case of Obstructive Jaundice in an adult female, occurring as a result of periportal and peripancreatic tubercular lymphadenitis causing compression of the biliary tract.
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Tubercular Lymphadenitis: As a Rare Cause of Obstructive Jaundice
Annals of Cytology and Pathology - Peertechz Publications, 2016Co-Authors: Rajat Jhamb, Abhishek Juneja, S. V. Madhu, Subhash GiriAbstract:Obstructive Jaundice is an extremely rare presentation of abdominal tubercular lymphadenitis. We hereby report a case of Obstructive Jaundice in an adult female, occurring as a result of periportal and peripancreatic tubercular lymphadenitis causing compression of the biliary tract. A 42-year-old female patient presented with fever for two months and Jaundice for 15 days. Contrast enhanced computed tomogram of the abdomen showed periportal, peripancreatic, gastro-hepatic, and retroperitoneal lymphadenopathy with caseation. Provisional diagnosis of abdominal tubercular lymphadenitis was made. Anti-tubercular drugs which are safe in hepatitis were started. Magnetic resonance cholangiopancreatography (MRCP) was done in view of worsening of liver function tests and development of clinical features of Obstructive Jaundice during hospital stay. Confluent lymph nodal mass showing necrotic areas was seen in the hepatogastric, portal, peripancreatic, retropancreatic and portocaval region pushing the pancreas and portal vein anteriorly on magnetic resonance cholangiopancreatography. In view of the clinical deterioration on treatment, ultra-sonography guided fine needle aspiration cytology was also done which revealed chronic granulomatous inflammation.AFB stain did not demonstrate acid-fast bacilli. Though Obstructive Jaundice secondary to abdominal tubercular lymphadenitis is rare, it should be considered as a differential diagnosis in TB endemic area.
M. H. Thompson - One of the best experts on this subject based on the ideXlab platform.
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annular pancreas and Obstructive Jaundice
The American Journal of Gastroenterology, 1997Co-Authors: Jonathan Benger, M. H. ThompsonAbstract:: Annular pancreas is a rare abnormality which, in some cases, will be an incidental finding. Recently, two case reports have highlighted the possibility that annular pancreas is responsible for extrahepatic biliary obstruction in the absence of pancreatitis. We present a case of Obstructive Jaundice in which an annular pancreas was noted at both ERCP and CT scanning, but in which the cause of the obstruction was a carcinoma of the ampulla of Vater. Obstructive Jaundice should not be attributed to an annular pancreas until the alternative differential diagnoses have been positively excluded.
Nobuyuki Nakajima - One of the best experts on this subject based on the ideXlab platform.
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injury by activated neutrophils in patients with Obstructive Jaundice
1997Co-Authors: Yoshiaki Shimizn, Koji Nakagawa, Hiroaki Shimizu, Masaru Miyazaki, Hiroshi Ito, Satoshi Ambiru, Nobuyuki NakajimaAbstract:BackgvoundAims: A high incidence of complications has been documented in patients with Obstructive Jaundice after operations. Recent reports have revealed that neutrophils are involved in the mechanism causing postoperative complications. However, there are few reports investigating the interaction between neutrophils and endotbelial cells in Obstructive Jaundice. The aim of this study was to evaluate neutrophilmediated endothelial cell injury in patients with Obstructive Jaundice. Merltods: Patients were divided into three groups: those with normal liver, Obstructive Jaundice, and relief of Obstructive Jaundice. Neutrophils were isolated from patients individually. Human umbilical vein endothelial cells and neutrophils were co-cultured after addition of phorbol myristate acetate. The release of lactate dehydrogenase and thrombomodulin was measured in the medium. Results: Lactate dehydrogenase and thrombomodulin were released in the co-culture medium, and Eglin C, which is an elastase inhibitor, reduced the release of
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Enhanced endothelial cell injury by activated neutrophils in patients with Obstructive Jaundice
Journal of hepatology, 1997Co-Authors: Yoshiaki Shimizu, Koji Nakagawa, Hiroaki Shimizu, Masaru Miyazaki, Hiroshi Ito, Satoshi Ambiru, Nobuyuki NakajimaAbstract:Abstract Background/Aims: A high incidence of complications has been documented in patients with Obstructive Jaundice after operations. Recent reports have revealed that neutrophils are involved in the mechanism causing postoperative complications. However, there are few reports investigating the interaction between neutrophils and endothelial cells in Obstructive Jaundice. The aim of this study was to evaluate neutrophil-mediated endothelial cell injury in patients with Obstructive Jaundice. Methods: Patients were divided into three groups: those with normal liver, Obstructive Jaundice, and relief of Obstructive Jaundice. Neutrophils were isolated from patients individually. Human umbilical vein endothelial cells and neutrophils were co-cultured after addition of phorbol myristate acetate. The release of lactate dehydrogenase and thrombomodulin was measured in the medium. Results: Lactate dehydrogenase and thrombomodulin were released in the co-culture medium, and Eglin C, which is an elastase inhibitor, reduced the release of lactate dehydrogenase and thrombomodulin in a dose-dependent manner. The release of lactate dehydrogenase and thrombomodulin in the group with relief of Obstructive Jaundice was significantly higher than in the group with normal liver. There was no significant difference between the group with Obstructive Jaundice and the group with normal liver. The elastase activity in neutrophil suspension was similarly higher in the group with relief of Obstructive Jaundice than in the group with normal liver. Conclusions: This study suggests that neutrophils in patients with Obstructive Jaundice are not activated before its relief. After relief of Obstructive Jaundice, neutrophils are strongly primed and have the potential to cause endothelial cell injury. The neutrophil "priming" in patients with Obstructive Jaundice may be associated wtih the frequent occurrence of postoperative complications.
Francisco C. Ramirez - One of the best experts on this subject based on the ideXlab platform.
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Obstructive Jaundice due to Coccidioides immitis.
Gastrointestinal endoscopy, 1996Co-Authors: Francisco C. Ramirez, George J. Walker, Robert A. Sanowski, Rao K. Manne, H.harlan StoneAbstract:Compared with malignancy, benign conditions causing porta hepatis lymphadenopathy and r esulting in Obstructive Jaundice may be either overlooked or ignored in the differential diagnosis because of their relative infrequency. We report for the first time a patient presenting with Obstructive Jaundice and eosinophilia and in whom extensive lymphadenopathy encasing the extrahepatic biliary system was secondary to a relatively frequent benign condition: coccidioidomycosis. Antifungal therapy resulted in complete resolution of the biliary obstruction.
