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Arina Hilmi Sari - One of the best experts on this subject based on the ideXlab platform.
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DAYA HAMBAT MINYAK ATSIRI DAUN KEMANGI (Ocimum BASILICUM) TERHADAP STREPTOCOCCUS SANGUINIS PADA BERBAGAI KONSENTRASI
FAKULTAS KEDOKTERAN GIGI UNIVERSITAS SYIAH KUALA, 2016Co-Authors: Arina Hilmi SariAbstract:ABSTRAKNama: Arina Hilmi SariProgram Studi: Pendidikan Dokter GigiFakultas: Kedokteran GigiJudul:Daya Hambat Minyak Atsiri Daun Kemangi (Ocimum basilicum) Terhadap Streptococcus sanguinis Pada Berbagai KonsentrasiDaun kemangi (Ocimum basilicum) merupakan tanaman yang sering digunakan untuk obat tradisional. Daun kemangi memiliki efek antibakteri karena mengandung linalool, cineol, terpineol, alfa terpineol, neral, geranial, flavonoid, sabinen, betapinen, limonene, terpinen 4 ol, cadina 3,5 diene, germacrene d, bicycle germacrene, beta elemene, eugenol, thymol, dan carvacrol. Streptococcus sanguinis adalah bakteri pertama yang berkolonisasi di permukaan gigi yang menyebabkan pembentukan plak. Penelitian ini dilakukan untuk mengetahui daya hambat minyak atsiri daun kemangi (Ocimum basilicum) terhadap Streptococcus sanguinis. Minyak atsiri daun kemangi dibuat menggunakan teknik destilasi uap dan air. Uji daya hambat minyak atsiri daun kemangi (Ocimum basilicum) terhadap Streptococcus sanguinis dilakukan dengan menggunakan teknik disc diffusion pada media MHA. Konsentrasi minyak atsiri daun kemangi (Ocimum basilicum) yang digunakan pada penelitian ini adalah 100%, 50%, 25%, dan 12,5%. Data hasil penelitian dianalisis dengan uji One Way ANOVA dengan pBanda Ace
Hanna Nurlita Rizqiyani - One of the best experts on this subject based on the ideXlab platform.
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DAYA HAMBAT MINYAK ATSIRI DAUN KEMANGI (Ocimum BASILICUM) TERHADAP PERTUMBUHAN ENTEROCOCCUS FAECALIS PADA BERBAGAI KONSENTRASI
Fakultas Kedokteran Gigi Universitas Syiah Kuala, 2016Co-Authors: Hanna Nurlita RizqiyaniAbstract:ABSTRAKNama: Hanna Nurlita RizqiyaniProgram Studi:Pendidikan Dokter GigiFakultas:Kedokteran GigiJudul:Daya Hambat Minyak Atsiri Daun Kemangi (Ocimum basilicum) Terhadap Pertumbuhan Enterococcus faecalis Pada berbagai KonsentrasiDaun kemangi merupakan salah satu bahan alam yang digunakan sebagai obat herbal karena mengandung ?-pinene, sabinene, limonene, eucalyptol, linalool, terpinen-4-ol, ?-terpineol, neral, geranial, carvacrol, ?-humulene, flavonoid, eugenol dan thymol. Enterococcus faecalis adalah bakteri Gram positif anaerob fakultatif yang menjadi penyebab kegagalan pada perawatan saluran akar. Penelitian ini dilakukan untuk mengetahui daya hambat minyak atsiri daun kemangi (Ocimum basilicum) terhadap pertumbuhan Enterococcus faecalis, serta perbedaan daya hambat pada setiap konsentrasi. Minyak atsiri daun kemangi dibuat menggunakan teknik destilasi uap dan air. Uji daya hambat minyak atsiri daun kemangi (Ocimum basilicum) terhadap pertumbuhan Enterococcus faecalis dilakukan dengan dengan menggunakan teknik disc diffusion pada media MHA. Konsentrasi minyak atsiri daun kemangi (Ocimum basilicum) yang digunakan pada penelitian ini adalah 100%, 50%, 25%, dan 12,5%. Data hasil penelitian dianalisis dengan uji One Way ANOVA dengan pBanda Ace
Lara O Orafidiya - One of the best experts on this subject based on the ideXlab platform.
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Research Paper - VASCULAR PERMEABILITY- INCREASING EFFECT OF THE LEAF ESSENTIAL OIL OF Ocimum GRATISSIMUM LINN AS A MECHANISM FOR ITS WOUND HEALING PROPERTY.
African Ethnomedicines Network, 2005Co-Authors: Lara O Orafidiya, F. A. Fakoya, E. O. Agbani, E. O. IwalewaAbstract:Persistent microvascular hyperpermeability to plasma proteins is a characteristic feature of normal wound healing. Does the leaf essential oil of Ocimum gratissimum heal wounds by promoting this feature? Evan's blue dye (20mg/kg body weight) in normal saline was administered intravenously through marginal ear vein of experimental rabbits (n=5). Each animal served as its own control. One hour after Evan's blue dye administration, 0.1ml each of Ocimum oil, histamine dihydrochloride (30μg/ml) and normal saline were randomly administered by intra-dermal injection at the prepared sites on each of the animals. Increase in vascular permeability was assessed by dye effusion test. Analysis of the differences in vascular permeability between treatment groups showed that, Ocimum oil, in intensity and duration, was significantly (p
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studies on the acute and sub chronic toxicity of the essential oil of Ocimum gratissimum l leaf
Phytomedicine, 2004Co-Authors: Lara O Orafidiya, E. O. Agbani, E. O. Iwalewa, K A Adelusola, O O OyedapoAbstract:Oral and intra-peritoneal acute toxicity and the sub-chronic intra-peritoneal toxicity of the essential oil of Ocimum gratissimum Linn, Lamiaceae (Ocimum oil), was investigated. The acute toxicity test involved the oral and intra-peritoneal administration of graded doses of Ocimum oil prepared as a 4% v/v emulsion to 2 groups each of 30 rats and mice. LD50 and LD100 were determined for both routes and species. In the sub-chronic toxicity study, 25 male Sprague-Dawley rats were randomized into 4 test groups (treated with three graded sub-lethal doses of Ocimum oil prepared as a 4% v/v emulsion) and a control. Organs and blood samples were taken for analyses after a 30 day treatment period. A dose-dependent sedative effect of Ocimum oil was observed during the acute toxicity study in mice and rats and in the sub-chronic test in rats. Evidence of treatment, route, and dose-dependent toxicity were detected in both studies. Changes in weight of the testes, hearts, kidneys, intestines and lungs of the rats were statistically insignificant (ANOVA P < 0.05). Data analyses of blood biochemical, haematological and histopathological findings showed significant differences between control and treated groups and revealed that Ocimum oil is capable of invoking an inflammatory response that transits from acute to chronic on persistent administration. While the study revealed that Ocimum oil might be better tolerated when administered orally for systemic delivery, the oil has toxic potentialities that should not be overlooked.
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preliminary clinical tests on topical preparations of Ocimum gratissimum linn leaf essential oil for the treatment of acne vulgaris
Clinical Drug Investigation, 2002Co-Authors: Lara O Orafidiya, A O Oyedele, E. O. Agbani, O O Babalola, Olaniyi OnayemiAbstract:This study was designed to determine the clinically effective concentration and most appropriate base for a topical Ocimum oil formulation in the management of acne vulgaris. 126 subjects, mainly university undergraduates, presenting with acne vulgaris were randomly assigned to treatment with Ocimum oil preparations, a reference product (benzoyl peroxide 10% lotion) or placebo. The test samples were applied in a dose of 0.25cm3 to the face after washing morning and evening. The number of lesions (papules and pustules) was counted prior to application and daily for 4 weeks. The efficacy of the preparations was rated in terms of product activity (DA), which is the reciprocal value of the number of days taken to achieve a 50% reduction in lesion count (D). Ocimum oil preparations containing 2% oil in alcohol (ethanol) and in a cetomacrogol blend base were more effective and reduced lesions faster than the reference product. Adverse effects reported for the Ocimum oil preparations were minimal and tolerable. The base in which the oil was incorporated exerted considerable influence on the activity of the oil. The DA values were lowest with petrolatum base (oleaginous) and highest with alcohol and cetomacrogol blend bases (hydrophilic). A topical preparation containing 2% Ocimum oil in cetomacrogol blend base is well tolerated and more effective in the management of acne vulgaris than benzoyl peroxide 10% lotion.
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the formulation of an effective topical antibacterial product containing Ocimum gratissimum leaf essential oil
International Journal of Pharmaceutics, 2001Co-Authors: Lara O Orafidiya, A O Oyedele, Adebayo Shittu, A A ElujobaAbstract:The antibacterial potential of Ocimum gratissimum essential oil was explored. Liquid and semisolid formulations of the oil were designed in a variety of bases for topical antiseptic medication. The products were evaluated by agar diffusion assay against type strains and clinical isolates from boil, wound and pimples. Remarkable antibacterial effects, higher than those of commercial antiseptic products, were demonstrated at 2% Ocimum oil concentration in some bases. The properties of base into which the oil was incorporated affected its activity. It was more effective in hydrophilic bases than in lipophilic bases. Solubilization and microemulsification grossly reduced its activity.
E. O. Iwalewa - One of the best experts on this subject based on the ideXlab platform.
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Research Paper - VASCULAR PERMEABILITY- INCREASING EFFECT OF THE LEAF ESSENTIAL OIL OF Ocimum GRATISSIMUM LINN AS A MECHANISM FOR ITS WOUND HEALING PROPERTY.
African Ethnomedicines Network, 2005Co-Authors: Lara O Orafidiya, F. A. Fakoya, E. O. Agbani, E. O. IwalewaAbstract:Persistent microvascular hyperpermeability to plasma proteins is a characteristic feature of normal wound healing. Does the leaf essential oil of Ocimum gratissimum heal wounds by promoting this feature? Evan's blue dye (20mg/kg body weight) in normal saline was administered intravenously through marginal ear vein of experimental rabbits (n=5). Each animal served as its own control. One hour after Evan's blue dye administration, 0.1ml each of Ocimum oil, histamine dihydrochloride (30μg/ml) and normal saline were randomly administered by intra-dermal injection at the prepared sites on each of the animals. Increase in vascular permeability was assessed by dye effusion test. Analysis of the differences in vascular permeability between treatment groups showed that, Ocimum oil, in intensity and duration, was significantly (p
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Vascular permeability-increasing effect of the leaf essential oil of Ocimum gratissimum Linn as a mechanism for its wound healing property
'African Journals Online (AJOL)', 2005Co-Authors: Orafidiya, 'lara O., F. A. Fakoya, E. O. Agbani, E. O. IwalewaAbstract:Persistent microvascular hyperpermeability to plasma proteins is a characteristic feature of normal wound healing. Does the leaf essential oil of Ocimum gratissimum heal wounds by promoting this feature? Evan\'s blue dye (20mg/kg body weight) in normal saline was administered intravenously through marginal ear vein of experimental rabbits (n = 5). Each animal served as its own control. One hour after Evan\'s blue dye administration, 0.1ml each of Ocimum oil, histamine dihydrochloride (30µg/ml) and normal saline were randomly administered by intra-dermal injection at the prepared sites on each of the animals. Increase in vascular permeability was assessed by dye effusion test. Analysis of the differences in vascular permeability between treatment groups showed that, Ocimum oil, in intensity and duration, was significantly (p < 0.05) more effective in increasing cutaneous capillary permeability over a 24h period after treatment. The ability of Ocimum oil in increasing vascular permeability may be one of the factors that contribute to its wound healing property. Key words: Ocimum gratissimum, vascular permeability, mechanism of action Afr. J. Trad. Comp. Alt. Med. Vol.2(3) 2005: 253 - 25
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studies on the acute and sub chronic toxicity of the essential oil of Ocimum gratissimum l leaf
Phytomedicine, 2004Co-Authors: Lara O Orafidiya, E. O. Agbani, E. O. Iwalewa, K A Adelusola, O O OyedapoAbstract:Oral and intra-peritoneal acute toxicity and the sub-chronic intra-peritoneal toxicity of the essential oil of Ocimum gratissimum Linn, Lamiaceae (Ocimum oil), was investigated. The acute toxicity test involved the oral and intra-peritoneal administration of graded doses of Ocimum oil prepared as a 4% v/v emulsion to 2 groups each of 30 rats and mice. LD50 and LD100 were determined for both routes and species. In the sub-chronic toxicity study, 25 male Sprague-Dawley rats were randomized into 4 test groups (treated with three graded sub-lethal doses of Ocimum oil prepared as a 4% v/v emulsion) and a control. Organs and blood samples were taken for analyses after a 30 day treatment period. A dose-dependent sedative effect of Ocimum oil was observed during the acute toxicity study in mice and rats and in the sub-chronic test in rats. Evidence of treatment, route, and dose-dependent toxicity were detected in both studies. Changes in weight of the testes, hearts, kidneys, intestines and lungs of the rats were statistically insignificant (ANOVA P < 0.05). Data analyses of blood biochemical, haematological and histopathological findings showed significant differences between control and treated groups and revealed that Ocimum oil is capable of invoking an inflammatory response that transits from acute to chronic on persistent administration. While the study revealed that Ocimum oil might be better tolerated when administered orally for systemic delivery, the oil has toxic potentialities that should not be overlooked.
E. O. Agbani - One of the best experts on this subject based on the ideXlab platform.
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Research Paper - VASCULAR PERMEABILITY- INCREASING EFFECT OF THE LEAF ESSENTIAL OIL OF Ocimum GRATISSIMUM LINN AS A MECHANISM FOR ITS WOUND HEALING PROPERTY.
African Ethnomedicines Network, 2005Co-Authors: Lara O Orafidiya, F. A. Fakoya, E. O. Agbani, E. O. IwalewaAbstract:Persistent microvascular hyperpermeability to plasma proteins is a characteristic feature of normal wound healing. Does the leaf essential oil of Ocimum gratissimum heal wounds by promoting this feature? Evan's blue dye (20mg/kg body weight) in normal saline was administered intravenously through marginal ear vein of experimental rabbits (n=5). Each animal served as its own control. One hour after Evan's blue dye administration, 0.1ml each of Ocimum oil, histamine dihydrochloride (30μg/ml) and normal saline were randomly administered by intra-dermal injection at the prepared sites on each of the animals. Increase in vascular permeability was assessed by dye effusion test. Analysis of the differences in vascular permeability between treatment groups showed that, Ocimum oil, in intensity and duration, was significantly (p
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Vascular permeability-increasing effect of the leaf essential oil of Ocimum gratissimum Linn as a mechanism for its wound healing property
'African Journals Online (AJOL)', 2005Co-Authors: Orafidiya, 'lara O., F. A. Fakoya, E. O. Agbani, E. O. IwalewaAbstract:Persistent microvascular hyperpermeability to plasma proteins is a characteristic feature of normal wound healing. Does the leaf essential oil of Ocimum gratissimum heal wounds by promoting this feature? Evan\'s blue dye (20mg/kg body weight) in normal saline was administered intravenously through marginal ear vein of experimental rabbits (n = 5). Each animal served as its own control. One hour after Evan\'s blue dye administration, 0.1ml each of Ocimum oil, histamine dihydrochloride (30µg/ml) and normal saline were randomly administered by intra-dermal injection at the prepared sites on each of the animals. Increase in vascular permeability was assessed by dye effusion test. Analysis of the differences in vascular permeability between treatment groups showed that, Ocimum oil, in intensity and duration, was significantly (p < 0.05) more effective in increasing cutaneous capillary permeability over a 24h period after treatment. The ability of Ocimum oil in increasing vascular permeability may be one of the factors that contribute to its wound healing property. Key words: Ocimum gratissimum, vascular permeability, mechanism of action Afr. J. Trad. Comp. Alt. Med. Vol.2(3) 2005: 253 - 25
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studies on the acute and sub chronic toxicity of the essential oil of Ocimum gratissimum l leaf
Phytomedicine, 2004Co-Authors: Lara O Orafidiya, E. O. Agbani, E. O. Iwalewa, K A Adelusola, O O OyedapoAbstract:Oral and intra-peritoneal acute toxicity and the sub-chronic intra-peritoneal toxicity of the essential oil of Ocimum gratissimum Linn, Lamiaceae (Ocimum oil), was investigated. The acute toxicity test involved the oral and intra-peritoneal administration of graded doses of Ocimum oil prepared as a 4% v/v emulsion to 2 groups each of 30 rats and mice. LD50 and LD100 were determined for both routes and species. In the sub-chronic toxicity study, 25 male Sprague-Dawley rats were randomized into 4 test groups (treated with three graded sub-lethal doses of Ocimum oil prepared as a 4% v/v emulsion) and a control. Organs and blood samples were taken for analyses after a 30 day treatment period. A dose-dependent sedative effect of Ocimum oil was observed during the acute toxicity study in mice and rats and in the sub-chronic test in rats. Evidence of treatment, route, and dose-dependent toxicity were detected in both studies. Changes in weight of the testes, hearts, kidneys, intestines and lungs of the rats were statistically insignificant (ANOVA P < 0.05). Data analyses of blood biochemical, haematological and histopathological findings showed significant differences between control and treated groups and revealed that Ocimum oil is capable of invoking an inflammatory response that transits from acute to chronic on persistent administration. While the study revealed that Ocimum oil might be better tolerated when administered orally for systemic delivery, the oil has toxic potentialities that should not be overlooked.
-
preliminary clinical tests on topical preparations of Ocimum gratissimum linn leaf essential oil for the treatment of acne vulgaris
Clinical Drug Investigation, 2002Co-Authors: Lara O Orafidiya, A O Oyedele, E. O. Agbani, O O Babalola, Olaniyi OnayemiAbstract:This study was designed to determine the clinically effective concentration and most appropriate base for a topical Ocimum oil formulation in the management of acne vulgaris. 126 subjects, mainly university undergraduates, presenting with acne vulgaris were randomly assigned to treatment with Ocimum oil preparations, a reference product (benzoyl peroxide 10% lotion) or placebo. The test samples were applied in a dose of 0.25cm3 to the face after washing morning and evening. The number of lesions (papules and pustules) was counted prior to application and daily for 4 weeks. The efficacy of the preparations was rated in terms of product activity (DA), which is the reciprocal value of the number of days taken to achieve a 50% reduction in lesion count (D). Ocimum oil preparations containing 2% oil in alcohol (ethanol) and in a cetomacrogol blend base were more effective and reduced lesions faster than the reference product. Adverse effects reported for the Ocimum oil preparations were minimal and tolerable. The base in which the oil was incorporated exerted considerable influence on the activity of the oil. The DA values were lowest with petrolatum base (oleaginous) and highest with alcohol and cetomacrogol blend bases (hydrophilic). A topical preparation containing 2% Ocimum oil in cetomacrogol blend base is well tolerated and more effective in the management of acne vulgaris than benzoyl peroxide 10% lotion.