The Experts below are selected from a list of 279 Experts worldwide ranked by ideXlab platform
Ching-hsi Hsiao - One of the best experts on this subject based on the ideXlab platform.
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staphylococcus aureus Ocular Infection methicillin resistance clinical features and antibiotic susceptibilities
PLOS ONE, 2012Co-Authors: Chih-chun Chuang, Ching-hsi Hsiao, Hsin-yuan Tan, Ken-kuo Lin, David Huikang, Chee-jen ChangAbstract:Background Methicillin-resistant Staphylococcus aureus (MRSA) Infection is an important public health issue. The study aimed to determine the prevalence of Ocular Infections caused by MRSA and to identify the clinical characteristics and antibiotic susceptibility of Ocular MRSA Infections by comparing those of Ocular methicillin-sensitive S. aureus (MSSA) Infections. Methodology/Principal Findings The medical records of the patients (n = 519) with culture-proven S. aureus Ocular Infections seen between January 1, 1999 and December 31, 2008 in Chang Gung Memorial Hospital were retrospectively reviewed. Two hundred and seventy-four patients with MRSA and 245 with MSSA Ocular Infections were identified. The average rate of MRSA in S. aureus Infections was 52.8% and the trend was stable over the ten years (P value for trend = 0.228). MRSA Ocular Infections were significantly more common among the patients with healthcare exposure (P = 0.024), but 66.1% (181/274) patients with MRSA Ocular Infections had no healthcare exposure. The most common clinical presentation for both MRSA and MSSA Ocular Infections was keratitis; MRSA and MSSA caused a similar disease spectrum except for lid Infections. MRSA was significantly more resistant than MSSA to clindamycin, erythromycin and sulfamethoxazole/trimethoprim (all P<0.001). Conclusions/significance We demonstrated a paralleled trend of Ocular MRSA Infection in a highly prevalent MRSA country by hospital-based survey. Except for lid disorder, MRSA shared similar spectrum of Ocular pathology with MSSA. Since S. aureus is a common Ocular pathogen, our results raise clinician’s attention to the existence of highly prevalent MRSA.
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Staphylococcus Aureus Ocular Infection: Methicillin-Resistance, Clinical Features, and Antibiotic Susceptibilities
PloS one, 2012Co-Authors: Chih-chun Chuang, Ching-hsi Hsiao, Hsin-yuan Tan, David Hui-kang, Ken-kuo Lin, Chee-jen Chang, Yhu-chering HuangAbstract:Methicillin-resistant Staphylococcus aureus (MRSA) Infection is an important public health issue. The study aimed to determine the prevalence of Ocular Infections caused by MRSA and to identify the clinical characteristics and antibiotic susceptibility of Ocular MRSA Infections by comparing those of Ocular methicillin-sensitive S. aureus (MSSA) Infections. The medical records of the patients (n = 519) with culture-proven S. aureus Ocular Infections seen between January 1, 1999 and December 31, 2008 in Chang Gung Memorial Hospital were retrospectively reviewed. Two hundred and seventy-four patients with MRSA and 245 with MSSA Ocular Infections were identified. The average rate of MRSA in S. aureus Infections was 52.8% and the trend was stable over the ten years (P value for trend = 0.228). MRSA Ocular Infections were significantly more common among the patients with healthcare exposure (P = 0.024), but 66.1% (181/274) patients with MRSA Ocular Infections had no healthcare exposure. The most common clinical presentation for both MRSA and MSSA Ocular Infections was keratitis; MRSA and MSSA caused a similar disease spectrum except for lid Infections. MRSA was significantly more resistant than MSSA to clindamycin, erythromycin and sulfamethoxazole/trimethoprim (all P<0.001). We demonstrated a paralleled trend of Ocular MRSA Infection in a highly prevalent MRSA country by hospital-based survey. Except for lid disorder, MRSA shared similar spectrum of Ocular pathology with MSSA. Since S. aureus is a common Ocular pathogen, our results raise clinician's attention to the existence of highly prevalent MRSA.
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Methicillin-resistant Staphylococcus aureus Ocular Infection: a 10-year hospital-based study.
Ophthalmology, 2011Co-Authors: Ching-hsi Hsiao, Chih-chun Chuang, Hsin-yuan Tan, David Hui-kang, Ken-kuo Lin, Chee-jen Chang, Yhu-chering HuangAbstract:Purpose To characterize the patient demographics, clinical features, and antibiotic susceptibility of Ocular Infections caused by methicillin-resistant Staphylococcus aureus (MRSA), including community-associated (CA) and healthcare-associated (HA) isolates. Design Retrospective, observational study. Participants Patients (n = 519) with culture-proven S. aureus Ocular Infections seen between January 1, 1999, and December 31, 2008, in Chang Gung Memorial Hospital. Methods Data collected included patient demographics and clinical information. Antibiotic susceptibility was verified by disc diffusion method. Main Outcome Measures Proportion of MRSA in S. aureus Ocular Infections and the clinical characteristics, diagnoses, and antibiotic susceptibility patterns of CA-MRSA versus HA-MRSA Ocular Infections. Results We identified 274 patients with MRSA Ocular Infections, which comprised 181 CA-MRSA and 93 HA-MRSA isolates. The average rate of MRSA in S. aureus Infections was 52.8% with a stable trend, whereas the annual ratio of CA-MRSA in Ocular MRSA Infections averaged 66.1% and tended to increase over the 10-year interval. Patients with Ocular CA-MRSA were younger. Lid and lacrimal system disorders were more common, but keratitis, endophthalmitis, and wound Infection were less common among CA-MRSA cases than HA-MRSA cases. Both CA-MRSA and HA-MRSA isolates were resistant to clindamycin and erythromycin, but CA-MRSA was more susceptible to sulfamethoxazole/trimethoprim. Conclusions Community-associated MRSA is an important pathogen of Ocular Infections; CA-MRSA and HA-MRSA Ocular Infections differ demographically and clinically, but both strains were multi-resistant in Chang Gung Memorial Hospital, one of the biggest referral centers in Taiwan. In a country with a high prevalence of MRSA, ophthalmologists should be aware of such epidemiologic information. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article.
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Recurrent Alcaligenes xylosoxidans keratitis.
Cornea, 2005Co-Authors: Zei-lun Huang, Yeong-fong Chen, Shu Wen Chang, Ching-hsi HsiaoAbstract:Purpose: To describe a case of postkeratoplasty recurrent Alcaligenes xylosoxidans keratitis. Methods: A 33-year-old man with a history of penetrating keratoplasty developed corneal infiltrate with intact epithelium and then was treated with broad-spectrum antibiotics. Corneal scraping was taken for microbiologic study. Results: The culture result identified A. xylosoxidans, sensitive to piperacillin and ceftazidime. There were 3 recurrent episodes within 2 months after each apparent resolution achieved after the instillation of topical piperacillin (10 mg/mL). During the fourth attack, the lesion responded poorly to piperacillin and ceftazidime (25 mg/mL), so therapeutic penetrating keratoplasty was performed to eradicate the recalcitrant Infection. Conclusions: A. xylosoxidans has probably been underreported as a cause of Ocular Infection. It does not respond to conventional antibiotic therapy and may be difficult to eradicate. Therapeutic penetrating keratoplasty might be necessary if medical treatment fails.
Yhu-chering Huang - One of the best experts on this subject based on the ideXlab platform.
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Staphylococcus Aureus Ocular Infection: Methicillin-Resistance, Clinical Features, and Antibiotic Susceptibilities
PloS one, 2012Co-Authors: Chih-chun Chuang, Ching-hsi Hsiao, Hsin-yuan Tan, David Hui-kang, Ken-kuo Lin, Chee-jen Chang, Yhu-chering HuangAbstract:Methicillin-resistant Staphylococcus aureus (MRSA) Infection is an important public health issue. The study aimed to determine the prevalence of Ocular Infections caused by MRSA and to identify the clinical characteristics and antibiotic susceptibility of Ocular MRSA Infections by comparing those of Ocular methicillin-sensitive S. aureus (MSSA) Infections. The medical records of the patients (n = 519) with culture-proven S. aureus Ocular Infections seen between January 1, 1999 and December 31, 2008 in Chang Gung Memorial Hospital were retrospectively reviewed. Two hundred and seventy-four patients with MRSA and 245 with MSSA Ocular Infections were identified. The average rate of MRSA in S. aureus Infections was 52.8% and the trend was stable over the ten years (P value for trend = 0.228). MRSA Ocular Infections were significantly more common among the patients with healthcare exposure (P = 0.024), but 66.1% (181/274) patients with MRSA Ocular Infections had no healthcare exposure. The most common clinical presentation for both MRSA and MSSA Ocular Infections was keratitis; MRSA and MSSA caused a similar disease spectrum except for lid Infections. MRSA was significantly more resistant than MSSA to clindamycin, erythromycin and sulfamethoxazole/trimethoprim (all P<0.001). We demonstrated a paralleled trend of Ocular MRSA Infection in a highly prevalent MRSA country by hospital-based survey. Except for lid disorder, MRSA shared similar spectrum of Ocular pathology with MSSA. Since S. aureus is a common Ocular pathogen, our results raise clinician's attention to the existence of highly prevalent MRSA.
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Methicillin-resistant Staphylococcus aureus Ocular Infection: a 10-year hospital-based study.
Ophthalmology, 2011Co-Authors: Ching-hsi Hsiao, Chih-chun Chuang, Hsin-yuan Tan, David Hui-kang, Ken-kuo Lin, Chee-jen Chang, Yhu-chering HuangAbstract:Purpose To characterize the patient demographics, clinical features, and antibiotic susceptibility of Ocular Infections caused by methicillin-resistant Staphylococcus aureus (MRSA), including community-associated (CA) and healthcare-associated (HA) isolates. Design Retrospective, observational study. Participants Patients (n = 519) with culture-proven S. aureus Ocular Infections seen between January 1, 1999, and December 31, 2008, in Chang Gung Memorial Hospital. Methods Data collected included patient demographics and clinical information. Antibiotic susceptibility was verified by disc diffusion method. Main Outcome Measures Proportion of MRSA in S. aureus Ocular Infections and the clinical characteristics, diagnoses, and antibiotic susceptibility patterns of CA-MRSA versus HA-MRSA Ocular Infections. Results We identified 274 patients with MRSA Ocular Infections, which comprised 181 CA-MRSA and 93 HA-MRSA isolates. The average rate of MRSA in S. aureus Infections was 52.8% with a stable trend, whereas the annual ratio of CA-MRSA in Ocular MRSA Infections averaged 66.1% and tended to increase over the 10-year interval. Patients with Ocular CA-MRSA were younger. Lid and lacrimal system disorders were more common, but keratitis, endophthalmitis, and wound Infection were less common among CA-MRSA cases than HA-MRSA cases. Both CA-MRSA and HA-MRSA isolates were resistant to clindamycin and erythromycin, but CA-MRSA was more susceptible to sulfamethoxazole/trimethoprim. Conclusions Community-associated MRSA is an important pathogen of Ocular Infections; CA-MRSA and HA-MRSA Ocular Infections differ demographically and clinically, but both strains were multi-resistant in Chang Gung Memorial Hospital, one of the biggest referral centers in Taiwan. In a country with a high prevalence of MRSA, ophthalmologists should be aware of such epidemiologic information. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Daniel J. J. Carr - One of the best experts on this subject based on the ideXlab platform.
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A Functional Type I Interferon Pathway Drives Resistance to Cornea Herpes Simplex Virus Type 1 Infection by Recruitment of Leukocytes.
Journal of biomedical research, 2011Co-Authors: Christopher D. Conrady, Heather Jones, Min Zheng, Daniel J. J. CarrAbstract:Type I interferons are critical antiviral cytokines produced following herpes simplex virus type-1 (HSV-1) Infection that act to inhibit viral spread. In the present study, we identify HSV-infected and adjacent uninfected corneal epithelial cells as the source of interferon-α. We also report mice deficient in the A1 chain of the type I IFN receptor (CD118−/−) are extremely sensitive to Ocular Infection with low doses (100 PFU) of HSV-1 as seen by significantly elevated viral titers in the cornea compared to wild type (WT) controls. The enhanced susceptibility correlated with a loss of CD4+ and CD8+ T cell recruitment and aberrant chemokine production in the cornea despite mounting an adaptive immune response in the draining mandibular lymph node of CD118−/− mice. Taken together, these results highlight the importance of IFN production in both the innate immune response as well as eliciting chemokine production required to facilitate adaptive immune cell trafficking.
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abnormal immune response of ccr5 deficient mice to Ocular Infection with herpes simplex virus type 1
Journal of General Virology, 2006Co-Authors: Daniel J. J. Carr, John D Ash, Thomas E Lane, William A KuzielAbstract:Ocular herpes simplex virus type 1 (HSV-1) Infection elicits a strong inflammatory response that is associated with production of the beta chemokines CCL3 and CCL5, which share a common receptor, CCR5. To gain insight into the role of these molecules in Ocular immune responses, the corneas of wild-type (WT) and CCR5-deficient (CCR5-/-) mice were infected with HSV-1 and inflammatory parameters were measured. In the absence of CCR5, the early infiltration of neutrophils into the cornea was diminished. Associated with this aberrant leukocyte recruitment, neutrophils in CCR5-/- mice were restricted to the stroma, whereas in WT mice, these cells trafficked to the stroma and epithelial layers of the infected cornea. Virus titres and cytokine/chemokine levels in the infected tissue of these mice were similar for the first 5 days after Infection. However, by day 7 post-Infection, the CCR5-/- mice showed a significant elevation in the chemokines CCL2, CCL5, CXCL9 and CXCL10 in the trigeminal ganglion and brainstem, as well as a significant increase in virus burden. The increase in chemokine expression was associated with an increase in the infiltration of CD4 and/or CD8 T cells into the trigeminal ganglion and brainstem of CCR5-/- mice. Surprisingly, even though infected CCR5-/- mice were less efficient at controlling the progression of virus replication, there was no difference in mortality. These results suggest that, although CCR5 plays a role in regulating leukocyte trafficking and control of virus burden, compensatory mechanisms are involved in preventing mortality following HSV-1 Infection.
Chee-jen Chang - One of the best experts on this subject based on the ideXlab platform.
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Staphylococcus Aureus Ocular Infection: Methicillin-Resistance, Clinical Features, and Antibiotic Susceptibilities
PloS one, 2012Co-Authors: Chih-chun Chuang, Ching-hsi Hsiao, Hsin-yuan Tan, David Hui-kang, Ken-kuo Lin, Chee-jen Chang, Yhu-chering HuangAbstract:Methicillin-resistant Staphylococcus aureus (MRSA) Infection is an important public health issue. The study aimed to determine the prevalence of Ocular Infections caused by MRSA and to identify the clinical characteristics and antibiotic susceptibility of Ocular MRSA Infections by comparing those of Ocular methicillin-sensitive S. aureus (MSSA) Infections. The medical records of the patients (n = 519) with culture-proven S. aureus Ocular Infections seen between January 1, 1999 and December 31, 2008 in Chang Gung Memorial Hospital were retrospectively reviewed. Two hundred and seventy-four patients with MRSA and 245 with MSSA Ocular Infections were identified. The average rate of MRSA in S. aureus Infections was 52.8% and the trend was stable over the ten years (P value for trend = 0.228). MRSA Ocular Infections were significantly more common among the patients with healthcare exposure (P = 0.024), but 66.1% (181/274) patients with MRSA Ocular Infections had no healthcare exposure. The most common clinical presentation for both MRSA and MSSA Ocular Infections was keratitis; MRSA and MSSA caused a similar disease spectrum except for lid Infections. MRSA was significantly more resistant than MSSA to clindamycin, erythromycin and sulfamethoxazole/trimethoprim (all P<0.001). We demonstrated a paralleled trend of Ocular MRSA Infection in a highly prevalent MRSA country by hospital-based survey. Except for lid disorder, MRSA shared similar spectrum of Ocular pathology with MSSA. Since S. aureus is a common Ocular pathogen, our results raise clinician's attention to the existence of highly prevalent MRSA.
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staphylococcus aureus Ocular Infection methicillin resistance clinical features and antibiotic susceptibilities
PLOS ONE, 2012Co-Authors: Chih-chun Chuang, Ching-hsi Hsiao, Hsin-yuan Tan, Ken-kuo Lin, David Huikang, Chee-jen ChangAbstract:Background Methicillin-resistant Staphylococcus aureus (MRSA) Infection is an important public health issue. The study aimed to determine the prevalence of Ocular Infections caused by MRSA and to identify the clinical characteristics and antibiotic susceptibility of Ocular MRSA Infections by comparing those of Ocular methicillin-sensitive S. aureus (MSSA) Infections. Methodology/Principal Findings The medical records of the patients (n = 519) with culture-proven S. aureus Ocular Infections seen between January 1, 1999 and December 31, 2008 in Chang Gung Memorial Hospital were retrospectively reviewed. Two hundred and seventy-four patients with MRSA and 245 with MSSA Ocular Infections were identified. The average rate of MRSA in S. aureus Infections was 52.8% and the trend was stable over the ten years (P value for trend = 0.228). MRSA Ocular Infections were significantly more common among the patients with healthcare exposure (P = 0.024), but 66.1% (181/274) patients with MRSA Ocular Infections had no healthcare exposure. The most common clinical presentation for both MRSA and MSSA Ocular Infections was keratitis; MRSA and MSSA caused a similar disease spectrum except for lid Infections. MRSA was significantly more resistant than MSSA to clindamycin, erythromycin and sulfamethoxazole/trimethoprim (all P<0.001). Conclusions/significance We demonstrated a paralleled trend of Ocular MRSA Infection in a highly prevalent MRSA country by hospital-based survey. Except for lid disorder, MRSA shared similar spectrum of Ocular pathology with MSSA. Since S. aureus is a common Ocular pathogen, our results raise clinician’s attention to the existence of highly prevalent MRSA.
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Methicillin-resistant Staphylococcus aureus Ocular Infection: a 10-year hospital-based study.
Ophthalmology, 2011Co-Authors: Ching-hsi Hsiao, Chih-chun Chuang, Hsin-yuan Tan, David Hui-kang, Ken-kuo Lin, Chee-jen Chang, Yhu-chering HuangAbstract:Purpose To characterize the patient demographics, clinical features, and antibiotic susceptibility of Ocular Infections caused by methicillin-resistant Staphylococcus aureus (MRSA), including community-associated (CA) and healthcare-associated (HA) isolates. Design Retrospective, observational study. Participants Patients (n = 519) with culture-proven S. aureus Ocular Infections seen between January 1, 1999, and December 31, 2008, in Chang Gung Memorial Hospital. Methods Data collected included patient demographics and clinical information. Antibiotic susceptibility was verified by disc diffusion method. Main Outcome Measures Proportion of MRSA in S. aureus Ocular Infections and the clinical characteristics, diagnoses, and antibiotic susceptibility patterns of CA-MRSA versus HA-MRSA Ocular Infections. Results We identified 274 patients with MRSA Ocular Infections, which comprised 181 CA-MRSA and 93 HA-MRSA isolates. The average rate of MRSA in S. aureus Infections was 52.8% with a stable trend, whereas the annual ratio of CA-MRSA in Ocular MRSA Infections averaged 66.1% and tended to increase over the 10-year interval. Patients with Ocular CA-MRSA were younger. Lid and lacrimal system disorders were more common, but keratitis, endophthalmitis, and wound Infection were less common among CA-MRSA cases than HA-MRSA cases. Both CA-MRSA and HA-MRSA isolates were resistant to clindamycin and erythromycin, but CA-MRSA was more susceptible to sulfamethoxazole/trimethoprim. Conclusions Community-associated MRSA is an important pathogen of Ocular Infections; CA-MRSA and HA-MRSA Ocular Infections differ demographically and clinically, but both strains were multi-resistant in Chang Gung Memorial Hospital, one of the biggest referral centers in Taiwan. In a country with a high prevalence of MRSA, ophthalmologists should be aware of such epidemiologic information. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Ken-kuo Lin - One of the best experts on this subject based on the ideXlab platform.
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Staphylococcus Aureus Ocular Infection: Methicillin-Resistance, Clinical Features, and Antibiotic Susceptibilities
PloS one, 2012Co-Authors: Chih-chun Chuang, Ching-hsi Hsiao, Hsin-yuan Tan, David Hui-kang, Ken-kuo Lin, Chee-jen Chang, Yhu-chering HuangAbstract:Methicillin-resistant Staphylococcus aureus (MRSA) Infection is an important public health issue. The study aimed to determine the prevalence of Ocular Infections caused by MRSA and to identify the clinical characteristics and antibiotic susceptibility of Ocular MRSA Infections by comparing those of Ocular methicillin-sensitive S. aureus (MSSA) Infections. The medical records of the patients (n = 519) with culture-proven S. aureus Ocular Infections seen between January 1, 1999 and December 31, 2008 in Chang Gung Memorial Hospital were retrospectively reviewed. Two hundred and seventy-four patients with MRSA and 245 with MSSA Ocular Infections were identified. The average rate of MRSA in S. aureus Infections was 52.8% and the trend was stable over the ten years (P value for trend = 0.228). MRSA Ocular Infections were significantly more common among the patients with healthcare exposure (P = 0.024), but 66.1% (181/274) patients with MRSA Ocular Infections had no healthcare exposure. The most common clinical presentation for both MRSA and MSSA Ocular Infections was keratitis; MRSA and MSSA caused a similar disease spectrum except for lid Infections. MRSA was significantly more resistant than MSSA to clindamycin, erythromycin and sulfamethoxazole/trimethoprim (all P<0.001). We demonstrated a paralleled trend of Ocular MRSA Infection in a highly prevalent MRSA country by hospital-based survey. Except for lid disorder, MRSA shared similar spectrum of Ocular pathology with MSSA. Since S. aureus is a common Ocular pathogen, our results raise clinician's attention to the existence of highly prevalent MRSA.
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staphylococcus aureus Ocular Infection methicillin resistance clinical features and antibiotic susceptibilities
PLOS ONE, 2012Co-Authors: Chih-chun Chuang, Ching-hsi Hsiao, Hsin-yuan Tan, Ken-kuo Lin, David Huikang, Chee-jen ChangAbstract:Background Methicillin-resistant Staphylococcus aureus (MRSA) Infection is an important public health issue. The study aimed to determine the prevalence of Ocular Infections caused by MRSA and to identify the clinical characteristics and antibiotic susceptibility of Ocular MRSA Infections by comparing those of Ocular methicillin-sensitive S. aureus (MSSA) Infections. Methodology/Principal Findings The medical records of the patients (n = 519) with culture-proven S. aureus Ocular Infections seen between January 1, 1999 and December 31, 2008 in Chang Gung Memorial Hospital were retrospectively reviewed. Two hundred and seventy-four patients with MRSA and 245 with MSSA Ocular Infections were identified. The average rate of MRSA in S. aureus Infections was 52.8% and the trend was stable over the ten years (P value for trend = 0.228). MRSA Ocular Infections were significantly more common among the patients with healthcare exposure (P = 0.024), but 66.1% (181/274) patients with MRSA Ocular Infections had no healthcare exposure. The most common clinical presentation for both MRSA and MSSA Ocular Infections was keratitis; MRSA and MSSA caused a similar disease spectrum except for lid Infections. MRSA was significantly more resistant than MSSA to clindamycin, erythromycin and sulfamethoxazole/trimethoprim (all P<0.001). Conclusions/significance We demonstrated a paralleled trend of Ocular MRSA Infection in a highly prevalent MRSA country by hospital-based survey. Except for lid disorder, MRSA shared similar spectrum of Ocular pathology with MSSA. Since S. aureus is a common Ocular pathogen, our results raise clinician’s attention to the existence of highly prevalent MRSA.
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Methicillin-resistant Staphylococcus aureus Ocular Infection: a 10-year hospital-based study.
Ophthalmology, 2011Co-Authors: Ching-hsi Hsiao, Chih-chun Chuang, Hsin-yuan Tan, David Hui-kang, Ken-kuo Lin, Chee-jen Chang, Yhu-chering HuangAbstract:Purpose To characterize the patient demographics, clinical features, and antibiotic susceptibility of Ocular Infections caused by methicillin-resistant Staphylococcus aureus (MRSA), including community-associated (CA) and healthcare-associated (HA) isolates. Design Retrospective, observational study. Participants Patients (n = 519) with culture-proven S. aureus Ocular Infections seen between January 1, 1999, and December 31, 2008, in Chang Gung Memorial Hospital. Methods Data collected included patient demographics and clinical information. Antibiotic susceptibility was verified by disc diffusion method. Main Outcome Measures Proportion of MRSA in S. aureus Ocular Infections and the clinical characteristics, diagnoses, and antibiotic susceptibility patterns of CA-MRSA versus HA-MRSA Ocular Infections. Results We identified 274 patients with MRSA Ocular Infections, which comprised 181 CA-MRSA and 93 HA-MRSA isolates. The average rate of MRSA in S. aureus Infections was 52.8% with a stable trend, whereas the annual ratio of CA-MRSA in Ocular MRSA Infections averaged 66.1% and tended to increase over the 10-year interval. Patients with Ocular CA-MRSA were younger. Lid and lacrimal system disorders were more common, but keratitis, endophthalmitis, and wound Infection were less common among CA-MRSA cases than HA-MRSA cases. Both CA-MRSA and HA-MRSA isolates were resistant to clindamycin and erythromycin, but CA-MRSA was more susceptible to sulfamethoxazole/trimethoprim. Conclusions Community-associated MRSA is an important pathogen of Ocular Infections; CA-MRSA and HA-MRSA Ocular Infections differ demographically and clinically, but both strains were multi-resistant in Chang Gung Memorial Hospital, one of the biggest referral centers in Taiwan. In a country with a high prevalence of MRSA, ophthalmologists should be aware of such epidemiologic information. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article.
