The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Mario Jose Romanach - One of the best experts on this subject based on the ideXlab platform.
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Primordial Odontogenic Tumor: Report of a New Case and Literature Review
Head and Neck Pathology, 2019Co-Authors: Bianca Bravim Bomfim, Bruno Augusto Benevenuto De Andrade, Roberto Prado, Renato Kobler Sampaio, Danielle Castex Conde, Michelle Agostini, Mario Jose RomanachAbstract:Primordial Odontogenic Tumor (POT) was recently recognized in the 2017 World Health Organization (WHO) Classification as a distinct mixed Odontogenic Tumor most commonly observed in the posterior mandible of young patients. POT appears as an expansile radiolucency associated to an unerupted tooth. The aim of the present study was to perform a retrospective microscopic evaluation of pediatric Odontogenic Tumors diagnosed in an Oral Pathology Laboratory from Rio de Janeiro—Brazil, in order to reclassify potential cases as POT. From 150 cases of Odontogenic Tumors in children diagnosed in the last 50 years, one case filled the criteria for POT, being therefore better diagnosed as such. The patient was in the first decade of life and presented a well-defined expansile Tumor in the posterior mandible, which had been initially diagnosed as immature complex odontoma. To the best of our knowledge, only 12 cases of POT have been reported in the English-language literature. We herein present an additional case of POT and review of its clinicopathological findings is offered.
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ghost cells in pilomatrixoma craniopharyngioma and calcifying cystic Odontogenic Tumor histological immunohistochemical and ultrastructural study
Journal of Oral Pathology & Medicine, 2015Co-Authors: Alicia Rumayor, Roman Carlos, Hernan Molina Kirsch, Bruno Augusto Benevenuto De Andrade, Mario Jose Romanach, Oslei Paes De AlmeidaAbstract:Background Pilomatrixoma, craniopharyngioma, and calcifying cystic Odontogenic Tumor are the main entities presenting ghost cells as an important histological feature, in spite their quite different clinical presentation; it seems that they share a common pathway in the formation of these cells. The aim of this study is to examine and compare the characteristics of ghost and other cells that form these lesions. Methods Forty-three cases including 21 pilomatrixomas, 14 craniopharyngiomas, and eight calcifying cystic Odontogenic Tumors were evaluated by immunohistochemistry for cytokeratins, CD138, β-catenin, D2-40, Glut-1, FAS, CD10 and also by scanning electron microscopy. Results The CKs, CD138, β-catenin, Glut-1, FAS, and CD10 were more often expressed by transitional cells of craniopharyngioma and calcifying cystic Odontogenic Tumor, compared with pilomatrixoma. Basaloid cells of pilomatrixoma showed strong positivity for CD138 and CD10. Differences on expression pattern were identified in transitional and basal cells, as ghost cells were negative for most antibodies used, except by low expression for cytokeratins. By scanning electron microscopy, the morphology of ghost cells were similar in their fibrillar cytoplasm, but their pattern varied from sheets in pilomatrixoma to small clusters in craniopharyngioma and calcifying cystic Odontogenic Tumor. Conclusions Mechanisms involved in formation of ghost cells are unknown, but probably they follow different pathways as protein expression in the basal/transitional cells was not uniform in the three Tumors studied.
Bruno Augusto Benevenuto De Andrade - One of the best experts on this subject based on the ideXlab platform.
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Primordial Odontogenic Tumor: Report of a New Case and Literature Review
Head and Neck Pathology, 2019Co-Authors: Bianca Bravim Bomfim, Bruno Augusto Benevenuto De Andrade, Roberto Prado, Renato Kobler Sampaio, Danielle Castex Conde, Michelle Agostini, Mario Jose RomanachAbstract:Primordial Odontogenic Tumor (POT) was recently recognized in the 2017 World Health Organization (WHO) Classification as a distinct mixed Odontogenic Tumor most commonly observed in the posterior mandible of young patients. POT appears as an expansile radiolucency associated to an unerupted tooth. The aim of the present study was to perform a retrospective microscopic evaluation of pediatric Odontogenic Tumors diagnosed in an Oral Pathology Laboratory from Rio de Janeiro—Brazil, in order to reclassify potential cases as POT. From 150 cases of Odontogenic Tumors in children diagnosed in the last 50 years, one case filled the criteria for POT, being therefore better diagnosed as such. The patient was in the first decade of life and presented a well-defined expansile Tumor in the posterior mandible, which had been initially diagnosed as immature complex odontoma. To the best of our knowledge, only 12 cases of POT have been reported in the English-language literature. We herein present an additional case of POT and review of its clinicopathological findings is offered.
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ghost cells in pilomatrixoma craniopharyngioma and calcifying cystic Odontogenic Tumor histological immunohistochemical and ultrastructural study
Journal of Oral Pathology & Medicine, 2015Co-Authors: Alicia Rumayor, Roman Carlos, Hernan Molina Kirsch, Bruno Augusto Benevenuto De Andrade, Mario Jose Romanach, Oslei Paes De AlmeidaAbstract:Background Pilomatrixoma, craniopharyngioma, and calcifying cystic Odontogenic Tumor are the main entities presenting ghost cells as an important histological feature, in spite their quite different clinical presentation; it seems that they share a common pathway in the formation of these cells. The aim of this study is to examine and compare the characteristics of ghost and other cells that form these lesions. Methods Forty-three cases including 21 pilomatrixomas, 14 craniopharyngiomas, and eight calcifying cystic Odontogenic Tumors were evaluated by immunohistochemistry for cytokeratins, CD138, β-catenin, D2-40, Glut-1, FAS, CD10 and also by scanning electron microscopy. Results The CKs, CD138, β-catenin, Glut-1, FAS, and CD10 were more often expressed by transitional cells of craniopharyngioma and calcifying cystic Odontogenic Tumor, compared with pilomatrixoma. Basaloid cells of pilomatrixoma showed strong positivity for CD138 and CD10. Differences on expression pattern were identified in transitional and basal cells, as ghost cells were negative for most antibodies used, except by low expression for cytokeratins. By scanning electron microscopy, the morphology of ghost cells were similar in their fibrillar cytoplasm, but their pattern varied from sheets in pilomatrixoma to small clusters in craniopharyngioma and calcifying cystic Odontogenic Tumor. Conclusions Mechanisms involved in formation of ghost cells are unknown, but probably they follow different pathways as protein expression in the basal/transitional cells was not uniform in the three Tumors studied.
Natee Nonpassopon - One of the best experts on this subject based on the ideXlab platform.
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primordial Odontogenic Tumor with prominent calcifications a rare case report
Journal of Clinical and Experimental Dentistry, 2019Co-Authors: Sopee Poomsawat, Supak Ngamsom, Natee NonpassoponAbstract:Primordial Odontogenic Tumor (POT) is a rare Odontogenic Tumor. It is a new entity in the latest edition of the World Health Organization classification in 2017. In the English-language literature, only 14 cases have been documented. Most POTs show a well-defined unilocular radiolucency surrounding a crown of an unerupted molar, resembling a dentigerous cyst. Microscopically, POT may be difficult to distinguish from Odontogenic myxoma, ameloblastic fibroma, hyperplastic dental follicle and dental papilla. Here, we reported a case of POT in a 17-year old female presenting with an asymptomatic bony hard swelling at the left posterior mandible. Interestingly, this case shows unique radiographic and microscopic features with prominent calcifications and stellate reticulum-like structures. These characteristics have rarely been described in all previously reported POTs. Importantly, this case is the first case of POT demonstrating radiopacity in the radiographs. We encourage more cases of POTs to be documented as POTs may have more variations in radiographic and microscopic features. Importantly, oral radiologists, surgeons and pathologists must be aware of this new and rare Tumor in order to avoid a misdiagnosis and an inappropriate treatment. Key words:Calcification, mandible, Odontogenic Tumor, primordial Odontogenic Tumor.
Qiaochu Sun - One of the best experts on this subject based on the ideXlab platform.
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Primordial Odontogenic Tumor: a case report and literature review
Diagnostic Pathology, 2019Co-Authors: Qiaochu Sun, Jae-seo Lee, Okjoon Kim, Young KimAbstract:Background A primordial Odontogenic Tumor (POT) is a rare, benign, mixed epithelial and mesenchymal Odontogenic Tumor that has been included as a new entity in the latest World Health Organization (WHO) classification (2017). POT consists of dental papilla-like myxoid connective tissue covered with a delicate membrane of ameloblastic epithelium. Only 15 cases have been documented worldwide, and here, we report the sixteenth case and the first one of South Korea. Case presentation An asymptomatic lesion was discovered as an incidental radiographic finding in a 10-year-old boy. The patient had no complaints about the lesion. Cone-beam computerized tomograms revealed a round cavity with a defined cortical border measuring approximately 5 × 5 × 5 mm in size. The lesion was a POT. The patient was treated with enucleation. The Tumor showed no recurrence for one year. Conclusion This is the first report of POT in South Korea using the novel diagnosis of POT after it was recognized and defined in the latest WHO classification. This novel diagnosis will be useful for pathologists and clinicians in diagnosing and differentiating this new and rare disease from other Odontogenic Tumors.
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primordial Odontogenic Tumor a case report and literature review
Diagnostic Pathology, 2019Co-Authors: Qiaochu Sun, Jae-seo Lee, Okjoon Kim, Young Ho KimAbstract:A primordial Odontogenic Tumor (POT) is a rare, benign, mixed epithelial and mesenchymal Odontogenic Tumor that has been included as a new entity in the latest World Health Organization (WHO) classification (2017). POT consists of dental papilla-like myxoid connective tissue covered with a delicate membrane of ameloblastic epithelium. Only 15 cases have been documented worldwide, and here, we report the sixteenth case and the first one of South Korea. An asymptomatic lesion was discovered as an incidental radiographic finding in a 10-year-old boy. The patient had no complaints about the lesion. Cone-beam computerized tomograms revealed a round cavity with a defined cortical border measuring approximately 5 × 5 × 5 mm in size. The lesion was a POT. The patient was treated with enucleation. The Tumor showed no recurrence for one year. This is the first report of POT in South Korea using the novel diagnosis of POT after it was recognized and defined in the latest WHO classification. This novel diagnosis will be useful for pathologists and clinicians in diagnosing and differentiating this new and rare disease from other Odontogenic Tumors.
Oslei Paes De Almeida - One of the best experts on this subject based on the ideXlab platform.
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ghost cells in pilomatrixoma craniopharyngioma and calcifying cystic Odontogenic Tumor histological immunohistochemical and ultrastructural study
Journal of Oral Pathology & Medicine, 2015Co-Authors: Alicia Rumayor, Roman Carlos, Hernan Molina Kirsch, Bruno Augusto Benevenuto De Andrade, Mario Jose Romanach, Oslei Paes De AlmeidaAbstract:Background Pilomatrixoma, craniopharyngioma, and calcifying cystic Odontogenic Tumor are the main entities presenting ghost cells as an important histological feature, in spite their quite different clinical presentation; it seems that they share a common pathway in the formation of these cells. The aim of this study is to examine and compare the characteristics of ghost and other cells that form these lesions. Methods Forty-three cases including 21 pilomatrixomas, 14 craniopharyngiomas, and eight calcifying cystic Odontogenic Tumors were evaluated by immunohistochemistry for cytokeratins, CD138, β-catenin, D2-40, Glut-1, FAS, CD10 and also by scanning electron microscopy. Results The CKs, CD138, β-catenin, Glut-1, FAS, and CD10 were more often expressed by transitional cells of craniopharyngioma and calcifying cystic Odontogenic Tumor, compared with pilomatrixoma. Basaloid cells of pilomatrixoma showed strong positivity for CD138 and CD10. Differences on expression pattern were identified in transitional and basal cells, as ghost cells were negative for most antibodies used, except by low expression for cytokeratins. By scanning electron microscopy, the morphology of ghost cells were similar in their fibrillar cytoplasm, but their pattern varied from sheets in pilomatrixoma to small clusters in craniopharyngioma and calcifying cystic Odontogenic Tumor. Conclusions Mechanisms involved in formation of ghost cells are unknown, but probably they follow different pathways as protein expression in the basal/transitional cells was not uniform in the three Tumors studied.
