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Gero Miesenbock - One of the best experts on this subject based on the ideXlab platform.
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Sparse, Decorrelated Odor Coding in the Mushroom Body Enhances Learned Odor Discrimination
2016Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding may be a general strategy of neural systems to augment memory capacity. In Drosophila, sparse Odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of Odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit show that Kenyon cells activate APL and APL inhibits Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreases the sparseness of Kenyon cell Odor responses, increases inter-Odor correlations, and prevents flies from learning to discriminate similar, but not dissimilar, Odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated Odor coding and thus the Odor-specificity of memories
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sparse decorrelated Odor coding in the mushroom body enhances learned Odor discrimination
Nature Neuroscience, 2014Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding may be a general strategy of neural systems for augmenting memory capacity. In Drosophila melanogaster, sparse Odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of Odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit showed that Kenyon cells activated APL and APL inhibited Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreased the sparseness of Kenyon cell Odor responses, increased inter-Odor correlations and prevented flies from learning to discriminate similar, but not dissimilar, Odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated Odor coding and thus the Odor specificity of memories.
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sparse decorrelated Odor coding in the mushroom body enhances learned Odor discrimination
Nature Neuroscience, 2014Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding is thought to facilitate pattern separation for associative memory, but behavioral evidence is scant. The authors show that in Drosophila, feedback inhibition enforces sparse Odor coding in Kenyon cells, the neurons that store olfactory associations. Disrupting this sparsening mechanism impairs learned discrimination of similar, but not dissimilar, Odors.
Masahiro Yamaguchi - One of the best experts on this subject based on the ideXlab platform.
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functional sub circuits of the olfactory system viewed from the olfactory bulb and the olfactory tubercle
Frontiers in Neuroanatomy, 2017Co-Authors: Masahiro YamaguchiAbstract:Understanding of the olfactory neural circuits has progressed beyond analysis of how Odor information from the external environment is processed in the brain. While spatially-organized sub-circuits were found to exist up to the olfactory bulb (OB), the arrangement in the olfactory cortex (OC), especially in its representative piriform cortex (PC), appears diffuse and dispersed. An emerging view is that the activity of OC neurons may not simply encode Odor identity but rather encode plastic Odor information such as Odor value. Although many studies support this notion, Odor value can be either positive or negative, and the existence of sub-circuits corresponding to individual value types is not well explored. To address this question, I introduce here two olfactory areas other than the PC, OB and olfactory tubercle (OT) whose analysis may facilitate understanding of functional sub-circuits related to different Odor values. Peripheral and centrifugal inputs to the OB are considered to relate to Odor identity and Odor value, respectively, and centrifugal inputs to the OB potentially represent different Odor values during different behavioral periods. The OT has spatially-segregated functional domains related to distinct motivated and hedonic behaviors. Thus, the OT provides a good starting point from which functional sub-circuits across various olfactory regions can be traced. Further analysis across wide areas of the olfactory system will likely reveal the functional sub-circuits that link Odor identity with distinct Odor values and direct distinct Odor-induced motivated and hedonic behaviors.
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Mapping of Learned Odor-Induced Motivated Behaviors in the Mouse Olfactory Tubercle
Journal of Neuroscience, 2015Co-Authors: Koshi Murata, Michiko Kanno, Nao Ieki, Masahiro YamaguchiAbstract:An Odor induces food-seeking behaviors when humans and animals learned to associate the Odor with food, whereas the same Odor elicits aversive behaviors following Odor-danger association learning. It is poorly understood how central olfactory circuits transform the learned Odor cue information into appropriate motivated behaviors. The olfactory tubercle (OT) is an intriguing area of the olfactory cortex in that it contains medium spiny neurons as principal neurons and constitutes a part of the ventral striatum. The OT is therefore a candidate area for participation in Odor-induced motivated behaviors. Here we mapped c-Fos activation of medium spiny neurons in different domains of the mouse OT following exposure to learned Odor cues. Mice were trained to associate Odor cues to a sugar reward or foot shock punishment to induce Odor-guided approach behaviors or aversive behaviors. Regardless of Odorant types, the anteromedial domain of the OT was activated by learned Odor cues that induced approach behaviors, whereas the lateral domain was activated by learned Odor cues that induced aversive behaviors. In each domain, a larger number of dopamine receptor D1 type neurons were activated than D2 type neurons. These results indicate that specific domains of the OT represent Odor-induced distinct motivated behaviors rather than Odor stimuli, and raise the possibility that neuronal type-specific activation in individual domains of the OT plays crucial roles in mediating the appropriate learned Odor-induced motivated behaviors. Significance statement: Although animals learn to associate Odor cues with various motivated behaviors, the underlying circuit mechanisms are poorly understood. The olfactory tubercle (OT), a subarea of the olfactory cortex, also constitutes the ventral striatum. Here, we trained mice to associate Odors with either reward or punishment and mapped Odor-induced c-Fos activation in the OT. Regardless of Odorant types, the anteromedial domain was activated by approach behavior-inducing Odors, whereas the lateral domain was activated by aversive behavior-inducing Odors. In each domain, dopamine receptor D1 neurons were preferentially activated over D2 neurons. The results indicate that specific OT domains represent Odor-induced distinct motivated behaviors rather than Odor types, and suggest the importance of neuronal type-specific activation in individual domains in mediating appropriate behaviors.
Andrew C. Lin - One of the best experts on this subject based on the ideXlab platform.
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Sparse, Decorrelated Odor Coding in the Mushroom Body Enhances Learned Odor Discrimination
2016Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding may be a general strategy of neural systems to augment memory capacity. In Drosophila, sparse Odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of Odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit show that Kenyon cells activate APL and APL inhibits Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreases the sparseness of Kenyon cell Odor responses, increases inter-Odor correlations, and prevents flies from learning to discriminate similar, but not dissimilar, Odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated Odor coding and thus the Odor-specificity of memories
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sparse decorrelated Odor coding in the mushroom body enhances learned Odor discrimination
Nature Neuroscience, 2014Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding may be a general strategy of neural systems for augmenting memory capacity. In Drosophila melanogaster, sparse Odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of Odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit showed that Kenyon cells activated APL and APL inhibited Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreased the sparseness of Kenyon cell Odor responses, increased inter-Odor correlations and prevented flies from learning to discriminate similar, but not dissimilar, Odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated Odor coding and thus the Odor specificity of memories.
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sparse decorrelated Odor coding in the mushroom body enhances learned Odor discrimination
Nature Neuroscience, 2014Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding is thought to facilitate pattern separation for associative memory, but behavioral evidence is scant. The authors show that in Drosophila, feedback inhibition enforces sparse Odor coding in Kenyon cells, the neurons that store olfactory associations. Disrupting this sparsening mechanism impairs learned discrimination of similar, but not dissimilar, Odors.
Alexei M Bygrave - One of the best experts on this subject based on the ideXlab platform.
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Sparse, Decorrelated Odor Coding in the Mushroom Body Enhances Learned Odor Discrimination
2016Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding may be a general strategy of neural systems to augment memory capacity. In Drosophila, sparse Odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of Odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit show that Kenyon cells activate APL and APL inhibits Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreases the sparseness of Kenyon cell Odor responses, increases inter-Odor correlations, and prevents flies from learning to discriminate similar, but not dissimilar, Odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated Odor coding and thus the Odor-specificity of memories
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sparse decorrelated Odor coding in the mushroom body enhances learned Odor discrimination
Nature Neuroscience, 2014Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding may be a general strategy of neural systems for augmenting memory capacity. In Drosophila melanogaster, sparse Odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of Odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit showed that Kenyon cells activated APL and APL inhibited Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreased the sparseness of Kenyon cell Odor responses, increased inter-Odor correlations and prevented flies from learning to discriminate similar, but not dissimilar, Odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated Odor coding and thus the Odor specificity of memories.
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sparse decorrelated Odor coding in the mushroom body enhances learned Odor discrimination
Nature Neuroscience, 2014Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding is thought to facilitate pattern separation for associative memory, but behavioral evidence is scant. The authors show that in Drosophila, feedback inhibition enforces sparse Odor coding in Kenyon cells, the neurons that store olfactory associations. Disrupting this sparsening mechanism impairs learned discrimination of similar, but not dissimilar, Odors.
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Sparse, decorrelated Odor coding in the mushroom body enhances learned Odor discrimination
'Springer Science and Business Media LLC', 2014Co-Authors: Ac Lin, Alexei M Bygrave, De Calignon A, Lee T, Miesenböck GAbstract:Sparse coding may be a general strategy of neural systems for augmenting memory capacity. In Drosophila melanogaster, sparse Odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of Odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit showed that Kenyon cells activated APL and APL inhibited Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreased the sparseness of Kenyon cell Odor responses, increased inter-Odor correlations and prevented flies from learning to discriminate similar, but not dissimilar, Odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated Odor coding and thus the Odor specificity of memories. © 2014 Nature America, Inc. All rights reserved
Alix De Calignon - One of the best experts on this subject based on the ideXlab platform.
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Sparse, Decorrelated Odor Coding in the Mushroom Body Enhances Learned Odor Discrimination
2016Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding may be a general strategy of neural systems to augment memory capacity. In Drosophila, sparse Odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of Odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit show that Kenyon cells activate APL and APL inhibits Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreases the sparseness of Kenyon cell Odor responses, increases inter-Odor correlations, and prevents flies from learning to discriminate similar, but not dissimilar, Odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated Odor coding and thus the Odor-specificity of memories
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sparse decorrelated Odor coding in the mushroom body enhances learned Odor discrimination
Nature Neuroscience, 2014Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding may be a general strategy of neural systems for augmenting memory capacity. In Drosophila melanogaster, sparse Odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of Odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic anterior paired lateral (APL) neuron. Systematic activation and blockade of each leg of this feedback circuit showed that Kenyon cells activated APL and APL inhibited Kenyon cells. Disrupting the Kenyon cell-APL feedback loop decreased the sparseness of Kenyon cell Odor responses, increased inter-Odor correlations and prevented flies from learning to discriminate similar, but not dissimilar, Odors. These results suggest that feedback inhibition suppresses Kenyon cell activity to maintain sparse, decorrelated Odor coding and thus the Odor specificity of memories.
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sparse decorrelated Odor coding in the mushroom body enhances learned Odor discrimination
Nature Neuroscience, 2014Co-Authors: Andrew C. Lin, Alexei M Bygrave, Alix De Calignon, Tzumin Lee, Gero MiesenbockAbstract:Sparse coding is thought to facilitate pattern separation for associative memory, but behavioral evidence is scant. The authors show that in Drosophila, feedback inhibition enforces sparse Odor coding in Kenyon cells, the neurons that store olfactory associations. Disrupting this sparsening mechanism impairs learned discrimination of similar, but not dissimilar, Odors.