The Experts below are selected from a list of 3159 Experts worldwide ranked by ideXlab platform
Marco Alessandrini - One of the best experts on this subject based on the ideXlab platform.
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Olfactory related quality of life in multiple chemical sensitivity a genetic acquired factors model
International Journal of Molecular Sciences, 2019Co-Authors: Alessandro Micarelli, Andrea Cormano, Daniela Caccamo, Marco AlessandriniAbstract:Genetic polymorphisms as well as environmental exposures to chemical compounds, iatrogenic, psychological, and physical trauma may play a pathophysiological role in multiple chemical sensitivity (MCS) Olfactory complaints, given that xenobiotic metabolism is influenced by sequence variations in genes of metabolizing enzymes. Thus, the aim of the present study was to depict—by means of multiple regression analysis—how different genetic conditions, grouped according to their function as well as clinical background and environmental exposure may interfere with those Olfactory complaints referred by MCS patients. Therefore, MCS patients after gene polymorphism sequencing, the Olfactory-related quality of life score—calculated by means of the Questionnaire of Olfactory Disorder in forty-six MCS patients—have been found to significantly rely on the phase I and II enzymes score and exposure to previous compounds and surgical treatments. The present work—implementing for the first time a genetic-acquired factors model on a regression analysis—further reinforces those theories, positing MCS as a complex, multifactorial, disease in which the genetic risk related to phase I and II enzymes involved in xenobiotic detoxification, Olfactory, and neurodegenerative diseases play a necessary, but probably not sufficient role, along the pathophysiological route of the disease.
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intranasal administration of hyaluronan as a further resource in Olfactory performance in multiple chemical sensitivity syndrome
International Journal of Immunopathology and Pharmacology, 2013Co-Authors: Marco Alessandrini, Alessandro Micarelli, Ernesto Bruno, Andrea Cormano, F Ottaviani, M Conetta, Giuseppe GenovesiAbstract:Multiple chemical sensitivity (MCS) is a relatively common clinical diagnosis in western populations and its symptoms (i.e. dysosmia) are mainly triggered by chemical compounds, such as common odorants. The aim of this study was to test the effect of intranasal administration of hyaluronic acid (HA) on odour threshold and related quality of life in MCS syndrome. Two randomized groups of MCS patients received 30 days administration of either a nasal spray (Ialumar®) containing HA [HA group (HAG); n=29] or only physiological solution[PS group (PG); n=30]. Both groups were investigated using the Sniffin Sticks test (SST) battery, Questionnaire of Olfactory Disorder (QOD) and Zung Anxiety Scale (SAS) before randomization and after treatment. Paired t-test analysis found a statistically significant reduction in odour threshold (OT) and an improvement in QOD and SAS between pre- and post-treatment results only in the HAG. Furthermore, positive correlations were found between the OT reduction, SAS and QOD improvement. Thus, intranasal administration of HA could be suggested as a further well-tolerated resource in alleviating MCS Olfactory discomfort.
Alessandro Micarelli - One of the best experts on this subject based on the ideXlab platform.
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Olfactory related quality of life in multiple chemical sensitivity a genetic acquired factors model
International Journal of Molecular Sciences, 2019Co-Authors: Alessandro Micarelli, Andrea Cormano, Daniela Caccamo, Marco AlessandriniAbstract:Genetic polymorphisms as well as environmental exposures to chemical compounds, iatrogenic, psychological, and physical trauma may play a pathophysiological role in multiple chemical sensitivity (MCS) Olfactory complaints, given that xenobiotic metabolism is influenced by sequence variations in genes of metabolizing enzymes. Thus, the aim of the present study was to depict—by means of multiple regression analysis—how different genetic conditions, grouped according to their function as well as clinical background and environmental exposure may interfere with those Olfactory complaints referred by MCS patients. Therefore, MCS patients after gene polymorphism sequencing, the Olfactory-related quality of life score—calculated by means of the Questionnaire of Olfactory Disorder in forty-six MCS patients—have been found to significantly rely on the phase I and II enzymes score and exposure to previous compounds and surgical treatments. The present work—implementing for the first time a genetic-acquired factors model on a regression analysis—further reinforces those theories, positing MCS as a complex, multifactorial, disease in which the genetic risk related to phase I and II enzymes involved in xenobiotic detoxification, Olfactory, and neurodegenerative diseases play a necessary, but probably not sufficient role, along the pathophysiological route of the disease.
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intranasal administration of hyaluronan as a further resource in Olfactory performance in multiple chemical sensitivity syndrome
International Journal of Immunopathology and Pharmacology, 2013Co-Authors: Marco Alessandrini, Alessandro Micarelli, Ernesto Bruno, Andrea Cormano, F Ottaviani, M Conetta, Giuseppe GenovesiAbstract:Multiple chemical sensitivity (MCS) is a relatively common clinical diagnosis in western populations and its symptoms (i.e. dysosmia) are mainly triggered by chemical compounds, such as common odorants. The aim of this study was to test the effect of intranasal administration of hyaluronic acid (HA) on odour threshold and related quality of life in MCS syndrome. Two randomized groups of MCS patients received 30 days administration of either a nasal spray (Ialumar®) containing HA [HA group (HAG); n=29] or only physiological solution[PS group (PG); n=30]. Both groups were investigated using the Sniffin Sticks test (SST) battery, Questionnaire of Olfactory Disorder (QOD) and Zung Anxiety Scale (SAS) before randomization and after treatment. Paired t-test analysis found a statistically significant reduction in odour threshold (OT) and an improvement in QOD and SAS between pre- and post-treatment results only in the HAG. Furthermore, positive correlations were found between the OT reduction, SAS and QOD improvement. Thus, intranasal administration of HA could be suggested as a further well-tolerated resource in alleviating MCS Olfactory discomfort.
Andrea Cormano - One of the best experts on this subject based on the ideXlab platform.
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Olfactory related quality of life in multiple chemical sensitivity a genetic acquired factors model
International Journal of Molecular Sciences, 2019Co-Authors: Alessandro Micarelli, Andrea Cormano, Daniela Caccamo, Marco AlessandriniAbstract:Genetic polymorphisms as well as environmental exposures to chemical compounds, iatrogenic, psychological, and physical trauma may play a pathophysiological role in multiple chemical sensitivity (MCS) Olfactory complaints, given that xenobiotic metabolism is influenced by sequence variations in genes of metabolizing enzymes. Thus, the aim of the present study was to depict—by means of multiple regression analysis—how different genetic conditions, grouped according to their function as well as clinical background and environmental exposure may interfere with those Olfactory complaints referred by MCS patients. Therefore, MCS patients after gene polymorphism sequencing, the Olfactory-related quality of life score—calculated by means of the Questionnaire of Olfactory Disorder in forty-six MCS patients—have been found to significantly rely on the phase I and II enzymes score and exposure to previous compounds and surgical treatments. The present work—implementing for the first time a genetic-acquired factors model on a regression analysis—further reinforces those theories, positing MCS as a complex, multifactorial, disease in which the genetic risk related to phase I and II enzymes involved in xenobiotic detoxification, Olfactory, and neurodegenerative diseases play a necessary, but probably not sufficient role, along the pathophysiological route of the disease.
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intranasal administration of hyaluronan as a further resource in Olfactory performance in multiple chemical sensitivity syndrome
International Journal of Immunopathology and Pharmacology, 2013Co-Authors: Marco Alessandrini, Alessandro Micarelli, Ernesto Bruno, Andrea Cormano, F Ottaviani, M Conetta, Giuseppe GenovesiAbstract:Multiple chemical sensitivity (MCS) is a relatively common clinical diagnosis in western populations and its symptoms (i.e. dysosmia) are mainly triggered by chemical compounds, such as common odorants. The aim of this study was to test the effect of intranasal administration of hyaluronic acid (HA) on odour threshold and related quality of life in MCS syndrome. Two randomized groups of MCS patients received 30 days administration of either a nasal spray (Ialumar®) containing HA [HA group (HAG); n=29] or only physiological solution[PS group (PG); n=30]. Both groups were investigated using the Sniffin Sticks test (SST) battery, Questionnaire of Olfactory Disorder (QOD) and Zung Anxiety Scale (SAS) before randomization and after treatment. Paired t-test analysis found a statistically significant reduction in odour threshold (OT) and an improvement in QOD and SAS between pre- and post-treatment results only in the HAG. Furthermore, positive correlations were found between the OT reduction, SAS and QOD improvement. Thus, intranasal administration of HA could be suggested as a further well-tolerated resource in alleviating MCS Olfactory discomfort.
Tatsuya Yamasoba - One of the best experts on this subject based on the ideXlab platform.
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innate immune responses and neuroepithelial degeneration and regeneration in the mouse Olfactory mucosa induced by intranasal administration of poly i c
Cell and Tissue Research, 2014Co-Authors: Kaori Kanaya, Keigo Suzukawa, Kazunari Okada, Kenji Kondo, Shu Kikuta, Takashi Sakamoto, Tatsuya YamasobaAbstract:The pathogenesis of postviral Olfactory Disorder (PVOD) has not been fully elucidated. We investigated morphological changes and innate immune responses in the mouse Olfactory mucosa induced by intranasal administration of polyinosinic-polycytidylic acid [Poly(I:C)], a synthetic analog of viral double-stranded RNA. Mice received three administrations of saline with or without Poly(I:C), once every 24 h. The Olfactory mucosa was harvested at various intervals after the first administration (8 h, 3, 9 and 24 days). In the Poly(I:C) group, the number of apoptotic cells in the Olfactory neuroepithelium had increased at 8 h. At 9 days, the Olfactory neuroepithelium had severely degenerated and behavioral tests demonstrated that the mice showed signs of Olfactory deterioration. At 24 days, the structure of the neuroepithelium had regenerated almost completely. Regarding the innate immune responses, many neutrophils had infiltrated the Olfactory neuroepithelium at 8 h and had exuded into the nasal cavity by 3 days. Macrophages had also infiltrated the Olfactory neuroepithelium at 8 h although to a lesser extent, but they still remained in the neuroepithelium at 24 days. Poly(I:C)-induced neuroepithelial damage was significantly inhibited by a neutrophil elastase inhibitor and was suppressed in neutropenic model mice. These findings suggest that the secondary damage caused by the neutrophil-mediated innate immune response plays an important role in the pathogenesis of PVOD.
Qintai Yang - One of the best experts on this subject based on the ideXlab platform.
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Olfactory sensitivity is related to erectile function in adult males
Frontiers in Cell and Developmental Biology, 2020Co-Authors: Huiyi Deng, Jiarong Feng, Wenhao Zhou, Weifeng Kong, Shaoge Luo, Yan Zhang, Qintai YangAbstract:Background: The Olfactory system influences human social behavior, especially in spousal selection, with vomeronasal organ (VNO) playing an important role. However, there is currently a lack of clinical research on the relationship between Olfactory and erectile dysfunction (ED) in male adults. Aim: We aimed to explore the connection between Olfactory sensitivity and erectile function and its possible mechanisms. Results: A retrospective analysis of 574 patients diagnosed with ED in the Department of Infertility and Sexual Medicine of the Third Affiliated Hospital, Sun Yat-sen University from 2015 to 2018, 459 patients (79.97%) without RD, and 115 patients (20.03%) with RD. Meanwhile, 201 cases of patients undergoing nasal surgery in ENT Department from 2012 to 2016, 172 cases (85.57%) without ED, and 29 cases (14.43%) with ED. Through telephone follow-up, we found that nasal congestion, nasal discharge, and hyposmia were the most common complains in VAS score. Additionally, 156 patients with RD and (or) ED in 2019 were enrolled, and 40 healthy volunteers for controls. Through Nocturnal Penile Tumescence and Rigidity (NPTR), International erectile function scale (IIEF-5), erection hardness score (EHS), VAS scale, Sniffin’ Sticks Test, we found that compared with ED patients, ED patients with RD had severe nasal discomfort and decreased erectile function(P=0.000). The Olfactory sensation of patients with ED was lower than that of normal people, and patients both with ED and RD had the worst Olfactory (P=0.000).The Spearman correlation analysis showed that the sense of smell was positively correlated with IIEF-5 (R=0.507, P=0.000) and EHS (R=0.341, P=0.000). Logistic regression analysis showed that whether with Olfactory Disorder (OD) or RD, age and VAS score were the risk of ED outcome, indicating that OD patients was a 16.479-fold increase in ED outcomes (P < 0.05). Conclusion: There is a significant correlation between Olfactory sensitivity and erectile function in male. We were considered that perception of certain body odors may contribute to the concept of erectile function by enhanced recruitment of reward areas through the VNO. The Olfactory sensitivity in patients with both ED and RD is worse than patients suffered from a single disease, exhibiting obvious superimposing effect.
