The Experts below are selected from a list of 1149 Experts worldwide ranked by ideXlab platform
Anas Subarnas - One of the best experts on this subject based on the ideXlab platform.
-
Physical study of Chloramphenicol In Situ Gel with Base Hydroxypropyl Methylcellulose and Poloxamer 188.
Journal of pharmacy & bioallied sciences, 2019Co-Authors: Insan S Kurniawansyah, Iyan Sopyan, Dolih Gozali, Muhammad Iqbal, Anas SubarnasAbstract:The aim of this study was to determine the best formulation of Ophthalmic in situ gel Preparation by two different bases, Poloxamer 188 and HPMC (hydroxypropyl methylcellulose), with physical evaluation, such as organoleptic, pH, viscosity, and gel capacity during 28 days of storage time. The two different concentrations of the gel made by using Poloxamer 188 were F1 (5%) and F2 (10%), and those made by using HPMC were F3 (0.45%) and F4 (1%). The results of this study showed that formulation 1 (F1) was the optimum formulation, having pH 6.45, viscosity of 5.47 cP, and a better gel capacity than other formulas. In situ gel for Ophthalmic Preparations is developed to mask the limitation of conventional forms of Ophthalmic Preparation. In situ gel technology significantly increase the effectivity of drugs in the raw material and drug bioavailability in new drug delivery systems based on in situ gel concept. Copyright: © 2019 Journal of Pharmacy and Bioallied Sciences.
-
Physical study of Chloramphenicol In Situ Gel with Base Hydroxypropyl Methylcellulose and Poloxamer 188.
Journal of Pharmacy And Bioallied Sciences, 2019Co-Authors: Insan Sunan Kurniawansyah, Iyan Sopyan, Dolih Gozali, Muhammad Iqbal, Anas SubarnasAbstract:Objective: The aim of this study was to determine the best formulation of Ophthalmic in situ gel Preparation by two different bases, Poloxamer 188 and HPMC (hydroxypropyl methylcellulose), with physical evaluation, such as organoleptic, pH, viscosity, and gel capacity during 28 days of storage time. Materials and Methods: The two different concentrations of the gel made by using Poloxamer 188 were F1 (5%) and F2 (10%), and those made by using HPMC were F3 (0.45%) and F4 (1%). Results: The results of this study showed that formulation 1 (F1) was the optimum formulation, having pH 6.45, viscosity of 5.47 cP, and a better gel capacity than other formulas. Conclusion: In situ gel for Ophthalmic Preparations is developed to mask the limitation of conventional forms of Ophthalmic Preparation. In situ gel technology significantly increase the effectivity of drugs in the raw material and drug bioavailability in new drug delivery systems based on in situ gel concept.
Samah S Abbas - One of the best experts on this subject based on the ideXlab platform.
-
validated hptlc and hplc methods for determination of fluorometholone and sodium cromoglycate in presence of their impurities and degradation products application to kinetic study and on rabbit aqueous humor
Journal of Liquid Chromatography & Related Technologies, 2018Co-Authors: Maha A Hegazy, May H Abdelwahab, Hassan A M Hendawy, Soheir A Weshahy, Samah S AbbasAbstract:ABSTRACTFluorometholone (FLM) and Sodium Cromoglycate (CMG) are co-formulated in Ophthalmic Preparation and showed marked instability under different conditions. Two specific, sensitive and precise stability-indicating chromatographic methods have been developed and validated for their determination in the presence of their degradation products and FLM impurity. Ten components were efficiently separated by them. The first method was HPTLC-spectrodensitometry, where the separation was achieved using silica gel 60 F254 HPTLC plates and developing system of ethyl acetate: methanol (9:1, v/v). The second method was a reversed phase HPLC associated with kinetic study of the degradation process and was successfully applied for determination of the studied compounds in spiked rabbit aqueous humor. The mobile phase was acetonitrile: methanol: 0.05 M potassium dihydrogenphosphate (0.1% trimethylamine); pH 2.5, adjusted with orthophosphoric acid (20: 30: 50, by volume). In both methods, the separated components wer...
-
Validated HPTLC and HPLC methods for determination of fluorometholone and sodium cromoglycate in presence of their impurities and degradation products; application to kinetic study and on rabbit aqueous humor
2018Co-Authors: Maha A Hegazy, May H Abdelwahab, Hassan A M Hendawy, Soheir A Weshahy, Samah S AbbasAbstract:Fluorometholone (FLM) and Sodium Cromoglycate (CMG) are co-formulated in Ophthalmic Preparation and showed marked instability under different conditions. Two specific, sensitive and precise stability-indicating chromatographic methods have been developed and validated for their determination in the presence of their degradation products and FLM impurity. Ten components were efficiently separated by them. The first method was HPTLC-spectrodensitometry, where the separation was achieved using silica gel 60 F254 HPTLC plates and developing system of ethyl acetate: methanol (9:1, v/v). The second method was a reversed phase HPLC associated with kinetic study of the degradation process and was successfully applied for determination of the studied compounds in spiked rabbit aqueous humor. The mobile phase was acetonitrile: methanol: 0.05 M potassium dihydrogenphosphate (0.1% trimethylamine); pH 2.5, adjusted with orthophosphoric acid (20: 30: 50, by volume). In both methods, the separated components were detected at 240 nm and system suitability was checked. Good correlation was obtained in the range of 0.10–24.00 and 0.20–48.00 µg band−1, for FLM and CMG by HPTLC. While for HPLC, the linearity ranges from 0.01–50.00 and 0.05–50.00 µg mL−1 for both drugs. The methods were applied in pharmaceutical formulation, where they were compared to the reported method with no significant difference.
Nadia Araci Bouchacra - One of the best experts on this subject based on the ideXlab platform.
-
advances in Ophthalmic Preparation the role of drug nanocrystals and lipid based nanosystems
Journal of Drug Targeting, 2020Co-Authors: Maria Christina Camasmie Peters, Edson Dos Santos Neto, Lis Marie Monteiro, Megumi Nishitani Yukuyama, Marcella Gabrielle Mendes Machado, Isabela Fernandes De Oliveira, Maria Helena Ambrosio Zanin, Raimar Lobenberg, Nadia Araci BouchacraAbstract:Nanocrystals and lipid-based nanosystems have the potential to play a crucial role in a significant shift in the treatment of Ophthalmic diseases. These drug delivery systems allow overcoming the b...
Iyan Sopyan - One of the best experts on this subject based on the ideXlab platform.
-
Physical study of Chloramphenicol In Situ Gel with Base Hydroxypropyl Methylcellulose and Poloxamer 188.
Journal of pharmacy & bioallied sciences, 2019Co-Authors: Insan S Kurniawansyah, Iyan Sopyan, Dolih Gozali, Muhammad Iqbal, Anas SubarnasAbstract:The aim of this study was to determine the best formulation of Ophthalmic in situ gel Preparation by two different bases, Poloxamer 188 and HPMC (hydroxypropyl methylcellulose), with physical evaluation, such as organoleptic, pH, viscosity, and gel capacity during 28 days of storage time. The two different concentrations of the gel made by using Poloxamer 188 were F1 (5%) and F2 (10%), and those made by using HPMC were F3 (0.45%) and F4 (1%). The results of this study showed that formulation 1 (F1) was the optimum formulation, having pH 6.45, viscosity of 5.47 cP, and a better gel capacity than other formulas. In situ gel for Ophthalmic Preparations is developed to mask the limitation of conventional forms of Ophthalmic Preparation. In situ gel technology significantly increase the effectivity of drugs in the raw material and drug bioavailability in new drug delivery systems based on in situ gel concept. Copyright: © 2019 Journal of Pharmacy and Bioallied Sciences.
-
Physical study of Chloramphenicol In Situ Gel with Base Hydroxypropyl Methylcellulose and Poloxamer 188.
Journal of Pharmacy And Bioallied Sciences, 2019Co-Authors: Insan Sunan Kurniawansyah, Iyan Sopyan, Dolih Gozali, Muhammad Iqbal, Anas SubarnasAbstract:Objective: The aim of this study was to determine the best formulation of Ophthalmic in situ gel Preparation by two different bases, Poloxamer 188 and HPMC (hydroxypropyl methylcellulose), with physical evaluation, such as organoleptic, pH, viscosity, and gel capacity during 28 days of storage time. Materials and Methods: The two different concentrations of the gel made by using Poloxamer 188 were F1 (5%) and F2 (10%), and those made by using HPMC were F3 (0.45%) and F4 (1%). Results: The results of this study showed that formulation 1 (F1) was the optimum formulation, having pH 6.45, viscosity of 5.47 cP, and a better gel capacity than other formulas. Conclusion: In situ gel for Ophthalmic Preparations is developed to mask the limitation of conventional forms of Ophthalmic Preparation. In situ gel technology significantly increase the effectivity of drugs in the raw material and drug bioavailability in new drug delivery systems based on in situ gel concept.
-
Formulation and Evaluation of Chloramphenicol Hydrogel Ophthalmic Preparation
Journal of Young Pharmacists, 2018Co-Authors: Insan Sunan Kurniawansyah, Iyan Sopyan, Yoga Windu Wardhana, Mohanapriya GunasekaranAbstract:Objective: To generate a hydrogel to increase the retention time of a drug in an Ophthalmic drug delivery system. Methods: Research was conducted on the formulation and evaluation of a safe-to-use chloramphenicol Ophthalmic hydrogel with various concentrations of hydroxypropyl methylcellulose (HPMC), F1 (0.2 % HPMC), F2 (0.3 % HPMC), F3 (0.4 % HPMC) and F4 (0.5 % HPMC). The organoleptic safety, pH, viscosity, sterility, potency, and in vitro drug release were evaluated. Results: The drug concentration had dissimilar effects on viscosity and release rate. F4 (0.5 % HPMC) had the least chloramphenicol diffused at 5 min (11.01 %) and after 8 h (71.13 %). The in vitro drug release from the hydrogel was significantly influenced by the HPMC concentration, which enhanced the bioavailability through longer pre-corneal residence time and the ability to sustain the release of the drug. Conclusion: The chloramphenicol hydrogel Ophthalmic Preparations formulated with HPMC have shown a good characteristic, and acceptable sustained released profile that may extend absorption of the drug for ensuring an optimum bioavailability at the site of action. The finding of this study indicated that chloramphenicol hydrogel Ophthalmic Preparations for the Ophthalmic treatment was good is effective and safe. Key words: Chloramphenicol, Hydrogel, Hydroxypropyl methylcellulose, Ophthalmic.
Maha A Hegazy - One of the best experts on this subject based on the ideXlab platform.
-
validated hptlc and hplc methods for determination of fluorometholone and sodium cromoglycate in presence of their impurities and degradation products application to kinetic study and on rabbit aqueous humor
Journal of Liquid Chromatography & Related Technologies, 2018Co-Authors: Maha A Hegazy, May H Abdelwahab, Hassan A M Hendawy, Soheir A Weshahy, Samah S AbbasAbstract:ABSTRACTFluorometholone (FLM) and Sodium Cromoglycate (CMG) are co-formulated in Ophthalmic Preparation and showed marked instability under different conditions. Two specific, sensitive and precise stability-indicating chromatographic methods have been developed and validated for their determination in the presence of their degradation products and FLM impurity. Ten components were efficiently separated by them. The first method was HPTLC-spectrodensitometry, where the separation was achieved using silica gel 60 F254 HPTLC plates and developing system of ethyl acetate: methanol (9:1, v/v). The second method was a reversed phase HPLC associated with kinetic study of the degradation process and was successfully applied for determination of the studied compounds in spiked rabbit aqueous humor. The mobile phase was acetonitrile: methanol: 0.05 M potassium dihydrogenphosphate (0.1% trimethylamine); pH 2.5, adjusted with orthophosphoric acid (20: 30: 50, by volume). In both methods, the separated components wer...
-
Validated HPTLC and HPLC methods for determination of fluorometholone and sodium cromoglycate in presence of their impurities and degradation products; application to kinetic study and on rabbit aqueous humor
2018Co-Authors: Maha A Hegazy, May H Abdelwahab, Hassan A M Hendawy, Soheir A Weshahy, Samah S AbbasAbstract:Fluorometholone (FLM) and Sodium Cromoglycate (CMG) are co-formulated in Ophthalmic Preparation and showed marked instability under different conditions. Two specific, sensitive and precise stability-indicating chromatographic methods have been developed and validated for their determination in the presence of their degradation products and FLM impurity. Ten components were efficiently separated by them. The first method was HPTLC-spectrodensitometry, where the separation was achieved using silica gel 60 F254 HPTLC plates and developing system of ethyl acetate: methanol (9:1, v/v). The second method was a reversed phase HPLC associated with kinetic study of the degradation process and was successfully applied for determination of the studied compounds in spiked rabbit aqueous humor. The mobile phase was acetonitrile: methanol: 0.05 M potassium dihydrogenphosphate (0.1% trimethylamine); pH 2.5, adjusted with orthophosphoric acid (20: 30: 50, by volume). In both methods, the separated components were detected at 240 nm and system suitability was checked. Good correlation was obtained in the range of 0.10–24.00 and 0.20–48.00 µg band−1, for FLM and CMG by HPTLC. While for HPLC, the linearity ranges from 0.01–50.00 and 0.05–50.00 µg mL−1 for both drugs. The methods were applied in pharmaceutical formulation, where they were compared to the reported method with no significant difference.