The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform

Carlos R Gordon - One of the best experts on this subject based on the ideXlab platform.

  • Opsoclonus myoclonus ataxia associated with west nile virus infection a dramatic presentation with benign prognosis
    Journal of the Neurological Sciences, 2017
    Co-Authors: Roy Zaltzman, Colin Klein, Carlos R Gordon
    Abstract:

    Opsoclonus myoclonus and ataxia is a combination of severe neurological signs associated with several pathologic agents and conditions. Only few cases of Opsoclonus have been related to West Nile virus infection. We report on a 61-year-old woman and on a 55-year-old man who had history of recent fever, who were hospitalized because of acute severe truncal ataxia, Opsoclonus and tremor with minimal myoclonic jerks. A through work-up revealed the presence of both IgM and IgG antibodies against West Nile virus both in the serum and Cerebrospinal Fluid and excluded other causes known to be associated with this combination of neurological signs. The first case was treated with corticosteroids, followed by significant improvement, and the second recovered spontaneously. The acute combination of Opsoclonus, severe truncal ataxia and tremor with a history of recent fever requires, during the relevant season and in the relevant geographic area, a search for a recent infection with West Nile virus. Though initially suffering from a devastating sickness, our patients eventually recovered.

Krishan Chandar - One of the best experts on this subject based on the ideXlab platform.

  • Opsoclonus Persisting During Sleep in West Nile Encephalitis
    Archives of neurology, 2006
    Co-Authors: Amer Alshekhlee, Badr Sultan, Krishan Chandar
    Abstract:

    Background Recent outbreaks of West Nile virus infection have alerted the public to disabling paralysis as an outcome. Ocular motor involvement with West Nile virus is rare. Objective To describe a patient with West Nile virus encephalitis that resulted in Opsoclonus-myoclonus syndrome with persistent ocular oscillation on electroencephalography during stage 2 sleep. Patient A 53-year-old man who presented with viral prodrome followed by intense vertigo and encephalopathy. In addition to multifocal myoclonic jerks in the extremities, his eye movements were disrupted by bursts of high-frequency, conjugate ocular oscillations that occurred in random directions. Results Electroencephalography showed eye movement artifacts during the awake state and stage 2 sleep. Opsoclonus-myoclonus syndrome remained disabling 3 months after onset but markedly improved 8 months after onset. Conclusions West Nile virus is another cause of Opsoclonus-myoclonus syndrome that can occur in conjunction with encephalitis. The presence of an eye movement artifact on results of electroencephalography during stage 2 sleep should raise suspicion for Opsoclonus.

J. De Bleecker - One of the best experts on this subject based on the ideXlab platform.

James C Perry - One of the best experts on this subject based on the ideXlab platform.

  • adult onset Opsoclonus myoclonus syndrome due to west nile virus treated with intravenous immunoglobulin
    Journal of NeuroVirology, 2017
    Co-Authors: Julien Hebert, D T Armstrong, Nick Daneman, Jennifer Jain, James C Perry
    Abstract:

    A 63-year-old female with no significant past medical history was presented with a 5-day history of progressive Opsoclonus-myoclonus, headaches, and fevers. Her workup was significant only for positive West-Nile Virus serum serologies. She received a 2-day course of intravenous immunoglobulin (IvIG). At an 8-week follow up, she had a complete neurological remission. Adult-onset Opsoclonus-myoclonus syndrome is a rare condition for which paraneoplastic and infectious causes have been attributed. To our knowledge, this is the first case reported of Opsoclonus-myoclonus secondary to West-Nile Virus treated with intravenous immunoglobulin monotherapy.

Alisa Wheeler - One of the best experts on this subject based on the ideXlab platform.

  • controlled pilot study of piracetam for pediatric Opsoclonus myoclonus
    Clinical Neuropharmacology, 2001
    Co-Authors: Michael R. Pranzatelli, Elizabeth D. Tate, Isabel Galvan, Alisa Wheeler
    Abstract:

    Piracetam is an effective symptomatic treatment for some types of myoclonus in adults. To survey the efficacy and safety of piracetam in pediatric Opsoclonus-myoclonus, we conducted an open, randomized, two-period, dose-ranging, double-blind, crossover, clinical trial of five children comparing the antimyoclonic properties of oral piracetam to placebo. We devised and validated a new rating scale, specifically for pediatric Opsoclonus-myoclonus. Two parents while blinded were able to identify the active phase by improvement in behavior, but another thought the behavior was worse. None of the patients showed improvement in myoclonus. The adult-equivalent dose of piracetam used in this study, which is threefold higher than that used in previous pediatric studies, was well tolerated and safe. We found our rating scale to be a reliable and useful tool for future studies of Opsoclonus-myoclonus in children.