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James G. Fujimoto - One of the best experts on this subject based on the ideXlab platform.

  • Optical Coherence Tomography Angiography.
    Retina (Philadelphia Pa.), 2015
    Co-Authors: Richard F. Spaide, James G. Fujimoto, Nadia K. Waheed
    Abstract:

    This issue of the journal RETINA is devoted to the use of Optical Coherence Tomography (OCT) in creation of a new form of angiography, known as OCT angiography. Optical Coherence Tomography produces depth-resolved evaluation of the reflectance data from tissue. A three-dimensional volume of tissue being evaluated gives rise to a three-dimensional volume of information. Optical Coherence Tomography angiography visualizes vasculature using motion contrast. Stationary tissue produces a nearly constant reflection or scattering whereas moving tissue produces OCT signals that change over time. Optical Coherence Tomography information can be compared from one time instance to the next by repeatedly scanning the same region of tissue. Optical Coherence Tomography angiography operates under the basic assumption, which is an over simplification, that the only moving thing in the retina is blood flow. Pixels from individual areas in repeated OCT images are compared over time, and those pixels which show changes or fluctuations are displayed as bright, whereas pixels from areas with little or no change are displayed as black. There are many different algorithms or methods for detection motion contrast. Some involve using OCT signal amplitude, phase, or a combination of the two. There are also different statistical techniques for assessing changes. However, all of these methods essentially visualize vasculature by detecting motion.

  • Optical Coherence Tomography
    2013
    Co-Authors: E Swanson, David Huang, Carmen A Puliafito, Joseph A Izatt, M Bee, C Lin, James G. Fujimoto
    Abstract:

    This invention relates to an Optical Coherence Tomography, in which a light source and an Optical linear beam forming system are adopted to obtain two dimensional image of high quality resolution within short time without affection by any mechanical movements. For such purpose, the Optical linear beam forming system(20) comprises semicy Under lens(21), convex lens(22) and slit(23) to implement the frequency domain Optical Coherence Tomography. Parallel light beam from the light source is incident on the surface of the semicylinder lens(21), and focal line of the semicylinder lens (21) is located in front of the convex lens (22). The convex lens (22) has short focal point where the parallel light component converges and long focal point where the diverging light component converges. The slit(23) is located between the short focal point and the long focal point.

  • Three-dimensional endomicroscopy using Optical Coherence Tomography
    Nature Photonics, 2007
    Co-Authors: Desmond C. Adler, Yu Chen, Robert Huber, Joseph Schmitt, James Connolly, James G. Fujimoto
    Abstract:

    Optical Coherence Tomography enables micrometre-scale, subsurface imaging of biological tissue by measuring the magnitude and echo time delay of backscattered light. Endoscopic Optical Coherence Tomography imaging inside the body can be performed using fibre-optic probes. To perform three-dimensional Optical Coherence Tomography endomicroscopy with ultrahigh volumetric resolution, however, requires extremely high imaging speeds. Here we report advances in Optical Coherence Tomography technology using a Fourier-domain mode-locked frequency-swept laser as the light source. The laser, with a 160-nm tuning range at a wavelength of 1,315 nm, can produce images with axial resolutions of 5–7 µm. In vivo three-dimensional Optical Coherence Tomography endomicroscopy is demonstrated at speeds of 100,000 axial lines per second and 50 frames per second. This enables virtual manipulation of tissue geometry, speckle reduction, synthesis of en face views similar to endoscopic images, generation of cross-sectional images with arbitrary orientation, and quantitative measurements of morphology. This technology can be scaled to even higher speeds and will open up three-dimensional Optical-Coherence-Tomography endomicroscopy to a wide range of medical applications.

  • Optical Coherence Tomography
    2006
    Co-Authors: James G. Fujimoto
    Abstract:

    Optical Coherence Tomography (OCT) performs resolution imaging in biological tissues and materials. Recent advances enable order of magnitude increases in imaging speed as well as resolutions, enabling a wide range of materials and medical applications.

  • argon laser retinal lesions evaluated in vivo by Optical Coherence Tomography
    American Journal of Ophthalmology, 1997
    Co-Authors: Cynthia A Toth, James G. Fujimoto, Michael R Hee, Eric A Swanson, Stephen A. Boppart, Reginald Birngruber, Cheryl D Dicarlo, Clarence P Cain, Drew G Narayan, Gary D Noojin
    Abstract:

    Purpose To assess the in vivo evolution of argon laser retinal lesions by correlating the cross-sectional structure from sequential Optical Coherence Tomography with histopathologic sectioning. Methods Argon laser lesions were created in the retinas of Macaca mulatta and evaluated by cross-section Optical Coherence Tomography, which was compared at selected time points with corresponding histopathology. Results Argon laser lesions induced an Optical Coherence Tomography pattern of early outer retinal relative high reflectivity with subsequent surrounding relative low reflectivity that correlated well with histopathologic findings. The in vivo Optical Coherence Tomography images of macular laser lesions clearly demonstrated differences in pathologic response by retinal layer over time. • CONCLUSION: The novel sequential imaging of rapidly evolving macular lesions with Optical Coherence Tomography provides new insight into the patterns of acute tissue response by cross-sectional layer. This sequential imaging technique will aid in our understanding of the rapid evolution of retinal pathology and response to treatment in the research and clinical setting.

Michael R Hee - One of the best experts on this subject based on the ideXlab platform.

  • argon laser retinal lesions evaluated in vivo by Optical Coherence Tomography
    American Journal of Ophthalmology, 1997
    Co-Authors: Cynthia A Toth, James G. Fujimoto, Michael R Hee, Eric A Swanson, Stephen A. Boppart, Reginald Birngruber, Cheryl D Dicarlo, Clarence P Cain, Drew G Narayan, Gary D Noojin
    Abstract:

    Purpose To assess the in vivo evolution of argon laser retinal lesions by correlating the cross-sectional structure from sequential Optical Coherence Tomography with histopathologic sectioning. Methods Argon laser lesions were created in the retinas of Macaca mulatta and evaluated by cross-section Optical Coherence Tomography, which was compared at selected time points with corresponding histopathology. Results Argon laser lesions induced an Optical Coherence Tomography pattern of early outer retinal relative high reflectivity with subsequent surrounding relative low reflectivity that correlated well with histopathologic findings. The in vivo Optical Coherence Tomography images of macular laser lesions clearly demonstrated differences in pathologic response by retinal layer over time. • CONCLUSION: The novel sequential imaging of rapidly evolving macular lesions with Optical Coherence Tomography provides new insight into the patterns of acute tissue response by cross-sectional layer. This sequential imaging technique will aid in our understanding of the rapid evolution of retinal pathology and response to treatment in the research and clinical setting.

  • Optical Coherence Tomography of central serous chorioretinopathy
    American Journal of Ophthalmology, 1995
    Co-Authors: Michael R Hee, Carmen A Puliafito, Carlton Wong, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, James G. Fujimoto
    Abstract:

    Purpose To assess the potential of a new imaging technique, Optical Coherence Tomography, for the diagnosis and monitoring of central serous chorioretinopathy. Optical Coherence Tomography is a novel noninvasive, noncontact imaging modality that produces high longitudinal resolution, cross-sectional tomographs of ocular tissue. Methods Optical Coherence Tomography is analogous to ultrasound, except that it uses light rather than sound to obtain higher image resolution in the retina. Cross-sectional tomographs of Optical reflectivity within the retina are produced with longitudinal resolution of 10 μm. Optical Coherence Tomography was used to examine 16 patients at a referral eye center whose initial examination disclosed the clinical diagnosis of central serous chorioretinopathy. The Optical Coherence Tomography results were correlated with slit-lamp biomicroscopy, fundus photography, and fluorescein angiography. Results The cross-sectional view produced by Optical Coherence Tomography was effective in objectively quantifying the amount of serous retinal detachment in the disease. Optical Coherence Tomography disclosed detachments that were undetected by slit-lamp biomicroscopy. Longitudinal measurements with Optical Coherence Tomography were successfully able to track the resolution of subretinal fluid accumulation. Conclusion Optical Coherence Tomography is potentially useful as a new, noninvasive diagnostic technique for quantitative examination of patients with central serous chorioretinopathy and objectively monitoring the clinical course of the serous retinal detachment in this disease.

  • Optical Coherence Tomography of the Human Retina
    Archives of ophthalmology (Chicago Ill. : 1960), 1995
    Co-Authors: Michael R Hee, David Huang, Carmen A Puliafito, Joel S Schuman, Eric A Swanson, Joseph A Izatt, Charles P. Lin, James G. Fujimoto
    Abstract:

    Objective: To demonstrate Optical Coherence Tomography for high-resolution, noninvasive imaging of the human retina. Optical Coherence Tomography is a new imaging technique analogous to ultrasound B scan that can provide cross-sectional images of the retina with micrometer-scale resolution. Design: Survey Optical Coherence tomographic examination of the retina, including the macula and optic nerve head in normal human subjects. Setting: Research laboratory. Participants: Convenience sample of normal human subjects. Main Outcome Measures: Correlation of Optical Coherence retinal tomographs with known normal retinal anatomy. Results: Optical Coherence tomographs can discriminate the cross-sectional morphologic features of the fovea and optic disc, the layered structure of the retina, and normal anatomic variations in retinal and retinal nerve fiber layer thicknesses with 10-??m depth resolution. Conclusion: Optical Coherence Tomography is a potentially useful technique for high depth resolution, cross-sectional examination of the fundus.

  • Optical Coherence Tomography of macular holes.
    Ophthalmology, 1995
    Co-Authors: Michael R Hee, Carmen A Puliafito, Carlton Wong, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, James G. Fujimoto
    Abstract:

    Purpose: To assess the potential of a new diagnostic technique called Optical Coherence Tomography (OCT) for diagnosing and monitoring macular holes. This technique is a novel noninvasive, noncontact imaging modality that produces high longitudinal resolution (10-μm) cross-sectional tomographs of ocular tissue. Methods: Optical Coherence Tomography is analogous to ultrasound except that Optical rather than acoustic reflectivity is measured. Cross-sectional tomographs of the retina profiling Optical reflectivity in a thin, Optical slice of tissue are obtained with a longitudinal resolution of 10 μm. Optical Coherence Tomography was used to examine 49 patients with the clinical diagnosis of idiopathic full-thickness macular hole, impending macular hole, epimacular membrane with macular pseudohole, or partial-thickness hole. The resulting OCTs were correlated with contact lens and slit-lamp biomicroscopy, fundus photography, and fluorescein angiography. Results: The cross-sectional view produced by OCT was effective in distinguishing full-thickness macular holes from partial-thickness holes, macular pseudoholes, and cysts. Optical Coherence Tomography was successful in staging macular holes and provided a quantitative measure of hole diameter and the amount of surrounding macular edema. Optical Coherence Tomography also was used to evaluate the vitreoretinal interface in patients' fellow eyes and was able to detect small separations of the posterior hyaloid from the retina. Conclusion: Optical Coherence Tomography appears potentially useful as a new, noninvasive, diagnostic technique for visualizing and quantitatively characterizing macular holes and assessing fellow eyes of patients with a macular hole. The tomographc information provided by OCT eventually may lead to a better understanding of the pathogenesis of macular hole formation.

  • Imaging of macular diseases with Optical Coherence Tomography.
    Ophthalmology, 1995
    Co-Authors: Carmen A Puliafito, Michael R Hee, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, Joseph A Izatt, Charles P. Lin, James G. Fujimoto
    Abstract:

    Background/ Purpose: To assess the potential of a new diagnostic technique called Optical Coherence Tomography for imaging macular disease. Optical Coherence Tomography is a novel noninvasive, noncontact imaging modality which produces high depth resolution (10 μm cross-sectional tomographs of ocular tissue. It is analogous to ultrasound, except that Optical rather than acoustic reflectivity is measured. Methods: Optical Coherence Tomography images of the macula were obtained in 51 eyes of 44 patients with selected macular diseases. Imaging is performed in a manner compatible with slit-lamp indirect biomicroscopy so that high-resolution Optical Tomography may be accomplished simultaneously with normal ophthalmic examination. The time-of-flight delay of light backscattered from different layers in the retina is determined using low-Coherence interferometry. Cross-sectional tomographs of the retina profiling Optical reflectivity versus distance into the tissue are obtained in 2.5 seconds and with a longitudinal resolution of 10 μm. Results: Correlation of fundus examination and fluorescein angiography with Optical Coherence Tomography tomographs was demonstrated in 12 eyes with the following pathologies: full- and partial-thickness macular hole, epiretinal membrane, macular edema, intraretinal exudate, idiopathic central serous chorioretinopathy, and detachments of the pigment epithelium and neurosensory retina. Conclusion: Optical Coherence Tomography is potentially a powerful tool for detecting and monitoring a variety of macular diseases, including macular edema, macular holes, and detachments of the neurosensory retina and pigment epithelium.

Eric A Swanson - One of the best experts on this subject based on the ideXlab platform.

  • argon laser retinal lesions evaluated in vivo by Optical Coherence Tomography
    American Journal of Ophthalmology, 1997
    Co-Authors: Cynthia A Toth, James G. Fujimoto, Michael R Hee, Eric A Swanson, Stephen A. Boppart, Reginald Birngruber, Cheryl D Dicarlo, Clarence P Cain, Drew G Narayan, Gary D Noojin
    Abstract:

    Purpose To assess the in vivo evolution of argon laser retinal lesions by correlating the cross-sectional structure from sequential Optical Coherence Tomography with histopathologic sectioning. Methods Argon laser lesions were created in the retinas of Macaca mulatta and evaluated by cross-section Optical Coherence Tomography, which was compared at selected time points with corresponding histopathology. Results Argon laser lesions induced an Optical Coherence Tomography pattern of early outer retinal relative high reflectivity with subsequent surrounding relative low reflectivity that correlated well with histopathologic findings. The in vivo Optical Coherence Tomography images of macular laser lesions clearly demonstrated differences in pathologic response by retinal layer over time. • CONCLUSION: The novel sequential imaging of rapidly evolving macular lesions with Optical Coherence Tomography provides new insight into the patterns of acute tissue response by cross-sectional layer. This sequential imaging technique will aid in our understanding of the rapid evolution of retinal pathology and response to treatment in the research and clinical setting.

  • Optical Coherence Tomography of central serous chorioretinopathy
    American Journal of Ophthalmology, 1995
    Co-Authors: Michael R Hee, Carmen A Puliafito, Carlton Wong, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, James G. Fujimoto
    Abstract:

    Purpose To assess the potential of a new imaging technique, Optical Coherence Tomography, for the diagnosis and monitoring of central serous chorioretinopathy. Optical Coherence Tomography is a novel noninvasive, noncontact imaging modality that produces high longitudinal resolution, cross-sectional tomographs of ocular tissue. Methods Optical Coherence Tomography is analogous to ultrasound, except that it uses light rather than sound to obtain higher image resolution in the retina. Cross-sectional tomographs of Optical reflectivity within the retina are produced with longitudinal resolution of 10 μm. Optical Coherence Tomography was used to examine 16 patients at a referral eye center whose initial examination disclosed the clinical diagnosis of central serous chorioretinopathy. The Optical Coherence Tomography results were correlated with slit-lamp biomicroscopy, fundus photography, and fluorescein angiography. Results The cross-sectional view produced by Optical Coherence Tomography was effective in objectively quantifying the amount of serous retinal detachment in the disease. Optical Coherence Tomography disclosed detachments that were undetected by slit-lamp biomicroscopy. Longitudinal measurements with Optical Coherence Tomography were successfully able to track the resolution of subretinal fluid accumulation. Conclusion Optical Coherence Tomography is potentially useful as a new, noninvasive diagnostic technique for quantitative examination of patients with central serous chorioretinopathy and objectively monitoring the clinical course of the serous retinal detachment in this disease.

  • Optical Coherence Tomography of the Human Retina
    Archives of ophthalmology (Chicago Ill. : 1960), 1995
    Co-Authors: Michael R Hee, David Huang, Carmen A Puliafito, Joel S Schuman, Eric A Swanson, Joseph A Izatt, Charles P. Lin, James G. Fujimoto
    Abstract:

    Objective: To demonstrate Optical Coherence Tomography for high-resolution, noninvasive imaging of the human retina. Optical Coherence Tomography is a new imaging technique analogous to ultrasound B scan that can provide cross-sectional images of the retina with micrometer-scale resolution. Design: Survey Optical Coherence tomographic examination of the retina, including the macula and optic nerve head in normal human subjects. Setting: Research laboratory. Participants: Convenience sample of normal human subjects. Main Outcome Measures: Correlation of Optical Coherence retinal tomographs with known normal retinal anatomy. Results: Optical Coherence tomographs can discriminate the cross-sectional morphologic features of the fovea and optic disc, the layered structure of the retina, and normal anatomic variations in retinal and retinal nerve fiber layer thicknesses with 10-??m depth resolution. Conclusion: Optical Coherence Tomography is a potentially useful technique for high depth resolution, cross-sectional examination of the fundus.

  • Optical Coherence Tomography of macular holes.
    Ophthalmology, 1995
    Co-Authors: Michael R Hee, Carmen A Puliafito, Carlton Wong, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, James G. Fujimoto
    Abstract:

    Purpose: To assess the potential of a new diagnostic technique called Optical Coherence Tomography (OCT) for diagnosing and monitoring macular holes. This technique is a novel noninvasive, noncontact imaging modality that produces high longitudinal resolution (10-μm) cross-sectional tomographs of ocular tissue. Methods: Optical Coherence Tomography is analogous to ultrasound except that Optical rather than acoustic reflectivity is measured. Cross-sectional tomographs of the retina profiling Optical reflectivity in a thin, Optical slice of tissue are obtained with a longitudinal resolution of 10 μm. Optical Coherence Tomography was used to examine 49 patients with the clinical diagnosis of idiopathic full-thickness macular hole, impending macular hole, epimacular membrane with macular pseudohole, or partial-thickness hole. The resulting OCTs were correlated with contact lens and slit-lamp biomicroscopy, fundus photography, and fluorescein angiography. Results: The cross-sectional view produced by OCT was effective in distinguishing full-thickness macular holes from partial-thickness holes, macular pseudoholes, and cysts. Optical Coherence Tomography was successful in staging macular holes and provided a quantitative measure of hole diameter and the amount of surrounding macular edema. Optical Coherence Tomography also was used to evaluate the vitreoretinal interface in patients' fellow eyes and was able to detect small separations of the posterior hyaloid from the retina. Conclusion: Optical Coherence Tomography appears potentially useful as a new, noninvasive, diagnostic technique for visualizing and quantitatively characterizing macular holes and assessing fellow eyes of patients with a macular hole. The tomographc information provided by OCT eventually may lead to a better understanding of the pathogenesis of macular hole formation.

  • Imaging of macular diseases with Optical Coherence Tomography.
    Ophthalmology, 1995
    Co-Authors: Carmen A Puliafito, Michael R Hee, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, Joseph A Izatt, Charles P. Lin, James G. Fujimoto
    Abstract:

    Background/ Purpose: To assess the potential of a new diagnostic technique called Optical Coherence Tomography for imaging macular disease. Optical Coherence Tomography is a novel noninvasive, noncontact imaging modality which produces high depth resolution (10 μm cross-sectional tomographs of ocular tissue. It is analogous to ultrasound, except that Optical rather than acoustic reflectivity is measured. Methods: Optical Coherence Tomography images of the macula were obtained in 51 eyes of 44 patients with selected macular diseases. Imaging is performed in a manner compatible with slit-lamp indirect biomicroscopy so that high-resolution Optical Tomography may be accomplished simultaneously with normal ophthalmic examination. The time-of-flight delay of light backscattered from different layers in the retina is determined using low-Coherence interferometry. Cross-sectional tomographs of the retina profiling Optical reflectivity versus distance into the tissue are obtained in 2.5 seconds and with a longitudinal resolution of 10 μm. Results: Correlation of fundus examination and fluorescein angiography with Optical Coherence Tomography tomographs was demonstrated in 12 eyes with the following pathologies: full- and partial-thickness macular hole, epiretinal membrane, macular edema, intraretinal exudate, idiopathic central serous chorioretinopathy, and detachments of the pigment epithelium and neurosensory retina. Conclusion: Optical Coherence Tomography is potentially a powerful tool for detecting and monitoring a variety of macular diseases, including macular edema, macular holes, and detachments of the neurosensory retina and pigment epithelium.

Carmen A Puliafito - One of the best experts on this subject based on the ideXlab platform.

  • Optical Coherence Tomography
    2013
    Co-Authors: E Swanson, David Huang, Carmen A Puliafito, Joseph A Izatt, M Bee, C Lin, James G. Fujimoto
    Abstract:

    This invention relates to an Optical Coherence Tomography, in which a light source and an Optical linear beam forming system are adopted to obtain two dimensional image of high quality resolution within short time without affection by any mechanical movements. For such purpose, the Optical linear beam forming system(20) comprises semicy Under lens(21), convex lens(22) and slit(23) to implement the frequency domain Optical Coherence Tomography. Parallel light beam from the light source is incident on the surface of the semicylinder lens(21), and focal line of the semicylinder lens (21) is located in front of the convex lens (22). The convex lens (22) has short focal point where the parallel light component converges and long focal point where the diverging light component converges. The slit(23) is located between the short focal point and the long focal point.

  • Optical Coherence Tomography of central serous chorioretinopathy
    American Journal of Ophthalmology, 1995
    Co-Authors: Michael R Hee, Carmen A Puliafito, Carlton Wong, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, James G. Fujimoto
    Abstract:

    Purpose To assess the potential of a new imaging technique, Optical Coherence Tomography, for the diagnosis and monitoring of central serous chorioretinopathy. Optical Coherence Tomography is a novel noninvasive, noncontact imaging modality that produces high longitudinal resolution, cross-sectional tomographs of ocular tissue. Methods Optical Coherence Tomography is analogous to ultrasound, except that it uses light rather than sound to obtain higher image resolution in the retina. Cross-sectional tomographs of Optical reflectivity within the retina are produced with longitudinal resolution of 10 μm. Optical Coherence Tomography was used to examine 16 patients at a referral eye center whose initial examination disclosed the clinical diagnosis of central serous chorioretinopathy. The Optical Coherence Tomography results were correlated with slit-lamp biomicroscopy, fundus photography, and fluorescein angiography. Results The cross-sectional view produced by Optical Coherence Tomography was effective in objectively quantifying the amount of serous retinal detachment in the disease. Optical Coherence Tomography disclosed detachments that were undetected by slit-lamp biomicroscopy. Longitudinal measurements with Optical Coherence Tomography were successfully able to track the resolution of subretinal fluid accumulation. Conclusion Optical Coherence Tomography is potentially useful as a new, noninvasive diagnostic technique for quantitative examination of patients with central serous chorioretinopathy and objectively monitoring the clinical course of the serous retinal detachment in this disease.

  • Optical Coherence Tomography of the Human Retina
    Archives of ophthalmology (Chicago Ill. : 1960), 1995
    Co-Authors: Michael R Hee, David Huang, Carmen A Puliafito, Joel S Schuman, Eric A Swanson, Joseph A Izatt, Charles P. Lin, James G. Fujimoto
    Abstract:

    Objective: To demonstrate Optical Coherence Tomography for high-resolution, noninvasive imaging of the human retina. Optical Coherence Tomography is a new imaging technique analogous to ultrasound B scan that can provide cross-sectional images of the retina with micrometer-scale resolution. Design: Survey Optical Coherence tomographic examination of the retina, including the macula and optic nerve head in normal human subjects. Setting: Research laboratory. Participants: Convenience sample of normal human subjects. Main Outcome Measures: Correlation of Optical Coherence retinal tomographs with known normal retinal anatomy. Results: Optical Coherence tomographs can discriminate the cross-sectional morphologic features of the fovea and optic disc, the layered structure of the retina, and normal anatomic variations in retinal and retinal nerve fiber layer thicknesses with 10-??m depth resolution. Conclusion: Optical Coherence Tomography is a potentially useful technique for high depth resolution, cross-sectional examination of the fundus.

  • Optical Coherence Tomography of macular holes.
    Ophthalmology, 1995
    Co-Authors: Michael R Hee, Carmen A Puliafito, Carlton Wong, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, James G. Fujimoto
    Abstract:

    Purpose: To assess the potential of a new diagnostic technique called Optical Coherence Tomography (OCT) for diagnosing and monitoring macular holes. This technique is a novel noninvasive, noncontact imaging modality that produces high longitudinal resolution (10-μm) cross-sectional tomographs of ocular tissue. Methods: Optical Coherence Tomography is analogous to ultrasound except that Optical rather than acoustic reflectivity is measured. Cross-sectional tomographs of the retina profiling Optical reflectivity in a thin, Optical slice of tissue are obtained with a longitudinal resolution of 10 μm. Optical Coherence Tomography was used to examine 49 patients with the clinical diagnosis of idiopathic full-thickness macular hole, impending macular hole, epimacular membrane with macular pseudohole, or partial-thickness hole. The resulting OCTs were correlated with contact lens and slit-lamp biomicroscopy, fundus photography, and fluorescein angiography. Results: The cross-sectional view produced by OCT was effective in distinguishing full-thickness macular holes from partial-thickness holes, macular pseudoholes, and cysts. Optical Coherence Tomography was successful in staging macular holes and provided a quantitative measure of hole diameter and the amount of surrounding macular edema. Optical Coherence Tomography also was used to evaluate the vitreoretinal interface in patients' fellow eyes and was able to detect small separations of the posterior hyaloid from the retina. Conclusion: Optical Coherence Tomography appears potentially useful as a new, noninvasive, diagnostic technique for visualizing and quantitatively characterizing macular holes and assessing fellow eyes of patients with a macular hole. The tomographc information provided by OCT eventually may lead to a better understanding of the pathogenesis of macular hole formation.

  • Imaging of macular diseases with Optical Coherence Tomography.
    Ophthalmology, 1995
    Co-Authors: Carmen A Puliafito, Michael R Hee, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, Joseph A Izatt, Charles P. Lin, James G. Fujimoto
    Abstract:

    Background/ Purpose: To assess the potential of a new diagnostic technique called Optical Coherence Tomography for imaging macular disease. Optical Coherence Tomography is a novel noninvasive, noncontact imaging modality which produces high depth resolution (10 μm cross-sectional tomographs of ocular tissue. It is analogous to ultrasound, except that Optical rather than acoustic reflectivity is measured. Methods: Optical Coherence Tomography images of the macula were obtained in 51 eyes of 44 patients with selected macular diseases. Imaging is performed in a manner compatible with slit-lamp indirect biomicroscopy so that high-resolution Optical Tomography may be accomplished simultaneously with normal ophthalmic examination. The time-of-flight delay of light backscattered from different layers in the retina is determined using low-Coherence interferometry. Cross-sectional tomographs of the retina profiling Optical reflectivity versus distance into the tissue are obtained in 2.5 seconds and with a longitudinal resolution of 10 μm. Results: Correlation of fundus examination and fluorescein angiography with Optical Coherence Tomography tomographs was demonstrated in 12 eyes with the following pathologies: full- and partial-thickness macular hole, epiretinal membrane, macular edema, intraretinal exudate, idiopathic central serous chorioretinopathy, and detachments of the pigment epithelium and neurosensory retina. Conclusion: Optical Coherence Tomography is potentially a powerful tool for detecting and monitoring a variety of macular diseases, including macular edema, macular holes, and detachments of the neurosensory retina and pigment epithelium.

Joel S Schuman - One of the best experts on this subject based on the ideXlab platform.

  • Optical Coherence Tomography of central serous chorioretinopathy
    American Journal of Ophthalmology, 1995
    Co-Authors: Michael R Hee, Carmen A Puliafito, Carlton Wong, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, James G. Fujimoto
    Abstract:

    Purpose To assess the potential of a new imaging technique, Optical Coherence Tomography, for the diagnosis and monitoring of central serous chorioretinopathy. Optical Coherence Tomography is a novel noninvasive, noncontact imaging modality that produces high longitudinal resolution, cross-sectional tomographs of ocular tissue. Methods Optical Coherence Tomography is analogous to ultrasound, except that it uses light rather than sound to obtain higher image resolution in the retina. Cross-sectional tomographs of Optical reflectivity within the retina are produced with longitudinal resolution of 10 μm. Optical Coherence Tomography was used to examine 16 patients at a referral eye center whose initial examination disclosed the clinical diagnosis of central serous chorioretinopathy. The Optical Coherence Tomography results were correlated with slit-lamp biomicroscopy, fundus photography, and fluorescein angiography. Results The cross-sectional view produced by Optical Coherence Tomography was effective in objectively quantifying the amount of serous retinal detachment in the disease. Optical Coherence Tomography disclosed detachments that were undetected by slit-lamp biomicroscopy. Longitudinal measurements with Optical Coherence Tomography were successfully able to track the resolution of subretinal fluid accumulation. Conclusion Optical Coherence Tomography is potentially useful as a new, noninvasive diagnostic technique for quantitative examination of patients with central serous chorioretinopathy and objectively monitoring the clinical course of the serous retinal detachment in this disease.

  • Optical Coherence Tomography of the Human Retina
    Archives of ophthalmology (Chicago Ill. : 1960), 1995
    Co-Authors: Michael R Hee, David Huang, Carmen A Puliafito, Joel S Schuman, Eric A Swanson, Joseph A Izatt, Charles P. Lin, James G. Fujimoto
    Abstract:

    Objective: To demonstrate Optical Coherence Tomography for high-resolution, noninvasive imaging of the human retina. Optical Coherence Tomography is a new imaging technique analogous to ultrasound B scan that can provide cross-sectional images of the retina with micrometer-scale resolution. Design: Survey Optical Coherence tomographic examination of the retina, including the macula and optic nerve head in normal human subjects. Setting: Research laboratory. Participants: Convenience sample of normal human subjects. Main Outcome Measures: Correlation of Optical Coherence retinal tomographs with known normal retinal anatomy. Results: Optical Coherence tomographs can discriminate the cross-sectional morphologic features of the fovea and optic disc, the layered structure of the retina, and normal anatomic variations in retinal and retinal nerve fiber layer thicknesses with 10-??m depth resolution. Conclusion: Optical Coherence Tomography is a potentially useful technique for high depth resolution, cross-sectional examination of the fundus.

  • Optical Coherence Tomography of macular holes.
    Ophthalmology, 1995
    Co-Authors: Michael R Hee, Carmen A Puliafito, Carlton Wong, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, James G. Fujimoto
    Abstract:

    Purpose: To assess the potential of a new diagnostic technique called Optical Coherence Tomography (OCT) for diagnosing and monitoring macular holes. This technique is a novel noninvasive, noncontact imaging modality that produces high longitudinal resolution (10-μm) cross-sectional tomographs of ocular tissue. Methods: Optical Coherence Tomography is analogous to ultrasound except that Optical rather than acoustic reflectivity is measured. Cross-sectional tomographs of the retina profiling Optical reflectivity in a thin, Optical slice of tissue are obtained with a longitudinal resolution of 10 μm. Optical Coherence Tomography was used to examine 49 patients with the clinical diagnosis of idiopathic full-thickness macular hole, impending macular hole, epimacular membrane with macular pseudohole, or partial-thickness hole. The resulting OCTs were correlated with contact lens and slit-lamp biomicroscopy, fundus photography, and fluorescein angiography. Results: The cross-sectional view produced by OCT was effective in distinguishing full-thickness macular holes from partial-thickness holes, macular pseudoholes, and cysts. Optical Coherence Tomography was successful in staging macular holes and provided a quantitative measure of hole diameter and the amount of surrounding macular edema. Optical Coherence Tomography also was used to evaluate the vitreoretinal interface in patients' fellow eyes and was able to detect small separations of the posterior hyaloid from the retina. Conclusion: Optical Coherence Tomography appears potentially useful as a new, noninvasive, diagnostic technique for visualizing and quantitatively characterizing macular holes and assessing fellow eyes of patients with a macular hole. The tomographc information provided by OCT eventually may lead to a better understanding of the pathogenesis of macular hole formation.

  • Imaging of macular diseases with Optical Coherence Tomography.
    Ophthalmology, 1995
    Co-Authors: Carmen A Puliafito, Michael R Hee, Elias Reichel, Jay S Duker, Joel S Schuman, Eric A Swanson, Joseph A Izatt, Charles P. Lin, James G. Fujimoto
    Abstract:

    Background/ Purpose: To assess the potential of a new diagnostic technique called Optical Coherence Tomography for imaging macular disease. Optical Coherence Tomography is a novel noninvasive, noncontact imaging modality which produces high depth resolution (10 μm cross-sectional tomographs of ocular tissue. It is analogous to ultrasound, except that Optical rather than acoustic reflectivity is measured. Methods: Optical Coherence Tomography images of the macula were obtained in 51 eyes of 44 patients with selected macular diseases. Imaging is performed in a manner compatible with slit-lamp indirect biomicroscopy so that high-resolution Optical Tomography may be accomplished simultaneously with normal ophthalmic examination. The time-of-flight delay of light backscattered from different layers in the retina is determined using low-Coherence interferometry. Cross-sectional tomographs of the retina profiling Optical reflectivity versus distance into the tissue are obtained in 2.5 seconds and with a longitudinal resolution of 10 μm. Results: Correlation of fundus examination and fluorescein angiography with Optical Coherence Tomography tomographs was demonstrated in 12 eyes with the following pathologies: full- and partial-thickness macular hole, epiretinal membrane, macular edema, intraretinal exudate, idiopathic central serous chorioretinopathy, and detachments of the pigment epithelium and neurosensory retina. Conclusion: Optical Coherence Tomography is potentially a powerful tool for detecting and monitoring a variety of macular diseases, including macular edema, macular holes, and detachments of the neurosensory retina and pigment epithelium.