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Christopher I Moore - One of the best experts on this subject based on the ideXlab platform.

  • systematic examination of the impact of depolarization duration on thalamic reticular nucleus firing in vivo
    Neuroscience, 2018
    Co-Authors: Bryan Higashikubo, Christopher I Moore
    Abstract:

    Abstract The thalamic reticular nucleus (TRN) is optimally positioned to regulate information processing and state dynamics in dorsal thalamus. Distinct inputs depolarize TRN on multiple time scales, including thalamocortical afferents, corticothalamic ‘feedback’, and neuromodulation. Here, we systematically tested the concurrent and after-effects of depolarization duration on TRN firing in vivo using selective optogenetic Drive. In VGAT-ChR2 mice, we isolated TRN single units (SU: N = 100 neurons) that responded at brief latency (≤5 ms) to stimulation. These units, and multi-unit activity (MUA) on corresponding electrodes, were analyzed in detail. Consistent with prior findings in relay neurons, after light cessation, burst-like events occurred in 74% of MUA sites, and 16% of SU. Increasing Optical duration from 2 to 330 ms enhanced this burst probability, and decreased the latency to the first burst after stimulation. During stimulation, neurons demonstrated a ‘plateau’ firing response lasting 20–30 ms in response to light, but significant heterogeneity existed in the minimal stimuli required to Drive this response. Two distinct types were evident, more sensitive ‘non-linear’ neurons that were Driven to the plateau response by 2 or 5 ms pulses, versus ‘linear’ neurons that fired proportionally to Optical duration, and reached the plateau with ∼20-ms Optical Drive. Non-linear neurons showed higher evoked firing rates and burst probability, but spontaneous rate did not differ between types. These findings provide direct predictions for TRN responses to a range of natural depolarizing inputs, and a guide for the Optical control of this key structure in studies of network function and behavior.

  • selective Optical Drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles
    Nature Neuroscience, 2011
    Co-Authors: Michael M Halassa, Joshua H Siegle, Jason T Ritt, Jonathan T Ting, Guoping Feng, Christopher I Moore
    Abstract:

    Using optogenetics and multi-electrode recording in behaving mice, the authors find that briefly driving the thalamic reticular nucleus (TRN) switches thalamocortical firing mode and generates neocortical spindles, which have been implicated in memory and disease. These findings provide causal support for the idea that the TRN is involved in state regulation and introduce a new model for addressing the role of spindles in behavior.

  • selective Optical Drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles
    Nature Neuroscience, 2011
    Co-Authors: Michael M Halassa, Joshua H Siegle, Jason T Ritt, Jonathan T Ting, Guoping Feng, Christopher I Moore
    Abstract:

    The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective Drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.

Michael M Halassa - One of the best experts on this subject based on the ideXlab platform.

Guoping Feng - One of the best experts on this subject based on the ideXlab platform.

Jason T Ritt - One of the best experts on this subject based on the ideXlab platform.

Jonathan T Ting - One of the best experts on this subject based on the ideXlab platform.