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Chia-jui Weng - One of the best experts on this subject based on the ideXlab platform.
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Cathepsin B SNPs elevate the pathological development of Oral Cancer and raise the susceptibility to carcinogen-mediated Oral Cancer
Human Genetics, 2012Co-Authors: Mu-kuan Chen, Chiao-wen Lin, Chiung-man Tsai, Shun-fa Yang, Chia-jui WengAbstract:Oral Cancer is causally associated with environmental carcinogens, and the susceptibility to carcinogen-mediated tumorigenesis is proposed to be genotype-dependent. Cathepsin B (CTSB) is a lysosomal cysteine protease and may serve as a candidate biomarker of Oral Cancer. The current study aimed to explore the influences of three single nucleotide polymorphisms (SNPs) in CTSB gene, combined with environmental carcinogens on the risk and clinicopathological development of Oral Cancer. Three SNPs of CTSB, CTSB C76G (rs12338) , CTSB A4383C (rs13332), and CTSB A8422G (rs8898), from 444 male patients with Oral Cancer and 426 control participants (males not diagnosed with Cancer) in Taiwan were analyzed. These three CTSB SNPs all exhibited insignificant ( P > 0.05) effects on the risk of Oral Cancer. However, the risk for developing the poor clinical stage of moderately or poorly differentiated cells was significantly ( P
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Cathepsin B SNPs elevate the pathological development of Oral Cancer and raise the susceptibility to carcinogen-mediated Oral Cancer.
Human genetics, 2012Co-Authors: Mu-kuan Chen, Chiao-wen Lin, Chiung-man Tsai, Shun-fa Yang, Chia-jui WengAbstract:Oral Cancer is causally associated with envi- ronmental carcinogens, and the susceptibility to carcino- gen-mediated tumorigenesis is proposed to be genotype- dependent. Cathepsin B (CTSB) is a lysosomal cysteine protease and may serve as a candidate biomarker of Oral Cancer. The current study aimed to explore the influences of three single nucleotide polymorphisms (SNPs) in CTSB gene, combined with environmental carcinogens on the risk and clinicopathological development of Oral Cancer. Three SNPs of CTSB, CTSB C76G (rs12338), CTSB A4383C (rs13332), and CTSB A8422G (rs8898), from 444 male patients with Oral Cancer and 426 control participants (males not diagnosed with Cancer) in Taiwan were ana- lyzed. These three CTSB SNPs all exhibited insignificant (P ( 0.05) effects on the risk of Oral Cancer. However, the risk for developing the poor clinical stage of moderately or poorly differentiated cells was significantly (P \ 0.001) increased to 3.325-fold in patients with Oral Cancer carrying the polymorphic genotype of rs8898 compared to patients with the ancestral genotype. Additionally, while consider- ing the exposure of environmental carcinogens, the pres- ence of these three CTSB SNPs, combined with betel quid chewing (adjusted odds ratio (AOR) was 36.570, 21.772, and 43.962 for rs12338, rs13332, and rs8898, respectively) and/or tobacco use (AOR was 3.794, and 8.972 for rs12338 and rs13332, respectively), robustly elevated the suscepti- bility to Oral Cancer. These results suggest that the genetic polymorphism of CTSB A8422G (rs8898) was associated with a high risk for the clinicopathological development of Oral Cancer and CTSB gene polymorphisms may increase the susceptibility to environmental carcinogens-mediated Oral Cancer.
Gustavo D. Cruz - One of the best experts on this subject based on the ideXlab platform.
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preventing and detecting Oral Cancer Oral health care providers readiness to provide health behavior counseling and Oral Cancer examinations
Journal of the American Dental Association, 2005Co-Authors: Gustavo D. Cruz, Jamie S. Ostroff, Jayanth V Kumar, Sangeeta GajendraAbstract:ABSTRACT Background The authors conducted a study to examine Oral Cancer prevention and early detection practice patterns in a population-based random sample of practicing Oral health care professionals in New York state. Methods The authors surveyed a population-based, self-weighting, stratified random sample of dentists (n = 1,025) and dental hygienists (n = 1,025) in New York state. They assessed the subjects' readiness to offer tobacco-use cessation and alcohol-abuse counseling and Oral Cancer examinations. Results The effective response rates were 55 and 66 percent for dentists and dental hygienists, respectively. In terms of readiness to perform Oral Cancer examinations for patients aged 40 years and older, the large majority (82 percent of dentists and 72 percent of dental hygienists) were in the maintenance stage of behavior, indicating that Oral Cancer examinations were a routine part of their practice. In terms of readiness to offer tobacco-use cessation counseling, only 12 percent of dentists and 21 percent of dental hygienists were in the maintenance stage, and only 2 percent of dentists and 4 percent of dental hygienists were in the maintenance stage of offering alcohol-abuse counseling. Conclusions Oral Cancer examinations seem to have been adopted as a standard of practice by most Oral health care providers in New York state, but Cancer prevention services, such as counseling regarding cessation of tobacco use and alcohol abuse, are lacking. Clinical Implications Oral health care providers should be trained in Oral Cancer prevention services such as tobacco-use cessation and alcohol-abuse counseling and encouraged to include these services, along with continued provision of Oral Cancer examinations, as a standard aspect of care.
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Oral Cancer Risk Perception among Participants in an Oral Cancer Screening Program
Cancer epidemiology biomarkers & prevention : a publication of the American Association for Cancer Research cosponsored by the American Society of Pre, 2002Co-Authors: Jennifer L. Hay, Jamie S. Ostroff, Gustavo D. Cruz, Racquel Z. Legeros, Herbert Kenigsberg, D. Mercedes FranklinAbstract:Oral Cancer screening provides an opportunity for early detection and for education to high-risk tobacco and alcohol users. To plan interventions that would motivate Oral Cancer screening and risk reduction, we surveyed Oral Cancer risk perception and risk behaviors among participants in a free Oral-Cancer screening. Participants (N = 803) were racially diverse; 43% had a history of smoking and 9%, a history of alcohol abuse. Current smokers and those with higher lifetime tobacco exposure perceived themselves to be at higher risk for Cancer than nonsmokers or those with less lifetime tobacco exposure (all p s, 0.05). Compared with women, men ( p = 0.01) felt more at risk; compared with other racial groups, Asians ( p < 0.05) felt less at risk. Demographic differences were explained by differences in risk behaviors. Current smoking status (beta, 0.196; p < 0.001) and level of tobacco exposure (beta, 0.100; p < 0.05) were the only significant independent predictors of heightened risk perception ( R 2 = 0.09). Those with alcohol abuse histories, and older smokers, may need increased education. These findings support the need for health education materials that incorporate the Oral Cancer risk perception of high-risk individuals.
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Oral Cancer knowledge, risk factors and characteristics of subjects in a large Oral Cancer screening program.
Journal of the American Dental Association (1939), 2002Co-Authors: Gustavo D. Cruz, Jennifer L. Hay, Jamie S. Ostroff, Herbert Kenigsberg, Racquel Z. Le Geros, D. Mercedes FranklinAbstract:ABSTRACT Background Screening people who are at high risk of developing Oral Cancers is a promising tool for decreasing morbidity and mortality attributable to this Cancer. Methods A consortium led by the New York University College of Dentistry conducted a three-day Oral Cancer screening during June 1999. As part of the screening intake, the authors conducted a survey to assess the sociodemographic characteristics, level of knowledge of risk factors and predictors of Oral Cancer awareness among the subjects. The authors performed bivariate and multivariate analyses using two indicators of Oral Cancer awareness as dependent variables. Results The 803 subjects were racially and ethnically diverse, 66 percent were 40 years of age or older, 43 percent had a history of smoking, and 9 percent were likely to have had a history of alcohol abuse. Race/ethnicity, education level and knowledge of risk factors for Oral Cancer were predictors of awareness of an Oral Cancer examination, whereas only knowledge and possible history of alcohol abuse were predictors of having a history of examinations. Conclusions This screening program attracted a diverse sample of people at high risk of developing Oral Cancer due to smoking and likely history of alcohol abuse. Consistent with other national and international studies, the authors found a lack of knowledge of the risk factors associated with Oral Cancer and a low rate of histories of Oral Cancer examinations among the subjects. Clinical Implications Oral Cancer screening programs represent potential opportunities not only for early detection of Oral Cancer but to raise awareness and educate the public about the disease.
Mu-kuan Chen - One of the best experts on this subject based on the ideXlab platform.
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Cathepsin B SNPs elevate the pathological development of Oral Cancer and raise the susceptibility to carcinogen-mediated Oral Cancer
Human Genetics, 2012Co-Authors: Mu-kuan Chen, Chiao-wen Lin, Chiung-man Tsai, Shun-fa Yang, Chia-jui WengAbstract:Oral Cancer is causally associated with environmental carcinogens, and the susceptibility to carcinogen-mediated tumorigenesis is proposed to be genotype-dependent. Cathepsin B (CTSB) is a lysosomal cysteine protease and may serve as a candidate biomarker of Oral Cancer. The current study aimed to explore the influences of three single nucleotide polymorphisms (SNPs) in CTSB gene, combined with environmental carcinogens on the risk and clinicopathological development of Oral Cancer. Three SNPs of CTSB, CTSB C76G (rs12338) , CTSB A4383C (rs13332), and CTSB A8422G (rs8898), from 444 male patients with Oral Cancer and 426 control participants (males not diagnosed with Cancer) in Taiwan were analyzed. These three CTSB SNPs all exhibited insignificant ( P > 0.05) effects on the risk of Oral Cancer. However, the risk for developing the poor clinical stage of moderately or poorly differentiated cells was significantly ( P
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Cathepsin B SNPs elevate the pathological development of Oral Cancer and raise the susceptibility to carcinogen-mediated Oral Cancer.
Human genetics, 2012Co-Authors: Mu-kuan Chen, Chiao-wen Lin, Chiung-man Tsai, Shun-fa Yang, Chia-jui WengAbstract:Oral Cancer is causally associated with envi- ronmental carcinogens, and the susceptibility to carcino- gen-mediated tumorigenesis is proposed to be genotype- dependent. Cathepsin B (CTSB) is a lysosomal cysteine protease and may serve as a candidate biomarker of Oral Cancer. The current study aimed to explore the influences of three single nucleotide polymorphisms (SNPs) in CTSB gene, combined with environmental carcinogens on the risk and clinicopathological development of Oral Cancer. Three SNPs of CTSB, CTSB C76G (rs12338), CTSB A4383C (rs13332), and CTSB A8422G (rs8898), from 444 male patients with Oral Cancer and 426 control participants (males not diagnosed with Cancer) in Taiwan were ana- lyzed. These three CTSB SNPs all exhibited insignificant (P ( 0.05) effects on the risk of Oral Cancer. However, the risk for developing the poor clinical stage of moderately or poorly differentiated cells was significantly (P \ 0.001) increased to 3.325-fold in patients with Oral Cancer carrying the polymorphic genotype of rs8898 compared to patients with the ancestral genotype. Additionally, while consider- ing the exposure of environmental carcinogens, the pres- ence of these three CTSB SNPs, combined with betel quid chewing (adjusted odds ratio (AOR) was 36.570, 21.772, and 43.962 for rs12338, rs13332, and rs8898, respectively) and/or tobacco use (AOR was 3.794, and 8.972 for rs12338 and rs13332, respectively), robustly elevated the suscepti- bility to Oral Cancer. These results suggest that the genetic polymorphism of CTSB A8422G (rs8898) was associated with a high risk for the clinicopathological development of Oral Cancer and CTSB gene polymorphisms may increase the susceptibility to environmental carcinogens-mediated Oral Cancer.
D. Mercedes Franklin - One of the best experts on this subject based on the ideXlab platform.
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Oral Cancer Risk Perception among Participants in an Oral Cancer Screening Program
Cancer epidemiology biomarkers & prevention : a publication of the American Association for Cancer Research cosponsored by the American Society of Pre, 2002Co-Authors: Jennifer L. Hay, Jamie S. Ostroff, Gustavo D. Cruz, Racquel Z. Legeros, Herbert Kenigsberg, D. Mercedes FranklinAbstract:Oral Cancer screening provides an opportunity for early detection and for education to high-risk tobacco and alcohol users. To plan interventions that would motivate Oral Cancer screening and risk reduction, we surveyed Oral Cancer risk perception and risk behaviors among participants in a free Oral-Cancer screening. Participants (N = 803) were racially diverse; 43% had a history of smoking and 9%, a history of alcohol abuse. Current smokers and those with higher lifetime tobacco exposure perceived themselves to be at higher risk for Cancer than nonsmokers or those with less lifetime tobacco exposure (all p s, 0.05). Compared with women, men ( p = 0.01) felt more at risk; compared with other racial groups, Asians ( p < 0.05) felt less at risk. Demographic differences were explained by differences in risk behaviors. Current smoking status (beta, 0.196; p < 0.001) and level of tobacco exposure (beta, 0.100; p < 0.05) were the only significant independent predictors of heightened risk perception ( R 2 = 0.09). Those with alcohol abuse histories, and older smokers, may need increased education. These findings support the need for health education materials that incorporate the Oral Cancer risk perception of high-risk individuals.
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Oral Cancer knowledge, risk factors and characteristics of subjects in a large Oral Cancer screening program.
Journal of the American Dental Association (1939), 2002Co-Authors: Gustavo D. Cruz, Jennifer L. Hay, Jamie S. Ostroff, Herbert Kenigsberg, Racquel Z. Le Geros, D. Mercedes FranklinAbstract:ABSTRACT Background Screening people who are at high risk of developing Oral Cancers is a promising tool for decreasing morbidity and mortality attributable to this Cancer. Methods A consortium led by the New York University College of Dentistry conducted a three-day Oral Cancer screening during June 1999. As part of the screening intake, the authors conducted a survey to assess the sociodemographic characteristics, level of knowledge of risk factors and predictors of Oral Cancer awareness among the subjects. The authors performed bivariate and multivariate analyses using two indicators of Oral Cancer awareness as dependent variables. Results The 803 subjects were racially and ethnically diverse, 66 percent were 40 years of age or older, 43 percent had a history of smoking, and 9 percent were likely to have had a history of alcohol abuse. Race/ethnicity, education level and knowledge of risk factors for Oral Cancer were predictors of awareness of an Oral Cancer examination, whereas only knowledge and possible history of alcohol abuse were predictors of having a history of examinations. Conclusions This screening program attracted a diverse sample of people at high risk of developing Oral Cancer due to smoking and likely history of alcohol abuse. Consistent with other national and international studies, the authors found a lack of knowledge of the risk factors associated with Oral Cancer and a low rate of histories of Oral Cancer examinations among the subjects. Clinical Implications Oral Cancer screening programs represent potential opportunities not only for early detection of Oral Cancer but to raise awareness and educate the public about the disease.
Jamie S. Ostroff - One of the best experts on this subject based on the ideXlab platform.
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preventing and detecting Oral Cancer Oral health care providers readiness to provide health behavior counseling and Oral Cancer examinations
Journal of the American Dental Association, 2005Co-Authors: Gustavo D. Cruz, Jamie S. Ostroff, Jayanth V Kumar, Sangeeta GajendraAbstract:ABSTRACT Background The authors conducted a study to examine Oral Cancer prevention and early detection practice patterns in a population-based random sample of practicing Oral health care professionals in New York state. Methods The authors surveyed a population-based, self-weighting, stratified random sample of dentists (n = 1,025) and dental hygienists (n = 1,025) in New York state. They assessed the subjects' readiness to offer tobacco-use cessation and alcohol-abuse counseling and Oral Cancer examinations. Results The effective response rates were 55 and 66 percent for dentists and dental hygienists, respectively. In terms of readiness to perform Oral Cancer examinations for patients aged 40 years and older, the large majority (82 percent of dentists and 72 percent of dental hygienists) were in the maintenance stage of behavior, indicating that Oral Cancer examinations were a routine part of their practice. In terms of readiness to offer tobacco-use cessation counseling, only 12 percent of dentists and 21 percent of dental hygienists were in the maintenance stage, and only 2 percent of dentists and 4 percent of dental hygienists were in the maintenance stage of offering alcohol-abuse counseling. Conclusions Oral Cancer examinations seem to have been adopted as a standard of practice by most Oral health care providers in New York state, but Cancer prevention services, such as counseling regarding cessation of tobacco use and alcohol abuse, are lacking. Clinical Implications Oral health care providers should be trained in Oral Cancer prevention services such as tobacco-use cessation and alcohol-abuse counseling and encouraged to include these services, along with continued provision of Oral Cancer examinations, as a standard aspect of care.
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Oral Cancer Risk Perception among Participants in an Oral Cancer Screening Program
Cancer epidemiology biomarkers & prevention : a publication of the American Association for Cancer Research cosponsored by the American Society of Pre, 2002Co-Authors: Jennifer L. Hay, Jamie S. Ostroff, Gustavo D. Cruz, Racquel Z. Legeros, Herbert Kenigsberg, D. Mercedes FranklinAbstract:Oral Cancer screening provides an opportunity for early detection and for education to high-risk tobacco and alcohol users. To plan interventions that would motivate Oral Cancer screening and risk reduction, we surveyed Oral Cancer risk perception and risk behaviors among participants in a free Oral-Cancer screening. Participants (N = 803) were racially diverse; 43% had a history of smoking and 9%, a history of alcohol abuse. Current smokers and those with higher lifetime tobacco exposure perceived themselves to be at higher risk for Cancer than nonsmokers or those with less lifetime tobacco exposure (all p s, 0.05). Compared with women, men ( p = 0.01) felt more at risk; compared with other racial groups, Asians ( p < 0.05) felt less at risk. Demographic differences were explained by differences in risk behaviors. Current smoking status (beta, 0.196; p < 0.001) and level of tobacco exposure (beta, 0.100; p < 0.05) were the only significant independent predictors of heightened risk perception ( R 2 = 0.09). Those with alcohol abuse histories, and older smokers, may need increased education. These findings support the need for health education materials that incorporate the Oral Cancer risk perception of high-risk individuals.
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Oral Cancer knowledge, risk factors and characteristics of subjects in a large Oral Cancer screening program.
Journal of the American Dental Association (1939), 2002Co-Authors: Gustavo D. Cruz, Jennifer L. Hay, Jamie S. Ostroff, Herbert Kenigsberg, Racquel Z. Le Geros, D. Mercedes FranklinAbstract:ABSTRACT Background Screening people who are at high risk of developing Oral Cancers is a promising tool for decreasing morbidity and mortality attributable to this Cancer. Methods A consortium led by the New York University College of Dentistry conducted a three-day Oral Cancer screening during June 1999. As part of the screening intake, the authors conducted a survey to assess the sociodemographic characteristics, level of knowledge of risk factors and predictors of Oral Cancer awareness among the subjects. The authors performed bivariate and multivariate analyses using two indicators of Oral Cancer awareness as dependent variables. Results The 803 subjects were racially and ethnically diverse, 66 percent were 40 years of age or older, 43 percent had a history of smoking, and 9 percent were likely to have had a history of alcohol abuse. Race/ethnicity, education level and knowledge of risk factors for Oral Cancer were predictors of awareness of an Oral Cancer examination, whereas only knowledge and possible history of alcohol abuse were predictors of having a history of examinations. Conclusions This screening program attracted a diverse sample of people at high risk of developing Oral Cancer due to smoking and likely history of alcohol abuse. Consistent with other national and international studies, the authors found a lack of knowledge of the risk factors associated with Oral Cancer and a low rate of histories of Oral Cancer examinations among the subjects. Clinical Implications Oral Cancer screening programs represent potential opportunities not only for early detection of Oral Cancer but to raise awareness and educate the public about the disease.
