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Rudolf Bauer - One of the best experts on this subject based on the ideXlab platform.
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effects of tenuiorin and methyl orsellinate from the lichen peltigera leucophlebia on 5 15 lipoxygenases and proliferation of malignant cell lines in vitro
Phytomedicine, 2002Co-Authors: K Ingolfsdottir, G F Gudmundsdottir, Sigurdis Haraldsdottir, Kerstin Paulus, Helga M. Ögmundsdóttir, Hjalti Kristinsson, Rudolf BauerAbstract:Summary The Orcinol derivatives tenuiorin (1) and methyl orsellinate (2) were identified as active components of an extract from the lichen Peltigera leucophlebia (Nyl.) Gyeln. showing in vitro inhibitory activity against 15-lipoxygenase from soybeans. The compounds were subsequently tested for in vitro activity against 5-lipoxygenase from porcine leucocytes and proved to be moderately active, with IC50 values of 41.6 μM and 59.6 μM respectively. Tenuiorin is a known constituent of several Peltigera species but has not previously been isolated from P. leucophlebia. As correlation between 5-lipoxygenase inhibition and antiproliferative effects has earlier been witnessed for related lichen metabolites, tenuiorin and methyl orsellinate were further tested for antiproliferative activity on cultured human breast (T-47D)-, pancreatic (PANC-1)- and colon (WIDR) cancer cell lines. The monomeric methyl orsellinate exhibited no detectable antiproliferative activity whereas the trimeric tenuiorin caused moderate/weak reduction in [3H]-thymidine uptake of the pancreatic- and colon cancer cells, with ED50 values of 87.9 and 98.3 μM respectively.
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effects of tenuiorin and methyl orsellinate from the lichen peltigera leucophlebia on 5 15 lipoxygenases and proliferation of malignant cell lines in vitro
Phytomedicine, 2002Co-Authors: K Ingolfsdottir, G F Gudmundsdottir, Sigurdis Haraldsdottir, Kerstin Paulus, Helga M. Ögmundsdóttir, Hjalti Kristinsson, Rudolf BauerAbstract:Summary The Orcinol derivatives tenuiorin (1) and methyl orsellinate (2) were identified as active components of an extract from the lichen Peltigera leucophlebia (Nyl.) Gyeln. showing in vitro inhibitory activity against 15-lipoxygenase from soybeans. The compounds were subsequently tested for in vitro activity against 5-lipoxygenase from porcine leucocytes and proved to be moderately active, with IC50 values of 41.6 μM and 59.6 μM respectively. Tenuiorin is a known constituent of several Peltigera species but has not previously been isolated from P. leucophlebia. As correlation between 5-lipoxygenase inhibition and antiproliferative effects has earlier been witnessed for related lichen metabolites, tenuiorin and methyl orsellinate were further tested for antiproliferative activity on cultured human breast (T-47D)-, pancreatic (PANC-1)- and colon (WIDR) cancer cell lines. The monomeric methyl orsellinate exhibited no detectable antiproliferative activity whereas the trimeric tenuiorin caused moderate/weak reduction in [3H]-thymidine uptake of the pancreatic- and colon cancer cells, with ED50 values of 87.9 and 98.3 μM respectively.
K Ingolfsdottir - One of the best experts on this subject based on the ideXlab platform.
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effects of tenuiorin and methyl orsellinate from the lichen peltigera leucophlebia on 5 15 lipoxygenases and proliferation of malignant cell lines in vitro
Phytomedicine, 2002Co-Authors: K Ingolfsdottir, G F Gudmundsdottir, Sigurdis Haraldsdottir, Kerstin Paulus, Helga M. Ögmundsdóttir, Hjalti Kristinsson, Rudolf BauerAbstract:Summary The Orcinol derivatives tenuiorin (1) and methyl orsellinate (2) were identified as active components of an extract from the lichen Peltigera leucophlebia (Nyl.) Gyeln. showing in vitro inhibitory activity against 15-lipoxygenase from soybeans. The compounds were subsequently tested for in vitro activity against 5-lipoxygenase from porcine leucocytes and proved to be moderately active, with IC50 values of 41.6 μM and 59.6 μM respectively. Tenuiorin is a known constituent of several Peltigera species but has not previously been isolated from P. leucophlebia. As correlation between 5-lipoxygenase inhibition and antiproliferative effects has earlier been witnessed for related lichen metabolites, tenuiorin and methyl orsellinate were further tested for antiproliferative activity on cultured human breast (T-47D)-, pancreatic (PANC-1)- and colon (WIDR) cancer cell lines. The monomeric methyl orsellinate exhibited no detectable antiproliferative activity whereas the trimeric tenuiorin caused moderate/weak reduction in [3H]-thymidine uptake of the pancreatic- and colon cancer cells, with ED50 values of 87.9 and 98.3 μM respectively.
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effects of tenuiorin and methyl orsellinate from the lichen peltigera leucophlebia on 5 15 lipoxygenases and proliferation of malignant cell lines in vitro
Phytomedicine, 2002Co-Authors: K Ingolfsdottir, G F Gudmundsdottir, Sigurdis Haraldsdottir, Kerstin Paulus, Helga M. Ögmundsdóttir, Hjalti Kristinsson, Rudolf BauerAbstract:Summary The Orcinol derivatives tenuiorin (1) and methyl orsellinate (2) were identified as active components of an extract from the lichen Peltigera leucophlebia (Nyl.) Gyeln. showing in vitro inhibitory activity against 15-lipoxygenase from soybeans. The compounds were subsequently tested for in vitro activity against 5-lipoxygenase from porcine leucocytes and proved to be moderately active, with IC50 values of 41.6 μM and 59.6 μM respectively. Tenuiorin is a known constituent of several Peltigera species but has not previously been isolated from P. leucophlebia. As correlation between 5-lipoxygenase inhibition and antiproliferative effects has earlier been witnessed for related lichen metabolites, tenuiorin and methyl orsellinate were further tested for antiproliferative activity on cultured human breast (T-47D)-, pancreatic (PANC-1)- and colon (WIDR) cancer cell lines. The monomeric methyl orsellinate exhibited no detectable antiproliferative activity whereas the trimeric tenuiorin caused moderate/weak reduction in [3H]-thymidine uptake of the pancreatic- and colon cancer cells, with ED50 values of 87.9 and 98.3 μM respectively.
Qiqi Wang - One of the best experts on this subject based on the ideXlab platform.
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β Orcinol type depsides from the lichen thamnolia vermicularis
Natural Product Research, 2013Co-Authors: Wenjuan Xiang, Qiqi WangAbstract:A phytochemical investigation of a herb tea made from Thamnolia vermicularis led to the isolation of three new β-Orcinol-type depsides (1, 2 and 3), along with seven known compounds hypothamnolic acid (4), 3′-methylevenic acid (5), baeomycesic acid (6), squamatic acid (7), methyl 3′-methyllecanorate (8), barbatinic acid (9) and atranorin (10). The structures of the new compounds were determined on the basis of spectroscopic evidence, including 1-D and 2-D NMR and ESI–MS techniques.
Isao Fujii - One of the best experts on this subject based on the ideXlab platform.
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aspergillus oryzae type iii polyketide synthase csya is involved in the biosynthesis of 3 5 dihydroxybenzoic acid
Bioorganic & Medicinal Chemistry Letters, 2010Co-Authors: Yasuyo Seshime, Praveen R Juvvadi, Katsuhiko Kitamoto, Yutaka Ebizuka, Takamasa Nonaka, Isao FujiiAbstract:Abstract As a novel superfamily of type III polyketide synthases in microbes, four genes csyA , csyB , csyC , and csyD , were found in the genome of Aspergillus oryzae , an industrially important filamentous fungus. In order to analyze their functions, we carried out the overexpression of csyA under the control of α-amylase promoter in A. oryzae and identified 3,5-dihydroxybenzoic acid (DHBA) as the major product. Feeding experiments using 13 C-labeled acetates confirmed that the acetate labeling pattern of DHBA coincided with that of Orcinol derived from orsellinic acid, a polyketide formed by the condensation and cyclization of four acetate units. Further oxidation of methyl group of Orcinol by the host fungus could lead to the production of DHBA. Comparative molecular modeling of CsyA with the crystal structure of Neurospora crassa 2′-oxoalkylresorcylic acid synthase indicated that CsyA cavity size can only accept short-chain acyl starter and tetraketide formation. Thus, CsyA is considered to be a tetraketide alkyl-resOrcinol/resorcylic acid synthase.
G F Gudmundsdottir - One of the best experts on this subject based on the ideXlab platform.
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effects of tenuiorin and methyl orsellinate from the lichen peltigera leucophlebia on 5 15 lipoxygenases and proliferation of malignant cell lines in vitro
Phytomedicine, 2002Co-Authors: K Ingolfsdottir, G F Gudmundsdottir, Sigurdis Haraldsdottir, Kerstin Paulus, Helga M. Ögmundsdóttir, Hjalti Kristinsson, Rudolf BauerAbstract:Summary The Orcinol derivatives tenuiorin (1) and methyl orsellinate (2) were identified as active components of an extract from the lichen Peltigera leucophlebia (Nyl.) Gyeln. showing in vitro inhibitory activity against 15-lipoxygenase from soybeans. The compounds were subsequently tested for in vitro activity against 5-lipoxygenase from porcine leucocytes and proved to be moderately active, with IC50 values of 41.6 μM and 59.6 μM respectively. Tenuiorin is a known constituent of several Peltigera species but has not previously been isolated from P. leucophlebia. As correlation between 5-lipoxygenase inhibition and antiproliferative effects has earlier been witnessed for related lichen metabolites, tenuiorin and methyl orsellinate were further tested for antiproliferative activity on cultured human breast (T-47D)-, pancreatic (PANC-1)- and colon (WIDR) cancer cell lines. The monomeric methyl orsellinate exhibited no detectable antiproliferative activity whereas the trimeric tenuiorin caused moderate/weak reduction in [3H]-thymidine uptake of the pancreatic- and colon cancer cells, with ED50 values of 87.9 and 98.3 μM respectively.
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effects of tenuiorin and methyl orsellinate from the lichen peltigera leucophlebia on 5 15 lipoxygenases and proliferation of malignant cell lines in vitro
Phytomedicine, 2002Co-Authors: K Ingolfsdottir, G F Gudmundsdottir, Sigurdis Haraldsdottir, Kerstin Paulus, Helga M. Ögmundsdóttir, Hjalti Kristinsson, Rudolf BauerAbstract:Summary The Orcinol derivatives tenuiorin (1) and methyl orsellinate (2) were identified as active components of an extract from the lichen Peltigera leucophlebia (Nyl.) Gyeln. showing in vitro inhibitory activity against 15-lipoxygenase from soybeans. The compounds were subsequently tested for in vitro activity against 5-lipoxygenase from porcine leucocytes and proved to be moderately active, with IC50 values of 41.6 μM and 59.6 μM respectively. Tenuiorin is a known constituent of several Peltigera species but has not previously been isolated from P. leucophlebia. As correlation between 5-lipoxygenase inhibition and antiproliferative effects has earlier been witnessed for related lichen metabolites, tenuiorin and methyl orsellinate were further tested for antiproliferative activity on cultured human breast (T-47D)-, pancreatic (PANC-1)- and colon (WIDR) cancer cell lines. The monomeric methyl orsellinate exhibited no detectable antiproliferative activity whereas the trimeric tenuiorin caused moderate/weak reduction in [3H]-thymidine uptake of the pancreatic- and colon cancer cells, with ED50 values of 87.9 and 98.3 μM respectively.