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Toshihiro Shinka - One of the best experts on this subject based on the ideXlab platform.
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Organic Acid disorders detected by urine Organic Acid analysis: twelve cases in Thailand over three-year experience.
Clinica Chimica Acta, 2008Co-Authors: Pornswan Wasant, Somporn Liammongkolkul, Chulaluck Kuptanon, Nithiwat Vatanavicharn, Achara Sathienkijakanchai, Toshihiro ShinkaAbstract:Abstract Background Disorders of Organic Acid (OA) metabolism are generally detected by qualitative analysis of urine Organic Acids by gas chromatography/mass spectrometry (GC/MS) which was well established in developed countries since 1980s. Confirmation of the diagnosis of Organic Acid disorders by OA analysis, enzyme analysis and molecular study is a difficult task in developing countries. Methods During 2001–2004, we had analysed 442 urine samples in 365 patients and identified 12 cases of Organic Acid disorders. Results We identified the following disorders: alkaptonuria (ALK) = 1, isovaleric Acidemia (IVA) = 3, propionic Acidemia (PA) = 2, methylmalonic Acidemia (MMA) = 3, glutaric Aciduria, type I (GA-I) = 1, multiple carboxylase deficiency (MCD) = 1, and glutaric Acidemia, type II (GA-II) = 1. Conclusions OA disorders had never been diagnosed in Thailand before, until GC/MS technology was introduced to Thailand in 2001. Urine OA analysis also provided a diagnostic clue to other inborn errors of metabolism including amino Acid disorders, urea cycle disorders, disorders of carbohydrate metabolism, and mitochondrial fatty Acid oxidation disorders. Since then, we were able to diagnose numerous disorders, which led to prompt treatment and better outcome in our patients.
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Organic Acid disorders detected by urine Organic Acid analysis: twelve cases in Thailand over three-year experience.
Clinica chimica acta; international journal of clinical chemistry, 2008Co-Authors: Pornswan Wasant, Somporn Liammongkolkul, Chulaluck Kuptanon, Nithiwat Vatanavicharn, Achara Sathienkijakanchai, Toshihiro ShinkaAbstract:Disorders of Organic Acid (OA) metabolism are generally detected by qualitative analysis of urine Organic Acids by gas chromatography/mass spectrometry (GC/MS) which was well established in developed countries since 1980s. Confirmation of the diagnosis of Organic Acid disorders by OA analysis, enzyme analysis and molecular study is a difficult task in developing countries. During 2001-2004, we had analysed 442 urine samples in 365 patients and identified 12 cases of Organic Acid disorders. We identified the following disorders: alkaptonuria (ALK)=1, isovaleric Acidemia (IVA)=3, propionic Acidemia (PA)=2, methylmalonic Acidemia (MMA)=3, glutaric Aciduria, type I (GA-I)=1, multiple carboxylase deficiency (MCD)=1, and glutaric Acidemia, type II (GA-II)=1. OA disorders had never been diagnosed in Thailand before, until GC/MS technology was introduced to Thailand in 2001. Urine OA analysis also provided a diagnostic clue to other inborn errors of metabolism including amino Acid disorders, urea cycle disorders, disorders of carbohydrate metabolism, and mitochondrial fatty Acid oxidation disorders. Since then, we were able to diagnose numerous disorders, which led to prompt treatment and better outcome in our patients.
P. Weir - One of the best experts on this subject based on the ideXlab platform.
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Increased HVA detected on Organic Acid analysis in a patient with Costello syndrome.
Journal of Inherited Metabolic Disease, 2005Co-Authors: Ann Bowron, J. G. Scott, C. Brewer, P. WeirAbstract:Urine Organic Acid analysis is routinely performed to investigate inborn errors of metbolism; however, interpretation can be difficult owing to the detection of compounds derived from other disease states or from nonpathological causes. We describe the finding of elevated homovanillc Acid (HVA) on urine Organic Acid analysis which was not associated with medication or a neuroendocrine tumour but with Costello syndrome.
Pornswan Wasant - One of the best experts on this subject based on the ideXlab platform.
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Organic Acid disorders detected by urine Organic Acid analysis: twelve cases in Thailand over three-year experience.
Clinica Chimica Acta, 2008Co-Authors: Pornswan Wasant, Somporn Liammongkolkul, Chulaluck Kuptanon, Nithiwat Vatanavicharn, Achara Sathienkijakanchai, Toshihiro ShinkaAbstract:Abstract Background Disorders of Organic Acid (OA) metabolism are generally detected by qualitative analysis of urine Organic Acids by gas chromatography/mass spectrometry (GC/MS) which was well established in developed countries since 1980s. Confirmation of the diagnosis of Organic Acid disorders by OA analysis, enzyme analysis and molecular study is a difficult task in developing countries. Methods During 2001–2004, we had analysed 442 urine samples in 365 patients and identified 12 cases of Organic Acid disorders. Results We identified the following disorders: alkaptonuria (ALK) = 1, isovaleric Acidemia (IVA) = 3, propionic Acidemia (PA) = 2, methylmalonic Acidemia (MMA) = 3, glutaric Aciduria, type I (GA-I) = 1, multiple carboxylase deficiency (MCD) = 1, and glutaric Acidemia, type II (GA-II) = 1. Conclusions OA disorders had never been diagnosed in Thailand before, until GC/MS technology was introduced to Thailand in 2001. Urine OA analysis also provided a diagnostic clue to other inborn errors of metabolism including amino Acid disorders, urea cycle disorders, disorders of carbohydrate metabolism, and mitochondrial fatty Acid oxidation disorders. Since then, we were able to diagnose numerous disorders, which led to prompt treatment and better outcome in our patients.
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Organic Acid disorders detected by urine Organic Acid analysis: twelve cases in Thailand over three-year experience.
Clinica chimica acta; international journal of clinical chemistry, 2008Co-Authors: Pornswan Wasant, Somporn Liammongkolkul, Chulaluck Kuptanon, Nithiwat Vatanavicharn, Achara Sathienkijakanchai, Toshihiro ShinkaAbstract:Disorders of Organic Acid (OA) metabolism are generally detected by qualitative analysis of urine Organic Acids by gas chromatography/mass spectrometry (GC/MS) which was well established in developed countries since 1980s. Confirmation of the diagnosis of Organic Acid disorders by OA analysis, enzyme analysis and molecular study is a difficult task in developing countries. During 2001-2004, we had analysed 442 urine samples in 365 patients and identified 12 cases of Organic Acid disorders. We identified the following disorders: alkaptonuria (ALK)=1, isovaleric Acidemia (IVA)=3, propionic Acidemia (PA)=2, methylmalonic Acidemia (MMA)=3, glutaric Aciduria, type I (GA-I)=1, multiple carboxylase deficiency (MCD)=1, and glutaric Acidemia, type II (GA-II)=1. OA disorders had never been diagnosed in Thailand before, until GC/MS technology was introduced to Thailand in 2001. Urine OA analysis also provided a diagnostic clue to other inborn errors of metabolism including amino Acid disorders, urea cycle disorders, disorders of carbohydrate metabolism, and mitochondrial fatty Acid oxidation disorders. Since then, we were able to diagnose numerous disorders, which led to prompt treatment and better outcome in our patients.
Ann Bowron - One of the best experts on this subject based on the ideXlab platform.
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Increased HVA detected on Organic Acid analysis in a patient with Costello syndrome.
Journal of Inherited Metabolic Disease, 2005Co-Authors: Ann Bowron, J. G. Scott, C. Brewer, P. WeirAbstract:Urine Organic Acid analysis is routinely performed to investigate inborn errors of metbolism; however, interpretation can be difficult owing to the detection of compounds derived from other disease states or from nonpathological causes. We describe the finding of elevated homovanillc Acid (HVA) on urine Organic Acid analysis which was not associated with medication or a neuroendocrine tumour but with Costello syndrome.
Steven C. Ricke - One of the best experts on this subject based on the ideXlab platform.
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Synergistic reduction of Salmonella in a model raw chicken media using a combined thermal and Acidified Organic Acid salt intervention treatment.
Journal of Food Science, 2010Co-Authors: S.r. Milillo, Steven C. RickeAbstract:: Salmonella-contaminated poultry products are considered major contributors to foodborne illness. The anti-Salmonella activity of Organic Acid salts has been studied in food products and poultry feed but rarely in combination with nonchemical treatments. Here, we investigated the combination of Acidified Organic Acid salt solutions with thermal treatment as an effective Salmonella intervention applicable in poultry carcass processing. A model raw chicken media was used to propagate Salmonella prior to the intervention treatment. Salmonella Typhimurium strains LT2 and ATCC nr 14028 grew similarly in the model raw chicken media at 37 and 42 degrees C, reaching stationary phase 24 h after inoculation. Four log(10)CFU of either Salmonella Typhimurium strain at stationary phase was exposed to 2.5% Organic Acid salt solutions (at pH 4) for 1 min at 55 degrees C. All Organic Acid salt treatments yielded significant Salmonella Typhimurium reductions, ranging from 1 log (sodium acetate) to almost 4 logs (sodium butyrate). Exposure to pH 4 water at 55 degrees C or the Organic Acid salt solutions at room temperature had no effect. The combined thermal and Acidified Organic Acid salt intervention produced a significant, synergistic reduction of Salmonella Typhimurium and may represent an effective method for decontamination of poultry carcasses during processing.
