The Experts below are selected from a list of 249 Experts worldwide ranked by ideXlab platform
Michael Petrides - One of the best experts on this subject based on the ideXlab platform.
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sulcal organization in the medial frontal cortex provides insights into primate brain evolution
Nature Communications, 2019Co-Authors: Celine Amiez, Jerome Sallet, Fadila Hadjbouziane, Ben S Hamed, Emmanuel Procyk, Adrien Meguerditchian, William D. Hopkins, Michael PetridesAbstract:Although the relative expansion of the frontal cortex in primate evolution is generally accepted, the nature of the human uniqueness, if any, and between-species anatomo-functional comparisons of the frontal areas remain controversial. To provide a novel interpretation of the evolution of primate brains, sulcal morphological variability of the medial frontal cortex was assessed in Old World monkeys (macaque/baboon) and Hominoidea (chimpanzee/human). We show that both Hominoidea possess a paracingulate sulcus, which was previously thought to be unique to the human brain and linked to higher cognitive functions, such as mentalizing. Also, we show systematic sulcal morphological organization of the medial frontal cortex that can be traced from Old World monkeys to Hominoidea species, demonstrating an evolutionarily conserved Organizational Principle. These data provide a new framework to compare sulcal morphology, cytoarchitectonic areal distribution, connectivity, and function across the primate order, leading to clear predictions about how other primate brains might be anatomo-functionally organized. The frontal cortex has expanded over primate evolution. Here, the authors use neuroimaging data from the brains of humans, chimpanzees, baboons, and macaques, to reveal shared and distinct sulcal morphology of the medial frontal cortex.
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sulcal organization in the medial frontal cortex reveals insights into primate brain evolution
bioRxiv, 2019Co-Authors: Celine Amiez, Jerome Sallet, Fadila Hadjbouziane, Suliann Benhamed, Charles R E Wilson, Emmanuel Procyk, Adrien Meguerditchian, William D. Hopkins, Michael PetridesAbstract:ABSTRACT Although the relative expansion of the frontal cortex in primate evolution is generally accepted, the nature of the human uniqueness, if any, and between-species anatomo-functional comparisons of the frontal areas remain controversial. To provide a novel interpretation of the evolution of primate brains, sulcal morphological variability of the medial frontal cortex was assessed in old-world monkeys (macaque, baboon) and Hominoidea (chimpanzee, human). We discovered that both Hominoidea do possess a paracingulate sulcus, which was previously thought to be uniquely human and linked to higher cognitive functions like mentalizing. Also, we revealed systematic sulcal morphological organisations of the medial frontal cortex that can be traced from multiple old-world monkey to Hominoidea species, demonstrating an evolutionary conserved Organizational Principle. Our data provide a new framework to compare sulcal morphology, cytoarchitectonic areal distribution, connectivity, and function across the primate order, leading to clear predictions on how other primate brains might be anatomo-functionally organized.
Adrien Meguerditchian - One of the best experts on this subject based on the ideXlab platform.
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sulcal organization in the medial frontal cortex provides insights into primate brain evolution
Nature Communications, 2019Co-Authors: Celine Amiez, Jerome Sallet, Fadila Hadjbouziane, Ben S Hamed, Emmanuel Procyk, Adrien Meguerditchian, William D. Hopkins, Michael PetridesAbstract:Although the relative expansion of the frontal cortex in primate evolution is generally accepted, the nature of the human uniqueness, if any, and between-species anatomo-functional comparisons of the frontal areas remain controversial. To provide a novel interpretation of the evolution of primate brains, sulcal morphological variability of the medial frontal cortex was assessed in Old World monkeys (macaque/baboon) and Hominoidea (chimpanzee/human). We show that both Hominoidea possess a paracingulate sulcus, which was previously thought to be unique to the human brain and linked to higher cognitive functions, such as mentalizing. Also, we show systematic sulcal morphological organization of the medial frontal cortex that can be traced from Old World monkeys to Hominoidea species, demonstrating an evolutionarily conserved Organizational Principle. These data provide a new framework to compare sulcal morphology, cytoarchitectonic areal distribution, connectivity, and function across the primate order, leading to clear predictions about how other primate brains might be anatomo-functionally organized. The frontal cortex has expanded over primate evolution. Here, the authors use neuroimaging data from the brains of humans, chimpanzees, baboons, and macaques, to reveal shared and distinct sulcal morphology of the medial frontal cortex.
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sulcal organization in the medial frontal cortex reveals insights into primate brain evolution
bioRxiv, 2019Co-Authors: Celine Amiez, Jerome Sallet, Fadila Hadjbouziane, Suliann Benhamed, Charles R E Wilson, Emmanuel Procyk, Adrien Meguerditchian, William D. Hopkins, Michael PetridesAbstract:ABSTRACT Although the relative expansion of the frontal cortex in primate evolution is generally accepted, the nature of the human uniqueness, if any, and between-species anatomo-functional comparisons of the frontal areas remain controversial. To provide a novel interpretation of the evolution of primate brains, sulcal morphological variability of the medial frontal cortex was assessed in old-world monkeys (macaque, baboon) and Hominoidea (chimpanzee, human). We discovered that both Hominoidea do possess a paracingulate sulcus, which was previously thought to be uniquely human and linked to higher cognitive functions like mentalizing. Also, we revealed systematic sulcal morphological organisations of the medial frontal cortex that can be traced from multiple old-world monkey to Hominoidea species, demonstrating an evolutionary conserved Organizational Principle. Our data provide a new framework to compare sulcal morphology, cytoarchitectonic areal distribution, connectivity, and function across the primate order, leading to clear predictions on how other primate brains might be anatomo-functionally organized.
Celine Amiez - One of the best experts on this subject based on the ideXlab platform.
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sulcal organization in the medial frontal cortex provides insights into primate brain evolution
Nature Communications, 2019Co-Authors: Celine Amiez, Jerome Sallet, Fadila Hadjbouziane, Ben S Hamed, Emmanuel Procyk, Adrien Meguerditchian, William D. Hopkins, Michael PetridesAbstract:Although the relative expansion of the frontal cortex in primate evolution is generally accepted, the nature of the human uniqueness, if any, and between-species anatomo-functional comparisons of the frontal areas remain controversial. To provide a novel interpretation of the evolution of primate brains, sulcal morphological variability of the medial frontal cortex was assessed in Old World monkeys (macaque/baboon) and Hominoidea (chimpanzee/human). We show that both Hominoidea possess a paracingulate sulcus, which was previously thought to be unique to the human brain and linked to higher cognitive functions, such as mentalizing. Also, we show systematic sulcal morphological organization of the medial frontal cortex that can be traced from Old World monkeys to Hominoidea species, demonstrating an evolutionarily conserved Organizational Principle. These data provide a new framework to compare sulcal morphology, cytoarchitectonic areal distribution, connectivity, and function across the primate order, leading to clear predictions about how other primate brains might be anatomo-functionally organized. The frontal cortex has expanded over primate evolution. Here, the authors use neuroimaging data from the brains of humans, chimpanzees, baboons, and macaques, to reveal shared and distinct sulcal morphology of the medial frontal cortex.
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sulcal organization in the medial frontal cortex reveals insights into primate brain evolution
bioRxiv, 2019Co-Authors: Celine Amiez, Jerome Sallet, Fadila Hadjbouziane, Suliann Benhamed, Charles R E Wilson, Emmanuel Procyk, Adrien Meguerditchian, William D. Hopkins, Michael PetridesAbstract:ABSTRACT Although the relative expansion of the frontal cortex in primate evolution is generally accepted, the nature of the human uniqueness, if any, and between-species anatomo-functional comparisons of the frontal areas remain controversial. To provide a novel interpretation of the evolution of primate brains, sulcal morphological variability of the medial frontal cortex was assessed in old-world monkeys (macaque, baboon) and Hominoidea (chimpanzee, human). We discovered that both Hominoidea do possess a paracingulate sulcus, which was previously thought to be uniquely human and linked to higher cognitive functions like mentalizing. Also, we revealed systematic sulcal morphological organisations of the medial frontal cortex that can be traced from multiple old-world monkey to Hominoidea species, demonstrating an evolutionary conserved Organizational Principle. Our data provide a new framework to compare sulcal morphology, cytoarchitectonic areal distribution, connectivity, and function across the primate order, leading to clear predictions on how other primate brains might be anatomo-functionally organized.
Thomas A Blanpied - One of the best experts on this subject based on the ideXlab platform.
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a trans synaptic nanocolumn aligns neurotransmitter release to receptors
Nature, 2016Co-Authors: Aihui Tang, Haiwen Chen, Sarah R Metzbower, Harold D Macgillavry, Thomas A BlanpiedAbstract:Synaptic transmission is maintained by a delicate, sub-synaptic molecular architecture, and even mild alterations in synapse structure drive functional changes during experience-dependent plasticity and pathological disorders. Key to this architecture is how the distribution of presynaptic vesicle fusion sites corresponds to the position of receptors in the postsynaptic density. However, while it has long been recognized that this spatial relationship modulates synaptic strength, it has not been precisely described, owing in part to the limited resolution of light microscopy. Using localization microscopy, here we show that key proteins mediating vesicle priming and fusion are mutually co-enriched within nanometre-scale subregions of the presynaptic active zone. Through development of a new method to map vesicle fusion positions within single synapses in cultured rat hippocampal neurons, we find that action-potential-evoked fusion is guided by this protein gradient and occurs preferentially in confined areas with higher local density of Rab3-interacting molecule (RIM) within the active zones. These presynaptic RIM nanoclusters closely align with concentrated postsynaptic receptors and scaffolding proteins, suggesting the existence of a trans-synaptic molecular 'nanocolumn'. Thus, we propose that the nanoarchitecture of the active zone directs action-potential-evoked vesicle fusion to occur preferentially at sites directly opposing postsynaptic receptor-scaffold ensembles. Remarkably, NMDA receptor activation triggered distinct phases of plasticity in which postsynaptic reorganization was followed by trans-synaptic nanoscale realignment. This architecture suggests a simple Organizational Principle of central nervous system synapses to maintain and modulate synaptic efficiency.
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a trans synaptic nanocolumn aligns neurotransmitter release to receptors
Nature, 2016Co-Authors: Aihui Tang, Haiwen Chen, Sarah R Metzbower, Harold D Macgillavry, Tuo P Li, Thomas A BlanpiedAbstract:Synaptic vesicle fusion, as evoked by action potentials, is confined to presynaptic protein nanoclusters, which are closely aligned with concentrated postsynaptic receptors and their scaffolding proteins—an organization termed a ‘nanocolumn’. Efficient neurotransmission has long been suspected to require precise alignment between pre-synaptic vesicle release sites and post-synaptic receptors, but direct observations have been hampered by the physics of light-microscopy. Thomas Blanpied and colleagues use hyper-resolution microscopy — which overcomes the diffraction barrier — to reveal that vesicular fusion at single synapses, as evoked by action potentials, is confined to pre-synaptic protein nanoclusters. The nanoclusters are closely aligned with concentrated post-synaptic receptors and their scaffolding proteins. The resulting molecular 'nanocolumns' are reorganized during NMDA receptor-dependent plasticity, and the authors suggest that they may contribute to the maintenance and regulation of synaptic efficiency. Synaptic transmission is maintained by a delicate, sub-synaptic molecular architecture, and even mild alterations in synapse structure drive functional changes during experience-dependent plasticity and pathological disorders1,2. Key to this architecture is how the distribution of presynaptic vesicle fusion sites corresponds to the position of receptors in the postsynaptic density. However, while it has long been recognized that this spatial relationship modulates synaptic strength3, it has not been precisely described, owing in part to the limited resolution of light microscopy. Using localization microscopy, here we show that key proteins mediating vesicle priming and fusion are mutually co-enriched within nanometre-scale subregions of the presynaptic active zone. Through development of a new method to map vesicle fusion positions within single synapses in cultured rat hippocampal neurons, we find that action-potential-evoked fusion is guided by this protein gradient and occurs preferentially in confined areas with higher local density of Rab3-interacting molecule (RIM) within the active zones. These presynaptic RIM nanoclusters closely align with concentrated postsynaptic receptors and scaffolding proteins4,5,6, suggesting the existence of a trans-synaptic molecular ‘nanocolumn’. Thus, we propose that the nanoarchitecture of the active zone directs action-potential-evoked vesicle fusion to occur preferentially at sites directly opposing postsynaptic receptor–scaffold ensembles. Remarkably, NMDA receptor activation triggered distinct phases of plasticity in which postsynaptic reorganization was followed by trans-synaptic nanoscale realignment. This architecture suggests a simple Organizational Principle of central nervous system synapses to maintain and modulate synaptic efficiency.
Jerome Sallet - One of the best experts on this subject based on the ideXlab platform.
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sulcal organization in the medial frontal cortex provides insights into primate brain evolution
Nature Communications, 2019Co-Authors: Celine Amiez, Jerome Sallet, Fadila Hadjbouziane, Ben S Hamed, Emmanuel Procyk, Adrien Meguerditchian, William D. Hopkins, Michael PetridesAbstract:Although the relative expansion of the frontal cortex in primate evolution is generally accepted, the nature of the human uniqueness, if any, and between-species anatomo-functional comparisons of the frontal areas remain controversial. To provide a novel interpretation of the evolution of primate brains, sulcal morphological variability of the medial frontal cortex was assessed in Old World monkeys (macaque/baboon) and Hominoidea (chimpanzee/human). We show that both Hominoidea possess a paracingulate sulcus, which was previously thought to be unique to the human brain and linked to higher cognitive functions, such as mentalizing. Also, we show systematic sulcal morphological organization of the medial frontal cortex that can be traced from Old World monkeys to Hominoidea species, demonstrating an evolutionarily conserved Organizational Principle. These data provide a new framework to compare sulcal morphology, cytoarchitectonic areal distribution, connectivity, and function across the primate order, leading to clear predictions about how other primate brains might be anatomo-functionally organized. The frontal cortex has expanded over primate evolution. Here, the authors use neuroimaging data from the brains of humans, chimpanzees, baboons, and macaques, to reveal shared and distinct sulcal morphology of the medial frontal cortex.
-
sulcal organization in the medial frontal cortex reveals insights into primate brain evolution
bioRxiv, 2019Co-Authors: Celine Amiez, Jerome Sallet, Fadila Hadjbouziane, Suliann Benhamed, Charles R E Wilson, Emmanuel Procyk, Adrien Meguerditchian, William D. Hopkins, Michael PetridesAbstract:ABSTRACT Although the relative expansion of the frontal cortex in primate evolution is generally accepted, the nature of the human uniqueness, if any, and between-species anatomo-functional comparisons of the frontal areas remain controversial. To provide a novel interpretation of the evolution of primate brains, sulcal morphological variability of the medial frontal cortex was assessed in old-world monkeys (macaque, baboon) and Hominoidea (chimpanzee, human). We discovered that both Hominoidea do possess a paracingulate sulcus, which was previously thought to be uniquely human and linked to higher cognitive functions like mentalizing. Also, we revealed systematic sulcal morphological organisations of the medial frontal cortex that can be traced from multiple old-world monkey to Hominoidea species, demonstrating an evolutionary conserved Organizational Principle. Our data provide a new framework to compare sulcal morphology, cytoarchitectonic areal distribution, connectivity, and function across the primate order, leading to clear predictions on how other primate brains might be anatomo-functionally organized.
