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Insop Shim - One of the best experts on this subject based on the ideXlab platform.

  • hypolipidemic effects of crude extract of adlay seed coix lachrymajobi var mayuen in obesity rat fed high fat diet relations of tnf α and leptin mrna expressions and serum lipid levels
    Life Sciences, 2004
    Co-Authors: Bomi Jung, Dae-hyun Hahm, Insop Shim
    Abstract:

    Abstract To find out whether the expressions of these adipocyte markers are influenced by Oriental Medicine, obesity rats induced by high fat diet (HFD) for 8 weeks were injected with 50 mg/100 g body weight adlay seed crude extract (ACE), daily for 4 weeks. The results are summarized as follows: HFD + ACE group significantly reduced food intakes and body weights. Weights of epididymal and peritoneal fat were dramatically increased in HFD groups compared with those of normal diet (ND) group but significantly decreased more in HFD + ACE group than those of HFD + saline group (sham). Those of brown adipocytes were increased in HFD + ACE group compared to ND and sham groups but there was no significant difference. The sizes in white adipose tissue (WAT) by microscope were markedly larger in HFD groups than ND group but considerably reduced in HFD + ACE group compared with sham group. The levels of triglyceride, total-cholesterol and leptin in blood serum were significantly decreased in HFD + ACE group compared to those of sham group. Leptin and TNF-α mRNA expressions in WAT of rats were remarkably increased more in sham group than in those of ND group. Those of HFD + ACE group were significantly decreased compared with those of sham group, especially. TNF-α mRNA expression in HFD + ACE group was declined more than that of ND group. In conclusion, treatments of ACE modulated expressions of leptin and TNF-α and reduced body weights, food intake, fat size, adipose tissue mass and serum hyperlipidemia in obesity rat fed HFD. Accordingly, the Oriental Medicine extract, adlay seed crude extract, can be considered for obesity therapies controlling.

  • hypolipidemic effects of crude extract of adlay seed coix lachrymajobi var mayuen in obesity rat fed high fat diet relations of tnf α and leptin mrna expressions and serum lipid levels
    Life Sciences, 2004
    Co-Authors: Bomi Jung, Dae-hyun Hahm, Insop Shim
    Abstract:

    Abstract To find out whether the expressions of these adipocyte markers are influenced by Oriental Medicine, obesity rats induced by high fat diet (HFD) for 8 weeks were injected with 50 mg/100 g body weight adlay seed crude extract (ACE), daily for 4 weeks. The results are summarized as follows: HFD + ACE group significantly reduced food intakes and body weights. Weights of epididymal and peritoneal fat were dramatically increased in HFD groups compared with those of normal diet (ND) group but significantly decreased more in HFD + ACE group than those of HFD + saline group (sham). Those of brown adipocytes were increased in HFD + ACE group compared to ND and sham groups but there was no significant difference. The sizes in white adipose tissue (WAT) by microscope were markedly larger in HFD groups than ND group but considerably reduced in HFD + ACE group compared with sham group. The levels of triglyceride, total-cholesterol and leptin in blood serum were significantly decreased in HFD + ACE group compared to those of sham group. Leptin and TNF-α mRNA expressions in WAT of rats were remarkably increased more in sham group than in those of ND group. Those of HFD + ACE group were significantly decreased compared with those of sham group, especially. TNF-α mRNA expression in HFD + ACE group was declined more than that of ND group. In conclusion, treatments of ACE modulated expressions of leptin and TNF-α and reduced body weights, food intake, fat size, adipose tissue mass and serum hyperlipidemia in obesity rat fed HFD. Accordingly, the Oriental Medicine extract, adlay seed crude extract, can be considered for obesity therapies controlling.

Bomi Jung - One of the best experts on this subject based on the ideXlab platform.

  • hypolipidemic effects of crude extract of adlay seed coix lachrymajobi var mayuen in obesity rat fed high fat diet relations of tnf α and leptin mrna expressions and serum lipid levels
    Life Sciences, 2004
    Co-Authors: Bomi Jung, Dae-hyun Hahm, Insop Shim
    Abstract:

    Abstract To find out whether the expressions of these adipocyte markers are influenced by Oriental Medicine, obesity rats induced by high fat diet (HFD) for 8 weeks were injected with 50 mg/100 g body weight adlay seed crude extract (ACE), daily for 4 weeks. The results are summarized as follows: HFD + ACE group significantly reduced food intakes and body weights. Weights of epididymal and peritoneal fat were dramatically increased in HFD groups compared with those of normal diet (ND) group but significantly decreased more in HFD + ACE group than those of HFD + saline group (sham). Those of brown adipocytes were increased in HFD + ACE group compared to ND and sham groups but there was no significant difference. The sizes in white adipose tissue (WAT) by microscope were markedly larger in HFD groups than ND group but considerably reduced in HFD + ACE group compared with sham group. The levels of triglyceride, total-cholesterol and leptin in blood serum were significantly decreased in HFD + ACE group compared to those of sham group. Leptin and TNF-α mRNA expressions in WAT of rats were remarkably increased more in sham group than in those of ND group. Those of HFD + ACE group were significantly decreased compared with those of sham group, especially. TNF-α mRNA expression in HFD + ACE group was declined more than that of ND group. In conclusion, treatments of ACE modulated expressions of leptin and TNF-α and reduced body weights, food intake, fat size, adipose tissue mass and serum hyperlipidemia in obesity rat fed HFD. Accordingly, the Oriental Medicine extract, adlay seed crude extract, can be considered for obesity therapies controlling.

  • hypolipidemic effects of crude extract of adlay seed coix lachrymajobi var mayuen in obesity rat fed high fat diet relations of tnf α and leptin mrna expressions and serum lipid levels
    Life Sciences, 2004
    Co-Authors: Bomi Jung, Dae-hyun Hahm, Insop Shim
    Abstract:

    Abstract To find out whether the expressions of these adipocyte markers are influenced by Oriental Medicine, obesity rats induced by high fat diet (HFD) for 8 weeks were injected with 50 mg/100 g body weight adlay seed crude extract (ACE), daily for 4 weeks. The results are summarized as follows: HFD + ACE group significantly reduced food intakes and body weights. Weights of epididymal and peritoneal fat were dramatically increased in HFD groups compared with those of normal diet (ND) group but significantly decreased more in HFD + ACE group than those of HFD + saline group (sham). Those of brown adipocytes were increased in HFD + ACE group compared to ND and sham groups but there was no significant difference. The sizes in white adipose tissue (WAT) by microscope were markedly larger in HFD groups than ND group but considerably reduced in HFD + ACE group compared with sham group. The levels of triglyceride, total-cholesterol and leptin in blood serum were significantly decreased in HFD + ACE group compared to those of sham group. Leptin and TNF-α mRNA expressions in WAT of rats were remarkably increased more in sham group than in those of ND group. Those of HFD + ACE group were significantly decreased compared with those of sham group, especially. TNF-α mRNA expression in HFD + ACE group was declined more than that of ND group. In conclusion, treatments of ACE modulated expressions of leptin and TNF-α and reduced body weights, food intake, fat size, adipose tissue mass and serum hyperlipidemia in obesity rat fed HFD. Accordingly, the Oriental Medicine extract, adlay seed crude extract, can be considered for obesity therapies controlling.

Dae-hyun Hahm - One of the best experts on this subject based on the ideXlab platform.

  • hypolipidemic effects of crude extract of adlay seed coix lachrymajobi var mayuen in obesity rat fed high fat diet relations of tnf α and leptin mrna expressions and serum lipid levels
    Life Sciences, 2004
    Co-Authors: Bomi Jung, Dae-hyun Hahm, Insop Shim
    Abstract:

    Abstract To find out whether the expressions of these adipocyte markers are influenced by Oriental Medicine, obesity rats induced by high fat diet (HFD) for 8 weeks were injected with 50 mg/100 g body weight adlay seed crude extract (ACE), daily for 4 weeks. The results are summarized as follows: HFD + ACE group significantly reduced food intakes and body weights. Weights of epididymal and peritoneal fat were dramatically increased in HFD groups compared with those of normal diet (ND) group but significantly decreased more in HFD + ACE group than those of HFD + saline group (sham). Those of brown adipocytes were increased in HFD + ACE group compared to ND and sham groups but there was no significant difference. The sizes in white adipose tissue (WAT) by microscope were markedly larger in HFD groups than ND group but considerably reduced in HFD + ACE group compared with sham group. The levels of triglyceride, total-cholesterol and leptin in blood serum were significantly decreased in HFD + ACE group compared to those of sham group. Leptin and TNF-α mRNA expressions in WAT of rats were remarkably increased more in sham group than in those of ND group. Those of HFD + ACE group were significantly decreased compared with those of sham group, especially. TNF-α mRNA expression in HFD + ACE group was declined more than that of ND group. In conclusion, treatments of ACE modulated expressions of leptin and TNF-α and reduced body weights, food intake, fat size, adipose tissue mass and serum hyperlipidemia in obesity rat fed HFD. Accordingly, the Oriental Medicine extract, adlay seed crude extract, can be considered for obesity therapies controlling.

  • hypolipidemic effects of crude extract of adlay seed coix lachrymajobi var mayuen in obesity rat fed high fat diet relations of tnf α and leptin mrna expressions and serum lipid levels
    Life Sciences, 2004
    Co-Authors: Bomi Jung, Dae-hyun Hahm, Insop Shim
    Abstract:

    Abstract To find out whether the expressions of these adipocyte markers are influenced by Oriental Medicine, obesity rats induced by high fat diet (HFD) for 8 weeks were injected with 50 mg/100 g body weight adlay seed crude extract (ACE), daily for 4 weeks. The results are summarized as follows: HFD + ACE group significantly reduced food intakes and body weights. Weights of epididymal and peritoneal fat were dramatically increased in HFD groups compared with those of normal diet (ND) group but significantly decreased more in HFD + ACE group than those of HFD + saline group (sham). Those of brown adipocytes were increased in HFD + ACE group compared to ND and sham groups but there was no significant difference. The sizes in white adipose tissue (WAT) by microscope were markedly larger in HFD groups than ND group but considerably reduced in HFD + ACE group compared with sham group. The levels of triglyceride, total-cholesterol and leptin in blood serum were significantly decreased in HFD + ACE group compared to those of sham group. Leptin and TNF-α mRNA expressions in WAT of rats were remarkably increased more in sham group than in those of ND group. Those of HFD + ACE group were significantly decreased compared with those of sham group, especially. TNF-α mRNA expression in HFD + ACE group was declined more than that of ND group. In conclusion, treatments of ACE modulated expressions of leptin and TNF-α and reduced body weights, food intake, fat size, adipose tissue mass and serum hyperlipidemia in obesity rat fed HFD. Accordingly, the Oriental Medicine extract, adlay seed crude extract, can be considered for obesity therapies controlling.

Jeongchae Lee - One of the best experts on this subject based on the ideXlab platform.

  • anti inflammatory potential of phaseolus calcaratus roxburgh a Oriental Medicine on lps stimulated raw 264 7 macrophages
    Journal of Pharmacy and Pharmacology, 2010
    Co-Authors: Minghao Fang, Seungyoup Lee, Seungmoon Park, Ki Choon Choi, Youngjae Lee, Hyoungkwon Cho, Seongwan Cho, Wan Kyunn Whang, Jeongchae Lee
    Abstract:

    Objectives  The seed of Phaseolus calcaratus Roxburgh (PHCR) has traditionally been used as a herbal Medicine, considered to have anti-inflammatory potential. Here we examined the ability of PHCR seed extract to inhibit inflammatory responses of macrophages to bacterial toxin and the mechanism involved. Methods  In the present study, we prepared four fractions from an ethanol extract of PHCR seed and investigated their effects on the production of nitric oxide and cytokines, and the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Key findings  The fractions inhibited LPS-induced nitric oxide production and cyclooxygenase-2 (COX-2) expression in the cells. The ethyl acetate fraction at 100 µg/ml almost completely suppressed NO production, iNOS and COX-2 expression, and TNF-α and IL-6 secretion in cells stimulated with LPS. The fraction also inhibited phosphorylation of extracellular signal-regulated kinase (ERK) and p38 in LPS-stimulated cells with the attendant suppression of IκBα nuclear translocation and nuclear factor (NF)-κB activation. Furthermore, PHCR seed extracts contained a large number of phenolic compounds having antioxidant potentials against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and hydroxyl radicals. We identified catechin-7-O-β-d-glucopyranoside as one of the active compounds responsible for the biological activity of PHCR seed extract. Conclusions  These results suggest for the first time that ethanol extracts from PHCR seed have anti-inflammatory potential on LPS-stimulated macrophages through the down-regulation of ERK/p38- and NF-κB-mediated signalling pathways.

Tzchong Chou - One of the best experts on this subject based on the ideXlab platform.

  • baicalein an active component of scutellaria baicalensis protects against lipopolysaccharide induced acute lung injury in rats
    Journal of Ethnopharmacology, 2014
    Co-Authors: Chenliang Tsai, Tzchong Chou, Huimin Wang
    Abstract:

    Ethnopharmacological relevance Baicalein (BE), a phenolic flavonoid extracted mainly from the root of Scutellaria baicalensis Georgi, a Chinese herb, is traditionally used in Oriental Medicine. Several studies have demonstrated that BE exerts many beneficial effects including anti-inflammatory and antioxidant activities. However, its effect on acute lung injury (ALI) and the molecular mechanisms involved remain unclear and warrant further investigation. The aim of the study is to investigate whether BE improves lipopolysaccharide (LPS, intratracheally, i.t.)-induced ALI in rats, and further study the underlying mechanisms of its activity.