The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Max Robinson - One of the best experts on this subject based on the ideXlab platform.
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squamous cell carcinoma of the head and neck outside the Oropharynx is rarely human papillomavirus related
Laryngoscope, 2014Co-Authors: Navdeep S Upile, Richard J Shaw, Terry Jones, Paul W A Goodyear, Triantafillos Liloglou, Janet M Risk, Mark T Boyd, Jon Sheard, Phil Sloan, Max RobinsonAbstract:Objectives/Hypothesis The incidence of human papillomavirus (HPV)-driven disease beyond the Oropharynx varies greatly in the reported literature. Study Design Case series. Methods Two hundred twenty-one samples were strictly classified to the subsites of oral cavity, larynx, or hypopharynx at the time of primary surgery. Formalin-fixed paraffin-embedded samples were subjected to a validated, tiered, diagnostic algorithm of p16 immunohistochemistry, high-risk HPV in situ hybridization, and quantitative polymerase chain reaction for HPV E6 DNA. An additional 60 oropharyngeal cases acted as an internal biological control. Results An incidence of 4% of HPV-driven cases was observed across the subsites outside the Oropharynx compared to 70% of tumors confined within it. Conclusions This is the first reporting of a broad range of nonoropharyngeal HPV rates using this validated diagnostic algorithm. It remains unclear whether patients with HPV-driven disease originating outside the Oropharynx enjoy the same survival advantage apparent in those patients with oropharyngeal squamous cell carcinomas. Level of Evidence 4 Laryngoscope, 124:2739–2744, 2014
Dongxu Liu - One of the best experts on this subject based on the ideXlab platform.
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cbct evaluation of the upper airway morphological changes in growing patients of class ii division 1 malocclusion with mandibular retrusion using twin block appliance a comparative research
PLOS ONE, 2014Co-Authors: Hong Liu, Huijua Cheng, Chunling Wang, Yu Che, Jinli Song, Dongxu LiuAbstract:Objective The purpose of this study was to evaluate the morphological changes of upper airway after Twin Block (TB) treatment in growing patients with Class II division 1 malocclusion and mandibular retrusion compared with untreated Class II patients by cone beam computed tomography (CBCT). Materials and Methods Thirty growing patients who have completed TB treatment were recruited into TB group. The control group (n = 30) was selected from the patients with the same diagnosis and without TB treatment. CBCT scans of the pre-treatment (T1) and post-treatment (T2) data of TB group and control data were collected. After three-dimensional (3D) reconstruction and registration of T1 and T2 data, the morphological changes of upper airway during TB treatment were measured. The statistical differences between T1 and T2 data of TB group as well as T2 and control data were accessed by t-test. Results During the TB treatment, the mandible moved advanced by 3.52±2.14 mm in the horizontal direction and 3.77±2.10 mm in the vertical direction. The hyoid bone was in a more forward and inferior place. The upper airway showed a significant enlargement in nasopharynx, Oropharynx and hypopharynx. In addition, the nasopharynx turned more circular, and the Oropharynx became more elliptic in transverse shape. However, the transverse shape of the hypopharynx showed no significant difference. After comparison between T2 and control data, only the horizontal movement of the hyoid bone, the volumetric expansion of the Oropharynx and hypopharynx, and changes of the oropharyngeal transverse shape showed significant difference. Conclusion Compared to the untreated Class II patients, the upper airway of growing patients with Class II division 1 malocclusion and mandibular retrusion showed a significant enlargement in the Oropharynx and hypopharynx as well as a more elliptic transverse shape in the Oropharynx, and the hyoid bone moved to an anterior position after TB treatment.
Jonathan J Beitler - One of the best experts on this subject based on the ideXlab platform.
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the value of tumor diameter in predicting prognosis of Oropharynx cancer treated with chemoradiation
Oral Oncology, 2012Co-Authors: Matthew C Ward, Amy Y. Chen, Jonathan J BeitlerAbstract:OBJECTIVES: The tumor node metastasis (TNM) system is the most widely used staging system for cancers of the Oropharynx, yet is known to omit key prognostic indicators. Tumor volume has been shown in other head and neck sites to add predictive power but is not as useful in the Oropharynx. This study investigates the value of other methods in quantifying tumor burden. METHODS: Treatment plans of oropharyngeal cancer patients treated non-operatively were retrospectively reviewed. Potential prognostic factors including TNM, demographics, smoking history, and various tumor dimensions were analyzed. RESULTS: Records identified 93 patients treated with definitive concurrent chemoradiation who had at least one year of follow-up and a clear GTV contour on the original treatment plan. On univariate analysis, tumor diameter and tumor volume showed a significant relationship to overall and disease-free survival. Tumor stage, age and smoking history showed significance in regard to overall survival. On multivariate analysis tumor diameter showed independent significance but not TNM or tumor volume. CONCLUSION: Our method of measuring tumor diameter has independent prognostic significance in the Oropharynx where GTV has shown questionable value.
Liu Yun-hui - One of the best experts on this subject based on the ideXlab platform.
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Trans-Oropharynx Microsurgical Treatment of Idiopathic Atlanto-axialdislocation
Journal of China Medical University, 2008Co-Authors: Chen Duo, Lu Tao, Guan Jun-hong, Wei Xiangtai, Zhang Li-ping, Wang Cheng-lin, Liu Yun-huiAbstract:Objective To discuss the therapeutic effect of trans-Oropharynx microsurgical treatment of idiopathic atlanto-axial dislocation.Methods 7 patients with idiopathic atlanto-axial dislocation underwent microsurgery by an Oropharynx approach.The clinical manifestations,image changes,surgical strategies and prognosis were summarized and analyzed retrospectively.Results 5 patients were followed up for 3 months-7 years,two of whom were fully cured and 3 were improved,with no operation-related death and infection.Conclusion Trans-Oropharynx microsurgical decompression is the first choice to treat atlanto-axial dislocation of compressed ventral area of medulla oblogata and cervical spinal cord.
Navdeep S Upile - One of the best experts on this subject based on the ideXlab platform.
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squamous cell carcinoma of the head and neck outside the Oropharynx is rarely human papillomavirus related
Laryngoscope, 2014Co-Authors: Navdeep S Upile, Richard J Shaw, Terry Jones, Paul W A Goodyear, Triantafillos Liloglou, Janet M Risk, Mark T Boyd, Jon Sheard, Phil Sloan, Max RobinsonAbstract:Objectives/Hypothesis The incidence of human papillomavirus (HPV)-driven disease beyond the Oropharynx varies greatly in the reported literature. Study Design Case series. Methods Two hundred twenty-one samples were strictly classified to the subsites of oral cavity, larynx, or hypopharynx at the time of primary surgery. Formalin-fixed paraffin-embedded samples were subjected to a validated, tiered, diagnostic algorithm of p16 immunohistochemistry, high-risk HPV in situ hybridization, and quantitative polymerase chain reaction for HPV E6 DNA. An additional 60 oropharyngeal cases acted as an internal biological control. Results An incidence of 4% of HPV-driven cases was observed across the subsites outside the Oropharynx compared to 70% of tumors confined within it. Conclusions This is the first reporting of a broad range of nonoropharyngeal HPV rates using this validated diagnostic algorithm. It remains unclear whether patients with HPV-driven disease originating outside the Oropharynx enjoy the same survival advantage apparent in those patients with oropharyngeal squamous cell carcinomas. Level of Evidence 4 Laryngoscope, 124:2739–2744, 2014
