The Experts below are selected from a list of 6234 Experts worldwide ranked by ideXlab platform
Eric J.w. Liou - One of the best experts on this subject based on the ideXlab platform.
-
The development of submucosal injection of platelet rich plasma for accelerating Orthodontic Tooth Movement and preserving pressure side alveolar bone
APOS Trends in Orthodontics, 2016Co-Authors: Eric J.w. LiouAbstract:Although the surgical-assisted accelerated Orthodontic Tooth Movement has been proved to be the most effective one currently, its disadvantages are it is a bone surgery, and it causes loss of alveolar bone that undermines the periodontal support of the target teeth. The submucosal injection of platelet rich plasma (PRP) is a technique developed for accelerating Orthodontic Tooth Movement by simulating the effects of bone insult without surgery and loss of alveolar bone. We have revealed clinically that submucosal injection of PRP accelerated the mandibular or maxillary alignment 1.7 folds faster in average, and the acceleration was dose-dependent when the PRP fold (platelet count in PRP/platelet count in blood) was en masse anterior retraction decreased 71–77% of alveolar bone loss, and this was dose-dependent. The pressure side of en masse anterior retraction had no alveolar bone loss when the PRP fold was higher than 11.0. In conclusion, the optimal PRP fold for the best performance in acceleration of Orthodontic Tooth Movement and preservation of the pressure side alveolar bone is 11.0–12.5.
-
surgery first accelerated orthognathic surgery postoperative rapid Orthodontic Tooth Movement
Journal of Oral and Maxillofacial Surgery, 2011Co-Authors: Eric J.w. Liou, P K T Chen, Yuchih Wang, Chiungshing Huang, Yuray ChenAbstract:Purpose Clinically, we have observed the phenomenon of postoperatively accelerated Orthodontic Tooth Movement in patients who had orthognathic surgery. This phenomenon lasts for a period of 3 to 4 months. However, the underlying mechanisms of this phenomenon have not been well studied yet. The purpose of this prospective clinical pilot study was to study the postoperative changes in bone physiology and metabolism and the corresponding responses in the dentoalveolus, such as the changes in Tooth mobility. Materials and Methods Twenty-two consecutive adult patients who had 2-jaw orthognathic surgery were included in this study. The levels of serum alkaline phosphatase and C-terminal telopeptide of type I collagen (ICTP), as well as the Tooth mobility of the maxillary and mandibular incisors based on the Periotest method (Siemens AG, Bensheim, Germany), were examined preoperatively and 1 week, 1 month, 2 months, 3 months, and 4 months postoperatively. The data were analyzed statistically. Results Both Tooth mobility of the maxillary and mandibular incisors and ICTP significantly increased from 1 week to 3 months postoperatively and then decreased to their preoperative levels in the fourth month postoperatively. The changes in Tooth mobility were significantly in correspondence with the changes in ICTP. The alkaline phosphatase level significantly increased from the first to fourth month postoperatively, but it was not significantly correlated to the changes in Tooth mobility. Conclusion The orthognathic surgery triggers a 3- to 4-month period of higher osteoclastic activities and metabolic changes in the dentoalveolus postoperatively, which possibly accelerates postoperative Orthodontic Tooth Movement.
Wenli Lai - One of the best experts on this subject based on the ideXlab platform.
-
Effect of endomorphin-2 on orofacial pain induced by Orthodontic Tooth Movement in rats.
European journal of oral sciences, 2019Co-Authors: Sixin Liu, Lu Liu, Yanlu Jiang, Jing Zhou, Hu Long, Wenli LaiAbstract:Endomorphin-2 demonstrates potent antinociceptive effects in various pain models. The objectives of the present study were to explore the role of endomorphin-2 in the modulation of orofacial pain induced by Orthodontic Tooth Movement in rats. An Orthodontic pain model was established in male Sprague-Dawley rats by ligating coiled springs to mimic Orthodontic force (40 g). On days 0, 1, 3, 5, 7, and 14 following Orthodontic Tooth Movement, bite force was recorded as a surrogate measure of Orthodontic pain. Ipsilateral trigeminal ganglia, trigeminal nucleus caudalis, and periodontal tissues were harvested for immunostaining. Endomorphin-2, endomorphin-2 + naloxone (a non-selective opioid receptor antagonist), naloxone, and saline were injected into trigeminal ganglia and periodontal tissues to explore the role of endomorphin-2 on Orthodontic pain. The results showed that following Orthodontic Tooth Movement, endomorphin-2 expression levels in trigeminal ganglia were elevated on days 1, 3, 5, and 7. Orthodontic pain levels were increased on days 1, 3, and 5. The administration of endomorphin-2 into both trigeminal ganglia and periodontal tissues alleviated Orthodontic pain. Moreover, the effects of endomorphin-2 could be blocked by naloxone completely in trigeminal ganglia but only partially in periodontal tissues. Therefore, endomorphin-2 plays an important role in the modulation of Orthodontic pain both centrally and peripherally, probably through different pathways.
-
bite force measurements for objective evaluations of Orthodontic Tooth Movement induced pain in rats
Archives of Oral Biology, 2019Co-Authors: Hu Long, Yan Wang, Yang Zhou, Di Shan, Renhuan Huang, He Liu, Muyun Gao, Fan Jian, Wenli LaiAbstract:Abstract Objective To examine the reliability of bite force for evaluating Orthodontic Tooth Movement-induced pain in rats. Design Orthodontic Tooth Movement-induced pain was induced by mounting springs (40 g) between incisors and ipsilateral molars in male Sprague-Dawley rats. Five group sets of animals were used: for the first group set, 20 rats were randomly divided into a force group (n = 10) and a sham group (n = 10); for the second group set, 20 rats were divided into a 20-g group and a 80-g group; for the third group set, 20 rats were randomly divided into either a CFA group (complete freund’s adjuvant) (n = 10) receiving periodontal injections of CFA at baseline or a control group (n = 10) receiving periodontal injections of saline at baseline; for the forth group set, 24 rats were randomly divided into the following four groups: force + saline, control + saline, force + antiNGF and control + NGF (NGF: nerve growth factor). Rats in the fifth group set were used for immunostaining against CGRP. Bite force and bite frequency were measured at baseline (day 0) and following interventions (day 1, day 3, day 5, day 7 and day 14). Two-way ANOVA with repeated measures was used for statistical analysis and a p value less than 0.05 was considered statistical significance. Results Our results revealed that bite force was significantly smaller in the force group than in the sham group at all time points (p .05) and between the control + NGF group and the force + saline group (p = .58 > .05). Similar results were found for bite frequency.
-
interventions for accelerating Orthodontic Tooth Movement a systematic review
Angle Orthodontist, 2013Co-Authors: Hu Long, Yan Wang, Ujjwal Pyakurel, Lina Liao, Yang Zhou, Wenli LaiAbstract:Objective: To evaluate the effectiveness of interventions on accelerating Orthodontic Tooth Movement. Materials and Methods: We searched the databases of PubMed, Embase, Science Citation Index, CENTRAL, and SIGLE from January 1990 to August 2011 for randomized or quasirandomized controlled trials that assessed the effectiveness of interventions on accelerating Orthodontic Tooth Movement. The processes of study search, selection, and quality assessment were conducted independently in duplicate by two review authors. Original outcome data, if possible, underwent statistical pooling by using Review Manager 5. Results: Through a predefined search strategy, we finally included nine eligible studies. Among them, five interventions were studied (ie, low-level laser therapy, corticotomy, electrical current, pulsed electromagnetic fields, and dentoalveolar or periodontal distraction). Six outcomes were evaluated in these studies (ie, accumulative moved distance or Movement rate, time required to move Tooth to its destination, anchorage loss, periodontal health, pulp vitality, and root resorption). Conclusion: Among the five interventions, corticotomy is effective and safe to accelerate Orthodontic Tooth Movement, low-level laser therapy was unable to accelerate Orthodontic Tooth Movement, current evidence does not reveal whether electrical current and pulsed electromagnetic fields are effective in accelerating Orthodontic Tooth Movement, and dentoalveolar or periodontal distraction is promising in accelerating Orthodontic Tooth Movement but lacks convincing evidence. (Angle Orthod. 2013;83:164–171.)
Theodore Eliades - One of the best experts on this subject based on the ideXlab platform.
-
intrinsic hormone like molecules and external root resorption during Orthodontic Tooth Movement a systematic review and meta analysis in preclinical in vivo research
Frontiers in Physiology, 2018Co-Authors: Andreas Spoerri, Despina Koletsi, Theodore EliadesAbstract:Background: External root resorption constitutes an adverse effect of Orthodontic treatment. The aim of the present meta-analysis was to identify the effect of induced intrinsic/ hormone-like molecules such as prostaglandins, interleukins and others on external root resorption after Orthodontic Tooth Movement in experimental animals Methods: An electronic database search of the literature was performed (Medline via PubMed, EMBASE, LILACS, and Open Gray). Search terms included root resorption, Tooth Movement and animal type. Risk of bias assessment was made using the SYRCLE guidelines for animal studies and reporting quality was assessed through ARRIVE. Random effects meta-analysis was performed for the outcome root resorption after Orthodontic Tooth Movement. Results: Of the 124 articles initially retrieved, 13 were eligible for inclusion in the systematic review, while only 2 were included in the quantitative synthesis. Five studies investigated the effect of Prostaglandin E2, four studies the effect of Thyroxine, two the effect of Calcium ions (Ca++), while the rest investigated Misoprostol, Interleukin-12 and Interleukin-4. Risk of Bias in all studies was judged to be high overall, while reporting quality was suboptimal. According to the quantitative synthesis, there was no difference in root resorption after Orthodontic Tooth Movement when Prostaglandin E2 coupled with Ca++ was administered in comparison to no substance administration (SMD: 0.48 mm2; 95% CI: -0.22, 1.19; p = 0.18). Conclusions: Overall, there was no evidence to suggest a variation in root resorption when Prostaglandin E2 and Ca++ were administered, while there is an overriding need for further high quality experimental studies to inform available evidence on the effect of intrinsic substances on external root resorption.
Abbadi Elkadi - One of the best experts on this subject based on the ideXlab platform.
-
comparison between the effect of low level laser therapy and corticotomy facilitated Orthodontics on rankl release during Orthodontic Tooth Movement a randomized controlled trial
Lasers in Dental Science, 2019Co-Authors: Youssef Sedky, Waleed Refaat, Norbert Gutknecht, Abbadi ElkadiAbstract:Bone resorption is the cornerstone in bone remodeling affecting the rate of Orthodontic Tooth Movement. RANKL has a direct effect on osteoclastogenesis. The aim of this study is to evaluate and compare the effect of low-level laser therapy (LLLT) and corticotomy-facilitated Orthodontics (CFO) on RANKL release during Orthodontic Tooth Movement. Twenty patients requiring Orthodontic therapeutic extraction of the maxillary first premolar were randomly selected. A split-mouth study design was performed where corticotomy-facilitated Orthodontics was randomly assigned to one side at the canine region (CG) before retraction, Laser group (LG) was assigned to the contralateral side using 940 nm diode laser irradiations (100 mW, 2.5 J, 3.9 J/cm2) at days 1, 3, 8, and 15. Canine retraction was done using nickel-titanium closed-coil spring applying a force of 150 g per side. Gingival crevicular fluid (GCF) samples were collected from distal surface of the canines on both sides, 1 day before the intervention treatment (T0), day 3 after the intervention (T1), and day 15 (T2). RANKL concentration levels were assessed using enzyme-linked immunosorbent assay. There was statistically significant increase in RANKL concentration levels in both groups (CG and LG) from T0 to T1, there was no statistically significant difference in concentration level from T1 o T2, but there was a statistically significant difference in RANKL concentration levels between T0 and T2 in both groups. CG and LG showed no statistically significant difference in RANKL concentration levels between them in T1 and T2. Low-level laser therapy and corticotomy-facilitated Orthodontics can increase the RANKL release during Orthodontic Tooth Movement which directly affects bone remodeling and the rate of Orthodontic Tooth Movement.
Despina Koletsi - One of the best experts on this subject based on the ideXlab platform.
-
intrinsic hormone like molecules and external root resorption during Orthodontic Tooth Movement a systematic review and meta analysis in preclinical in vivo research
Frontiers in Physiology, 2018Co-Authors: Andreas Spoerri, Despina Koletsi, Theodore EliadesAbstract:Background: External root resorption constitutes an adverse effect of Orthodontic treatment. The aim of the present meta-analysis was to identify the effect of induced intrinsic/ hormone-like molecules such as prostaglandins, interleukins and others on external root resorption after Orthodontic Tooth Movement in experimental animals Methods: An electronic database search of the literature was performed (Medline via PubMed, EMBASE, LILACS, and Open Gray). Search terms included root resorption, Tooth Movement and animal type. Risk of bias assessment was made using the SYRCLE guidelines for animal studies and reporting quality was assessed through ARRIVE. Random effects meta-analysis was performed for the outcome root resorption after Orthodontic Tooth Movement. Results: Of the 124 articles initially retrieved, 13 were eligible for inclusion in the systematic review, while only 2 were included in the quantitative synthesis. Five studies investigated the effect of Prostaglandin E2, four studies the effect of Thyroxine, two the effect of Calcium ions (Ca++), while the rest investigated Misoprostol, Interleukin-12 and Interleukin-4. Risk of Bias in all studies was judged to be high overall, while reporting quality was suboptimal. According to the quantitative synthesis, there was no difference in root resorption after Orthodontic Tooth Movement when Prostaglandin E2 coupled with Ca++ was administered in comparison to no substance administration (SMD: 0.48 mm2; 95% CI: -0.22, 1.19; p = 0.18). Conclusions: Overall, there was no evidence to suggest a variation in root resorption when Prostaglandin E2 and Ca++ were administered, while there is an overriding need for further high quality experimental studies to inform available evidence on the effect of intrinsic substances on external root resorption.