The Experts below are selected from a list of 10176 Experts worldwide ranked by ideXlab platform
Thomas M. Halaszynski - One of the best experts on this subject based on the ideXlab platform.
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Complexities of Perioperative Pain Management in Orthopedic Trauma
Current Pain and Headache Reports, 2018Co-Authors: Daniel H Wiznia, Theodore Zaki, Michael P. Leslie, Thomas M. HalaszynskiAbstract:Purpose of ReviewThis review discusses both obvious and hidden barriers in Trauma patient access to pain management specialists and provides some suggestions focusing on outcome optimization in the perioperative period.Recent FindingsOrthopedic Trauma surgeons strive to provide patients the best possible perioperative pain management, while balancing against potential risks of opioid abuse and addiction. Surgeons often find they are ill-prepared to effectively manage postoperative pain in patients returning several months following Trauma surgery, many times still dependent on opioids for pain control. Some individuals from this Trauma patient population may also require the care of pain management specialists and/or consultation with drug addiction specialists. As the US opioid epidemic continues to worsen, Orthopedic Trauma surgeons can find it difficult to obtain access to pain management specialists for those patients requiring complex pain medication management and substance abuse counseling.SummaryThe current state of perioperative pain management for Orthopedic Trauma patients remains troubling due to reliance on only opioid analgesics, society-associated risks of opioid medication addiction, an “underground” prescription drug marketplace, and an uncertain legal atmosphere related to opioid pain medication management that can deter pain management physicians from accepting narcotic-addicted patients and discourage future physicians from pursuing advanced training in the specialty of pain management. Additionally, barriers continue to exist among Medicaid patients that deter this patient population from access to pain medicine subspecialty care, diminishing medication management reimbursement rates make it increasingly difficult for Trauma patients to receive proper opioid analgesic pain medication management, and a lack of proper opioid analgesic medication management training among PCPs and Orthopedic Trauma surgeons further contributes to an environment ill-prepared to provide effective perioperative pain management for Orthopedic Trauma patients.
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complexities of perioperative pain management in Orthopedic Trauma
Current Pain and Headache Reports, 2018Co-Authors: Daniel H Wiznia, Theodore Zaki, Michael P. Leslie, Thomas M. HalaszynskiAbstract:This review discusses both obvious and hidden barriers in Trauma patient access to pain management specialists and provides some suggestions focusing on outcome optimization in the perioperative period. Orthopedic Trauma surgeons strive to provide patients the best possible perioperative pain management, while balancing against potential risks of opioid abuse and addiction. Surgeons often find they are ill-prepared to effectively manage postoperative pain in patients returning several months following Trauma surgery, many times still dependent on opioids for pain control. Some individuals from this Trauma patient population may also require the care of pain management specialists and/or consultation with drug addiction specialists. As the US opioid epidemic continues to worsen, Orthopedic Trauma surgeons can find it difficult to obtain access to pain management specialists for those patients requiring complex pain medication management and substance abuse counseling. The current state of perioperative pain management for Orthopedic Trauma patients remains troubling due to reliance on only opioid analgesics, society-associated risks of opioid medication addiction, an “underground” prescription drug marketplace, and an uncertain legal atmosphere related to opioid pain medication management that can deter pain management physicians from accepting narcotic-addicted patients and discourage future physicians from pursuing advanced training in the specialty of pain management. Additionally, barriers continue to exist among Medicaid patients that deter this patient population from access to pain medicine subspecialty care, diminishing medication management reimbursement rates make it increasingly difficult for Trauma patients to receive proper opioid analgesic pain medication management, and a lack of proper opioid analgesic medication management training among PCPs and Orthopedic Trauma surgeons further contributes to an environment ill-prepared to provide effective perioperative pain management for Orthopedic Trauma patients.
Rocky S Tuan - One of the best experts on this subject based on the ideXlab platform.
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Clinical Applications of Bone Tissue Engineering in Orthopedic Trauma
Current Pathobiology Reports, 2018Co-Authors: Peter N. Mittwede, Riccardo Gottardi, Peter G Alexander, Ivan S Tarkin, Rocky S TuanAbstract:Purpose of Review Orthopedic Trauma is a major cause of morbidity and mortality worldwide. Although many fractures tend to heal if treated appropriately either by non-operative or operative methods, delayed or failed healing, as well as infections, can lead to devastating complications. Tissue engineering is an exciting, emerging field with much scientific and clinical relevance in potentially overcoming the current limitations in the treatment of Orthopedic injuries. Recent Findings While direct translation of bone tissue engineering technologies to clinical use remains challenging, considerable research has been done in studying how cells, scaffolds, and signals may be used to enhance acute fracture healing and to address the problematic scenarios of nonunion and critical-sized bone defects. Taken together, the research findings suggest that tissue engineering may be considered to stimulate angiogenesis and osteogenesis, to modulate the immune response to fractures, to improve the biocompatibility of implants, to prevent or combat infection, and to fill large gaps created by Traumatic bone loss. The abundance of preclinical data supports the high potential of bone tissue engineering for clinical application, although a number of barriers to translation must first be overcome. Summary This review focuses on the current and potential applications of bone tissue engineering approaches in Orthopedic Trauma with specific attention paid to acute fracture healing, nonunion, and critical-sized bone defects.
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clinical applications of bone tissue engineering in Orthopedic Trauma
Current Pathobiology Reports, 2018Co-Authors: Peter N. Mittwede, Riccardo Gottardi, Peter G Alexander, Ivan S Tarkin, Rocky S TuanAbstract:Orthopedic Trauma is a major cause of morbidity and mortality worldwide. Although many fractures tend to heal if treated appropriately either by non-operative or operative methods, delayed or failed healing, as well as infections, can lead to devastating complications. Tissue engineering is an exciting, emerging field with much scientific and clinical relevance in potentially overcoming the current limitations in the treatment of Orthopedic injuries. While direct translation of bone tissue engineering technologies to clinical use remains challenging, considerable research has been done in studying how cells, scaffolds, and signals may be used to enhance acute fracture healing and to address the problematic scenarios of nonunion and critical-sized bone defects. Taken together, the research findings suggest that tissue engineering may be considered to stimulate angiogenesis and osteogenesis, to modulate the immune response to fractures, to improve the biocompatibility of implants, to prevent or combat infection, and to fill large gaps created by Traumatic bone loss. The abundance of preclinical data supports the high potential of bone tissue engineering for clinical application, although a number of barriers to translation must first be overcome. This review focuses on the current and potential applications of bone tissue engineering approaches in Orthopedic Trauma with specific attention paid to acute fracture healing, nonunion, and critical-sized bone defects.
Daniel H Wiznia - One of the best experts on this subject based on the ideXlab platform.
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Complexities of Perioperative Pain Management in Orthopedic Trauma
Current Pain and Headache Reports, 2018Co-Authors: Daniel H Wiznia, Theodore Zaki, Michael P. Leslie, Thomas M. HalaszynskiAbstract:Purpose of ReviewThis review discusses both obvious and hidden barriers in Trauma patient access to pain management specialists and provides some suggestions focusing on outcome optimization in the perioperative period.Recent FindingsOrthopedic Trauma surgeons strive to provide patients the best possible perioperative pain management, while balancing against potential risks of opioid abuse and addiction. Surgeons often find they are ill-prepared to effectively manage postoperative pain in patients returning several months following Trauma surgery, many times still dependent on opioids for pain control. Some individuals from this Trauma patient population may also require the care of pain management specialists and/or consultation with drug addiction specialists. As the US opioid epidemic continues to worsen, Orthopedic Trauma surgeons can find it difficult to obtain access to pain management specialists for those patients requiring complex pain medication management and substance abuse counseling.SummaryThe current state of perioperative pain management for Orthopedic Trauma patients remains troubling due to reliance on only opioid analgesics, society-associated risks of opioid medication addiction, an “underground” prescription drug marketplace, and an uncertain legal atmosphere related to opioid pain medication management that can deter pain management physicians from accepting narcotic-addicted patients and discourage future physicians from pursuing advanced training in the specialty of pain management. Additionally, barriers continue to exist among Medicaid patients that deter this patient population from access to pain medicine subspecialty care, diminishing medication management reimbursement rates make it increasingly difficult for Trauma patients to receive proper opioid analgesic pain medication management, and a lack of proper opioid analgesic medication management training among PCPs and Orthopedic Trauma surgeons further contributes to an environment ill-prepared to provide effective perioperative pain management for Orthopedic Trauma patients.
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complexities of perioperative pain management in Orthopedic Trauma
Current Pain and Headache Reports, 2018Co-Authors: Daniel H Wiznia, Theodore Zaki, Michael P. Leslie, Thomas M. HalaszynskiAbstract:This review discusses both obvious and hidden barriers in Trauma patient access to pain management specialists and provides some suggestions focusing on outcome optimization in the perioperative period. Orthopedic Trauma surgeons strive to provide patients the best possible perioperative pain management, while balancing against potential risks of opioid abuse and addiction. Surgeons often find they are ill-prepared to effectively manage postoperative pain in patients returning several months following Trauma surgery, many times still dependent on opioids for pain control. Some individuals from this Trauma patient population may also require the care of pain management specialists and/or consultation with drug addiction specialists. As the US opioid epidemic continues to worsen, Orthopedic Trauma surgeons can find it difficult to obtain access to pain management specialists for those patients requiring complex pain medication management and substance abuse counseling. The current state of perioperative pain management for Orthopedic Trauma patients remains troubling due to reliance on only opioid analgesics, society-associated risks of opioid medication addiction, an “underground” prescription drug marketplace, and an uncertain legal atmosphere related to opioid pain medication management that can deter pain management physicians from accepting narcotic-addicted patients and discourage future physicians from pursuing advanced training in the specialty of pain management. Additionally, barriers continue to exist among Medicaid patients that deter this patient population from access to pain medicine subspecialty care, diminishing medication management reimbursement rates make it increasingly difficult for Trauma patients to receive proper opioid analgesic pain medication management, and a lack of proper opioid analgesic medication management training among PCPs and Orthopedic Trauma surgeons further contributes to an environment ill-prepared to provide effective perioperative pain management for Orthopedic Trauma patients.
Peter N. Mittwede - One of the best experts on this subject based on the ideXlab platform.
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Clinical Applications of Bone Tissue Engineering in Orthopedic Trauma
Current Pathobiology Reports, 2018Co-Authors: Peter N. Mittwede, Riccardo Gottardi, Peter G Alexander, Ivan S Tarkin, Rocky S TuanAbstract:Purpose of Review Orthopedic Trauma is a major cause of morbidity and mortality worldwide. Although many fractures tend to heal if treated appropriately either by non-operative or operative methods, delayed or failed healing, as well as infections, can lead to devastating complications. Tissue engineering is an exciting, emerging field with much scientific and clinical relevance in potentially overcoming the current limitations in the treatment of Orthopedic injuries. Recent Findings While direct translation of bone tissue engineering technologies to clinical use remains challenging, considerable research has been done in studying how cells, scaffolds, and signals may be used to enhance acute fracture healing and to address the problematic scenarios of nonunion and critical-sized bone defects. Taken together, the research findings suggest that tissue engineering may be considered to stimulate angiogenesis and osteogenesis, to modulate the immune response to fractures, to improve the biocompatibility of implants, to prevent or combat infection, and to fill large gaps created by Traumatic bone loss. The abundance of preclinical data supports the high potential of bone tissue engineering for clinical application, although a number of barriers to translation must first be overcome. Summary This review focuses on the current and potential applications of bone tissue engineering approaches in Orthopedic Trauma with specific attention paid to acute fracture healing, nonunion, and critical-sized bone defects.
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clinical applications of bone tissue engineering in Orthopedic Trauma
Current Pathobiology Reports, 2018Co-Authors: Peter N. Mittwede, Riccardo Gottardi, Peter G Alexander, Ivan S Tarkin, Rocky S TuanAbstract:Orthopedic Trauma is a major cause of morbidity and mortality worldwide. Although many fractures tend to heal if treated appropriately either by non-operative or operative methods, delayed or failed healing, as well as infections, can lead to devastating complications. Tissue engineering is an exciting, emerging field with much scientific and clinical relevance in potentially overcoming the current limitations in the treatment of Orthopedic injuries. While direct translation of bone tissue engineering technologies to clinical use remains challenging, considerable research has been done in studying how cells, scaffolds, and signals may be used to enhance acute fracture healing and to address the problematic scenarios of nonunion and critical-sized bone defects. Taken together, the research findings suggest that tissue engineering may be considered to stimulate angiogenesis and osteogenesis, to modulate the immune response to fractures, to improve the biocompatibility of implants, to prevent or combat infection, and to fill large gaps created by Traumatic bone loss. The abundance of preclinical data supports the high potential of bone tissue engineering for clinical application, although a number of barriers to translation must first be overcome. This review focuses on the current and potential applications of bone tissue engineering approaches in Orthopedic Trauma with specific attention paid to acute fracture healing, nonunion, and critical-sized bone defects.
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Orthopedic Trauma-induced pulmonary injury in the obese Zucker rat.
Microcirculation, 2010Co-Authors: Lusha Xiang, Robert L. Hester, William L. Fuller, Mohamad E. Sebai, Peter N. Mittwede, Elizabeth Jones, Arun Aneja, George V. RussellAbstract:Obese subjects with Orthopedic Trauma exhibit increased inflammation and an increased risk of pulmonary edema. Prostaglandin E(2) (PGE(2) ) production is elevated during inflammation and associated with increased vascular permeability. We hypothesize that pulmonary edema in obesity following Orthopedic Trauma is due to elevated PGE(2) and resultant increases in pulmonary permeability.Orthopedic Trauma was induced in both hindlimbs in lean (LZ) and obese Zucker rats (OZ). On the following day, plasma interleukin-6 (IL-6) and PGE(2) levels, pulmonary edema, and pulmonary gas exchange capability were compared between groups: LZ, OZ, LZ with Trauma (LZT), and OZ with Trauma (OZT). Vascular permeability in isolated lungs was measured in LZ and OZ before and after application of PGE(2) .As compared with the other groups, the OZT exhibited elevated plasma IL-6 and PGE(2) levels, increased lung wet/dry weight ratio and bronchoalveolar protein concentration, and an impaired pulmonary gas exchange. Indomethacin treatment normalized plasma PGE(2) levels and pulmonary edema. Basal pulmonary permeability in isolated lungs was higher in OZ than LZ, with a further increase in permeability following treatment with PGE(2) .These results suggest that pulmonary edema in OZ following Orthopedic Trauma is due to an elevated PGE(2) and resultant increases in pulmonary permeability.
Michael P. Leslie - One of the best experts on this subject based on the ideXlab platform.
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Complexities of Perioperative Pain Management in Orthopedic Trauma
Current Pain and Headache Reports, 2018Co-Authors: Daniel H Wiznia, Theodore Zaki, Michael P. Leslie, Thomas M. HalaszynskiAbstract:Purpose of ReviewThis review discusses both obvious and hidden barriers in Trauma patient access to pain management specialists and provides some suggestions focusing on outcome optimization in the perioperative period.Recent FindingsOrthopedic Trauma surgeons strive to provide patients the best possible perioperative pain management, while balancing against potential risks of opioid abuse and addiction. Surgeons often find they are ill-prepared to effectively manage postoperative pain in patients returning several months following Trauma surgery, many times still dependent on opioids for pain control. Some individuals from this Trauma patient population may also require the care of pain management specialists and/or consultation with drug addiction specialists. As the US opioid epidemic continues to worsen, Orthopedic Trauma surgeons can find it difficult to obtain access to pain management specialists for those patients requiring complex pain medication management and substance abuse counseling.SummaryThe current state of perioperative pain management for Orthopedic Trauma patients remains troubling due to reliance on only opioid analgesics, society-associated risks of opioid medication addiction, an “underground” prescription drug marketplace, and an uncertain legal atmosphere related to opioid pain medication management that can deter pain management physicians from accepting narcotic-addicted patients and discourage future physicians from pursuing advanced training in the specialty of pain management. Additionally, barriers continue to exist among Medicaid patients that deter this patient population from access to pain medicine subspecialty care, diminishing medication management reimbursement rates make it increasingly difficult for Trauma patients to receive proper opioid analgesic pain medication management, and a lack of proper opioid analgesic medication management training among PCPs and Orthopedic Trauma surgeons further contributes to an environment ill-prepared to provide effective perioperative pain management for Orthopedic Trauma patients.
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complexities of perioperative pain management in Orthopedic Trauma
Current Pain and Headache Reports, 2018Co-Authors: Daniel H Wiznia, Theodore Zaki, Michael P. Leslie, Thomas M. HalaszynskiAbstract:This review discusses both obvious and hidden barriers in Trauma patient access to pain management specialists and provides some suggestions focusing on outcome optimization in the perioperative period. Orthopedic Trauma surgeons strive to provide patients the best possible perioperative pain management, while balancing against potential risks of opioid abuse and addiction. Surgeons often find they are ill-prepared to effectively manage postoperative pain in patients returning several months following Trauma surgery, many times still dependent on opioids for pain control. Some individuals from this Trauma patient population may also require the care of pain management specialists and/or consultation with drug addiction specialists. As the US opioid epidemic continues to worsen, Orthopedic Trauma surgeons can find it difficult to obtain access to pain management specialists for those patients requiring complex pain medication management and substance abuse counseling. The current state of perioperative pain management for Orthopedic Trauma patients remains troubling due to reliance on only opioid analgesics, society-associated risks of opioid medication addiction, an “underground” prescription drug marketplace, and an uncertain legal atmosphere related to opioid pain medication management that can deter pain management physicians from accepting narcotic-addicted patients and discourage future physicians from pursuing advanced training in the specialty of pain management. Additionally, barriers continue to exist among Medicaid patients that deter this patient population from access to pain medicine subspecialty care, diminishing medication management reimbursement rates make it increasingly difficult for Trauma patients to receive proper opioid analgesic pain medication management, and a lack of proper opioid analgesic medication management training among PCPs and Orthopedic Trauma surgeons further contributes to an environment ill-prepared to provide effective perioperative pain management for Orthopedic Trauma patients.
