The Experts below are selected from a list of 402 Experts worldwide ranked by ideXlab platform

Paul E. Marik - One of the best experts on this subject based on the ideXlab platform.

Daniel Salerno - One of the best experts on this subject based on the ideXlab platform.

Bobbak Vahid - One of the best experts on this subject based on the ideXlab platform.

Anthony N Damato - One of the best experts on this subject based on the ideXlab platform.

  • The Osborn Wave of hypothermeia in normothermic patients
    Clinical cardiology, 1994
    Co-Authors: Archana Patel, John P. Getsos, Ghias Moussa, Anthony N Damato
    Abstract:

    The Osborn Wave (also referred to as "the J Wave," "the J deflection," or "the camel's hump") is a distinctive deflection occurring at the QRS-ST junction of approximately 80% of hypothermic patients (core body temperature < or = 95 degrees F). Generally, the amplitude and duration of Osborn Waves are inversely related to core temperature. We report on eight normothermic patients whose 12-lead electrocardiograms demonstrated QRS-ST junction notches similar to those seen in hypothermia. These data support the concept that the Osborn Wave is not pathognomonic of hypothermia.

Charles Antzelevitch - One of the best experts on this subject based on the ideXlab platform.

  • The J Wave Syndromes and Their Role in Sudden Cardiac Death
    Cardiac electrophysiology clinics, 2011
    Co-Authors: Dongqi Wang, Gan-xin Yan, Charles Antzelevitch
    Abstract:

    The electrocardiographic J Wave, also referred as the Osborn Wave, is a deflection with a dome or hump morphology at the junction between the QRS complex and the ST segment on the body surface ECG. Earlier studies attributed the J Wave to a variety of factors including hypoxia, injury current, acidosis, delayed ventricular depolarization, and early ventricular repolarization.1 Clinical and arrhythmogenic significance of the J Wave abnormalities had largely been ignored until 1996 when Yan and Antzelevitch published a study elucidating the ionic and cellular basis of the J Wave, indicating that a prominent Ito-mediated action potential notch in ventricular epicardium but not endocardium may produce a transmural voltage gradient during early ventricular repolarization that could register as a J Wave or J point elevation in the ECG.2 Growing evidence has since been advanced indicating that J Wave abnormalities, which are often accompanied by early repolarization and ST segment elevation on the ECG, are in some cases associated with a risk of sudden cardiac death. The J Wave syndromes, which represent a variable spectrum of phenotypic expression with accentuation of the J Wave, can be inherited or acquired.3–6 This review attempts to summarize current knowledge about J-Wave syndromes- linking bench work with the bedside.

  • Cellular Basis for the Electrocardiographic J Wave
    Circulation, 1996
    Co-Authors: Gan-xin Yan, Charles Antzelevitch
    Abstract:

    Background The J Wave is a deflection that appears in the ECG as a late delta Wave following the QRS or as a small secondary R Wave (R′). Also referred to as an Osborn Wave, the J Wave has been observed in the ECG of animals and humans for more than four decades, yet the mechanism underlying its manifestation is poorly understood. The present study investigates the cellular basis for the J Wave using an isolated arterially perfused preparation consisting of a wedge of canine right or left ventricle. Methods and Results A 12-lead ECG was initially recorded in vivo. After isolation and arterial perfusion of the right or left ventricular wedge, transmembrane action potentials were simultaneously recorded from epicardial, M region, and endocardial transmural sites with three floating microelectrodes. A transmural ECG was recorded concurrently. A J Wave was observed at the R-ST junction of the ECG in 17 of 20 adult dogs, usually in leads II, III, aVR, and aVF and the mid to lateral precordial leads. The J Wave...