The Experts below are selected from a list of 276 Experts worldwide ranked by ideXlab platform
Thomas O. Carpenter - One of the best experts on this subject based on the ideXlab platform.
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Rickets: The Skeletal Disorders of Impaired Calcium or Phosphate Availability
Pediatric Endocrinology, 2018Co-Authors: Erik A Imel, Thomas O. CarpenterAbstract:Rickets derives from the old English word “ wrikken ” meaning to twist or bend and refers to conditions of impaired mineralization of growing bones, ultimately resulting in their bowing and twisting. Rickets and osteomalacia refer to similar processes occurring in different compartments of the bone. Rickets is evident histologically and radiographically as a disorganized and expanded growth plate (physis) of the growing bone, together with the accompanying osteomalacia (accumulation of excess unmineralized Osteoid Matrix due to a delayed mineral apposition rate) of the trabecular and cortical bone. Children with untreated rickets may develop severe curvature deformities of the lower extremities, primarily due to the effect of weight bearing on an under-mineralized skeleton. This chapter will describe the pathophysiology and clinical diagnostic and treatment approach to rickets from a variety of calciopenic and phosphopenic causes.
M. Fadda - One of the best experts on this subject based on the ideXlab platform.
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Scanning electron microscopy of Osteoid osteoma
International Orthopaedics, 1994Co-Authors: M. Fadda, G. Zirattu, P. Laneri, E. SantisAbstract:Les auteurs ont examiné par microscopie électronique à balayage les composants organiques du nidus dans quatre cas d'ostéome ostéoïde. L'analyse des résultats montre des zones différentes en ce qui concerne l'organisation des ostéoblastes et des structures fibreuses de la matrice ostéoïde. Dans la zone centrale on note un plus haut degré d'immaturité tandis que dans la zone périlésionnelle le processus de différenciation est plus évident (ostéoblaste — préostéocyte — ostéocyte). We have exammed the organic components of the nidus of an Osteoid osteoma in 4 patients using scanning electron microscopy. Different organisation of the osteoblastic cells and of the fibrous structures of the Osteoid Matrix in different zones was demonstrated. These findings indicated a greater degree of immaturity in the centre, as compared with the peripheral area where the process of differentiation was more evident.
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Scanning electron microscopy of Osteoid osteoma.
International orthopaedics, 1994Co-Authors: M. Fadda, G. Zirattu, P. Laneri, E.p.l. De SantisAbstract:We have exammed the organic components of the nidus of an Osteoid osteoma in 4 patients using scanning electron microscopy. Different organisation of the osteoblastic cells and of the fibrous structures of the Osteoid Matrix in different zones was demonstrated. These findings indicated a greater degree of immaturity in the centre, as compared with the peripheral area where the process of differentiation was more evident.
Adriano Piattelli - One of the best experts on this subject based on the ideXlab platform.
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histologic and ultrastructural analysis of regenerated bone in maxillary sinus augmentation using a porcine bone derived biomaterial
Journal of Periodontology, 2006Co-Authors: Giovanna Orsini, Antonio Scarano, Maurizio Piattelli, Marcello Piccirilli, Sergio Caputi, Adriano PiattelliAbstract:Background: The purpose of the present study was the histologic and ultrastructural evaluation of a biomaterial composed of cortical pig bone in the form of granules.Methods: After maxillary sinus augmentation using this biomaterial, 10 specimens were retrieved after 5 months in 10 patients using this biomaterial. The specimens were processed to be observed under light microscopy (LM) and transmission electron microscopy (TEM). Histomorphometric measurements were presented by means ± standard deviations.Results: LM showed that most of the particles were surrounded by newly formed bone. In some areas, the Osteoid Matrix was present; however, mainly compact bone was present at the interface. There was no evidence of an acute inflammatory infiltrate. The newly formed bone was 36% ± 2.8% and marrow spaces were 38% ± 1.6%, whereas residual grafted material was 31% ± 1.6%. Under TEM, all phases of bone formation (Osteoid Matrix, woven, and lamellar bone) were observed in proximity with the biomaterial particles...
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Histologic and Ultrastructural Analysis of Regenerated Bone in Maxillary Sinus Augmentation Using a Porcine Bone–Derived Biomaterial
Journal of periodontology, 2006Co-Authors: Giovanna Orsini, Antonio Scarano, Maurizio Piattelli, Marcello Piccirilli, Sergio Caputi, Adriano PiattelliAbstract:Background: The purpose of the present study was the histologic and ultrastructural evaluation of a biomaterial composed of cortical pig bone in the form of granules.Methods: After maxillary sinus augmentation using this biomaterial, 10 specimens were retrieved after 5 months in 10 patients using this biomaterial. The specimens were processed to be observed under light microscopy (LM) and transmission electron microscopy (TEM). Histomorphometric measurements were presented by means ± standard deviations.Results: LM showed that most of the particles were surrounded by newly formed bone. In some areas, the Osteoid Matrix was present; however, mainly compact bone was present at the interface. There was no evidence of an acute inflammatory infiltrate. The newly formed bone was 36% ± 2.8% and marrow spaces were 38% ± 1.6%, whereas residual grafted material was 31% ± 1.6%. Under TEM, all phases of bone formation (Osteoid Matrix, woven, and lamellar bone) were observed in proximity with the biomaterial particles...
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Maxillary sinus augmentation using a synthetic cell-binding peptide: a histologic and transmission electron microscopy case study in man.
Implant dentistry, 2005Co-Authors: Marco Degidi, Giovanna Orsini, Antonio Scarano, Giovanna Iezzi, Vittoria Perrotti, Rita Strocchi, Adriano PiattelliAbstract:PepGen P-15 is a combination natural anorganic bovine-derived hydroxyapatite Matrix coupled with a synthetic cell-binding peptide (P-15). This material has improved bone formation in periodontal osseous defects and bone regenerative procedures. There were 3 specimens retrieved 18 months after a sinus lifting procedure using PepGen P-15. These specimens were treated to be observed under light microscopy and transmission electron microscopy. Light microscopy showed that most of the particles were surrounded by newly formed bone. In some areas, Osteoid Matrix was present. No acute inflammatory infiltrate was present. In transmission electron microscopy, all phases of bone formation (i.e., Osteoid Matrix, woven bone, and lamellar bone) were observed in the newly formed bone around the biomaterial particles. In some regions, this newly formed bone seemed to present interdigitations connecting to or entering into the particle surface. To our knowledge, this is the first report presenting data on transmission electron microscopy of PepGen P-15 used in a sinus augmentation procedure in man. Our results confirm previous reports on the clinical effectiveness of this material.
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Bone regeneration using Bioglass: an experimental study in rabbit tibia.
The Journal of oral implantology, 2000Co-Authors: Adriano Piattelli, Antonio Scarano, Maurizio Piattelli, Franco Coraggio, S. MatarassoAbstract:Abstract Bioglass (BG) has been shown recently to be osteoconductive and osteopromotive in different experimental and clinical conditions. The aim of the present study was to evaluate BG particles in bone defects in rabbit tibia. In control sites, bone was observed only in the peripheral areas of the defects, while in test sites, newly formed bone was found around all BG particles, even those located in the central portion of the defect. Osteoblasts were actively secreting Osteoid Matrix directly on the granules’ surface. BG seems to be a highly osteoconductive material.
E.p.l. De Santis - One of the best experts on this subject based on the ideXlab platform.
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Scanning electron microscopy of Osteoid osteoma.
International orthopaedics, 1994Co-Authors: M. Fadda, G. Zirattu, P. Laneri, E.p.l. De SantisAbstract:We have exammed the organic components of the nidus of an Osteoid osteoma in 4 patients using scanning electron microscopy. Different organisation of the osteoblastic cells and of the fibrous structures of the Osteoid Matrix in different zones was demonstrated. These findings indicated a greater degree of immaturity in the centre, as compared with the peripheral area where the process of differentiation was more evident.
Erik A Imel - One of the best experts on this subject based on the ideXlab platform.
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Rickets: The Skeletal Disorders of Impaired Calcium or Phosphate Availability
Pediatric Endocrinology, 2018Co-Authors: Erik A Imel, Thomas O. CarpenterAbstract:Rickets derives from the old English word “ wrikken ” meaning to twist or bend and refers to conditions of impaired mineralization of growing bones, ultimately resulting in their bowing and twisting. Rickets and osteomalacia refer to similar processes occurring in different compartments of the bone. Rickets is evident histologically and radiographically as a disorganized and expanded growth plate (physis) of the growing bone, together with the accompanying osteomalacia (accumulation of excess unmineralized Osteoid Matrix due to a delayed mineral apposition rate) of the trabecular and cortical bone. Children with untreated rickets may develop severe curvature deformities of the lower extremities, primarily due to the effect of weight bearing on an under-mineralized skeleton. This chapter will describe the pathophysiology and clinical diagnostic and treatment approach to rickets from a variety of calciopenic and phosphopenic causes.
