The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Zarni Win - One of the best experts on this subject based on the ideXlab platform.
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Osteoporosis Circumscripta on 68ga dotatate pet ct
Clinical Nuclear Medicine, 2019Co-Authors: Nemi Gandy, Katherine Ordidge, Mubarik Arshad, Zarni WinAbstract:AbstractIncidental findings on PET CT studies are common. The distribution of 68Ga-DOTATATE is dependent on cell surface expression of somatostatin receptors, which may be pathologic or physiologic. Osteoporosis Circumscripta is the early lytic phase of Paget disease associated with well-defined ost
Nemi Gandy - One of the best experts on this subject based on the ideXlab platform.
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Osteoporosis Circumscripta on 68ga dotatate pet ct
Clinical Nuclear Medicine, 2019Co-Authors: Nemi Gandy, Katherine Ordidge, Mubarik Arshad, Zarni WinAbstract:AbstractIncidental findings on PET CT studies are common. The distribution of 68Ga-DOTATATE is dependent on cell surface expression of somatostatin receptors, which may be pathologic or physiologic. Osteoporosis Circumscripta is the early lytic phase of Paget disease associated with well-defined ost
Katherine Ordidge - One of the best experts on this subject based on the ideXlab platform.
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Osteoporosis Circumscripta on 68ga dotatate pet ct
Clinical Nuclear Medicine, 2019Co-Authors: Nemi Gandy, Katherine Ordidge, Mubarik Arshad, Zarni WinAbstract:AbstractIncidental findings on PET CT studies are common. The distribution of 68Ga-DOTATATE is dependent on cell surface expression of somatostatin receptors, which may be pathologic or physiologic. Osteoporosis Circumscripta is the early lytic phase of Paget disease associated with well-defined ost
Mubarik Arshad - One of the best experts on this subject based on the ideXlab platform.
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Osteoporosis Circumscripta on 68ga dotatate pet ct
Clinical Nuclear Medicine, 2019Co-Authors: Nemi Gandy, Katherine Ordidge, Mubarik Arshad, Zarni WinAbstract:AbstractIncidental findings on PET CT studies are common. The distribution of 68Ga-DOTATATE is dependent on cell surface expression of somatostatin receptors, which may be pathologic or physiologic. Osteoporosis Circumscripta is the early lytic phase of Paget disease associated with well-defined ost
Francis H Gannon - One of the best experts on this subject based on the ideXlab platform.
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from the archives of the afip radiologic spectrum of paget disease of bone and its complications with pathologic correlation
Radiographics, 2002Co-Authors: Stacy E Smith, Michael E Mulligan, Kambiz Motamedi, Charles S Resnik, Mark D Murphey, Francis H GannonAbstract:Paget disease of bone is a common disorder affecting approximately 3%-4% of the population over 40 years of age. The pathologic abnormality in Paget disease is excessive and abnormal remodeling of bone. Three pathologic phases have been described: the lytic phase (incipient-active), in which osteoclasts predominate; the mixed phase (active), in which osteoblasts cause repair superimposed on the resorption; and the blastic phase (late-inactive) in which osteoblasts predominate. Radiographic appearance of Paget disease reflects these pathologic changes and is often characteristic. Initially, there is osteolysis, particularly affecting the skull (Osteoporosis Circumscripta) and subchondral long bones, with subsequent development of trabecular and cortical thickening and enlargement of bone in the mixed phase of the disease. Finally, areas of sclerosis may develop in the blastic phase. Frequent sites of involvement include the skull (25%-65% of cases), spine (30%-75%), pelvis (30%-75%), and proximal long bones (25%-30%). Bone scintigraphy typically demonstrates marked increased uptake of radionuclide in all phases of Paget disease. Computed tomography and magnetic resonance imaging often show changes similar to those seen radiographically in noncomplicated Paget disease with maintenance of yellow marrow. Complications of Paget disease include the effects of osseous weakening (deformity and fracture), arthritis, neurologic symptoms, and neoplastic involvement. Sarcomatous transformation is the most feared complication, occurring in approximately 1% of cases, and is seen on images as focal bone destruction extending through the cortex with an associated soft-tissue mass. Recognition of the radiologic spectrum of the appearances of Paget disease usually allows prospective diagnosis and differentiation of its associated complications, which helps guide therapy and improve patient management.
