The Experts below are selected from a list of 168 Experts worldwide ranked by ideXlab platform
Ronald J. Sigal - One of the best experts on this subject based on the ideXlab platform.
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Exercise Training and Reproductive Outcomes in Women with Polycystic Ovary Syndrome: A Pilot Randomized Controlled Trial.
Clinical endocrinology, 2021Co-Authors: Jamie L. Benham, Jane E. Booth, Bernard Corenblum, Steve Doucette, Christine M. Friedenreich, Doreen M. Rabi, Ronald J. SigalAbstract:OBJECTIVE Exercise is recommended for polycystic ovary syndrome (PCOS), but the most effective exercise prescription is unclear. This trial compared effects of high-intensity interval training (HIIT), continuous aerobic exercise training (CAET), and no-exercise control on reproductive, anthropometric and cardiometabolic outcomes in PCOS. DESIGN Pilot randomized controlled trial. PARTICIPANTS Previously-inactive women aged 18-40 years with PCOS. MEASUREMENTS Feasibility outcomes included recruitment, retention, adherence to exercise and daily Ovulation Prediction kit (OPK) testing. Preliminary efficacy outcomes included reproductive, anthropometric and cardiometabolic health markers. RESULTS 47 women were randomized to no-exercise control (n=17), HIIT (n=16), or CAET (n=14). Forty (85%) participants completed the trial. Median exercise adherence was 68% (IQR 53%, 86%). Median daily OPK-testing adherence in the first half of the intervention was 87% (IQR 61%, 97%) compared with 65% (IQR 0%, 96%) in the second half. Body mass index decreased significantly in CAET compared with control (-1.0 kg/m2 , p=0.01) and HIIT (-0.9 kg/m2 , p=0.04). Mean waist circumference decreased in all groups (-7.3 cm, -6.9 cm, -4.5 cm in HIIT, CAET and control) with no significant between-group differences. Mean LDL-C was significantly reduced for HIIT compared to CAET (-0.33 mmol/L, p=0.03). HDL-C increased in HIIT compared with control (0.18 mmol/L, p=0.04). CONCLUSIONS There were feasibility challenges with adherence daily Ovulation assessment limiting the ability to analyze the effect of the exercise interventions on Ovulation. CAET and HIIT were both effective at improving anthropometrics and some cardiometabolic health markers. Further studies need to determine optimal and acceptable exercise prescriptions for this population.
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MON-042 The Effect of Exercise Training on Reproductive and Cardiometabolic Outcomes in Women with Polycystic Ovary Syndrome: A Pilot Randomized Controlled Trial
Journal of the Endocrine Society, 2020Co-Authors: Jamie L. Benham, Jane E. Booth, Steve Doucette, Christine M. Friedenreich, Doreen M. Rabi, Ronald J. SigalAbstract:Abstract Exercise may improve cardiometabolic, reproductive and psychological outcomes in women with Polycystic Ovary Syndrome (PCOS). Clinical Practice Guidelines recommend exercise to treat PCOS, but the most effective exercise prescription is unclear. The aim of this randomized controlled trial was to evaluate the effects of six months of thrice weekly high-intensity interval training (HIIT) and continuous aerobic exercise training (CAET) programs compared with no exercise in previously-inactive women aged 18–40 years with PCOS. The primary outcome was change in Ovulation rate. Ovulation was assessed with daily at home Ovulation Prediction kits, and confirmed with serum progesterone levels. Fisher’s exact test was used to compare groups. Secondary outcomes included change in BMI, waist circumference, blood pressure, A1C, fasting glucose, fasting insulin, and lipids and were analyzed using repeated measures mixed models. 47 women were randomly assigned to no exercise control (n=17), HIIT (n=16), or CAET (n=14). 22/33 (66.7%) women ovulated during the intervention period: no exercise: 8/12 (66.7%), HIIT: 8/11 (72.7%), and CAET: 6/10 (60%); NS between groups. BMI decreased significantly in the CAET group compared with control (-1 kg/m2, p=0.01) and compared with HIIT (-0.9 kg/m2, p=0.04). Mean waist circumference decreased significantly in all groups with no significant difference between groups. There were no significant within- or between- group changes for body weight. No within- or between group differences were identified for mean blood pressure, A1C, fasting glucose, fasting insulin, or triglycerides. Mean LDL-C was significantly different between the HIIT and CAET groups (-0.33 mmol/L, p=0.03), as LDL-C decreased in the HIIT group but not in the CAET group. HDL-C increased in the HIIT group compared with the no exercise group (0.18 mmol/L, p=0.04), with no significant difference between the CAET and no exercise groups (p=0.47). In conclusion, CAET and HIIT interventions in women with PCOS did not affect Ovulation rates. CAET and HIIT both were effective at improving anthropometrics and some cardiometabolic health markers in women with PCOS. Further studies are needed to determine optimal exercise prescriptions for reproductive, anthropometric and cardiometabolic outcomes in women with PCOS.
M. Gaur - One of the best experts on this subject based on the ideXlab platform.
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86 ultrasonographic evaluation of preovulatory follicle and endometrial echo texture for Ovulation Prediction in marwari mares
Reproduction Fertility and Development, 2021Co-Authors: D. Yadav, D. Jhamb, S. S. Nirwan, M. GaurAbstract:The objective of the present study was to evaluate the application of ultrasonographic changes in the preovulatory follicle and uterus for Ovulation Prediction in Marwari mares. Mares (n = 20) were teased daily by a teaser pony and, from the day of first detected oestrus, the ovaries and uterus were examined by transrectal ultrasonography using Exago ECM ultrasound equipped with linear rectal probe (10 MHz) until Ovulation. Recorded data were analysed by one-way ANOVA and correlation coefficients. The duration of the oestrus period ranged from 5 to 7 days in all mares, with an average of 6.35 ± 0.13 days, consistent with rectal findings. The last day of oestrus was marked by disappearance of the preovulatory follicle and presence of a corpus haemorrhagicum. The mean diameter of the follicles increased significantly (P < 0.01) from Day 1 to Day 7, and the diameter of follicles before Ovulation was 44.88 ± 0.46 mm; follicles changed from round to oval or irregular before Ovulation. In 65% (13/20) of the mares, Ovulation occurred on the left ovary. The daily mean growth rate of size of ovulating follicles from the first day of oestrus until Ovulation was 3.51 ± 0.42 mm/d. The mean average growth rate of follicles was significantly different (P ≤ 0.01) on different days of oestrus. The mean endometrial echo texture score was 1.30 ± 0.10 on Day 1, 2.10 ± 0.16 on Day 2, 3.20 ± 0.15 on Day 3, and highest 3.85 ± 0.08 on Day 4, declining thereafter to reach a score of 1.36 ± 0.11 on Day 7 of the oestrous cycle. The mean slope values of pixel intensity for the granulosa and anechoic layers of the preovulatory follicles determined by Image-Pro software (Media Cybernetics) from Days −3 to −1 was 13.8 ± 0.7 on Day −3, 15.7 ± 0.9 on Day −2, and 20.1 ± 1.3 on Day −1. None of the follicles ovulated before granulosa layer echogenicity reached a score of ≥2.5 and prominence of anechoic layer reached a score of ≥2. Significant positive correlations were found between the cross-sectional diameter of the uterine horn and estrual endometrial echotexture score (P < 0.01; r = 0.95), estrual endometrial echo texture score and preovulatory follicle diameter (P < 0.01; r = 0.25), and preovulatory follicle diameter and cross-sectional diameter of uterine horn (P < 0.01; r = 0.36) during the oestrous cycle. We conclude that various ultrasonographic characteristics of preovulatory follicle and uterus can be used to predict Ovulation in Marwari mares.
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86 Ultrasonographic evaluation of preovulatory follicle and endometrial echo texture for Ovulation Prediction in Marwari mares
Reproduction Fertility and Development, 2021Co-Authors: D. Yadav, D. Jhamb, S. S. Nirwan, M. GaurAbstract:The objective of the present study was to evaluate the application of ultrasonographic changes in the preovulatory follicle and uterus for Ovulation Prediction in Marwari mares. Mares (n = 20) were teased daily by a teaser pony and, from the day of first detected oestrus, the ovaries and uterus were examined by transrectal ultrasonography using Exago ECM ultrasound equipped with linear rectal probe (10 MHz) until Ovulation. Recorded data were analysed by one-way ANOVA and correlation coefficients. The duration of the oestrus period ranged from 5 to 7 days in all mares, with an average of 6.35 ± 0.13 days, consistent with rectal findings. The last day of oestrus was marked by disappearance of the preovulatory follicle and presence of a corpus haemorrhagicum. The mean diameter of the follicles increased significantly (P
Jamie L. Benham - One of the best experts on this subject based on the ideXlab platform.
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Exercise Training and Reproductive Outcomes in Women with Polycystic Ovary Syndrome: A Pilot Randomized Controlled Trial.
Clinical endocrinology, 2021Co-Authors: Jamie L. Benham, Jane E. Booth, Bernard Corenblum, Steve Doucette, Christine M. Friedenreich, Doreen M. Rabi, Ronald J. SigalAbstract:OBJECTIVE Exercise is recommended for polycystic ovary syndrome (PCOS), but the most effective exercise prescription is unclear. This trial compared effects of high-intensity interval training (HIIT), continuous aerobic exercise training (CAET), and no-exercise control on reproductive, anthropometric and cardiometabolic outcomes in PCOS. DESIGN Pilot randomized controlled trial. PARTICIPANTS Previously-inactive women aged 18-40 years with PCOS. MEASUREMENTS Feasibility outcomes included recruitment, retention, adherence to exercise and daily Ovulation Prediction kit (OPK) testing. Preliminary efficacy outcomes included reproductive, anthropometric and cardiometabolic health markers. RESULTS 47 women were randomized to no-exercise control (n=17), HIIT (n=16), or CAET (n=14). Forty (85%) participants completed the trial. Median exercise adherence was 68% (IQR 53%, 86%). Median daily OPK-testing adherence in the first half of the intervention was 87% (IQR 61%, 97%) compared with 65% (IQR 0%, 96%) in the second half. Body mass index decreased significantly in CAET compared with control (-1.0 kg/m2 , p=0.01) and HIIT (-0.9 kg/m2 , p=0.04). Mean waist circumference decreased in all groups (-7.3 cm, -6.9 cm, -4.5 cm in HIIT, CAET and control) with no significant between-group differences. Mean LDL-C was significantly reduced for HIIT compared to CAET (-0.33 mmol/L, p=0.03). HDL-C increased in HIIT compared with control (0.18 mmol/L, p=0.04). CONCLUSIONS There were feasibility challenges with adherence daily Ovulation assessment limiting the ability to analyze the effect of the exercise interventions on Ovulation. CAET and HIIT were both effective at improving anthropometrics and some cardiometabolic health markers. Further studies need to determine optimal and acceptable exercise prescriptions for this population.
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MON-042 The Effect of Exercise Training on Reproductive and Cardiometabolic Outcomes in Women with Polycystic Ovary Syndrome: A Pilot Randomized Controlled Trial
Journal of the Endocrine Society, 2020Co-Authors: Jamie L. Benham, Jane E. Booth, Steve Doucette, Christine M. Friedenreich, Doreen M. Rabi, Ronald J. SigalAbstract:Abstract Exercise may improve cardiometabolic, reproductive and psychological outcomes in women with Polycystic Ovary Syndrome (PCOS). Clinical Practice Guidelines recommend exercise to treat PCOS, but the most effective exercise prescription is unclear. The aim of this randomized controlled trial was to evaluate the effects of six months of thrice weekly high-intensity interval training (HIIT) and continuous aerobic exercise training (CAET) programs compared with no exercise in previously-inactive women aged 18–40 years with PCOS. The primary outcome was change in Ovulation rate. Ovulation was assessed with daily at home Ovulation Prediction kits, and confirmed with serum progesterone levels. Fisher’s exact test was used to compare groups. Secondary outcomes included change in BMI, waist circumference, blood pressure, A1C, fasting glucose, fasting insulin, and lipids and were analyzed using repeated measures mixed models. 47 women were randomly assigned to no exercise control (n=17), HIIT (n=16), or CAET (n=14). 22/33 (66.7%) women ovulated during the intervention period: no exercise: 8/12 (66.7%), HIIT: 8/11 (72.7%), and CAET: 6/10 (60%); NS between groups. BMI decreased significantly in the CAET group compared with control (-1 kg/m2, p=0.01) and compared with HIIT (-0.9 kg/m2, p=0.04). Mean waist circumference decreased significantly in all groups with no significant difference between groups. There were no significant within- or between- group changes for body weight. No within- or between group differences were identified for mean blood pressure, A1C, fasting glucose, fasting insulin, or triglycerides. Mean LDL-C was significantly different between the HIIT and CAET groups (-0.33 mmol/L, p=0.03), as LDL-C decreased in the HIIT group but not in the CAET group. HDL-C increased in the HIIT group compared with the no exercise group (0.18 mmol/L, p=0.04), with no significant difference between the CAET and no exercise groups (p=0.47). In conclusion, CAET and HIIT interventions in women with PCOS did not affect Ovulation rates. CAET and HIIT both were effective at improving anthropometrics and some cardiometabolic health markers in women with PCOS. Further studies are needed to determine optimal exercise prescriptions for reproductive, anthropometric and cardiometabolic outcomes in women with PCOS.
D. Yadav - One of the best experts on this subject based on the ideXlab platform.
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86 ultrasonographic evaluation of preovulatory follicle and endometrial echo texture for Ovulation Prediction in marwari mares
Reproduction Fertility and Development, 2021Co-Authors: D. Yadav, D. Jhamb, S. S. Nirwan, M. GaurAbstract:The objective of the present study was to evaluate the application of ultrasonographic changes in the preovulatory follicle and uterus for Ovulation Prediction in Marwari mares. Mares (n = 20) were teased daily by a teaser pony and, from the day of first detected oestrus, the ovaries and uterus were examined by transrectal ultrasonography using Exago ECM ultrasound equipped with linear rectal probe (10 MHz) until Ovulation. Recorded data were analysed by one-way ANOVA and correlation coefficients. The duration of the oestrus period ranged from 5 to 7 days in all mares, with an average of 6.35 ± 0.13 days, consistent with rectal findings. The last day of oestrus was marked by disappearance of the preovulatory follicle and presence of a corpus haemorrhagicum. The mean diameter of the follicles increased significantly (P < 0.01) from Day 1 to Day 7, and the diameter of follicles before Ovulation was 44.88 ± 0.46 mm; follicles changed from round to oval or irregular before Ovulation. In 65% (13/20) of the mares, Ovulation occurred on the left ovary. The daily mean growth rate of size of ovulating follicles from the first day of oestrus until Ovulation was 3.51 ± 0.42 mm/d. The mean average growth rate of follicles was significantly different (P ≤ 0.01) on different days of oestrus. The mean endometrial echo texture score was 1.30 ± 0.10 on Day 1, 2.10 ± 0.16 on Day 2, 3.20 ± 0.15 on Day 3, and highest 3.85 ± 0.08 on Day 4, declining thereafter to reach a score of 1.36 ± 0.11 on Day 7 of the oestrous cycle. The mean slope values of pixel intensity for the granulosa and anechoic layers of the preovulatory follicles determined by Image-Pro software (Media Cybernetics) from Days −3 to −1 was 13.8 ± 0.7 on Day −3, 15.7 ± 0.9 on Day −2, and 20.1 ± 1.3 on Day −1. None of the follicles ovulated before granulosa layer echogenicity reached a score of ≥2.5 and prominence of anechoic layer reached a score of ≥2. Significant positive correlations were found between the cross-sectional diameter of the uterine horn and estrual endometrial echotexture score (P < 0.01; r = 0.95), estrual endometrial echo texture score and preovulatory follicle diameter (P < 0.01; r = 0.25), and preovulatory follicle diameter and cross-sectional diameter of uterine horn (P < 0.01; r = 0.36) during the oestrous cycle. We conclude that various ultrasonographic characteristics of preovulatory follicle and uterus can be used to predict Ovulation in Marwari mares.
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86 Ultrasonographic evaluation of preovulatory follicle and endometrial echo texture for Ovulation Prediction in Marwari mares
Reproduction Fertility and Development, 2021Co-Authors: D. Yadav, D. Jhamb, S. S. Nirwan, M. GaurAbstract:The objective of the present study was to evaluate the application of ultrasonographic changes in the preovulatory follicle and uterus for Ovulation Prediction in Marwari mares. Mares (n = 20) were teased daily by a teaser pony and, from the day of first detected oestrus, the ovaries and uterus were examined by transrectal ultrasonography using Exago ECM ultrasound equipped with linear rectal probe (10 MHz) until Ovulation. Recorded data were analysed by one-way ANOVA and correlation coefficients. The duration of the oestrus period ranged from 5 to 7 days in all mares, with an average of 6.35 ± 0.13 days, consistent with rectal findings. The last day of oestrus was marked by disappearance of the preovulatory follicle and presence of a corpus haemorrhagicum. The mean diameter of the follicles increased significantly (P
Camille Hawkins - One of the best experts on this subject based on the ideXlab platform.
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“When Am I Fertile?”: A Pilot Study Comparing Ovulation Prediction Accuracy of Apps and LH Kits
Journal of Student Research, 2021Co-Authors: Molly Enenbach, Cassandra Haworth, Camille Hawkins, Matthias KochmannAbstract:Prediction of peak fertility is critical yet challenging in both planning and preventing pregnancy. Period tracking applications for the smartphone are ubiquitous, free of charge, and user friendly with many providing Ovulation estimates. The objective of this study was to analyze the period tracking applications (apps)’ ability to accurately predict fertility windows and Ovulation. Three medical students tracked their menstrual cycle over four months in seven commercially available menstrual period tracking applications. Six of the apps were analyzed for fertility window, Ovulation Prediction, and usability. Two home Ovulation kits were utilized to confirm Ovulation. The sensitivity to predict the fertility window ranged from 35% to 94% (p<0.05) while sensitivity to predict Ovulation ranged from 0% to 31% (p>0.05). Four of the apps allowed for menstrual cycle lengths greater than 35 day and offered an adjustable algorithm. Apps had increased sensitivity due to an expanded fertility window with increased number of predicted fertile days, but a low Ovulation sensitivity and an inability to predict the day of Ovulation. Additionally, apps allowed for additional personal information to be added with some apps sharing this data with a third party, raising the question of data protection for users. Solely using period tracking apps is not the gold standard for contraception or conception. The use of these apps in conjunction with luteinizing hormone home kits for detection of physiologic Ovulation provides an accurate tool that allows a woman to take charge of her reproductive health.
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when am i fertile a pilot study comparing Ovulation Prediction accuracy of menstrual tracking apps versus lh home Ovulation kits
Pediatrics, 2021Co-Authors: Molly Enenbach, Cassandra Haworth, Matthias Kochmann, Camille HawkinsAbstract:Background: Prediction of peak fertility is critical yet challenging in preventing pregnancy(1). Period tracking applications for the smartphone are ubiquitous, free of charge, and user friendly with many providing Ovulation estimates. The objective of this study is to analyze the period tracking apps’ ability to predict fertility windows and Ovulation. Methods: Three medical students tracked their menstrual cycle over …
