The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
E N Mokhova - One of the best experts on this subject based on the ideXlab platform.
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Oxidative Phosphorylation Uncoupling by fatty acids in liver and muscle mitochondria
Biochemistry, 1993Co-Authors: E N Mokhova, Anatoly A Starkov, V A BobylevaAbstract:Pathways and mechanisms of Oxidative Phosphorylation Uncoupling by long-chain fatty acids in liver and muscle mitochondria are considered. A conclusion is drawn that there exist at least three different pathways of Uncoupling by fatty acids, namely: (i) a Ca(2+)-dependent cyclosporin A-sensitive pathway; (ii) Uncoupling which is inhibited by carboxyatractylate or other inhibitors of the ADP/ATP-antiporter, (iii) Uncoupling due to the low protonophoric activity of fatty acids.
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participation of the atp adp antiporter and fatty acids in Oxidative Phosphorylation Uncoupling in squirrel liver mitochondria during winter hibernation and awakening
Biochemistry, 1991Co-Authors: N N Brustovetskiĭ, E N Mokhova, Z G Amerkhanov, M V Egorova, V P SkulachevAbstract:The parameters of energy coupling of mitochondria isolated from the livers of hibernating and awakening gophers were studied. The ATP/ADP-antiporter inhibitor carboxyatractylate slowed down the respiration rate, increased delta psi and decreased the ionic conductivity of the inner mitochondrial membrane as measured by the rate of the delta psi decline after addition of cyanide (in the presence of oligomycin and EGTA). A similar effect was produced by BSA, carboxyatractylate being fairly ineffective in the presence of BSA. In hibernating gophers the maximal rate of the uncoupled respiration and the ionic conductivity of the inner mitochondrial membrane were markedly decreased as compared with awakening gophers. The data obtained suggest that in awakening animals fatty acids induce the Uncoupling of Oxidative Phosphorylation by the ATP/ADP-antiporter, this process being simultaneous with the activation of the respiratory chain.
V A Bobyleva - One of the best experts on this subject based on the ideXlab platform.
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Oxidative Phosphorylation Uncoupling by fatty acids in liver and muscle mitochondria
Biochemistry, 1993Co-Authors: E N Mokhova, Anatoly A Starkov, V A BobylevaAbstract:Pathways and mechanisms of Oxidative Phosphorylation Uncoupling by long-chain fatty acids in liver and muscle mitochondria are considered. A conclusion is drawn that there exist at least three different pathways of Uncoupling by fatty acids, namely: (i) a Ca(2+)-dependent cyclosporin A-sensitive pathway; (ii) Uncoupling which is inhibited by carboxyatractylate or other inhibitors of the ADP/ATP-antiporter, (iii) Uncoupling due to the low protonophoric activity of fatty acids.
Anatoly A Starkov - One of the best experts on this subject based on the ideXlab platform.
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Oxidative Phosphorylation Uncoupling by fatty acids in liver and muscle mitochondria
Biochemistry, 1993Co-Authors: E N Mokhova, Anatoly A Starkov, V A BobylevaAbstract:Pathways and mechanisms of Oxidative Phosphorylation Uncoupling by long-chain fatty acids in liver and muscle mitochondria are considered. A conclusion is drawn that there exist at least three different pathways of Uncoupling by fatty acids, namely: (i) a Ca(2+)-dependent cyclosporin A-sensitive pathway; (ii) Uncoupling which is inhibited by carboxyatractylate or other inhibitors of the ADP/ATP-antiporter, (iii) Uncoupling due to the low protonophoric activity of fatty acids.
V P Skulachev - One of the best experts on this subject based on the ideXlab platform.
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participation of the atp adp antiporter and fatty acids in Oxidative Phosphorylation Uncoupling in squirrel liver mitochondria during winter hibernation and awakening
Biochemistry, 1991Co-Authors: N N Brustovetskiĭ, E N Mokhova, Z G Amerkhanov, M V Egorova, V P SkulachevAbstract:The parameters of energy coupling of mitochondria isolated from the livers of hibernating and awakening gophers were studied. The ATP/ADP-antiporter inhibitor carboxyatractylate slowed down the respiration rate, increased delta psi and decreased the ionic conductivity of the inner mitochondrial membrane as measured by the rate of the delta psi decline after addition of cyanide (in the presence of oligomycin and EGTA). A similar effect was produced by BSA, carboxyatractylate being fairly ineffective in the presence of BSA. In hibernating gophers the maximal rate of the uncoupled respiration and the ionic conductivity of the inner mitochondrial membrane were markedly decreased as compared with awakening gophers. The data obtained suggest that in awakening animals fatty acids induce the Uncoupling of Oxidative Phosphorylation by the ATP/ADP-antiporter, this process being simultaneous with the activation of the respiratory chain.
A V Kolesnichenko - One of the best experts on this subject based on the ideXlab platform.
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the importance of Oxidative Phosphorylation Uncoupling systems function for surviving of winter wheat seedling shoots during short term cold stress
Journal of Stress Physiology & Biochemistry, 2005Co-Authors: V V Tourchaninova, O I Grabelnych, T P Pobezhimova, A M Korzun, V K Voinikov, V V Kolesnichenko, A V KolesnichenkoAbstract:The influence of Uncoupling of Oxidative Phosphorylation in mitochondria on surviving of winter wheat seedling during low-temperature stress was investigated. It was shown that infiltration of winter wheat seedling by exogenous uncouplers caused the increase of oxygen consumption, seedling's temperature and surviving. Vice verse inhibition of electron transport through the main cytochrome and alternative pathways decreased surviving of winter wheat seedlings during cold stress..
