The Experts below are selected from a list of 54489 Experts worldwide ranked by ideXlab platform
Jason D. Sacks - One of the best experts on this subject based on the ideXlab platform.
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Evaluating potential response-modifying factors for associations between Ozone and health outcomes: a weight-of-evidence approach.
Environmental health perspectives, 2014Co-Authors: Lisa Vinikoor-imler, Elizabeth Oesterling Owens, Jennifer L. Nichols, Mary Ross, James S. Brown, Jason D. SacksAbstract:Background: Epidemiologic and experimental studies have reported a variety of health effects in response to Ozone (O3) exposure, and some have indicated that certain populations may be at increased...
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The Effect of Ambient Air Pollution on Sperm Quality
Environmental health perspectives, 2010Co-Authors: Craig Hansen, Thomas J. Luben, Jason D. Sacks, Andrew F. Olshan, Susan C. Jeffay, Lillian F. Strader, Sally D. PerreaultAbstract:BackgroundResearch has suggested an association with ambient air pollution and sperm quality.ObjectivesWe investigated the effect of exposure to Ozone (O3) and particulate matter < 2.5 μm in aerody...
Stephanie A Shore - One of the best experts on this subject based on the ideXlab platform.
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diet induced obesity causes innate airway hyperresponsiveness to methacholine and enhances Ozone induced pulmonary inflammation
Journal of Applied Physiology, 2008Co-Authors: Richard A Johnston, Todd A Theman, Raya D Terry, Erin S Williams, Stephanie A ShoreAbstract:We previously reported that genetically obese mice exhibit innate airway hyperresponsiveness (AHR) and enhanced Ozone (O3)-induced pulmonary inflammation. Such genetic deficiencies in mice are rare...
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increased pulmonary responses to acute Ozone exposure in obese db db mice
American Journal of Physiology-lung Cellular and Molecular Physiology, 2006Co-Authors: Richard A Johnston, Todd A Theman, Raya D Terry, Frank Leigh Lu, Lesley Flynt, Igor N Schwartzman, Stephanie A ShoreAbstract:Epidemiological studies indicate the incidence of asthma is increased in obese and overweight humans. Responses to Ozone (O3), an asthma trigger, are increased in obese (ob/ob) mice lacking the sat...
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augmented responses to Ozone in obese carboxypeptidase e deficient mice
American Journal of Physiology-regulatory Integrative and Comparative Physiology, 2006Co-Authors: Richard A Johnston, Todd A Theman, Stephanie A ShoreAbstract:We reported previously that mice obese as a result of leptin deficiency (ob/ob) have enhanced Ozone (O3)-induced airway hyperresponsiveness (AHR) and inflammation compared with wild-type (C57BL/6) ...
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cxcr2 is essential for maximal neutrophil recruitment and methacholine responsiveness after Ozone exposure
American Journal of Physiology-lung Cellular and Molecular Physiology, 2005Co-Authors: Richard A Johnston, Joseph P Mizgerd, Stephanie A ShoreAbstract:Ozone (O3), a common air pollutant, induces airway inflammation and airway hyperresponsiveness. In mice, the neutrophil chemokines KC and macrophage inflammatory protein-2 (MIP-2) are expressed in ...
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Responses to Ozone are increased in obese mice
Journal of applied physiology (Bethesda Md. : 1985), 2003Co-Authors: Stephanie A Shore, Igor N Schwartzman, Yadira Rivera-sanchez, Richard A JohnstonAbstract:Epidemiological data indicate an increased incidence of asthma in overweight adults and children. Ozone (O3) is a common trigger for asthma. Accordingly, the purpose of this study was to compare O3...
Agustin Ciapponi - One of the best experts on this subject based on the ideXlab platform.
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short term exposure to particulate matter pm10 and pm2 5 nitrogen dioxide no2 and Ozone O3 and all cause and cause specific mortality systematic review and meta analysis
Environment International, 2020Co-Authors: Pablo Wenceslao Orellano, Julieta Itati Reynoso, Nancy Esther Quaranta, Ariel Bardach, Agustin CiapponiAbstract:Abstract Background Air pollution is a leading cause of mortality and morbidity worldwide. Short-term exposure (from one hour to days) to selected air pollutants has been associated with human mortality. This systematic review was conducted to analyse the evidence on the effects of short-term exposure to particulate matter with aerodynamic diameters less or equal than 10 and 2.5 µm (PM10, PM2.5), nitrogen dioxide (NO2), and Ozone (O3), on all-cause mortality, and PM10 and PM2.5 on cardiovascular, respiratory, and cerebrovascular mortality. Methods We included studies on human populations exposed to outdoor air pollution from any source, excluding occupational exposures. Relative risks (RRs) per 10 µg/m3 increase in air pollutants concentrations were used as the effect estimates. Heterogeneity between studies was assessed using 80% prediction intervals. Risk of bias (RoB) in individual studies was analysed using a new domain-based assessment tool, developed by a working group convened by the World Health Organization and designed specifically to evaluate RoB within eligible air pollution studies included in systematic reviews. We conducted subgroup and sensitivity analyses by age, sex, continent, study design, single or multicity studies, time lag, and RoB. The certainty of evidence was assessed for each exposure-outcome combination. The protocol for this review was registered with PROSPERO (CRD42018087749). Results We included 196 articles in quantitative analysis. All combinations of pollutants and all-cause and cause-specific mortality were positively associated in the main analysis, and in a wide range of sensitivity analyses. The only exception was NO2, but when considering a 1-hour maximum exposure. We found positive associations between pollutants and all-cause mortality for PM10 (RR: 1.0041; 95% CI: 1.0034–1.0049), PM2.5 (RR: 1.0065; 95% CI: 1.0044–1.0086), NO2 (24-hour average) (RR: 1.0072; 95% CI: 1.0059–1.0085), and O3 (RR: 1.0043; 95% CI: 1.0034–1.0052). PM10 and PM2.5 were also positively associated with cardiovascular, respiratory, and cerebrovascular mortality. We found some degree of heterogeneity between studies in three exposure-outcome combinations, and this heterogeneity could not be explained after subgroup analysis. RoB was low or moderate in the majority of articles. The certainty of evidence was judged as high in 10 out of 11 combinations, and moderate in one combination. Conclusions This study found evidence of a positive association between short-term exposure to PM10, PM2.5, NO2, and O3 and all-cause mortality, and between PM10 and PM2.5 and cardiovascular, respiratory and cerebrovascular mortality. These results were robust through several sensitivity analyses. In general, the level of evidence was high, meaning that we can be confident in the associations found in this study.
Mehrdad Arjomandi - One of the best experts on this subject based on the ideXlab platform.
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do ambient Ozone or other pollutants modify effects of controlled Ozone exposure on pulmonary function
Annals of the American Thoracic Society, 2020Co-Authors: David Q Rich, Sally W Thurston, John R Balmes, Philip A Bromberg, Mehrdad Arjomandi, Milan J Hazucha, Neil E Alexis, Peter Ganz, Wojciech Zareba, Kelly ThevenetmorrisonAbstract:Rationale: In a previous trial (MOSES [Multicenter Ozone Study of oldEr Subjects]), 3 hours of controlled Ozone (O3) exposure caused concentration-related reductions in lung function with evidence ...
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Effects of chronic and acute Ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults.
Environmental health perspectives, 2007Co-Authors: Connie Chen, John R Balmes, Mehrdad Arjomandi, Ira B. Tager, Nina HollandAbstract:BackgroundThere is growing evidence for the role of oxidative damage in chronic diseases. Although Ozone (O3) is an oxidant pollutant to which many people are exposed, few studies have examined whe...
John R Balmes - One of the best experts on this subject based on the ideXlab platform.
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do ambient Ozone or other pollutants modify effects of controlled Ozone exposure on pulmonary function
Annals of the American Thoracic Society, 2020Co-Authors: David Q Rich, Sally W Thurston, John R Balmes, Philip A Bromberg, Mehrdad Arjomandi, Milan J Hazucha, Neil E Alexis, Peter Ganz, Wojciech Zareba, Kelly ThevenetmorrisonAbstract:Rationale: In a previous trial (MOSES [Multicenter Ozone Study of oldEr Subjects]), 3 hours of controlled Ozone (O3) exposure caused concentration-related reductions in lung function with evidence ...
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Effects of chronic and acute Ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults.
Environmental health perspectives, 2007Co-Authors: Connie Chen, John R Balmes, Mehrdad Arjomandi, Ira B. Tager, Nina HollandAbstract:BackgroundThere is growing evidence for the role of oxidative damage in chronic diseases. Although Ozone (O3) is an oxidant pollutant to which many people are exposed, few studies have examined whe...
