The Experts below are selected from a list of 23364 Experts worldwide ranked by ideXlab platform
William Maixner - One of the best experts on this subject based on the ideXlab platform.
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genetic architecture of human Pain Perception
Trends in Genetics, 2007Co-Authors: Luda Diatchenko, Andrea G Nackley, Inna E Tchivileva, Svetlana A Shabalina, William MaixnerAbstract:Pain is emotionally detrimental and consciously avoided; however, it is absolutely crucial for our survival. Pain Perception is one of the most complicated measurable traits because it is an aggregate of several phenotypes associated with peripheral and central nervous system dynamics, stress responsiveness and inflammatory state. As a complex trait, it is expected to have a polygenic nature shaped by environmental pressures. Here we discuss what is known about these contributing genetic variants, including recent discoveries that show a crucial role of voltage-gated sodium channel Nav1.7 in Pain Perception and how we can advance our understanding of the Pain genetic network. We propose how both rare deleterious genetic variants and common genetic polymorphisms are mediators of human Pain Perception and clinical Pain phenotypes.
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Race and Sex Differences in Cutaneous Pain Perception
Psychosomatic Medicine July/August 2000, 2000Co-Authors: David Sheffield, P. L. Biles, Heather Orom, William Maixner, David S. ShepsAbstract:Objective: The purpose of this study was to determine race and sex differences in cutaneous Pain Perception., Methods: Pain Perception was measured using a suprathreshold evaluation of Pain intensity and Pain unpleasantness to a series of thermal stimuli in 27 whites (14 men and 13 women) and 24 African Americans (12 men and 12 women). Blood pressure, depressive symptoms, anxiety state levels, and negative mood were assessed before Pain testing to examine whether they might account for any sex or race differences in Pain Perception that emerged., Results: African Americans rated the stimuli as more unpleasant and showed a tendency to rate it as more intense than whites. Women showed a tendency to rate the stimuli as more unpleasant and more intense than men. In addition, systolic blood pressure was inversely related to Pain intensity. After statistically adjusting for systolic blood pressure, sex differences in Pain unpleasantness were reduced and sex differences in Pain intensity were abolished; race differences were unaltered., Conclusions: These differences in Pain Perception may be associated with different Pain mechanisms: in the case of sex, differences in opioid activity and baroreceptor-regulated Pain systems; in the case of race, unmeasured psychological characteristics are suggested by the larger differences in ratings of Pain unpleasantness than Pain intensity., Copyright (C) 2000 by American Psychosomatic Society
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race and sex differences in cutaneous Pain Perception
Psychosomatic Medicine, 2000Co-Authors: David Sheffield, P. L. Biles, Heather Orom, William Maixner, David S. ShepsAbstract:Objective: The purpose of this study was to determine race and sex differences in cutaneous Pain Perception. Methods: Pain Perception was measured using a suprathreshold evaluation of Pain intensity and Pain unpleasantness to a series of thermal stimuli in 27 whites (14 men and 13 women) and 24 African Americans (12 men and 12 women). Blood pressure, depressive symptoms, anxiety state levels, and negative mood were assessed before Pain testing to examine whether they might account for any sex or race differences in Pain Perception that emerged. Results: African Americans rated the stimuli as more unpleasant and showed a tendency to rate it as more intense than whites. Women showed a tendency to rate the stimuli as more unpleasant and more intense than men. In addition, systolic blood pressure was inversely related to Pain intensity. After statistically adjusting for systolic blood pressure, sex differences in Pain unpleasantness were reduced and sex differences in Pain intensity were abolished; race differences were unaltered. Conclusions: These differences in Pain Perception may be associated with different Pain mechanisms: in the case of sex, differences in opioid activity and baroreceptor-regulated Pain systems; in the case of race, unmeasured psychological characteristics are suggested by the larger differences in ratings of Pain unpleasantness than Pain intensity.
Adrian S Dobs - One of the best experts on this subject based on the ideXlab platform.
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sex based differences in Pain Perception and treatment
Pain Medicine, 2009Co-Authors: Channing J Paller, C Campbell, Robert R Edwards, Adrian S DobsAbstract:Objective—This review highlights research on sex-based differences in Pain Perception and treatment. We sought to illuminate the complex factors contributing to differences in Pain and analgesic responses between males and females, ranging from psychosocial to biological processes. Design—We reviewed published studies of Pain induction by chemical, electric, heat, surgical, or psychological means, and opioid and nonopioid analgesia comparing responses in men and women. Results—A substantial body of research indicates that women experience greater clinical Pain, suffer greater Pain-related distress, and show heightened sensitivity to experimentally induced Pain compared with men. Research on sex-based differences in the Pain experience and treatment is beginning to uncover patterns that may enable tailoring of Pain treatment to individual characteristics. The factors underpinning sex differences in the experience of Pain are multifactorial and complex; for example, psychosocial factors such as Pain-related catastrophizing may explain sex-based differences in reporting certain types of Pain, as women tend to use catastrophizing to a greater degree. Gonadal hormone levels in cycling women also have a substantial impact on Pain Perception and analgesic response. Women perceive more Pain during the luteal phase, and estrogen antagonists provide long-term Pain relief in certain situations. Conclusions—Collectively, greater understanding of the factors that commonly and differentially affect the disparity in Pain Perception, as well as analgesic response, are beginning to illuminate research targets and promising areas of therapeutic intervention for improved Pain management.
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Sex‐Based Differences in Pain Perception and Treatment
Pain Medicine, 2009Co-Authors: Channing J Paller, Robert R Edwards, Claudia M. Campbell, Adrian S DobsAbstract:Objective—This review highlights research on sex-based differences in Pain Perception and treatment. We sought to illuminate the complex factors contributing to differences in Pain and analgesic responses between males and females, ranging from psychosocial to biological processes. Design—We reviewed published studies of Pain induction by chemical, electric, heat, surgical, or psychological means, and opioid and nonopioid analgesia comparing responses in men and women. Results—A substantial body of research indicates that women experience greater clinical Pain, suffer greater Pain-related distress, and show heightened sensitivity to experimentally induced Pain compared with men. Research on sex-based differences in the Pain experience and treatment is beginning to uncover patterns that may enable tailoring of Pain treatment to individual characteristics. The factors underpinning sex differences in the experience of Pain are multifactorial and complex; for example, psychosocial factors such as Pain-related catastrophizing may explain sex-based differences in reporting certain types of Pain, as women tend to use catastrophizing to a greater degree. Gonadal hormone levels in cycling women also have a substantial impact on Pain Perception and analgesic response. Women perceive more Pain during the luteal phase, and estrogen antagonists provide long-term Pain relief in certain situations. Conclusions—Collectively, greater understanding of the factors that commonly and differentially affect the disparity in Pain Perception, as well as analgesic response, are beginning to illuminate research targets and promising areas of therapeutic intervention for improved Pain management.
David S. Sheps - One of the best experts on this subject based on the ideXlab platform.
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Race and Sex Differences in Cutaneous Pain Perception
Psychosomatic Medicine July/August 2000, 2000Co-Authors: David Sheffield, P. L. Biles, Heather Orom, William Maixner, David S. ShepsAbstract:Objective: The purpose of this study was to determine race and sex differences in cutaneous Pain Perception., Methods: Pain Perception was measured using a suprathreshold evaluation of Pain intensity and Pain unpleasantness to a series of thermal stimuli in 27 whites (14 men and 13 women) and 24 African Americans (12 men and 12 women). Blood pressure, depressive symptoms, anxiety state levels, and negative mood were assessed before Pain testing to examine whether they might account for any sex or race differences in Pain Perception that emerged., Results: African Americans rated the stimuli as more unpleasant and showed a tendency to rate it as more intense than whites. Women showed a tendency to rate the stimuli as more unpleasant and more intense than men. In addition, systolic blood pressure was inversely related to Pain intensity. After statistically adjusting for systolic blood pressure, sex differences in Pain unpleasantness were reduced and sex differences in Pain intensity were abolished; race differences were unaltered., Conclusions: These differences in Pain Perception may be associated with different Pain mechanisms: in the case of sex, differences in opioid activity and baroreceptor-regulated Pain systems; in the case of race, unmeasured psychological characteristics are suggested by the larger differences in ratings of Pain unpleasantness than Pain intensity., Copyright (C) 2000 by American Psychosomatic Society
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race and sex differences in cutaneous Pain Perception
Psychosomatic Medicine, 2000Co-Authors: David Sheffield, P. L. Biles, Heather Orom, William Maixner, David S. ShepsAbstract:Objective: The purpose of this study was to determine race and sex differences in cutaneous Pain Perception. Methods: Pain Perception was measured using a suprathreshold evaluation of Pain intensity and Pain unpleasantness to a series of thermal stimuli in 27 whites (14 men and 13 women) and 24 African Americans (12 men and 12 women). Blood pressure, depressive symptoms, anxiety state levels, and negative mood were assessed before Pain testing to examine whether they might account for any sex or race differences in Pain Perception that emerged. Results: African Americans rated the stimuli as more unpleasant and showed a tendency to rate it as more intense than whites. Women showed a tendency to rate the stimuli as more unpleasant and more intense than men. In addition, systolic blood pressure was inversely related to Pain intensity. After statistically adjusting for systolic blood pressure, sex differences in Pain unpleasantness were reduced and sex differences in Pain intensity were abolished; race differences were unaltered. Conclusions: These differences in Pain Perception may be associated with different Pain mechanisms: in the case of sex, differences in opioid activity and baroreceptor-regulated Pain systems; in the case of race, unmeasured psychological characteristics are suggested by the larger differences in ratings of Pain unpleasantness than Pain intensity.
Channing J Paller - One of the best experts on this subject based on the ideXlab platform.
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sex based differences in Pain Perception and treatment
Pain Medicine, 2009Co-Authors: Channing J Paller, C Campbell, Robert R Edwards, Adrian S DobsAbstract:Objective—This review highlights research on sex-based differences in Pain Perception and treatment. We sought to illuminate the complex factors contributing to differences in Pain and analgesic responses between males and females, ranging from psychosocial to biological processes. Design—We reviewed published studies of Pain induction by chemical, electric, heat, surgical, or psychological means, and opioid and nonopioid analgesia comparing responses in men and women. Results—A substantial body of research indicates that women experience greater clinical Pain, suffer greater Pain-related distress, and show heightened sensitivity to experimentally induced Pain compared with men. Research on sex-based differences in the Pain experience and treatment is beginning to uncover patterns that may enable tailoring of Pain treatment to individual characteristics. The factors underpinning sex differences in the experience of Pain are multifactorial and complex; for example, psychosocial factors such as Pain-related catastrophizing may explain sex-based differences in reporting certain types of Pain, as women tend to use catastrophizing to a greater degree. Gonadal hormone levels in cycling women also have a substantial impact on Pain Perception and analgesic response. Women perceive more Pain during the luteal phase, and estrogen antagonists provide long-term Pain relief in certain situations. Conclusions—Collectively, greater understanding of the factors that commonly and differentially affect the disparity in Pain Perception, as well as analgesic response, are beginning to illuminate research targets and promising areas of therapeutic intervention for improved Pain management.
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Sex‐Based Differences in Pain Perception and Treatment
Pain Medicine, 2009Co-Authors: Channing J Paller, Robert R Edwards, Claudia M. Campbell, Adrian S DobsAbstract:Objective—This review highlights research on sex-based differences in Pain Perception and treatment. We sought to illuminate the complex factors contributing to differences in Pain and analgesic responses between males and females, ranging from psychosocial to biological processes. Design—We reviewed published studies of Pain induction by chemical, electric, heat, surgical, or psychological means, and opioid and nonopioid analgesia comparing responses in men and women. Results—A substantial body of research indicates that women experience greater clinical Pain, suffer greater Pain-related distress, and show heightened sensitivity to experimentally induced Pain compared with men. Research on sex-based differences in the Pain experience and treatment is beginning to uncover patterns that may enable tailoring of Pain treatment to individual characteristics. The factors underpinning sex differences in the experience of Pain are multifactorial and complex; for example, psychosocial factors such as Pain-related catastrophizing may explain sex-based differences in reporting certain types of Pain, as women tend to use catastrophizing to a greater degree. Gonadal hormone levels in cycling women also have a substantial impact on Pain Perception and analgesic response. Women perceive more Pain during the luteal phase, and estrogen antagonists provide long-term Pain relief in certain situations. Conclusions—Collectively, greater understanding of the factors that commonly and differentially affect the disparity in Pain Perception, as well as analgesic response, are beginning to illuminate research targets and promising areas of therapeutic intervention for improved Pain management.
David Sheffield - One of the best experts on this subject based on the ideXlab platform.
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Race and Sex Differences in Cutaneous Pain Perception
Psychosomatic Medicine July/August 2000, 2000Co-Authors: David Sheffield, P. L. Biles, Heather Orom, William Maixner, David S. ShepsAbstract:Objective: The purpose of this study was to determine race and sex differences in cutaneous Pain Perception., Methods: Pain Perception was measured using a suprathreshold evaluation of Pain intensity and Pain unpleasantness to a series of thermal stimuli in 27 whites (14 men and 13 women) and 24 African Americans (12 men and 12 women). Blood pressure, depressive symptoms, anxiety state levels, and negative mood were assessed before Pain testing to examine whether they might account for any sex or race differences in Pain Perception that emerged., Results: African Americans rated the stimuli as more unpleasant and showed a tendency to rate it as more intense than whites. Women showed a tendency to rate the stimuli as more unpleasant and more intense than men. In addition, systolic blood pressure was inversely related to Pain intensity. After statistically adjusting for systolic blood pressure, sex differences in Pain unpleasantness were reduced and sex differences in Pain intensity were abolished; race differences were unaltered., Conclusions: These differences in Pain Perception may be associated with different Pain mechanisms: in the case of sex, differences in opioid activity and baroreceptor-regulated Pain systems; in the case of race, unmeasured psychological characteristics are suggested by the larger differences in ratings of Pain unpleasantness than Pain intensity., Copyright (C) 2000 by American Psychosomatic Society
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race and sex differences in cutaneous Pain Perception
Psychosomatic Medicine, 2000Co-Authors: David Sheffield, P. L. Biles, Heather Orom, William Maixner, David S. ShepsAbstract:Objective: The purpose of this study was to determine race and sex differences in cutaneous Pain Perception. Methods: Pain Perception was measured using a suprathreshold evaluation of Pain intensity and Pain unpleasantness to a series of thermal stimuli in 27 whites (14 men and 13 women) and 24 African Americans (12 men and 12 women). Blood pressure, depressive symptoms, anxiety state levels, and negative mood were assessed before Pain testing to examine whether they might account for any sex or race differences in Pain Perception that emerged. Results: African Americans rated the stimuli as more unpleasant and showed a tendency to rate it as more intense than whites. Women showed a tendency to rate the stimuli as more unpleasant and more intense than men. In addition, systolic blood pressure was inversely related to Pain intensity. After statistically adjusting for systolic blood pressure, sex differences in Pain unpleasantness were reduced and sex differences in Pain intensity were abolished; race differences were unaltered. Conclusions: These differences in Pain Perception may be associated with different Pain mechanisms: in the case of sex, differences in opioid activity and baroreceptor-regulated Pain systems; in the case of race, unmeasured psychological characteristics are suggested by the larger differences in ratings of Pain unpleasantness than Pain intensity.
