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Tommy Olsson - One of the best experts on this subject based on the ideXlab platform.

Julia Otten - One of the best experts on this subject based on the ideXlab platform.

Mats Ryberg - One of the best experts on this subject based on the ideXlab platform.

Terry L Wahls - One of the best experts on this subject based on the ideXlab platform.

  • a modified mct based ketogenic Diet increases plasma β hydroxybutyrate but has less effect on fatigue and quality of life in people with multiple sclerosis compared to a modified Paleolithic Diet a waitlist controlled randomized pilot study
    Journal of The American College of Nutrition, 2021
    Co-Authors: Babita Bisht, Tyler J Titcomb, Jennifer E Lee, Linda M Rubenstein, Rebecca Louison, Terry L Wahls
    Abstract:

    Objective: To investigate the feasibility of a modified MCT-based ketogenic Diet and its impact on plasma β-hydroxybutyrate and MS outcomes compared to a modified Paleolithic Diet and usual Diet in...

  • eating pattern and nutritional risks among people with multiple sclerosis following a modified Paleolithic Diet
    Nutrients, 2020
    Co-Authors: Tyler J Titcomb, Linda Snetselaar, Babita Bisht, David D Moore, Yashpal S Chhonker, Daryl J Murry, Terry L Wahls
    Abstract:

    Preliminary studies suggest that a modified Paleolithic Diet may benefit symptoms of fatigue in progressive multiple sclerosis (MS). However, this Diet restricts the consumption of eggs, dairy, and gluten-containing grains, which may increase the risk of micronutrient deficiencies. Therefore, we evaluated the nutritional safety of this Diet among people with progressive MS. Three nonconsecutive 24-h Dietary recalls were collected from (n = 19) progressive MS participants in the final months of a Diet intervention study and analyzed using Nutrition Data System for Research (NDSR) software. Food group intake was calculated, and intake of micronutrients was evaluated and compared to individual recommendations using Nutrient Adequacy Ratios (NARs). Blood was drawn at baseline and the end of the study to evaluate biomarker changes. Mean intake of fruits and vegetables exceeded nine servings/day and most participants excluded food groups. The intake of all micronutrients from food were above 100% NAR except for vitamin D (29.6 ± 34.6%), choline (73.2 ± 27.2%), and calcium (60.3 ± 22.8%), and one participant (1/19) exceeded the Tolerable Upper Limit (UL) for zinc, one (1/19) for vitamin A, and 37% (7/19) exceeded the chronic disease risk reduction (CDRR) for sodium. When intake from supplements was included in the analysis, several individuals exceeded ULs for magnesium (5/19), zinc (2/19), sodium (7/19), and vitamins A (2/19), D (9/19), C (1/19), B6 (3/19), and niacin (10/19). Serum values of vitamins D, B12, K1, K2, and folate significantly increased compared to respective baseline values, while homocysteine and magnesium values were significantly lower at 12 months. Calcium and vitamin A serum levels did not change. This modified Paleolithic Diet is associated with minimal nutritional risks. However, excessive intake from supplements may be of concern.

  • Degenerative Neurological and Neuromuscular Disease Dovepress Multimodal intervention improves fatigue and quality of life in subjects with progressive multiple sclerosis: a pilot study
    2020
    Co-Authors: Babita Bisht, Warren G Darling, Torage E Shivapour, Susan K Lutgendorf, Terry L Wahls
    Abstract:

    Background: Fatigue is a disabling symptom of multiple sclerosis (MS) and reduces quality of life. The aim of this study was to investigate the effects of a multimodal intervention, including a modified Paleolithic Diet, nutritional supplements, stretching, strengthening exercises with electrical stimulation of trunk and lower limb muscles, and stress management on perceived fatigue and quality of life of persons with progressive MS. Methods: Twenty subjects with progressive MS and average Expanded Disability Status Scale (EDSS) score of 6.2 (range: 3.5-8.0) participated in the 12-month phase of the study. Assessments were completed at baseline and at 3 months, 6 months, 9 months, and 12 months. Safety analyses were based on monthly side effects questionnaires and blood analyses at 1 month, 3 months, 6 months, 9 months, and 12 months. Results: Subjects showed good adherence (assessed from subjects' daily logs) with this intervention and did not report any serious side effects. Fatigue Severity Scale (FSS) and Performance Scales-fatigue subscale scores decreased in 12 months (P,0.0005). Average FSS scores of eleven subjects showed clinically significant reduction (more than two points, high response) at 3 months, and this improvement was sustained until 12 months. Remaining subjects (n=9, low responders) either showed inconsistent or less than one point decrease in average FSS scores in the 12 months. Energy and general health scores of RAND 36-item Health Survey (Short Form-36) increased during the study (P,0.05). Decrease in FSS scores during the 12 months was associated with shorter disease duration (r=0.511, P=0.011), and lower baseline Patient Determined Disease Steps score (r s =0.563, P=0.005) and EDSS scores (r s =0.501, P=0.012). Compared to low responders, high responders had lower level of physical disability (P,0.05) and lower intake of gluten, dairy products, and eggs (P=0.036) at baseline. High responders undertook longer duration of massage and stretches per muscle (P,0.05) in 12 months. Conclusion: A multimodal intervention may reduce fatigue and improve quality of life of subjects with progressive MS. Larger randomized controlled trials with blinded raters are needed to prove efficacy of this intervention on MS-related fatigue

  • nutrient composition comparison between a modified Paleolithic Diet for multiple sclerosis and the recommended healthy u s style eating pattern
    Nutrients, 2019
    Co-Authors: Catherine A. Chenard, Linda Snetselaar, Linda M Rubenstein, Terry L Wahls
    Abstract:

    Multiple sclerosis (MS) is a demyelinating disease that attacks the central nervous system. Evidence-based Dietary guidelines do not exist for MS; the default advice is to follow the Dietary Guidelines for Americans (DGA). A modified Paleolithic Wahls Elimination (WahlsElim) Diet promoted for MS excludes grains and dairy and encourages 9+ cups fruits and vegetables (F/V) and saturated fat for cooking. This study evaluated the nutritional adequacy of seven-day menus and modeled them with varying amounts of F/V for comparison with the DGA Healthy US-Style Eating Pattern (HEP) for ages 31–50 years. WahlsElim menus had low added sugar and glycemic index. Nutritional adequacy of the menus and modeled versions were similar to HEP for 17 vitamins and minerals (mean adequacy ratio ≥92%). Nutrient shortfalls for the modeled Diet with 60% F/V were identical to HEP for vitamin D, iron (females), magnesium (marginally males), choline and potassium; this modeled Diet was also low in Dietary fiber and calcium but met vitamin E requirements while HEP did not. WahlsElim-prescribed supplements corrected vitamin D and magnesium shortfalls; careful selection of foods are needed to meet requirements of other shortfall nutrients and reduce saturated fat and sodium. Doctors should monitor nutritional status, supplement doses, and possible contraindications to high vitamin K intake in individuals following the WahlsElim Diet.

  • Nutrient Composition Comparison between a Modified Paleolithic Diet for Multiple Sclerosis and the Recommended Healthy U.S.-Style Eating Pattern
    'MDPI AG', 2019
    Co-Authors: Catherine A. Chenard, Linda Snetselaar, Linda M Rubenstein, Terry L Wahls
    Abstract:

    Multiple sclerosis (MS) is a demyelinating disease that attacks the central nervous system. Evidence-based Dietary guidelines do not exist for MS; the default advice is to follow the Dietary Guidelines for Americans (DGA). A modified Paleolithic Wahls Elimination (WahlsElim) Diet promoted for MS excludes grains and dairy and encourages 9+ cups fruits and vegetables (F/V) and saturated fat for cooking. This study evaluated the nutritional adequacy of seven-day menus and modeled them with varying amounts of F/V for comparison with the DGA Healthy US-Style Eating Pattern (HEP) for ages 31–50 years. WahlsElim menus had low added sugar and glycemic index. Nutritional adequacy of the menus and modeled versions were similar to HEP for 17 vitamins and minerals (mean adequacy ratio ≥92%). Nutrient shortfalls for the modeled Diet with 60% F/V were identical to HEP for vitamin D, iron (females), magnesium (marginally males), choline and potassium; this modeled Diet was also low in Dietary fiber and calcium but met vitamin E requirements while HEP did not. WahlsElim-prescribed supplements corrected vitamin D and magnesium shortfalls; careful selection of foods are needed to meet requirements of other shortfall nutrients and reduce saturated fat and sodium. Doctors should monitor nutritional status, supplement doses, and possible contraindications to high vitamin K intake in individuals following the WahlsElim Diet

Andreas Stomby - One of the best experts on this subject based on the ideXlab platform.