Palmitoleic Acid

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Maria Isabel C Alonsovale - One of the best experts on this subject based on the ideXlab platform.

  • Palmitoleic Acid 16 1n7 increases oxygen consumption fatty Acid oxidation and atp content in white adipocytes
    Lipids in Health and Disease, 2018
    Co-Authors: Maysa Mariana Cruz, Rui Curi, Paula B M De Andrade, Andressa B Lopes, Amanda Rabello Crisma, Roberta Dourado Cavalcante Da Cunha De Sa, Wilson M T Kuwabara, Maria Isabel C Alonsovale
    Abstract:

    We have recently demonstrated that Palmitoleic Acid (16:1n7) increases lipolysis, glucose uptake and glucose utilization for energy production in white adipose cells. In the present study, we tested the hypothesis that Palmitoleic Acid modulates bioenergetic activity in white adipocytes. For this, 3 T3-L1 pre-adipocytes were differentiated into mature adipocytes in the presence (or absence) of palmitic (16:0) or Palmitoleic (16:1n7) Acid at 100 or 200 μM. The following parameters were evaluated: lipolysis, lipogenesis, fatty Acid (FA) oxidation, ATP content, oxygen consumption, mitochondrial mass, citrate synthase activity and protein content of mitochondrial oxidative phosphorylation (OXPHOS) complexes. Treatment with 16:1n7 during 9 days raised basal and isoproterenol-stimulated lipolysis, FA incorporation into triacylglycerol (TAG), FA oxidation, oxygen consumption, protein expression of subunits representing OXPHOS complex II, III, and V and intracellular ATP content. These effects were not observed in adipocytes treated with 16:0. Palmitoleic Acid, by concerted action on lipolysis, FA esterification, mitochondrial FA oxidation, oxygen consumption and ATP content, does enhance white adipocyte energy expenditure and may act as local hormone.

  • Palmitoleic Acid c16 1n7 treatment enhances fatty Acid oxidation and oxygen consumption in white adipocytes
    The FASEB Journal, 2015
    Co-Authors: Maria Isabel C Alonsovale, Andressa Bolsonilopes, Maysa Mariana Cruz, Roberta Dourado Cavalcante Da Cunha De Sa, Paula De Andrade
    Abstract:

    Palmitoleic Acid is a monounsaturated n-7 fatty Acid (16:1n7), produced and released by adipocytes, that has been shown to enhance whole body glucose disposal, to attenuate high-fat-fed mice hepati...

  • Palmitoleic Acid n 7 increases white adipocytes glut4 content and glucose uptake in association with ampk activation
    Lipids in Health and Disease, 2014
    Co-Authors: Andressa Bolsonilopes, William T Festuccia, Patricia Chimin, Talita Da Silva Mendes De Farias, Francisco Leonardo Torresleal, Maysa Mariana Cruz, Paula B M De Andrade, Sandro M Hirabara, Fabio Bessa Lima, Maria Isabel C Alonsovale
    Abstract:

    Background Palmitoleic Acid was previously shown to improve glucose homeostasis by reducing hepatic glucose production and by enhancing insulin-stimulated glucose uptake in skeletal muscle. Herein we tested the hypothesis that Palmitoleic Acid positively modulates glucose uptake and metabolism in adipocytes.

Philippe Legrand - One of the best experts on this subject based on the ideXlab platform.

  • chemical synthesis and isolation of trans Palmitoleic Acid trans c16 1 n 7 suitable for nutritional studies
    European Journal of Lipid Science and Technology, 2020
    Co-Authors: Etienne Guillocheau, Daniel Catheline, Philippe Legrand, Gaetan Drouin, Clement Orione, Vincent Rioux
    Abstract:

    Trans‐Palmitoleic Acid (trans‐9 C16:1, or trans‐C16:1 n‐7, TPA) is typically found in ruminant‐derived foods (milk and meat). Of note, previous epidemiological studies associated high levels of circulating TPA with a lower risk of type 2 diabetes and metabolic syndrome in humans. At the current time, TPA intakes in humans are ensured by ruminant‐derived foods. However, due to the very low commercial availability of TPA, there are no supplementation studies carried out so far. Therefore, the ability for dietary TPA to prevent type 2 diabetes and metabolic syndrome has never been experimentally assessed. Here, we report a method (among others) to get dozens of grams of pure TPA as ethyl ester, to perform dedicated supplementation studies. For that purpose, we started from food sources containing high amounts of cis‐Palmitoleic Acid (cis‐9 C16:1, or cis‐C16:1 n‐7, CPA), dealing with fatty Acids ethyl esters all along with the experiment. CPA was purified with flash LC, then submitted to a cis/trans isomerization step. Finally, TPA was separated from CPA by low‐temperature crystallization in methanol. The final product was fully characterized by 1H and 13C nuclear magnetic resonance spectrometry. We were able to produce approx. 70 g of 85%‐purity TPA suitable for nutritional studies.

  • Chemical Synthesis and Isolation of Trans‐Palmitoleic Acid (Trans‐C16:1 n‐7) Suitable for Nutritional Studies
    European Journal of Lipid Science and Technology, 2020
    Co-Authors: Etienne Guillocheau, Daniel Catheline, Philippe Legrand, Gaetan Drouin, Clement Orione, Vincent Rioux
    Abstract:

    Trans‐Palmitoleic Acid (trans‐9 C16:1, or trans‐C16:1 n‐7, TPA) is typically found in ruminant‐derived foods (milk and meat). Of note, previous epidemiological studies associated high levels of circulating TPA with a lower risk of type 2 diabetes and metabolic syndrome in humans. At the current time, TPA intakes in humans are ensured by ruminant‐derived foods. However, due to the very low commercial availability of TPA, there are no supplementation studies carried out so far. Therefore, the ability for dietary TPA to prevent type 2 diabetes and metabolic syndrome has never been experimentally assessed. Here, we report a method (among others) to get dozens of grams of pure TPA as ethyl ester, to perform dedicated supplementation studies. For that purpose, we started from food sources containing high amounts of cis‐Palmitoleic Acid (cis‐9 C16:1, or cis‐C16:1 n‐7, CPA), dealing with fatty Acids ethyl esters all along with the experiment. CPA was purified with flash LC, then submitted to a cis/trans isomerization step. Finally, TPA was separated from CPA by low‐temperature crystallization in methanol. The final product was fully characterized by 1H and 13C nuclear magnetic resonance spectrometry. We were able to produce approx. 70 g of 85%‐purity TPA suitable for nutritional studies.

  • plasma Palmitoleic Acid a product of stearoyl coa desaturase activity is an independent marker of triglyceridemia and abdominal adiposity
    Nutrition Metabolism and Cardiovascular Diseases, 2008
    Co-Authors: Francois Paillard, Daniel Catheline, Franck Le Duff, Monique Bouriel, Yves Deugnier, Michel Pouchard, Jeanclaude Daubert, Philippe Legrand
    Abstract:

    BACKGROUND AND AIM: In an animal model VLDL-triglyceride secretion is highly dependent on stearoyl-coA desaturase (SCD) activity and could explain abdominal fattening. The aim was to assess the relationship of plasma Palmitoleic Acid content, a product of SCD activity, with triglyceridemia and abdominal adiposity in humans. METHODS: We evaluated 134 healthy men. Plasma Palmitoleic Acid content was used as an indirect measurement of SCD activity because that enzyme catalyzes the desaturation from saturated to monounsaturated fatty Acids and Palmitoleic Acid intake is very small. RESULTS: Subjects with triglycerides > or =75th percentile had a higher Palmitoleic Acid content than those with triglycerides <75th percentile (3.8+/-0.8 vs 2.8+/-0.9%, p<0.0001). Triglyceridemia was strongly correlated with Palmitoleic Acid content (PAC) (r=0.533, p<0.001). Mean triglyceridemia was 114% higher (1.43+/-0.75 vs 0.67+/-0.22 mmol/l) in the fourth quartile than in the first quartile of Palmitoleic Acid content. In a stepwise logistic regression analysis, Palmitoleic Acid content was the most strongly and independently associated parameter with triglyceridemia, and also with waist circumference when triglyceridemia was not included in the analysis. CONCLUSION: Plasma Palmitoleic Acid content, a product of SCD activity, is an independent marker of triglyceridemia and abdominal adiposity in men. This enzyme (SCD) could represent a target for prevention and treatment of these metabolic disorders in particular in subjects at risk of developing a metabolic syndrome.

  • Plasma Palmitoleic Acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity
    Nutrition Metabolism and Cardiovascular Diseases, 2008
    Co-Authors: Francois Paillard, Daniel Catheline, Monique Bouriel, Yves Deugnier, Michel Pouchard, Jeanclaude Daubert, Franck Le Duff, Philippe Legrand
    Abstract:

    BACKGROUND AND AIM: In an animal model VLDL-triglyceride secretion is highly dependent on stearoyl-coA desaturase (SCD) activity and could explain abdominal fattening. The aim was to assess the relationship of plasma Palmitoleic Acid content, a product of SCD activity, with triglyceridemia and abdominal adiposity in humans. METHODS: We evaluated 134 healthy men. Plasma Palmitoleic Acid content was used as an indirect measurement of SCD activity because that enzyme catalyzes the desaturation from saturated to monounsaturated fatty Acids and Palmitoleic Acid intake is very small. RESULTS: Subjects with triglycerides > or =75th percentile had a higher Palmitoleic Acid content than those with triglycerides

Maysa Mariana Cruz - One of the best experts on this subject based on the ideXlab platform.

  • Palmitoleic Acid 16 1n7 increases oxygen consumption fatty Acid oxidation and atp content in white adipocytes
    Lipids in Health and Disease, 2018
    Co-Authors: Maysa Mariana Cruz, Rui Curi, Paula B M De Andrade, Andressa B Lopes, Amanda Rabello Crisma, Roberta Dourado Cavalcante Da Cunha De Sa, Wilson M T Kuwabara, Maria Isabel C Alonsovale
    Abstract:

    We have recently demonstrated that Palmitoleic Acid (16:1n7) increases lipolysis, glucose uptake and glucose utilization for energy production in white adipose cells. In the present study, we tested the hypothesis that Palmitoleic Acid modulates bioenergetic activity in white adipocytes. For this, 3 T3-L1 pre-adipocytes were differentiated into mature adipocytes in the presence (or absence) of palmitic (16:0) or Palmitoleic (16:1n7) Acid at 100 or 200 μM. The following parameters were evaluated: lipolysis, lipogenesis, fatty Acid (FA) oxidation, ATP content, oxygen consumption, mitochondrial mass, citrate synthase activity and protein content of mitochondrial oxidative phosphorylation (OXPHOS) complexes. Treatment with 16:1n7 during 9 days raised basal and isoproterenol-stimulated lipolysis, FA incorporation into triacylglycerol (TAG), FA oxidation, oxygen consumption, protein expression of subunits representing OXPHOS complex II, III, and V and intracellular ATP content. These effects were not observed in adipocytes treated with 16:0. Palmitoleic Acid, by concerted action on lipolysis, FA esterification, mitochondrial FA oxidation, oxygen consumption and ATP content, does enhance white adipocyte energy expenditure and may act as local hormone.

  • Palmitoleic Acid c16 1n7 treatment enhances fatty Acid oxidation and oxygen consumption in white adipocytes
    The FASEB Journal, 2015
    Co-Authors: Maria Isabel C Alonsovale, Andressa Bolsonilopes, Maysa Mariana Cruz, Roberta Dourado Cavalcante Da Cunha De Sa, Paula De Andrade
    Abstract:

    Palmitoleic Acid is a monounsaturated n-7 fatty Acid (16:1n7), produced and released by adipocytes, that has been shown to enhance whole body glucose disposal, to attenuate high-fat-fed mice hepati...

  • Palmitoleic Acid n 7 increases white adipocytes glut4 content and glucose uptake in association with ampk activation
    Lipids in Health and Disease, 2014
    Co-Authors: Andressa Bolsonilopes, William T Festuccia, Patricia Chimin, Talita Da Silva Mendes De Farias, Francisco Leonardo Torresleal, Maysa Mariana Cruz, Paula B M De Andrade, Sandro M Hirabara, Fabio Bessa Lima, Maria Isabel C Alonsovale
    Abstract:

    Background Palmitoleic Acid was previously shown to improve glucose homeostasis by reducing hepatic glucose production and by enhancing insulin-stimulated glucose uptake in skeletal muscle. Herein we tested the hypothesis that Palmitoleic Acid positively modulates glucose uptake and metabolism in adipocytes.

  • Palmitoleic Acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation
    Lipids in Health and Disease, 2014
    Co-Authors: Andressa Bolsoni-lopes, William T Festuccia, Patricia Chimin, Talita Da Silva Mendes De Farias, Maysa Mariana Cruz, Paula B M De Andrade, Sandro M Hirabara, Fabio Bessa Lima, Francisco Leonardo Torres-leal, Maria Isabel C. Alonso-vale
    Abstract:

    Background: Palmitoleic Acid was previously shown to improve glucose homeostasis by reducing hepatic glucose production and by enhancing insulin-stimulated glucose uptake in skeletal muscle. Herein we tested the hypothesis that Palmitoleic Acid positively modulates glucose uptake and metabolism in adipocytes. Methods: For this, both differentiated 3 T3-L1 cells treated with either Palmitoleic Acid (16:1n7, 200 μM) or palmitic Acid (16:0, 200 μM) for 24 h and primary adipocytes from mice treated with 16:1n7 (300 mg/kg/day) or oleic Acid (18:1n9, 300 mg/kg/day) by gavage for 10 days were evaluated for glucose uptake, oxidation, conversion to lactate and incorporation into fatty Acids and glycerol components of TAG along with the activity and expression of lipogenic enzymes. Results: Treatment of adipocytes with Palmitoleic, but not oleic (in vivo) or palmitic (in vitro) Acids, increased basal and insulin-stimulated glucose uptake and GLUT4 mRNA levels and protein content. Along with uptake, Palmitoleic Acid enhanced glucose oxidation (aerobic glycolysis), conversion to lactate (anaerobic glycolysis) and incorporation into glycerol-TAG, but reduced de novo fatty Acid synthesis from glucose and acetate and the activity of lipogenic enzymes glucose 6-phosphate dehydrogenase and ATP-citrate lyase. Importantly, Palmitoleic Acid induction of adipocyte glucose uptake and metabolism were associated with AMPK activation as evidenced by the increased protein content of phospho(p)Thr172AMPKα, but no changes in pSer473Akt and pThr308Akt. Importantly, such increase in GLUT4 content induced by 16:1n7, was prevented by pharmacological inhibition of AMPK with compound C. Conclusions: In conclusion, Palmitoleic Acid increases glucose uptake and the GLUT4 content in association with AMPK activation.

Andressa Bolsonilopes - One of the best experts on this subject based on the ideXlab platform.

Paula B M De Andrade - One of the best experts on this subject based on the ideXlab platform.

  • Palmitoleic Acid 16 1n7 increases oxygen consumption fatty Acid oxidation and atp content in white adipocytes
    Lipids in Health and Disease, 2018
    Co-Authors: Maysa Mariana Cruz, Rui Curi, Paula B M De Andrade, Andressa B Lopes, Amanda Rabello Crisma, Roberta Dourado Cavalcante Da Cunha De Sa, Wilson M T Kuwabara, Maria Isabel C Alonsovale
    Abstract:

    We have recently demonstrated that Palmitoleic Acid (16:1n7) increases lipolysis, glucose uptake and glucose utilization for energy production in white adipose cells. In the present study, we tested the hypothesis that Palmitoleic Acid modulates bioenergetic activity in white adipocytes. For this, 3 T3-L1 pre-adipocytes were differentiated into mature adipocytes in the presence (or absence) of palmitic (16:0) or Palmitoleic (16:1n7) Acid at 100 or 200 μM. The following parameters were evaluated: lipolysis, lipogenesis, fatty Acid (FA) oxidation, ATP content, oxygen consumption, mitochondrial mass, citrate synthase activity and protein content of mitochondrial oxidative phosphorylation (OXPHOS) complexes. Treatment with 16:1n7 during 9 days raised basal and isoproterenol-stimulated lipolysis, FA incorporation into triacylglycerol (TAG), FA oxidation, oxygen consumption, protein expression of subunits representing OXPHOS complex II, III, and V and intracellular ATP content. These effects were not observed in adipocytes treated with 16:0. Palmitoleic Acid, by concerted action on lipolysis, FA esterification, mitochondrial FA oxidation, oxygen consumption and ATP content, does enhance white adipocyte energy expenditure and may act as local hormone.

  • Palmitoleic Acid n 7 increases white adipocytes glut4 content and glucose uptake in association with ampk activation
    Lipids in Health and Disease, 2014
    Co-Authors: Andressa Bolsonilopes, William T Festuccia, Patricia Chimin, Talita Da Silva Mendes De Farias, Francisco Leonardo Torresleal, Maysa Mariana Cruz, Paula B M De Andrade, Sandro M Hirabara, Fabio Bessa Lima, Maria Isabel C Alonsovale
    Abstract:

    Background Palmitoleic Acid was previously shown to improve glucose homeostasis by reducing hepatic glucose production and by enhancing insulin-stimulated glucose uptake in skeletal muscle. Herein we tested the hypothesis that Palmitoleic Acid positively modulates glucose uptake and metabolism in adipocytes.

  • Palmitoleic Acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation
    Lipids in Health and Disease, 2014
    Co-Authors: Andressa Bolsoni-lopes, William T Festuccia, Patricia Chimin, Talita Da Silva Mendes De Farias, Maysa Mariana Cruz, Paula B M De Andrade, Sandro M Hirabara, Fabio Bessa Lima, Francisco Leonardo Torres-leal, Maria Isabel C. Alonso-vale
    Abstract:

    Background: Palmitoleic Acid was previously shown to improve glucose homeostasis by reducing hepatic glucose production and by enhancing insulin-stimulated glucose uptake in skeletal muscle. Herein we tested the hypothesis that Palmitoleic Acid positively modulates glucose uptake and metabolism in adipocytes. Methods: For this, both differentiated 3 T3-L1 cells treated with either Palmitoleic Acid (16:1n7, 200 μM) or palmitic Acid (16:0, 200 μM) for 24 h and primary adipocytes from mice treated with 16:1n7 (300 mg/kg/day) or oleic Acid (18:1n9, 300 mg/kg/day) by gavage for 10 days were evaluated for glucose uptake, oxidation, conversion to lactate and incorporation into fatty Acids and glycerol components of TAG along with the activity and expression of lipogenic enzymes. Results: Treatment of adipocytes with Palmitoleic, but not oleic (in vivo) or palmitic (in vitro) Acids, increased basal and insulin-stimulated glucose uptake and GLUT4 mRNA levels and protein content. Along with uptake, Palmitoleic Acid enhanced glucose oxidation (aerobic glycolysis), conversion to lactate (anaerobic glycolysis) and incorporation into glycerol-TAG, but reduced de novo fatty Acid synthesis from glucose and acetate and the activity of lipogenic enzymes glucose 6-phosphate dehydrogenase and ATP-citrate lyase. Importantly, Palmitoleic Acid induction of adipocyte glucose uptake and metabolism were associated with AMPK activation as evidenced by the increased protein content of phospho(p)Thr172AMPKα, but no changes in pSer473Akt and pThr308Akt. Importantly, such increase in GLUT4 content induced by 16:1n7, was prevented by pharmacological inhibition of AMPK with compound C. Conclusions: In conclusion, Palmitoleic Acid increases glucose uptake and the GLUT4 content in association with AMPK activation.

  • Palmitoleic Acid n 7 increases white adipocyte lipolysis and lipase content in a pparα dependent manner
    American Journal of Physiology-endocrinology and Metabolism, 2013
    Co-Authors: Andressa Bolsonilopes, William T Festuccia, Patricia Chimin, Talita Da Silva Mendes De Farias, Francisco Leonardo Torresleal, Paula B M De Andrade, Fabio Bessa Lima, Priscilla Bento Mattos Cruz Derogis, Sayuri Miyamoto, Rui Curi
    Abstract:

    We investigated whether Palmitoleic Acid, a fatty Acid that enhances whole body glucose disposal and suppresses hepatic steatosis, modulates triacylglycerol (TAG) metabolism in adipocytes. For this...

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