The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Christopher B. Bunker - One of the best experts on this subject based on the ideXlab platform.
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Panniculitis with pseudomonas septicaemia in AIDS
Journal of the European Academy of Dermatology and Venereology, 2006Co-Authors: Ruth A. Smith, Janet S. Ross, Anthony C. Branfoot, David Asboe, David C. Shanson, Brian Gazzard, Christopher B. BunkerAbstract:A 27 year old female with acquired immunodeficiency syndrome (AIDS) developed tender erythematous nodules on her thighs. A skin biopsy of the lesions showed septal Panniculitis and venulitis and Pseudomonas species was cultured from both the urine and the skin biopsy tissue. The lesions resolved on antibiotic therapy. Panniculitic nodules may represent an early stage of ecthyma gangrenosum which is a well recognised cutaneous complication of pseudomonas septicaemia.
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Case reportPanniculitis with pseudomonas septicaemia in AIDS
Journal of the European Academy of Dermatology and Venereology, 1995Co-Authors: Ruth A. Smith, Janet S. Ross, Anthony C. Branfoot, David Asboe, David C. Shanson, Brian Gazzard, Christopher B. BunkerAbstract:A 27 year old female with acquired immunodeficiency syndrome (AIDS) developed tender erythematous nodules on her thighs. A skin biopsy of the lesions showed septal Panniculitis and venulitis and Pseudomonas species was cultured from both the urine and the skin biopsy tissue. The lesions resolved on antibiotic therapy. Panniculitic nodules may represent an early stage of ecthyma gangrenosum which is a well recognised cutaneous complication of pseudomonas septicaemia.
Celeste Lebbe - One of the best experts on this subject based on the ideXlab platform.
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Vemurafenib-induced neutrophilic Panniculitis.
Melanoma research, 2012Co-Authors: J.-b. Monfort, Cécile Pagès, P. Schneider, Bart Neyns, Christelle Comte, Martine Bagot, Marie-dominique Vignon-pennamen, Manuelle Viguier, Celeste LebbeAbstract:Vemurafenib is a targeted therapy, used in patients with metastatic cutaneous melanoma who carry the BRAF V600E mutation, with a relative reduction of 63% in the risk of death. Several adverse events have been described previously, such as photosensitivity or squamous-cell carcinomas. Two cases of Panniculitis have been reported recently with two different selective BRAF inhibitors. We report two cases of neutrophilic Panniculitis in patients treated by vemurafenib for a metastatic melanoma. Clinical and biological examinations showed no indications for an immune nor an infectious cause of neutrophilic Panniculitis. Thus, we believe that vemurafenib caused this Panniculitis. Treatment with vemurafenib was maintained in both patients because of the clinical and radiological tumoral responses. One patient showed spontaneous recovery, whereas the other patient presented several recurrences of Panniculitis. We believe that physicians should be aware of this cutaneous side effect of vemurafenib, but it should not lead to discontinuation of this treatment.
Frank A. Frizelle - One of the best experts on this subject based on the ideXlab platform.
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mesenteric Panniculitis a paraneoplastic phenomenon
Diseases of The Colon & Rectum, 2012Co-Authors: Anna Wilkes, Nick Griffin, Liane Dixon, B R Dobbs, Frank A. FrizelleAbstract:Background Mesenteric Panniculitis is an inflammatory condition of mesenteric adipose tissue with characteristic features on abdominal CT imaging. Although its cause is unknown, it has been associated with malignancy. Objective The aim of this study was to determine the prevalence of malignancy in patients identified as having mesenteric Panniculitis on CT imaging and to identify demographic, clinical, and radiological features that may predict an unknown underlying malignancy. Design This study is a retrospective analysis of medical records and imaging. Setting This study was conducted at Christchurch Hospital, Canterbury District Health Board, New Zealand. Patients Individuals with mesenteric Panniculitis on abdominal CT imaging performed between 2003 and 2010 were included. Results One hundred eighteen (92 male; median age, 61 years; range, 20-88 years) patients were identified with mesenteric Panniculitis. Malignancy was identified in 45 patients (38%) (34 male). The most common malignancies were colorectal (14), lymphoma (13), and urogenital tract (7). Malignancies were diagnosed after the detection of mesenteric Panniculitis in 13 patients. Univariate analysis of demographic, clinical, and radiological features revealed that lymph node size >12 mm (relative risk 4.5 (CI 1.4-14.6); p = 0.0266) and the absence of the fat ring sign (relative risk 0.6 (0.3-1.1); p = 0.047) were associated with the subsequent diagnosis of malignancy in patients with mesenteric Panniculitis. Limitations This review was limited by its retrospective nature and the small number of individuals with diagnosis of malignancy after the detection of mesenteric Panniculitis. Conclusion Mesenteric Panniculitis is often associated with an underlying malignancy. In most cases, malignancy is diagnosed before mesenteric Panniculitis. Lymph node size (>12 mm) and the absence of the fat ring sign were identified as predictors of subsequent diagnosis of malignancy in patients with mesenteric Panniculitis. Identification of mesenteric Panniculitis on imaging should prompt an awareness for possible malignancy in these patients.
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Mesenteric Panniculitis: a paraneoplastic phenomenon?
Diseases of the colon and rectum, 2012Co-Authors: Anna Wilkes, Nick Griffin, Liane Dixon, Bruce Dobbs, Frank A. FrizelleAbstract:Mesenteric Panniculitis is an inflammatory condition of mesenteric adipose tissue with characteristic features on abdominal CT imaging. Although its cause is unknown, it has been associated with malignancy. The aim of this study was to determine the prevalence of malignancy in patients identified as having mesenteric Panniculitis on CT imaging and to identify demographic, clinical, and radiological features that may predict an unknown underlying malignancy. This study is a retrospective analysis of medical records and imaging. This study was conducted at Christchurch Hospital, Canterbury District Health Board, New Zealand. Individuals with mesenteric Panniculitis on abdominal CT imaging performed between 2003 and 2010 were included. One hundred eighteen (92 male; median age, 61 years; range, 20-88 years) patients were identified with mesenteric Panniculitis. Malignancy was identified in 45 patients (38%) (34 male). The most common malignancies were colorectal (14), lymphoma (13), and urogenital tract (7). Malignancies were diagnosed after the detection of mesenteric Panniculitis in 13 patients. Univariate analysis of demographic, clinical, and radiological features revealed that lymph node size >12 mm (relative risk 4.5 (CI 1.4-14.6); p = 0.0266) and the absence of the fat ring sign (relative risk 0.6 (0.3-1.1); p = 0.047) were associated with the subsequent diagnosis of malignancy in patients with mesenteric Panniculitis. This review was limited by its retrospective nature and the small number of individuals with diagnosis of malignancy after the detection of mesenteric Panniculitis. Mesenteric Panniculitis is often associated with an underlying malignancy. In most cases, malignancy is diagnosed before mesenteric Panniculitis. Lymph node size (>12 mm) and the absence of the fat ring sign were identified as predictors of subsequent diagnosis of malignancy in patients with mesenteric Panniculitis. Identification of mesenteric Panniculitis on imaging should prompt an awareness for possible malignancy in these patients.
Ruth A. Smith - One of the best experts on this subject based on the ideXlab platform.
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Panniculitis with pseudomonas septicaemia in AIDS
Journal of the European Academy of Dermatology and Venereology, 2006Co-Authors: Ruth A. Smith, Janet S. Ross, Anthony C. Branfoot, David Asboe, David C. Shanson, Brian Gazzard, Christopher B. BunkerAbstract:A 27 year old female with acquired immunodeficiency syndrome (AIDS) developed tender erythematous nodules on her thighs. A skin biopsy of the lesions showed septal Panniculitis and venulitis and Pseudomonas species was cultured from both the urine and the skin biopsy tissue. The lesions resolved on antibiotic therapy. Panniculitic nodules may represent an early stage of ecthyma gangrenosum which is a well recognised cutaneous complication of pseudomonas septicaemia.
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Case reportPanniculitis with pseudomonas septicaemia in AIDS
Journal of the European Academy of Dermatology and Venereology, 1995Co-Authors: Ruth A. Smith, Janet S. Ross, Anthony C. Branfoot, David Asboe, David C. Shanson, Brian Gazzard, Christopher B. BunkerAbstract:A 27 year old female with acquired immunodeficiency syndrome (AIDS) developed tender erythematous nodules on her thighs. A skin biopsy of the lesions showed septal Panniculitis and venulitis and Pseudomonas species was cultured from both the urine and the skin biopsy tissue. The lesions resolved on antibiotic therapy. Panniculitic nodules may represent an early stage of ecthyma gangrenosum which is a well recognised cutaneous complication of pseudomonas septicaemia.
Rajiv M. Patel - One of the best experts on this subject based on the ideXlab platform.
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Lupus Profundus (Panniculitis): A Potential Mimic of Subcutaneous Panniculitis-like T-Cell Lymphoma
Archives of pathology & laboratory medicine, 2013Co-Authors: David P. Arps, Rajiv M. PatelAbstract:Lupus profundus is a rare manifestation of cutaneous lupus erythematosus, seen in 1% to 3% of patients. It most commonly presents in association with classic chronic cutaneous lesions of discoid lupus erythematosus; however, such lesions, as well as a clinical history of lupus erythematosus, may be lacking. The differential diagnosis for lymphocytic lobular panniculitides is broad; however, the consideration of subcutaneous Panniculitis-like T-cell lymphoma is most critical. Recently, there have been several reports emphasizing the overlapping histomorphologic features between lupus profundus and subcutaneous Panniculitis-like T-cell lymphoma. Although this is controversial, some authors suggest that patients with lupus profundus are at risk for the development of abnormal, clonal T-cell proliferations and/or overt subcutaneous Panniculitis-like T-cell lymphoma. In cases of atypical lymphocytic lobular Panniculitis that fail to meet diagnostic criteria for subcutaneous Panniculitis-like T-cell lymphoma, patients should be clinically followed indefinitely, as future subcutaneous lymphoma cannot be excluded.
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lupus profundus Panniculitis a potential mimic of subcutaneous Panniculitis like t cell lymphoma
Archives of Pathology & Laboratory Medicine, 2013Co-Authors: David P. Arps, Rajiv M. PatelAbstract:� Lupus profundus is a rare manifestation of cutaneous lupus erythematosus, seen in 1% to 3% of patients. It most commonly presents in association with classic chronic cutaneous lesions of discoid lupus erythematosus; however, such lesions, as well as a clinical history of lupus erythematosus, may be lacking. The differential diagnosis for lymphocytic lobular panniculitides is broad; however, the consideration of subcutaneous Panniculitis-like T-cell lymphoma is most critical. Recently, there have been several reports emphasizing the overlapping histomorphologic features between lupus profundus and subcutaneous Panniculitis-like T-cell lymphoma. Although this is controversial, some authors suggest that patients with lupus profundus are at risk for the development of abnormal, clonal T-cell proliferations and/or overt subcutaneous Panniculitis-like T-cell lymphoma. In cases of atypical lymphocytic lobular Panniculitis that fail to meet diagnostic criteria for subcutaneous Panniculitis-like T-cell lymphoma, patients should be clinically followed indefinitely, as future subcutaneous lymphoma cannot be excluded. (Arch Pathol Lab Med. 2013;137:1211–1215; doi: 10.5858/arpa.2013-0253-CR)
