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Chengquan Zhao - One of the best experts on this subject based on the ideXlab platform.
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bethesda system reporting rates for conventional Papanicolaou Tests and liquid based cytology in a large chinese college of american pathologists certified independent medical laboratory analysis of 1 394 389 Papanicolaou Test reports
Archives of Pathology & Laboratory Medicine, 2015Co-Authors: Baowen Zheng, Marshall R Austin, Zaibo Li, Congde Chen, Xiaoman Liang, Chengquan ZhaoAbstract:Context.— Reports that use the Bethesda System categories for Chinese Papanicolaou Test results are rare. Objective.— To document and analyze rates reported in the Bethesda System for conventional Papanicolaou Tests and liquid-based cytology between 2007 and 2012 in China's largest College of American Pathologists–accredited laboratory. Design.— Results from 1 394 389 Papanicolaou Tests, rendered between 2007 and 2012 by the Guangzhou Kingmed Diagnostics Cytology Laboratory, were documented by the Bethesda System report categories and Papanicolaou Test methodology, which included both conventional Papanicolaou Tests and 4 different liquid-based cytology preparations. Results.— Results were documented for 326 297 conventional Papanicolaou Tests and 1 068 092 liquid-based cytology specimens, which included 928 884 ThinPrep (Hologic, Bedford, Massachusetts), 63 465 SurePath (BD Diagnostics, Franklin Lakes, New Jersey), 50 422 Liqui-Prep (LGM International, Melbourne, Florida), and 25 321 Lituo liquid-cytolog...
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false positive Papanicolaou pap Test rates in the college of american pathologists pap education and pap proficiency Test programs evaluation of false positive responses of high grade squamous intraepithelial lesion or cancer to a negative reference diagnosis
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Christine N Booth, Ann T MoriartyAbstract:Context.—In cytology proficiency Testing (PT), participants fail for incorrectly interpreting a high-grade squamous intraepithelial lesion or cancer (HSIL+) Papanicolaou Test result as negative. This penalty may lead to a false-positive interpretation of negative slides as HSIL+ to avoid failure. Objective.—To investigate factors related to false-positive responses in a PT versus an educational environment. Design.—We analyzed 420 079 responses from 9414 validated negative reference slides in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytopathology (PAP Education) and compared them with responses from the Gynecologic Cytology Proficiency Testing Program for the percentage of false-positive (HSIL+) interpretations in each of 7 negative subcategories. We evaluated the influence of preparation type (ThinPrep, SurePath, and conventional Papanicolaou Test), participant type (pathologist or cytotechnologist), and program time interval (preproficiency Test or PT) on a ...
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correlation of histopathologic follow up findings with vaginal human papillomavirus and low grade squamous intraepithelial lesion Papanicolaou Test results
Archives of Pathology & Laboratory Medicine, 2011Co-Authors: Mona Bansal, Marshall R Austin, Chengquan ZhaoAbstract:Context.—Data on high-risk human papillomavirus (hrHPV) DNA Test results in vaginal, liquid-based cytology (LBC) specimens and corresponding cytologic and histopathologic correlation data are limited. Objective.—To analyze follow-up correlation data associated with vaginal (after hysterectomy) low-grade squamous intraepithelial lesion (LSIL) LBC and hrHPV Test results. Design.—Hospital records were searched for vaginal LSIL LBC and hrHPV results between July 1, 2005, and July 30, 2009. Histopathologic and Papanicolaou Test follow-up correlation data were analyzed. Results.—During the study period, 2892 patients with Test results from both posthysterectomy vaginal LBC and hrHPV were identified: 148 (5.1%) of the patients had vaginal Papanicolaou Test results reported as LSIL, with hrHPV detected in 113 of the 148 patients (76.4%). Of 148 patients, 59 of those with vaginal LSIL including 48 (81.4%) with positive HPV Testing and 11 (18.6%) with negative HPV Testing results had a follow-up vaginal biopsy. His...
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follow up findings in young females with high grade squamous intraepithelial lesion Papanicolaou Test results
Archives of Pathology & Laboratory Medicine, 2011Co-Authors: Chengquan Zhao, Pal Kalposinovak, Marshall R AustinAbstract:Abstract Context.—New guidelines discourage cervical screening and procedures in young females, given available human papillomavirus vaccines, concerns regarding procedure-associated harms, and the rarity of cervical cancers. Objective.—To analyze histopathologic follow-up data on a large number of young females with high-grade squamous intraepithelial lesion (HSIL) Papanicolaou (Pap) Test results. Design.—Hospital records were searched for HSIL Pap Test results in females 20 years or younger between January 2002 and December 2007. Histopathologic and Pap Test follow-up, age group variations, and impact of Pap Test transformation zone/endocervical sampling were analyzed. Results.—Four hundred seventy-four females aged 20 years or younger had HSIL Pap Test results during the study period. Three hundred thirty-five young females with at least one cervical biopsy were included. The average age was 18.6 years (range, 13–20 years). The average follow-up period was 24 months (range, 0.1–75 months), with a media...
Ann T Moriarty - One of the best experts on this subject based on the ideXlab platform.
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the tahoe study bias in the interpretation of Papanicolaou Test results when human papillomavirus status is known
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Ann T Moriarty, Nicole Thomas, Ritu Nayar, Terry Arnold, Lisa Gearries, Andrew A Renshaw, Rhona J SouersAbstract:Context.—Knowledge of human papillomavirus (HPV) status is expected to bias the morphologic evaluation of Papanicolaou (Pap) Test results. Objective.—To characterize Pap Test result interpretive bias when the HPV status is known at the microscopic evaluation. Design.—Forty HPV-positive liquid-based Pap Test results initially interpreted as negative for squamous intraepithelial lesion or malignancy were selected from a quality assurance program, separated into 2 groups of 20 slides each, and circulated in 2 groups to 22 members of the College of American Pathologists Cytopathology Committee. Each member reviewed each case and indicated whether the result was negative for squamous intraepithelial lesion or malignancy or was an epithelial cell abnormality (ECA). The participants assessed the severity of ECAs using the Bethesda System. The participants were not informed of the HPV status in the initial review round. Each group of 20 slides was then distributed to the opposite group (to avoid slide recall), an...
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false positive Papanicolaou pap Test rates in the college of american pathologists pap education and pap proficiency Test programs evaluation of false positive responses of high grade squamous intraepithelial lesion or cancer to a negative reference diagnosis
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Christine N Booth, Ann T MoriartyAbstract:Context.—In cytology proficiency Testing (PT), participants fail for incorrectly interpreting a high-grade squamous intraepithelial lesion or cancer (HSIL+) Papanicolaou Test result as negative. This penalty may lead to a false-positive interpretation of negative slides as HSIL+ to avoid failure. Objective.—To investigate factors related to false-positive responses in a PT versus an educational environment. Design.—We analyzed 420 079 responses from 9414 validated negative reference slides in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytopathology (PAP Education) and compared them with responses from the Gynecologic Cytology Proficiency Testing Program for the percentage of false-positive (HSIL+) interpretations in each of 7 negative subcategories. We evaluated the influence of preparation type (ThinPrep, SurePath, and conventional Papanicolaou Test), participant type (pathologist or cytotechnologist), and program time interval (preproficiency Test or PT) on a ...
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identification of trichomonas vaginalis in different Papanicolaou Test preparations trends over time in the college of american pathologists educational interlaboratory comparison program
Archives of Pathology & Laboratory Medicine, 2013Co-Authors: Lydia P Howell, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Ann T MoriartyAbstract:Context.—The College of American Pathologists' Interlaboratory Comparison Program in Gynecologic Cytology has seen an increase in enrollment in liquid-based Papanicolaou Test challenges with a decr...
Rhona J Souers - One of the best experts on this subject based on the ideXlab platform.
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the tahoe study bias in the interpretation of Papanicolaou Test results when human papillomavirus status is known
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Ann T Moriarty, Nicole Thomas, Ritu Nayar, Terry Arnold, Lisa Gearries, Andrew A Renshaw, Rhona J SouersAbstract:Context.—Knowledge of human papillomavirus (HPV) status is expected to bias the morphologic evaluation of Papanicolaou (Pap) Test results. Objective.—To characterize Pap Test result interpretive bias when the HPV status is known at the microscopic evaluation. Design.—Forty HPV-positive liquid-based Pap Test results initially interpreted as negative for squamous intraepithelial lesion or malignancy were selected from a quality assurance program, separated into 2 groups of 20 slides each, and circulated in 2 groups to 22 members of the College of American Pathologists Cytopathology Committee. Each member reviewed each case and indicated whether the result was negative for squamous intraepithelial lesion or malignancy or was an epithelial cell abnormality (ECA). The participants assessed the severity of ECAs using the Bethesda System. The participants were not informed of the HPV status in the initial review round. Each group of 20 slides was then distributed to the opposite group (to avoid slide recall), an...
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false positive Papanicolaou pap Test rates in the college of american pathologists pap education and pap proficiency Test programs evaluation of false positive responses of high grade squamous intraepithelial lesion or cancer to a negative reference diagnosis
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Christine N Booth, Ann T MoriartyAbstract:Context.—In cytology proficiency Testing (PT), participants fail for incorrectly interpreting a high-grade squamous intraepithelial lesion or cancer (HSIL+) Papanicolaou Test result as negative. This penalty may lead to a false-positive interpretation of negative slides as HSIL+ to avoid failure. Objective.—To investigate factors related to false-positive responses in a PT versus an educational environment. Design.—We analyzed 420 079 responses from 9414 validated negative reference slides in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytopathology (PAP Education) and compared them with responses from the Gynecologic Cytology Proficiency Testing Program for the percentage of false-positive (HSIL+) interpretations in each of 7 negative subcategories. We evaluated the influence of preparation type (ThinPrep, SurePath, and conventional Papanicolaou Test), participant type (pathologist or cytotechnologist), and program time interval (preproficiency Test or PT) on a ...
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identification of trichomonas vaginalis in different Papanicolaou Test preparations trends over time in the college of american pathologists educational interlaboratory comparison program
Archives of Pathology & Laboratory Medicine, 2013Co-Authors: Lydia P Howell, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Ann T MoriartyAbstract:Context.—The College of American Pathologists' Interlaboratory Comparison Program in Gynecologic Cytology has seen an increase in enrollment in liquid-based Papanicolaou Test challenges with a decr...
Marshall R Austin - One of the best experts on this subject based on the ideXlab platform.
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bethesda system reporting rates for conventional Papanicolaou Tests and liquid based cytology in a large chinese college of american pathologists certified independent medical laboratory analysis of 1 394 389 Papanicolaou Test reports
Archives of Pathology & Laboratory Medicine, 2015Co-Authors: Baowen Zheng, Marshall R Austin, Zaibo Li, Congde Chen, Xiaoman Liang, Chengquan ZhaoAbstract:Context.— Reports that use the Bethesda System categories for Chinese Papanicolaou Test results are rare. Objective.— To document and analyze rates reported in the Bethesda System for conventional Papanicolaou Tests and liquid-based cytology between 2007 and 2012 in China's largest College of American Pathologists–accredited laboratory. Design.— Results from 1 394 389 Papanicolaou Tests, rendered between 2007 and 2012 by the Guangzhou Kingmed Diagnostics Cytology Laboratory, were documented by the Bethesda System report categories and Papanicolaou Test methodology, which included both conventional Papanicolaou Tests and 4 different liquid-based cytology preparations. Results.— Results were documented for 326 297 conventional Papanicolaou Tests and 1 068 092 liquid-based cytology specimens, which included 928 884 ThinPrep (Hologic, Bedford, Massachusetts), 63 465 SurePath (BD Diagnostics, Franklin Lakes, New Jersey), 50 422 Liqui-Prep (LGM International, Melbourne, Florida), and 25 321 Lituo liquid-cytolog...
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correlation of histopathologic follow up findings with vaginal human papillomavirus and low grade squamous intraepithelial lesion Papanicolaou Test results
Archives of Pathology & Laboratory Medicine, 2011Co-Authors: Mona Bansal, Marshall R Austin, Chengquan ZhaoAbstract:Context.—Data on high-risk human papillomavirus (hrHPV) DNA Test results in vaginal, liquid-based cytology (LBC) specimens and corresponding cytologic and histopathologic correlation data are limited. Objective.—To analyze follow-up correlation data associated with vaginal (after hysterectomy) low-grade squamous intraepithelial lesion (LSIL) LBC and hrHPV Test results. Design.—Hospital records were searched for vaginal LSIL LBC and hrHPV results between July 1, 2005, and July 30, 2009. Histopathologic and Papanicolaou Test follow-up correlation data were analyzed. Results.—During the study period, 2892 patients with Test results from both posthysterectomy vaginal LBC and hrHPV were identified: 148 (5.1%) of the patients had vaginal Papanicolaou Test results reported as LSIL, with hrHPV detected in 113 of the 148 patients (76.4%). Of 148 patients, 59 of those with vaginal LSIL including 48 (81.4%) with positive HPV Testing and 11 (18.6%) with negative HPV Testing results had a follow-up vaginal biopsy. His...
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follow up findings in young females with high grade squamous intraepithelial lesion Papanicolaou Test results
Archives of Pathology & Laboratory Medicine, 2011Co-Authors: Chengquan Zhao, Pal Kalposinovak, Marshall R AustinAbstract:Abstract Context.—New guidelines discourage cervical screening and procedures in young females, given available human papillomavirus vaccines, concerns regarding procedure-associated harms, and the rarity of cervical cancers. Objective.—To analyze histopathologic follow-up data on a large number of young females with high-grade squamous intraepithelial lesion (HSIL) Papanicolaou (Pap) Test results. Design.—Hospital records were searched for HSIL Pap Test results in females 20 years or younger between January 2002 and December 2007. Histopathologic and Pap Test follow-up, age group variations, and impact of Pap Test transformation zone/endocervical sampling were analyzed. Results.—Four hundred seventy-four females aged 20 years or younger had HSIL Pap Test results during the study period. Three hundred thirty-five young females with at least one cervical biopsy were included. The average age was 18.6 years (range, 13–20 years). The average follow-up period was 24 months (range, 0.1–75 months), with a media...
Nicole Thomas - One of the best experts on this subject based on the ideXlab platform.
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the tahoe study bias in the interpretation of Papanicolaou Test results when human papillomavirus status is known
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Ann T Moriarty, Nicole Thomas, Ritu Nayar, Terry Arnold, Lisa Gearries, Andrew A Renshaw, Rhona J SouersAbstract:Context.—Knowledge of human papillomavirus (HPV) status is expected to bias the morphologic evaluation of Papanicolaou (Pap) Test results. Objective.—To characterize Pap Test result interpretive bias when the HPV status is known at the microscopic evaluation. Design.—Forty HPV-positive liquid-based Pap Test results initially interpreted as negative for squamous intraepithelial lesion or malignancy were selected from a quality assurance program, separated into 2 groups of 20 slides each, and circulated in 2 groups to 22 members of the College of American Pathologists Cytopathology Committee. Each member reviewed each case and indicated whether the result was negative for squamous intraepithelial lesion or malignancy or was an epithelial cell abnormality (ECA). The participants assessed the severity of ECAs using the Bethesda System. The participants were not informed of the HPV status in the initial review round. Each group of 20 slides was then distributed to the opposite group (to avoid slide recall), an...
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false positive Papanicolaou pap Test rates in the college of american pathologists pap education and pap proficiency Test programs evaluation of false positive responses of high grade squamous intraepithelial lesion or cancer to a negative reference diagnosis
Archives of Pathology & Laboratory Medicine, 2014Co-Authors: Barbara A Crothers, Chengquan Zhao, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Christine N Booth, Ann T MoriartyAbstract:Context.—In cytology proficiency Testing (PT), participants fail for incorrectly interpreting a high-grade squamous intraepithelial lesion or cancer (HSIL+) Papanicolaou Test result as negative. This penalty may lead to a false-positive interpretation of negative slides as HSIL+ to avoid failure. Objective.—To investigate factors related to false-positive responses in a PT versus an educational environment. Design.—We analyzed 420 079 responses from 9414 validated negative reference slides in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytopathology (PAP Education) and compared them with responses from the Gynecologic Cytology Proficiency Testing Program for the percentage of false-positive (HSIL+) interpretations in each of 7 negative subcategories. We evaluated the influence of preparation type (ThinPrep, SurePath, and conventional Papanicolaou Test), participant type (pathologist or cytotechnologist), and program time interval (preproficiency Test or PT) on a ...
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identification of trichomonas vaginalis in different Papanicolaou Test preparations trends over time in the college of american pathologists educational interlaboratory comparison program
Archives of Pathology & Laboratory Medicine, 2013Co-Authors: Lydia P Howell, Teresa M Darragh, Rhona J Souers, Nicole Thomas, Ann T MoriartyAbstract:Context.—The College of American Pathologists' Interlaboratory Comparison Program in Gynecologic Cytology has seen an increase in enrollment in liquid-based Papanicolaou Test challenges with a decr...
