The Experts below are selected from a list of 867 Experts worldwide ranked by ideXlab platform
Satvir Stevethia - One of the best experts on this subject based on the ideXlab platform.
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Localization of common cytotoxic T lymphocyte recognition epitopes on Simian Papovavirus sv40 and human Papovavirus JC virus T antigens
Virology, 1991Co-Authors: Alison M. Deckhut, Mary J. Tevethia, Sheryl Haggerty, Richard J. Frisque, Satvir StevethiaAbstract:Human Papovavirus JC virus (JCV) and Simian virus 40 (SV40) tumor or T antigens demonstrate considerable sequence homology which is reflected by antibody cross-reactivity. This similarity raised the possibility that JCV and SV40 T antigen also might contain common cytotoxic T lymphocyte (CTL) recognition epitopes. In this study we identified and mapped such sites on the JCV T antigen. C57Bl/6 cell lines transformed by JCV/SV40 T antigen chimeras were generated and tested for susceptibility to lysis by five H-2b restricted SV40-specific CTL clones: Y-1, Y-2, Y-3, Y-4, and Y-5. These CTL clones recognize specific epitopes within amino acids 205-219 (site I), 220-233 (sites II and III), 369-511 (site IV), and 489-503 (site V) on SV40 T Ag, respectively. The results show that sites I, II, III, and IV (recognized by CTL clones Y-1, Y-2, Y-3, and Y-4, respectively) represent common epitopes on SV40 and JCV T antigens. CTL clone Y-5 failed to recognize JCV T antigen indicating that CTL can discriminate between the two antigenically related T antigens.
Janet S Butel - One of the best experts on this subject based on the ideXlab platform.
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pcr detection and dna sequence analysis of the regulatory region of lymphotropic Papovavirus in peripheral blood mononuclear cells of an immunocompromised rhesus macaque
Journal of Clinical Microbiology, 2002Co-Authors: John A Lednicky, Steven J Halvorson, Janet S ButelAbstract:A lymphotropic Papovavirus (LPV) archetypal regulatory region was amplified from DNA from the blood of an immunocompromised rhesus monkey. We believe this is the first nonserological evidence of LPV infection in rhesus monkeys.
Alison M. Deckhut - One of the best experts on this subject based on the ideXlab platform.
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Localization of common cytotoxic T lymphocyte recognition epitopes on Simian Papovavirus sv40 and human Papovavirus JC virus T antigens
Virology, 1991Co-Authors: Alison M. Deckhut, Mary J. Tevethia, Sheryl Haggerty, Richard J. Frisque, Satvir StevethiaAbstract:Human Papovavirus JC virus (JCV) and Simian virus 40 (SV40) tumor or T antigens demonstrate considerable sequence homology which is reflected by antibody cross-reactivity. This similarity raised the possibility that JCV and SV40 T antigen also might contain common cytotoxic T lymphocyte (CTL) recognition epitopes. In this study we identified and mapped such sites on the JCV T antigen. C57Bl/6 cell lines transformed by JCV/SV40 T antigen chimeras were generated and tested for susceptibility to lysis by five H-2b restricted SV40-specific CTL clones: Y-1, Y-2, Y-3, Y-4, and Y-5. These CTL clones recognize specific epitopes within amino acids 205-219 (site I), 220-233 (sites II and III), 369-511 (site IV), and 489-503 (site V) on SV40 T Ag, respectively. The results show that sites I, II, III, and IV (recognized by CTL clones Y-1, Y-2, Y-3, and Y-4, respectively) represent common epitopes on SV40 and JCV T antigens. CTL clone Y-5 failed to recognize JCV T antigen indicating that CTL can discriminate between the two antigenically related T antigens.
Daniel W Drolet - One of the best experts on this subject based on the ideXlab platform.
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regulation of jc virus by the pou domain transcription factor tst 1 implications for progressive multifocal leukoencephalopathy
Proceedings of the National Academy of Sciences of the United States of America, 1993Co-Authors: Daniel W DroletAbstract:Abstract Progressive multifocal leukoencephalopathy results from an opportunistic infection of myelin-producing oligodendrocytes by the glia-specific human Papovavirus JC. In this report, evidence is presented that the glial transcription factor Tst-1, a member of the POU-domain family, stimulates transcription of both early and late viral genes. Stimulation was dependent on site-specific binding of Tst-1 to the JC viral regulatory region and on the presence of an intact amino-terminal transactivation domain within Tst-1. Because of its ability to increase the expression of viral large tumor antigen, Tst-1 stimulated viral DNA replication, without participating directly in the replication event. Our results suggest that Tst-1 is one of the determining factors in the glia specificity of JC virus.
Reda Bouabdallah - One of the best experts on this subject based on the ideXlab platform.
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jc Papovavirus leukoencephalopathy after first line treatment with chop and rituximab
Haematologica, 2007Co-Authors: Jerome Rey, N Belmecheri, N Bouayed, Vadim Ivanov, Diane Coso, J A Gastaut, Reda BouabdallahAbstract:Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating infection of the central nervous system caused by the JC Papovavirus usually seen among immunocompromised patients. PML arises upon JC virus reactivation during periods of immunosuppression. PML may be seen among patients with
