The Experts below are selected from a list of 813 Experts worldwide ranked by ideXlab platform
Erika M Felixgetzik - One of the best experts on this subject based on the ideXlab platform.
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vancomycin induced leukocytoclastic vasculitis
Pharmacotherapy, 2009Co-Authors: Erika M Felixgetzik, Lynne M SylviaAbstract:Vancomycin is well recognized as causing the nonallergic skin reaction known as red man syndrome; however, it is rarely suspected as causative in the setting of an immune-mediated skin reaction. We describe a 76-year-old Caucasian woman with a history of penicillin and sulfa allergies who was transferred to our medical center while receiving vancomycin for treatment of persistent methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia. After admission, the patient's pacemaker was explanted; cultures from the pacemaker grew MSSA. Based on the culture data and her allergy to penicillin, vancomycin was continued. On day 4 of therapy, the patient developed a Papular Rash with small blisters on her distal upper extremities. Furosemide, which she was receiving intermittently to maintain fluid balance, was initially suspected as the likely cause. Furosemide was withheld; however, the Rash worsened and spread to her neck and torso. Results of skin biopsy confirmed a severe leukocytoclastic, necrotizing small-cell vasculitis that met the criteria for a hypersensitivity vasculitis associated with drug therapy. Five days after discontinuation of vancomycin, the vasculitis was resolving and continued to resolve throughout the remainder of her hospitalization. Furosemide was readministered without worsening of the vasculitis. Use of the Naranjo adverse drug reaction probability scale indicated that the likelihood of vancomycin being the cause of the vasculitis was probable (score of 5). Clinicians should be aware of vancomycin as a potential cause of small-vessel vasculitis.
Xi Chun Hu - One of the best experts on this subject based on the ideXlab platform.
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higher rate of skin Rash in a phase ii trial with weekly nanoparticle albumin bound paclitaxel and cisplatin combination in chinese breast cancer patients
BMC Cancer, 2013Co-Authors: Li Chen Tang, Bi Yun Wang, Jian Zhang, Yun Hua Lu, Geng Hong Di, Zhi Ming Shao, Xi Chun HuAbstract:The aim of this sub-study is to explore the incidence of skin Rash among advanced breast cancer(ABC) patients in a phase II trial treated with weekly nab-paclitaxel and cisplatin combination. Nab-paclitaxel(125 mg/m2) was administered on days 1, 8, 15, followed by cisplatin(75 mg/m2) on day 1 every 28 day cycle until disease progression, intolerable toxicities or the maximum of 6 cycles. Patients who received at least one injection of the study drug were included in this analysis of the incidence of skin Rash among Chinese patients. Toxicity was graded using the CTCAE4.0 criteria. Statistical analysis was carried out by using SPSS 16.0 (SPSS Inc, Chicago, IL). Seventy three patients were enrolled and eligible for analysis. A total of 384 cycles were administered at the time of this analysis. Rash was presented in 27 patients (37.0%). The most common sites involved were face (14/27), neck (14/27), limbs (18/27) and frictional parts of the trunk (10/27). Macular and Papular Rash with pruritus commonly occurred 2 (95% CI: 1–7) days after the first day of chemotherapy. Only one patient developed Grade 3 skin toxicity with generalized erythroderma and disfigurement of the face requiring dose reduction. The Rash gradually regressed 2 (95% CI: 1–10) days after antihistamines used, but pigmentation remained in 13/27 cases. The incidence rate of skin Rash was significantly higher than what has been described for western patients (approximate 4%, P < 0.0001). A higher rate of maculo-Papular Rash occurred in Chinese breast cancer patients treated with weekly nab-paclitaxel compared to western patients. The albumin component of nab-paclitaxel might be the cause of the skin disorder. NCT01149798
Appenzeller Simone - One of the best experts on this subject based on the ideXlab platform.
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Ultrasound findings in infantile systemic hyalinosis
'Springer Science and Business Media LLC', 2020Co-Authors: Mendonca, Jose Alexandre, Marini Roberto, Schincariol, Nadia Bossolan, Laurindo, Ieda Maria Magalhaes, Appenzeller SimoneAbstract:To describe clinical and ultrasound findings in a patient with infantile systemic hyalinosis (ISH). A 5-month-old boy was evaluated of joint contractures. In addition to clinical and laboratory investigations, an ultrasound of his joints was done and compared to a child with similar age. On examination, a short neck, gingival hyperplasia and Papular Rash were noted. Joint examination showed painful passive movement, reduced range of motion, and joint contractures in knees, elbows, and small joints of the hands, without any evidence of synovial thickness. Ultrasound of the affected joints showed irregular cortical surface of MCPs and PIP, the presence of osteophytes and bone erosions, increased synovial fluid without evidence of synovial hyperplasia. This is the first report to show evidence of US findings in ISH. Ultrasound findings may help to distinguish ISH from JIA in early stages311013931395FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP2008-02917-0; 2009-06049-
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Ultrasound findings in infantile systemic hyalinosis
SPRINGER HEIDELBERG, 2011Co-Authors: Mendonca, Jose Alexandre, Marini Roberto, Schincariol, Nadia Bossolan, Laurindo, Ieda Maria Magalhaes, Appenzeller SimoneAbstract:To describe clinical and ultrasound findings in a patient with infantile systemic hyalinosis (ISH). A 5-month-old boy was evaluated of joint contractures. In addition to clinical and laboratory investigations, an ultrasound of his joints was done and compared to a child with similar age. On examination, a short neck, gingival hyperplasia and Papular Rash were noted. Joint examination showed painful passive movement, reduced range of motion, and joint contractures in knees, elbows, and small joints of the hands, without any evidence of synovial thickness. Ultrasound of the affected joints showed irregular cortical surface of MCPs and PIP, the presence of osteophytes and bone erosions, increased synovial fluid without evidence of synovial hyperplasia. This is the first report to show evidence of US findings in ISH. Ultrasound findings may help to distinguish ISH from JIA in early stages.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[2008-02917-0]Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[2009-06049-6
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Ultrasound findings in infantile systemic hyalinosis
'Springer Science and Business Media LLC', 2011Co-Authors: Mendonca, Jose Alexandre, Marini Roberto, Schincariol, Nadia Bossolan, Magalhaes Laurindo, Ieda Maria, Appenzeller SimoneAbstract:To describe clinical and ultrasound findings in a patient with infantile systemic hyalinosis (ISH). A 5-month-old boy was evaluated of joint contractures. in addition to clinical and laboratory investigations, an ultrasound of his joints was done and compared to a child with similar age. On examination, a short neck, gingival hyperplasia and Papular Rash were noted. Joint examination showed painful passive movement, reduced range of motion, and joint contractures in knees, elbows, and small joints of the hands, without any evidence of synovial thickness. Ultrasound of the affected joints showed irregular cortical surface of MCPs and PIP, the presence of osteophytes and bone erosions, increased synovial fluid without evidence of synovial hyperplasia. This is the first report to show evidence of US findings in ISH. Ultrasound findings may help to distinguish ISH from JIA in early stages.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Campinas UNICAMP CEP, Dept Clin Med, Fac Ciencias Med, BR-13083970 Campinas, SP, BrazilPontifica Univ Campinas, Rheumatol Serv, Campinas, SP, BrazilUniv Estadual Campinas, Fac Med Sci, Dept Pediat, Pediat Rheumatol Unit, Campinas, SP, BrazilUniv São Paulo, Dept Med, Rheumatol Unit, São Paulo, BrazilFAPESP: 2008-02917-0FAPESP: 2009-06049-6Web of Scienc
Haruhiko Hirata - One of the best experts on this subject based on the ideXlab platform.
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a lung abscess caused by secondary syphilis the utility of polymerase chain reaction techniques in transbronchial biopsy a case report
BMC Infectious Diseases, 2019Co-Authors: Shinji Futami, Takayuki Takimoto, Futoshi Nakagami, Shingo Satoh, Masanari Hamaguchi, Muneyoshi Kuroyama, Kotaro Miyake, Shohei Koyama, Kota Iwahori, Haruhiko HirataAbstract:In Japan and other countries, the number of patients with syphilis is increasing year by year. Recently, the cases of the pulmonary involvement in patients with secondary syphilis have been reported. However, it is still undetermined how to obtain a desirable specimen for a diagnosis of the pulmonary involvement, and how to treat it if not cured. A 34-year-old man presented with cough and swelling of the right inguinal nodes. A physical examination revealed erythematous Papular Rash over the palms, soles and abdomen. A 4 cm mass in the right lower lobe of the lung was detected on computed tomography. He was diagnosed as having secondary syphilis, because he was tested positive for the rapid plasma reagin and Treponema pallidum hemagglutination assay. Amoxycillin and probenecid were orally administered for 2 weeks. Subsequently, Rash and serological markers were improved, however, the lung mass remained unchanged in size. Transbronchial biopsy (TBB) confirmed the pulmonary involvement of syphilis using polymerase chain reaction techniques (tpp47- and polA-PCR). Furthermore, following surgical resection revealed the lung mass to be an abscess. To our knowledge, this is the first surgically treated case of a lung abscess caused by syphilis, which was diagnosed by PCR techniques in TBB. This report could propose a useful diagnostic method for the pulmonary involvement of syphilis.
Lynne M Sylvia - One of the best experts on this subject based on the ideXlab platform.
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vancomycin induced leukocytoclastic vasculitis
Pharmacotherapy, 2009Co-Authors: Erika M Felixgetzik, Lynne M SylviaAbstract:Vancomycin is well recognized as causing the nonallergic skin reaction known as red man syndrome; however, it is rarely suspected as causative in the setting of an immune-mediated skin reaction. We describe a 76-year-old Caucasian woman with a history of penicillin and sulfa allergies who was transferred to our medical center while receiving vancomycin for treatment of persistent methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia. After admission, the patient's pacemaker was explanted; cultures from the pacemaker grew MSSA. Based on the culture data and her allergy to penicillin, vancomycin was continued. On day 4 of therapy, the patient developed a Papular Rash with small blisters on her distal upper extremities. Furosemide, which she was receiving intermittently to maintain fluid balance, was initially suspected as the likely cause. Furosemide was withheld; however, the Rash worsened and spread to her neck and torso. Results of skin biopsy confirmed a severe leukocytoclastic, necrotizing small-cell vasculitis that met the criteria for a hypersensitivity vasculitis associated with drug therapy. Five days after discontinuation of vancomycin, the vasculitis was resolving and continued to resolve throughout the remainder of her hospitalization. Furosemide was readministered without worsening of the vasculitis. Use of the Naranjo adverse drug reaction probability scale indicated that the likelihood of vancomycin being the cause of the vasculitis was probable (score of 5). Clinicians should be aware of vancomycin as a potential cause of small-vessel vasculitis.
