The Experts below are selected from a list of 28881 Experts worldwide ranked by ideXlab platform
Huijing Zhao - One of the best experts on this subject based on the ideXlab platform.
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scene aware error modeling of lidar visual odometry for fusion based vehicle localization
IEEE Transactions on Intelligent Transportation Systems, 2021Co-Authors: Huijing ZhaoAbstract:Localization is an essential technique in mobile robotics. In a complex environment, it is necessary to fuse different localization modules to obtain more robust results, in which the error model plays a Paramount Role. However, exteroceptive sensor-based odometries(ESOs), such as LiDAR/visual odometry, often deliver results with scene-related error, which is difficult to model accurately. To address this problem, this research designs a scene-aware error model for ESO, based on which a multimodal localization fusion framework is developed. In addition, an end-to-end learning method is proposed to train this error model using sparse global poses such as results from global positioning system(GPS) and inertial measurement unit(IMU). The proposed method is realized for error modeling of LiDAR/visual odometry, and the results are fused with dead reckoning to examine the performance of vehicle localization. Experiments are conducted using both simulation and real-world data of experienced and unexperienced environments, and the experimental results demonstrate that with the learned scene-aware error models, vehicle localization accuracy can be largely improved and shows adaptiveness in unexperienced scenes.
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scene aware error modeling of lidar visual odometry for fusion based vehicle localization
arXiv: Robotics, 2020Co-Authors: Huijing ZhaoAbstract:Localization is an essential technique in mobile robotics. In a complex environment, it is necessary to fuse different localization modules to obtain more robust results, in which the error model plays a Paramount Role. However, exteroceptive sensor-based odometries (ESOs), such as LiDAR/visual odometry, often deliver results with scene-related error, which is difficult to model accurately. To address this problem, this research designs a scene-aware error model for ESO, based on which a multimodal localization fusion framework is developed. In addition, an end-to-end learning method is proposed to train this error model using sparse global poses such as GPS/IMU results. The proposed method is realized for error modeling of LiDAR/visual odometry, and the results are fused with dead reckoning to examine the performance of vehicle localization. Experiments are conducted using both simulation and real-world data of experienced and unexperienced environments, and the experimental results demonstrate that with the learned scene-aware error models, vehicle localization accuracy can be largely improved and shows adaptiveness in unexperienced scenes.
Amal Saleh Altamimi - One of the best experts on this subject based on the ideXlab platform.
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emerging paradigms of viral diseases and Paramount Role of natural resources as antiviral agents
Science of The Total Environment, 2021Co-Authors: Sagaya R Jansi, Ameer Khusro, Paul Agastian, Ahmed H Alfarhan, Naif Abdullah Aldhabi, Mariadhas Valan Arasu, Rajakrishnan Rajagopal, Damia Barcelo, Amal Saleh AltamimiAbstract:In the current scenario, the increasing prevalence of diverse microbial infections as well as emergence and re-emergence of viral epidemics with high morbidity and mortality rates are major public health threat. Despite the persistent production of antiviral drugs and vaccines in the global market, viruses still remain as one of the leading causes of deadly human diseases. Effective control of viral diseases, particularly Zika virus disease, Nipah virus disease, Severe acute respiratory syndrome, Coronavirus disease, Herpes simplex virus infection, Acquired immunodeficiency syndrome, and Ebola virus disease remain promising goal amidst the mutating viral strains. Current trends in the development of antiviral drugs focus solely on testing novel drugs or repurposing drugs against potential targets of the viruses. Compared to synthetic drugs, medicines from natural resources offer less side-effect to humans and are often cost-effective in the productivity approaches. This review intends not only to emphasize on the major viral disease outbreaks in the past few decades and but also explores the potentialities of natural substances as antiviral traits to combat viral pathogens. Here, we spotlighted a comprehensive overview of antiviral components present in varied natural sources, including plants, fungi, and microorganisms in order to identify potent antiviral agents for developing alternative therapy in future.
Damia Barcelo - One of the best experts on this subject based on the ideXlab platform.
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emerging paradigms of viral diseases and Paramount Role of natural resources as antiviral agents
Science of The Total Environment, 2021Co-Authors: Sagaya R Jansi, Ameer Khusro, Paul Agastian, Ahmed H Alfarhan, Naif Abdullah Aldhabi, Mariadhas Valan Arasu, Rajakrishnan Rajagopal, Damia Barcelo, Amal Saleh AltamimiAbstract:In the current scenario, the increasing prevalence of diverse microbial infections as well as emergence and re-emergence of viral epidemics with high morbidity and mortality rates are major public health threat. Despite the persistent production of antiviral drugs and vaccines in the global market, viruses still remain as one of the leading causes of deadly human diseases. Effective control of viral diseases, particularly Zika virus disease, Nipah virus disease, Severe acute respiratory syndrome, Coronavirus disease, Herpes simplex virus infection, Acquired immunodeficiency syndrome, and Ebola virus disease remain promising goal amidst the mutating viral strains. Current trends in the development of antiviral drugs focus solely on testing novel drugs or repurposing drugs against potential targets of the viruses. Compared to synthetic drugs, medicines from natural resources offer less side-effect to humans and are often cost-effective in the productivity approaches. This review intends not only to emphasize on the major viral disease outbreaks in the past few decades and but also explores the potentialities of natural substances as antiviral traits to combat viral pathogens. Here, we spotlighted a comprehensive overview of antiviral components present in varied natural sources, including plants, fungi, and microorganisms in order to identify potent antiviral agents for developing alternative therapy in future.
Michael D Griswold - One of the best experts on this subject based on the ideXlab platform.
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knockout of cyp26a1 and cyp26b1 during postnatal life causes reduced lifespan dermatitis splenomegaly and systemic inflammation in mice
The FASEB Journal, 2020Co-Authors: Jessica M Snyder, Guo Zhong, Cathryn A Hogarth, Weize Huang, Traci B Topping, Jeffrey T Lafrance, Laura Palau, Lindsay C Czuba, Michael D GriswoldAbstract:All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is an essential signaling molecule in all chordates. Global knockouts of the atRA clearing enzymes Cyp26a1 or Cyp26b1 are embryonic lethal. In adult rodents, inhibition of Cyp26a1 and Cyp26b1 increases atRA concentrations and signaling. However, postnatal knockout of Cyp26a1 does not cause a severe phenotype. We hypothesized that Cyp26b1 is the main atRA clearing Cyp in postnatal mammals. This hypothesis was tested by generating tamoxifen-inducible knockout mouse models of Cyp26b1 alone or with Cyp26a1. Both mouse models showed dermatitis, blepharitis, and splenomegaly. Histology showed infiltration of inflammatory cells including neutrophils and T lymphocytes into the skin and hyperkeratosis/hyperplasia of the nonglandular stomach. The mice lacking both Cyp26a1 and Cyp26b1 also had a reduced lifespan, failed to gain weight, and showed fat atrophy. There were significant changes in vitamin A homeostasis. Postnatal knockout of Cyp26b1 resulted in increased atRA concentrations in the skin while the postnatal knockout of both Cyp26a1 and Cyp26b1 resulted in increased atRA concentrations in the liver, serum, skin, spleen, and intestines. This study demonstrates the Paramount Role of Cyp26b1 in regulating retinoid homeostasis in postnatal life.
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knockout of cyp26a1 and cyp26b1 during post natal life causes reduced lifespan dermatitis splenomegaly and systemic inflammation in mice
bioRxiv, 2020Co-Authors: Jessica M Snyder, Guo Zhong, Cathryn A Hogarth, Weize Huang, Traci B Topping, Jeffrey T Lafrance, Laura Palau, Lindsay C Czuba, Michael D GriswoldAbstract:Abstract All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is an essential signaling molecule. Global knockout of the atRA clearing enzymes Cyp26a1 or Cyp26b1 is embryonic lethal. In adults, inhibition of Cyp26a1 and Cyp26b1 increases atRA concentrations and signaling. However, post-natal knockout of Cyp26a1 does not cause a severe phenotype. We hypothesized that Cyp26b1 is the main atRA clearing Cyp in post-natal mammals. This hypothesis was tested by generating tamoxifen inducible knockout mouse models of Cyp26b1 alone or with Cyp26a1. Both mouse models showed dermatitis, blepharitis and splenomegaly. Histology showed infiltration of inflammatory cells including neutrophils and T-lymphocytes into the skin and hyperkeratosis/hyperplasia of the non-glandular stomach. The mice lacking both Cyp26a1 and Cyp26b1 also failed to gain weight and showed fat atrophy. There were significant changes in vitamin A homeostasis demonstrating the Paramount Role of Cyp26b1 in regulating retinoid homeostasis in post-natal life.
Cathryn A Hogarth - One of the best experts on this subject based on the ideXlab platform.
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knockout of cyp26a1 and cyp26b1 during postnatal life causes reduced lifespan dermatitis splenomegaly and systemic inflammation in mice
The FASEB Journal, 2020Co-Authors: Jessica M Snyder, Guo Zhong, Cathryn A Hogarth, Weize Huang, Traci B Topping, Jeffrey T Lafrance, Laura Palau, Lindsay C Czuba, Michael D GriswoldAbstract:All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is an essential signaling molecule in all chordates. Global knockouts of the atRA clearing enzymes Cyp26a1 or Cyp26b1 are embryonic lethal. In adult rodents, inhibition of Cyp26a1 and Cyp26b1 increases atRA concentrations and signaling. However, postnatal knockout of Cyp26a1 does not cause a severe phenotype. We hypothesized that Cyp26b1 is the main atRA clearing Cyp in postnatal mammals. This hypothesis was tested by generating tamoxifen-inducible knockout mouse models of Cyp26b1 alone or with Cyp26a1. Both mouse models showed dermatitis, blepharitis, and splenomegaly. Histology showed infiltration of inflammatory cells including neutrophils and T lymphocytes into the skin and hyperkeratosis/hyperplasia of the nonglandular stomach. The mice lacking both Cyp26a1 and Cyp26b1 also had a reduced lifespan, failed to gain weight, and showed fat atrophy. There were significant changes in vitamin A homeostasis. Postnatal knockout of Cyp26b1 resulted in increased atRA concentrations in the skin while the postnatal knockout of both Cyp26a1 and Cyp26b1 resulted in increased atRA concentrations in the liver, serum, skin, spleen, and intestines. This study demonstrates the Paramount Role of Cyp26b1 in regulating retinoid homeostasis in postnatal life.
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knockout of cyp26a1 and cyp26b1 during post natal life causes reduced lifespan dermatitis splenomegaly and systemic inflammation in mice
bioRxiv, 2020Co-Authors: Jessica M Snyder, Guo Zhong, Cathryn A Hogarth, Weize Huang, Traci B Topping, Jeffrey T Lafrance, Laura Palau, Lindsay C Czuba, Michael D GriswoldAbstract:Abstract All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is an essential signaling molecule. Global knockout of the atRA clearing enzymes Cyp26a1 or Cyp26b1 is embryonic lethal. In adults, inhibition of Cyp26a1 and Cyp26b1 increases atRA concentrations and signaling. However, post-natal knockout of Cyp26a1 does not cause a severe phenotype. We hypothesized that Cyp26b1 is the main atRA clearing Cyp in post-natal mammals. This hypothesis was tested by generating tamoxifen inducible knockout mouse models of Cyp26b1 alone or with Cyp26a1. Both mouse models showed dermatitis, blepharitis and splenomegaly. Histology showed infiltration of inflammatory cells including neutrophils and T-lymphocytes into the skin and hyperkeratosis/hyperplasia of the non-glandular stomach. The mice lacking both Cyp26a1 and Cyp26b1 also failed to gain weight and showed fat atrophy. There were significant changes in vitamin A homeostasis demonstrating the Paramount Role of Cyp26b1 in regulating retinoid homeostasis in post-natal life.