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Philip Lazarus - One of the best experts on this subject based on the ideXlab platform.

  • p53 alteration and human papilloma virus infection in Paranasal Sinus cancer
    Cancer, 1997
    Co-Authors: Salvatore Caruana, N Zwiebel, A Steven M D Mccormick, R C Eberle, Rubina Cocker, Philip Lazarus
    Abstract:

    BACKGROUND Inverted papilloma (IP) of the Paranasal Sinus is a benign neoplastic condition that can be associated with squamous cell carcinoma (SCC). To understand the etiology of the disease better, Paranasal Sinus Tumor specimens were examined for alterations in either p53 protein expression or genomic DNA sequence, and for infection by human papilloma virus (HPV). METHODS Tumor specimens were categorized as follows: benign, nondysplastic IP; IP with dysplasia; SCC arising within IP; or SCC without IP. Sections of each Tumor specimen were stained for p53 protein overexpression, and mutations in exons 5-9 of the p53 gene were determined in DNA purified from all Tumor samples. HPV infection was screened by degenerate polymerase chain reaction (PCR) amplification and typed by multiplex PCR and direct DNA sequencing of PCR-amplified HPV sequences. RESULTS Altered p53, either in genetic sequence or protein overexpression, was observed in 0 of 7 benign, nondysplastic IP specimens. A significantly higher p53 alteration incidence was observed for IP specimens exhibiting dysplasia (57%; P < 0.05) and IP specimens that were associated with SCC (75%; P < 0.025). HPV sequences were detected in 9 of 24 (38%) Tumor specimens, 78% of which were of the oncogenic HPV16 strain. A significantly higher incidence (P < 0.05) of HPV infection was observed in IP Tumors exhibiting dysplasia or containing SCC than in nondysplastic IPs. None of the p53-mutated Tumors were infected with oncogenic HPV16. CONCLUSIONS These data suggest that p53 alterations and/or HPV infection are associated predominantly with IPs exhibiting evidence of dysplasia or IPs associated with SCC, but not in nondysplastic, benign IPs. In addition, an inverse correlation may exist between oncogenic HPV infection and p53 alterations in Paranasal Sinus Tumors. The authors postulate that patients with IPs containing altered p53 may be at increased risk for SCC of the Paranasal Sinus. Cancer 1997; 79:1320-8. © 1997 American Cancer Society.

  • p53 alteration and human papilloma virus infection in Paranasal Sinus cancer
    American Association for Cancer Research Meeting, 1997
    Co-Authors: Salvatore Caruana, N Zwiebel, A Steven M D Mccormick, R C Eberle, Rubina Cocker, Philip Lazarus
    Abstract:

    BACKGROUND. Inverted papilloma (IP) of the Paranasal Sinus is a benign neoplastic condition that can be associated with squamous cell carcinoma (SCC). To understand the etiology of the disease better, Paranasal Sinus Tumor specimens were examined for alterations in either p53 protein expression or genomic DNA sequence, and for infection by human papilloma virus (HPV). METHODS. Tumor specimens were categorized as follows: benign, nondysplastic IP; IP with dysplasia; SCC arising within IP; or SCC without IP. Sections of each Tumor specimen were stained for p53 protein overexpression, and mutations in exons 5-9 of the p53 gene were determined in DNA purified from all Tumor samples. HPV infection was screened by degenerate polymerase chain reaction (PCR) amplification and typed by multiplex PCR and direct DNA sequencing of PCR-amplified HPV sequences. RESULTS. Altered p53, either in genetic sequence or protein overexpression, was observed in 0 of 7 benign, nondysplastic IP specimens. A significantly higher p53 alteration incidence was observed for IP specimens exhibiting dysplasia (57%; P < 0.05) and IP specimens that were associated with SCC (75%; P < 0.025). HPV sequences were detected in 9 of 24 (38%) Tumor specimens, 78% of which were of the oncogenic HPV16 strain. A significantly higher incidence (P < 0.05) of HPV infection was observed in IP Tumors exhibiting dysplasia or containing SCC than in nondysplastic IPs. None of the p53-mutated Tumors were infected with oncogenic HPV16. CONCLUSIONS. These data suggest that p53 alterations and/or HPV infection are associated predominantly with IPs exhibiting evidence of dysplasia or IPs associated with SCC, but not in nondysplastic, benign IPs. In addition, an inverse correlation may exist between oncogenic HPV infection and p53 alterations in Paranasal Sinus Tumors. The authors postulate that patients with IPs containing altered p53 may be at increased risk for SCC of the Paranasal Sinus.

Salvatore Caruana - One of the best experts on this subject based on the ideXlab platform.

  • p53 alteration and human papilloma virus infection in Paranasal Sinus cancer
    Cancer, 1997
    Co-Authors: Salvatore Caruana, N Zwiebel, A Steven M D Mccormick, R C Eberle, Rubina Cocker, Philip Lazarus
    Abstract:

    BACKGROUND Inverted papilloma (IP) of the Paranasal Sinus is a benign neoplastic condition that can be associated with squamous cell carcinoma (SCC). To understand the etiology of the disease better, Paranasal Sinus Tumor specimens were examined for alterations in either p53 protein expression or genomic DNA sequence, and for infection by human papilloma virus (HPV). METHODS Tumor specimens were categorized as follows: benign, nondysplastic IP; IP with dysplasia; SCC arising within IP; or SCC without IP. Sections of each Tumor specimen were stained for p53 protein overexpression, and mutations in exons 5-9 of the p53 gene were determined in DNA purified from all Tumor samples. HPV infection was screened by degenerate polymerase chain reaction (PCR) amplification and typed by multiplex PCR and direct DNA sequencing of PCR-amplified HPV sequences. RESULTS Altered p53, either in genetic sequence or protein overexpression, was observed in 0 of 7 benign, nondysplastic IP specimens. A significantly higher p53 alteration incidence was observed for IP specimens exhibiting dysplasia (57%; P < 0.05) and IP specimens that were associated with SCC (75%; P < 0.025). HPV sequences were detected in 9 of 24 (38%) Tumor specimens, 78% of which were of the oncogenic HPV16 strain. A significantly higher incidence (P < 0.05) of HPV infection was observed in IP Tumors exhibiting dysplasia or containing SCC than in nondysplastic IPs. None of the p53-mutated Tumors were infected with oncogenic HPV16. CONCLUSIONS These data suggest that p53 alterations and/or HPV infection are associated predominantly with IPs exhibiting evidence of dysplasia or IPs associated with SCC, but not in nondysplastic, benign IPs. In addition, an inverse correlation may exist between oncogenic HPV infection and p53 alterations in Paranasal Sinus Tumors. The authors postulate that patients with IPs containing altered p53 may be at increased risk for SCC of the Paranasal Sinus. Cancer 1997; 79:1320-8. © 1997 American Cancer Society.

  • p53 alteration and human papilloma virus infection in Paranasal Sinus cancer
    American Association for Cancer Research Meeting, 1997
    Co-Authors: Salvatore Caruana, N Zwiebel, A Steven M D Mccormick, R C Eberle, Rubina Cocker, Philip Lazarus
    Abstract:

    BACKGROUND. Inverted papilloma (IP) of the Paranasal Sinus is a benign neoplastic condition that can be associated with squamous cell carcinoma (SCC). To understand the etiology of the disease better, Paranasal Sinus Tumor specimens were examined for alterations in either p53 protein expression or genomic DNA sequence, and for infection by human papilloma virus (HPV). METHODS. Tumor specimens were categorized as follows: benign, nondysplastic IP; IP with dysplasia; SCC arising within IP; or SCC without IP. Sections of each Tumor specimen were stained for p53 protein overexpression, and mutations in exons 5-9 of the p53 gene were determined in DNA purified from all Tumor samples. HPV infection was screened by degenerate polymerase chain reaction (PCR) amplification and typed by multiplex PCR and direct DNA sequencing of PCR-amplified HPV sequences. RESULTS. Altered p53, either in genetic sequence or protein overexpression, was observed in 0 of 7 benign, nondysplastic IP specimens. A significantly higher p53 alteration incidence was observed for IP specimens exhibiting dysplasia (57%; P < 0.05) and IP specimens that were associated with SCC (75%; P < 0.025). HPV sequences were detected in 9 of 24 (38%) Tumor specimens, 78% of which were of the oncogenic HPV16 strain. A significantly higher incidence (P < 0.05) of HPV infection was observed in IP Tumors exhibiting dysplasia or containing SCC than in nondysplastic IPs. None of the p53-mutated Tumors were infected with oncogenic HPV16. CONCLUSIONS. These data suggest that p53 alterations and/or HPV infection are associated predominantly with IPs exhibiting evidence of dysplasia or IPs associated with SCC, but not in nondysplastic, benign IPs. In addition, an inverse correlation may exist between oncogenic HPV infection and p53 alterations in Paranasal Sinus Tumors. The authors postulate that patients with IPs containing altered p53 may be at increased risk for SCC of the Paranasal Sinus.

Ying-jen Chen - One of the best experts on this subject based on the ideXlab platform.

  • Orbital apex syndrome secondary to aspergilloma masquerading as a Paranasal Sinus Tumor: A case report and literature review.
    Medicine, 2018
    Co-Authors: Yu-min Chang, Yun-hsiang Chang, Ke-hung Chien, Chang-min Liang, Ming-cheng Tai, Shin Nieh, Ying-jen Chen
    Abstract:

    Rationale Orbital apex syndrome is a complex clinical disorder featuring a collection of cranial nerve deficits characterized by impairment of the extraocular muscles, the ophthalmic branch of the trigeminal nerve, and even the optic nerve. Sino-orbital aspergillosis is rare but aggressive infection. Surgical resection accompanied by antifungal medication is advised currently. Patient concerns We report a 61-year-old woman diagnosed as aspergilloma presenting with the characteristic manifestations and imaging features of orbital apex syndrome. Diagnoses Paranasal Sinus Tumor was misdiagnosed initially according to magnetic resonance imaging of the orbit. Finally aspergilloma was diagnosed by pathologic report. Interventions The anti-fungal medication, voriconazole, was administered immediately. Surgical excision was also done due to the poor response to medical treatment. Outcomes Postoperative follow-up showed no recurrence of aspergillosis but the vision was lost permanently. Lessons Invasive sino-orbital aspergillosis as an aggressive disease with highly invasive patterns and it may be misdiagnosed as Tumors. To achieve better prognosis and survival, clinicians should be aware of this distinct manifestation.

Nobuyuki Takasu - One of the best experts on this subject based on the ideXlab platform.

  • adult t cell leukemia lymphoma with multiple integration of htlv 1 provirus presenting as an isolated Paranasal Sinus Tumor a case report
    Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2008
    Co-Authors: Akitoshi Nagasaki, Takashi Miyagi, Tamiko Taira, Akihiko Shinhama, Shizuo Kojya, Mikio Suzuki, Miyuki Aonahata, Naoki Yoshimi, Nobuyuki Takasu
    Abstract:

    Background. Adult T-cell leukemia/lymphoma (ATLL) is a highly aggressive T-cell lymphoma and etiologically associated with human T-lymphotropic virus type 1 (HTLV-1). Patients with ATLL commonly present with leukemic changes, systemic lymphadenopathy, and/or extranodal lesion and have very poor prognosis. Methods and Results. We describe a rare case of ATLL presenting as an isolated Paranasal mass. Southern blot analysis of the biopsied specimens demonstrated multiple integration bands of HTLV-1 provirus of different intensities. Chemotherapy resulted in complete resolution of the Paranasal mass. Thereafter, the patient showed an indolent clinical course with leukemic changes and pulmonary and cutaneous ATLL lesions and remains alive more than 5 years from diagnosis. Conclusion. ATLL should be included in the differential diagnosis of sinonasal lymphoma, although the event is rare. Multiple HTLV-1 provirus integrations of different intensities may be indicative of good prognosis for ATLL. © 2007 Wiley Periodicals, Inc. Head Neck, 2008

A Steven M D Mccormick - One of the best experts on this subject based on the ideXlab platform.

  • p53 alteration and human papilloma virus infection in Paranasal Sinus cancer
    Cancer, 1997
    Co-Authors: Salvatore Caruana, N Zwiebel, A Steven M D Mccormick, R C Eberle, Rubina Cocker, Philip Lazarus
    Abstract:

    BACKGROUND Inverted papilloma (IP) of the Paranasal Sinus is a benign neoplastic condition that can be associated with squamous cell carcinoma (SCC). To understand the etiology of the disease better, Paranasal Sinus Tumor specimens were examined for alterations in either p53 protein expression or genomic DNA sequence, and for infection by human papilloma virus (HPV). METHODS Tumor specimens were categorized as follows: benign, nondysplastic IP; IP with dysplasia; SCC arising within IP; or SCC without IP. Sections of each Tumor specimen were stained for p53 protein overexpression, and mutations in exons 5-9 of the p53 gene were determined in DNA purified from all Tumor samples. HPV infection was screened by degenerate polymerase chain reaction (PCR) amplification and typed by multiplex PCR and direct DNA sequencing of PCR-amplified HPV sequences. RESULTS Altered p53, either in genetic sequence or protein overexpression, was observed in 0 of 7 benign, nondysplastic IP specimens. A significantly higher p53 alteration incidence was observed for IP specimens exhibiting dysplasia (57%; P < 0.05) and IP specimens that were associated with SCC (75%; P < 0.025). HPV sequences were detected in 9 of 24 (38%) Tumor specimens, 78% of which were of the oncogenic HPV16 strain. A significantly higher incidence (P < 0.05) of HPV infection was observed in IP Tumors exhibiting dysplasia or containing SCC than in nondysplastic IPs. None of the p53-mutated Tumors were infected with oncogenic HPV16. CONCLUSIONS These data suggest that p53 alterations and/or HPV infection are associated predominantly with IPs exhibiting evidence of dysplasia or IPs associated with SCC, but not in nondysplastic, benign IPs. In addition, an inverse correlation may exist between oncogenic HPV infection and p53 alterations in Paranasal Sinus Tumors. The authors postulate that patients with IPs containing altered p53 may be at increased risk for SCC of the Paranasal Sinus. Cancer 1997; 79:1320-8. © 1997 American Cancer Society.

  • p53 alteration and human papilloma virus infection in Paranasal Sinus cancer
    American Association for Cancer Research Meeting, 1997
    Co-Authors: Salvatore Caruana, N Zwiebel, A Steven M D Mccormick, R C Eberle, Rubina Cocker, Philip Lazarus
    Abstract:

    BACKGROUND. Inverted papilloma (IP) of the Paranasal Sinus is a benign neoplastic condition that can be associated with squamous cell carcinoma (SCC). To understand the etiology of the disease better, Paranasal Sinus Tumor specimens were examined for alterations in either p53 protein expression or genomic DNA sequence, and for infection by human papilloma virus (HPV). METHODS. Tumor specimens were categorized as follows: benign, nondysplastic IP; IP with dysplasia; SCC arising within IP; or SCC without IP. Sections of each Tumor specimen were stained for p53 protein overexpression, and mutations in exons 5-9 of the p53 gene were determined in DNA purified from all Tumor samples. HPV infection was screened by degenerate polymerase chain reaction (PCR) amplification and typed by multiplex PCR and direct DNA sequencing of PCR-amplified HPV sequences. RESULTS. Altered p53, either in genetic sequence or protein overexpression, was observed in 0 of 7 benign, nondysplastic IP specimens. A significantly higher p53 alteration incidence was observed for IP specimens exhibiting dysplasia (57%; P < 0.05) and IP specimens that were associated with SCC (75%; P < 0.025). HPV sequences were detected in 9 of 24 (38%) Tumor specimens, 78% of which were of the oncogenic HPV16 strain. A significantly higher incidence (P < 0.05) of HPV infection was observed in IP Tumors exhibiting dysplasia or containing SCC than in nondysplastic IPs. None of the p53-mutated Tumors were infected with oncogenic HPV16. CONCLUSIONS. These data suggest that p53 alterations and/or HPV infection are associated predominantly with IPs exhibiting evidence of dysplasia or IPs associated with SCC, but not in nondysplastic, benign IPs. In addition, an inverse correlation may exist between oncogenic HPV infection and p53 alterations in Paranasal Sinus Tumors. The authors postulate that patients with IPs containing altered p53 may be at increased risk for SCC of the Paranasal Sinus.