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Shizuko Shoumura - One of the best experts on this subject based on the ideXlab platform.
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Nerve fibres in the Parathyroid Gland of the golden hamster (Mesocricetus auratus): immunohistochemical and ultrastructural investigations.
Anatomia Histologia Embryologia, 2005Co-Authors: Huayue Chen, Shizuko Shoumura, Shoichi EmuraAbstract:Summary We investigated the morphology and the distribution of the nerve fibres in golden hamster (Mesocricetus auratus) Parathyroid Glands using antibodies to calcitonin gene-related peptide (CGRP) and substance P, and electron microscopy. CGRP-immunoreactive nerve fibres were densely distributed in the interstitial tissues and the capsules of the hamster Parathyroid Glands. Some nerve fibres were detected in close proximity of the Parathyroid chief cells. The distribution pattern for substance P-immunoreactive nerve fibres was roughly the same as for CGRP-immunoreactive fibres. Ultrastructurally, we found numerous nerve fibres joining the blood vessels. Axon bundles were located adjacent to the smooth muscle cells of the arterioles. The axons formed structurally specialized neuromuscular junctions with the vascular smooth muscle cells. Some axons were in close vicinity to the Parathyroid chief cells. These findings indicate that the hamster Parathyroid Gland contain CGRP and substance P, which may regulate the blood flow and the secretory activity of the Gland.
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Morphological study of the Parathyroid Gland and thyroid C cell in senescence-accelerated mouse (SAMP6), a murine model for senile osteoporosis
Tissue & Cell, 2004Co-Authors: Huayue Chen, Shoichi Emura, Shizuko ShoumuraAbstract:Abstract SAMP6, a substrain of senescence-accelerated mouse, was developed as an animal model for senile osteoporosis. We investigated the morphology of the Parathyroid Gland and thyroid C cell, together with the serum Parathyroid hormone (PTH) and calcitonin (CT) in SAMP6 and age-matched normal mice SAMR1. We did not find any significant differences between SAMR1 and SAMP6 at 1 month of age with regard to the serum PTH level and the morphology of the Parathyroid Glands. As compared with SAMR1, the serum PTH level was significantly higher in SAMP6 at 2, 5 and 12 months of age. In the Parathyroid chief cells of SAMP6 at 2, 5 and 12 months of age, the Golgi complexes and the cisternae of the granular endoplasmic reticulum were well developed. Numerous secretory granules were located near the plasma membranes and mitoses were sometimes observed. There was no marked difference between SAMR1 and SAMP6 regarding the morphology of the thyroid C cells and the serum CT level. These findings suggest that the secretory activity of the Parathyroid Gland is stimulated in SAMP6 at 2, 5 and 12 months of age. The Parathyroid follicle was sometimes found in SAMP6, and the significance of this structure was also discussed.
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Ultrastructure of the Parathyroid Gland of the young golden hamster after short-term treatment with ethanol
Histology and Histopathology, 1998Co-Authors: Huayue Chen, Shoichi Emura, Hideo Isono, Daisuke Hayakawa, A. Tamada, Marjan Jamali, Tomo Yamahira, Kishiko Yoshida-terasawa, Shizuko ShoumuraAbstract:We studied the ultrastructure of the Parathyroid Gland of young golden hamsters after short-term treatment with ethanol (1.5 gkg bw or 6.0 gkg bw). We did not find any ultrastructural changes of the Parathyroid Gland after administration of 1.5 g/kg ethanol. In the hamsters, 3 hours after administration of 6.0 g!kg ethanol, the mean serum calcium concentration was significantly low as compared to that of the control animals. In the Parathyroid Gland 1 hour after administration of 6.0 glkg ethanol, the Golgi complexes associated with a few prosecretory granules and the volume density occupied by the Golgi complexes decreased compared with that of the control animals. In the Parathyroid Glands 3 hours after administration of 6.0 g/kg ethanol, the Golgi complexes decreased as compared with those of the control animals, while the large vacuolar bodies increased. These findings suggest that the cellular activity of the Parathyroid Gland is suppressed after short-term treatment with ethanol. Intracellular lumen was found in the Parathyroid chief cells 3 hours after administration of 6.0 &kg ethanol, and the significance of this structure is discussed.
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Effects of short-term treatment with ethanol on the ultrastructure of the adult golden hamster Parathyroid Gland
Medical Electron Microscopy, 1997Co-Authors: Huayue Chen, Shoichi Emura, Hideo Isono, Daisuke Hayakawa, A. Tamada, Marjan Jamali, Tomo Yamahira, Kishiko Terasawa, Shizuko ShoumuraAbstract:Several previous studies have indicated that ingestion of ethanol can induce hypocalcemia or osteoporosis. However, few data are available concerning the effects of ethanol on the Parathyroid Gland. To clarify the mechanism of ethanol-induced hypocalcemia, we studied the ultrastructure to the Parathyroid Gland in golden hamsters after shortterm treatment with ethanol. Ethanol was administered by gavage via an intragastric tube at 6g/kg of 50% ethanol in distilled water. The mean serum calcium concentration was significantly low at 3 and 5h after administration. The Golgi complexes of the Parathyroid chief cells significantly decreased 1 and 3h after administration. The lipid droplets and the large vacuolar bodies significantly increased 5h after administration. These findings suggest that the cellular activity of the Parathyroid Gland is suppressed after shortterm treatment with ethanol.
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The Parathyroid Gland under normal and experimental conditions
Japanese Journal of anatomy, 1993Co-Authors: Shizuko Shoumura, Shoichi Emura, Hideo IsonoAbstract:: Since Sandstrom reported the first detailed description of the Parathyroid Glands of human beings in 1880, and Lever first described the ultrastructure of the Parathyroid chief cells of rat in 1957, a large number of light and electron microscopic studies have been done on the Parathyroid Glands of numerous animal species under normal and experimental conditions. This review deals with the comparative morphology of the Parathyroid Glands in amphibians, reptiles, birds and mammals under normal conditions, and the problem concerning the effects of various experimental conditions on the Parathyroid Glands in mice, rabbits and hamsters. The Parathyroid Glands were recognized in all vertebrate animals higher than fish, and arose from the third and fourth branchial pouches. Several animals, such as the newt, lizard, gecko, mouse, rat, hamster and gerbil, had only two Parathyroid Glands, but most animals had four. In mammals, most of the Parathyroid Glands were closely associated with the thyroid Gland, but in amphibians, reptiles and birds, the Glands separated from the thyroid Gland. In some mammals, the parenchymal cells of the Parathyroid Gland were classified under a light microscope into two main types of cells: chief cells and oxyphil cells. Examinations under an electron microscope also showed the chief cells having many cell organelles and the oxyphil cells filled with numerous mitochondria in the Parathyroid Glands of human beings, monkeys, cows, horses, bats and turtles. In addition, the chief cells in most animals were classified at the light microscopic level into light cells and dark cells, moreover the chief cells were also electron microscopically divided into a light and dark type showing different functional phases of a single cell type when osmium or glutaraldehyde fixative was used. However, it is widely accepted today that differences in cytoplasmic density of the chief cells are due to artifacts produced in the process of tissue preparation. The parenchymal cells of the Parathyroid Gland of the newt were divided into the basal cells (supporting cells) and the suprabasal cells (chief cells). In the Parathyroid Gland of the frog and toad, blood vessels and connective tissues were not present. In the Parathyroid Gland of the rabbit and hamster, the water-clear cell was observed. In the electron microscopic radioautograph of the Parathyroid Gland treated with 3H-leucine, most of the silver grains were seen over cisternae of the granular endoplasmic reticulum at 15 minutes, over the Golgi complexes at 30 minutes, and over secretory granules at 60 minutes.(ABSTRACT TRUNCATED AT 400 WORDS)
Huayue Chen - One of the best experts on this subject based on the ideXlab platform.
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Nerve fibres in the Parathyroid Gland of the golden hamster (Mesocricetus auratus): immunohistochemical and ultrastructural investigations.
Anatomia Histologia Embryologia, 2005Co-Authors: Huayue Chen, Shizuko Shoumura, Shoichi EmuraAbstract:Summary We investigated the morphology and the distribution of the nerve fibres in golden hamster (Mesocricetus auratus) Parathyroid Glands using antibodies to calcitonin gene-related peptide (CGRP) and substance P, and electron microscopy. CGRP-immunoreactive nerve fibres were densely distributed in the interstitial tissues and the capsules of the hamster Parathyroid Glands. Some nerve fibres were detected in close proximity of the Parathyroid chief cells. The distribution pattern for substance P-immunoreactive nerve fibres was roughly the same as for CGRP-immunoreactive fibres. Ultrastructurally, we found numerous nerve fibres joining the blood vessels. Axon bundles were located adjacent to the smooth muscle cells of the arterioles. The axons formed structurally specialized neuromuscular junctions with the vascular smooth muscle cells. Some axons were in close vicinity to the Parathyroid chief cells. These findings indicate that the hamster Parathyroid Gland contain CGRP and substance P, which may regulate the blood flow and the secretory activity of the Gland.
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Morphological study of the Parathyroid Gland and thyroid C cell in senescence-accelerated mouse (SAMP6), a murine model for senile osteoporosis
Tissue & Cell, 2004Co-Authors: Huayue Chen, Shoichi Emura, Shizuko ShoumuraAbstract:Abstract SAMP6, a substrain of senescence-accelerated mouse, was developed as an animal model for senile osteoporosis. We investigated the morphology of the Parathyroid Gland and thyroid C cell, together with the serum Parathyroid hormone (PTH) and calcitonin (CT) in SAMP6 and age-matched normal mice SAMR1. We did not find any significant differences between SAMR1 and SAMP6 at 1 month of age with regard to the serum PTH level and the morphology of the Parathyroid Glands. As compared with SAMR1, the serum PTH level was significantly higher in SAMP6 at 2, 5 and 12 months of age. In the Parathyroid chief cells of SAMP6 at 2, 5 and 12 months of age, the Golgi complexes and the cisternae of the granular endoplasmic reticulum were well developed. Numerous secretory granules were located near the plasma membranes and mitoses were sometimes observed. There was no marked difference between SAMR1 and SAMP6 regarding the morphology of the thyroid C cells and the serum CT level. These findings suggest that the secretory activity of the Parathyroid Gland is stimulated in SAMP6 at 2, 5 and 12 months of age. The Parathyroid follicle was sometimes found in SAMP6, and the significance of this structure was also discussed.
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Ultrastructure of the Parathyroid Gland of the young golden hamster after short-term treatment with ethanol
Histology and Histopathology, 1998Co-Authors: Huayue Chen, Shoichi Emura, Hideo Isono, Daisuke Hayakawa, A. Tamada, Marjan Jamali, Tomo Yamahira, Kishiko Yoshida-terasawa, Shizuko ShoumuraAbstract:We studied the ultrastructure of the Parathyroid Gland of young golden hamsters after short-term treatment with ethanol (1.5 gkg bw or 6.0 gkg bw). We did not find any ultrastructural changes of the Parathyroid Gland after administration of 1.5 g/kg ethanol. In the hamsters, 3 hours after administration of 6.0 g!kg ethanol, the mean serum calcium concentration was significantly low as compared to that of the control animals. In the Parathyroid Gland 1 hour after administration of 6.0 glkg ethanol, the Golgi complexes associated with a few prosecretory granules and the volume density occupied by the Golgi complexes decreased compared with that of the control animals. In the Parathyroid Glands 3 hours after administration of 6.0 g/kg ethanol, the Golgi complexes decreased as compared with those of the control animals, while the large vacuolar bodies increased. These findings suggest that the cellular activity of the Parathyroid Gland is suppressed after short-term treatment with ethanol. Intracellular lumen was found in the Parathyroid chief cells 3 hours after administration of 6.0 &kg ethanol, and the significance of this structure is discussed.
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Effects of short-term treatment with ethanol on the ultrastructure of the adult golden hamster Parathyroid Gland
Medical Electron Microscopy, 1997Co-Authors: Huayue Chen, Shoichi Emura, Hideo Isono, Daisuke Hayakawa, A. Tamada, Marjan Jamali, Tomo Yamahira, Kishiko Terasawa, Shizuko ShoumuraAbstract:Several previous studies have indicated that ingestion of ethanol can induce hypocalcemia or osteoporosis. However, few data are available concerning the effects of ethanol on the Parathyroid Gland. To clarify the mechanism of ethanol-induced hypocalcemia, we studied the ultrastructure to the Parathyroid Gland in golden hamsters after shortterm treatment with ethanol. Ethanol was administered by gavage via an intragastric tube at 6g/kg of 50% ethanol in distilled water. The mean serum calcium concentration was significantly low at 3 and 5h after administration. The Golgi complexes of the Parathyroid chief cells significantly decreased 1 and 3h after administration. The lipid droplets and the large vacuolar bodies significantly increased 5h after administration. These findings suggest that the cellular activity of the Parathyroid Gland is suppressed after shortterm treatment with ethanol.
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Effects of melatonin on the ultrastructure of the golden hamster Parathyroid Gland.
Histology and Histopathology, 1991Co-Authors: Huayue Chen, Shizuko Shoumura, Shoichi Emura, Tomo Yamahira, M. Utsumi, Hideo IsonoAbstract:: Ultrastructural changes of the Parathyroid Glands of melatonin-treated golden hamsters were studied. Many chief cells in the Parathyroid Glands after 1 hour of administration of melatonin contained poorly-developed Golgi complexes associated with a few prosecretory granules and numerous lipid droplets as compared with those of the control animals. The morphology of the Parathyroid Glands after 5 hours of administration resembled that of the control animals. Many chief cells in the Parathyroid Glands after 24 hours of administration had well-developed Golgi complexes and cisternae of the granular endoplasmic reticulum, numerous prosecretory granules, a few lipid droplets and many secretory granules in the peripheral cytoplasm as compared with those of the control animals. The ultrastructure of the Parathyroid Glands after 48 hours of administration was almost similar to that of the control animals. It is considered that melatonin affects the secretory activity of the Parathyroid Gland.
Hideo Isono - One of the best experts on this subject based on the ideXlab platform.
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Ultrastructure of the Parathyroid Gland of the young golden hamster after short-term treatment with ethanol
Histology and Histopathology, 1998Co-Authors: Huayue Chen, Shoichi Emura, Hideo Isono, Daisuke Hayakawa, A. Tamada, Marjan Jamali, Tomo Yamahira, Kishiko Yoshida-terasawa, Shizuko ShoumuraAbstract:We studied the ultrastructure of the Parathyroid Gland of young golden hamsters after short-term treatment with ethanol (1.5 gkg bw or 6.0 gkg bw). We did not find any ultrastructural changes of the Parathyroid Gland after administration of 1.5 g/kg ethanol. In the hamsters, 3 hours after administration of 6.0 g!kg ethanol, the mean serum calcium concentration was significantly low as compared to that of the control animals. In the Parathyroid Gland 1 hour after administration of 6.0 glkg ethanol, the Golgi complexes associated with a few prosecretory granules and the volume density occupied by the Golgi complexes decreased compared with that of the control animals. In the Parathyroid Glands 3 hours after administration of 6.0 g/kg ethanol, the Golgi complexes decreased as compared with those of the control animals, while the large vacuolar bodies increased. These findings suggest that the cellular activity of the Parathyroid Gland is suppressed after short-term treatment with ethanol. Intracellular lumen was found in the Parathyroid chief cells 3 hours after administration of 6.0 &kg ethanol, and the significance of this structure is discussed.
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Effects of short-term treatment with ethanol on the ultrastructure of the adult golden hamster Parathyroid Gland
Medical Electron Microscopy, 1997Co-Authors: Huayue Chen, Shoichi Emura, Hideo Isono, Daisuke Hayakawa, A. Tamada, Marjan Jamali, Tomo Yamahira, Kishiko Terasawa, Shizuko ShoumuraAbstract:Several previous studies have indicated that ingestion of ethanol can induce hypocalcemia or osteoporosis. However, few data are available concerning the effects of ethanol on the Parathyroid Gland. To clarify the mechanism of ethanol-induced hypocalcemia, we studied the ultrastructure to the Parathyroid Gland in golden hamsters after shortterm treatment with ethanol. Ethanol was administered by gavage via an intragastric tube at 6g/kg of 50% ethanol in distilled water. The mean serum calcium concentration was significantly low at 3 and 5h after administration. The Golgi complexes of the Parathyroid chief cells significantly decreased 1 and 3h after administration. The lipid droplets and the large vacuolar bodies significantly increased 5h after administration. These findings suggest that the cellular activity of the Parathyroid Gland is suppressed after shortterm treatment with ethanol.
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The Parathyroid Gland under normal and experimental conditions
Japanese Journal of anatomy, 1993Co-Authors: Shizuko Shoumura, Shoichi Emura, Hideo IsonoAbstract:: Since Sandstrom reported the first detailed description of the Parathyroid Glands of human beings in 1880, and Lever first described the ultrastructure of the Parathyroid chief cells of rat in 1957, a large number of light and electron microscopic studies have been done on the Parathyroid Glands of numerous animal species under normal and experimental conditions. This review deals with the comparative morphology of the Parathyroid Glands in amphibians, reptiles, birds and mammals under normal conditions, and the problem concerning the effects of various experimental conditions on the Parathyroid Glands in mice, rabbits and hamsters. The Parathyroid Glands were recognized in all vertebrate animals higher than fish, and arose from the third and fourth branchial pouches. Several animals, such as the newt, lizard, gecko, mouse, rat, hamster and gerbil, had only two Parathyroid Glands, but most animals had four. In mammals, most of the Parathyroid Glands were closely associated with the thyroid Gland, but in amphibians, reptiles and birds, the Glands separated from the thyroid Gland. In some mammals, the parenchymal cells of the Parathyroid Gland were classified under a light microscope into two main types of cells: chief cells and oxyphil cells. Examinations under an electron microscope also showed the chief cells having many cell organelles and the oxyphil cells filled with numerous mitochondria in the Parathyroid Glands of human beings, monkeys, cows, horses, bats and turtles. In addition, the chief cells in most animals were classified at the light microscopic level into light cells and dark cells, moreover the chief cells were also electron microscopically divided into a light and dark type showing different functional phases of a single cell type when osmium or glutaraldehyde fixative was used. However, it is widely accepted today that differences in cytoplasmic density of the chief cells are due to artifacts produced in the process of tissue preparation. The parenchymal cells of the Parathyroid Gland of the newt were divided into the basal cells (supporting cells) and the suprabasal cells (chief cells). In the Parathyroid Gland of the frog and toad, blood vessels and connective tissues were not present. In the Parathyroid Gland of the rabbit and hamster, the water-clear cell was observed. In the electron microscopic radioautograph of the Parathyroid Gland treated with 3H-leucine, most of the silver grains were seen over cisternae of the granular endoplasmic reticulum at 15 minutes, over the Golgi complexes at 30 minutes, and over secretory granules at 60 minutes.(ABSTRACT TRUNCATED AT 400 WORDS)
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Effects of melatonin on the ultrastructure of the golden hamster Parathyroid Gland.
Histology and Histopathology, 1991Co-Authors: Huayue Chen, Shizuko Shoumura, Shoichi Emura, Tomo Yamahira, M. Utsumi, Hideo IsonoAbstract:: Ultrastructural changes of the Parathyroid Glands of melatonin-treated golden hamsters were studied. Many chief cells in the Parathyroid Glands after 1 hour of administration of melatonin contained poorly-developed Golgi complexes associated with a few prosecretory granules and numerous lipid droplets as compared with those of the control animals. The morphology of the Parathyroid Glands after 5 hours of administration resembled that of the control animals. Many chief cells in the Parathyroid Glands after 24 hours of administration had well-developed Golgi complexes and cisternae of the granular endoplasmic reticulum, numerous prosecretory granules, a few lipid droplets and many secretory granules in the peripheral cytoplasm as compared with those of the control animals. The ultrastructure of the Parathyroid Glands after 48 hours of administration was almost similar to that of the control animals. It is considered that melatonin affects the secretory activity of the Parathyroid Gland.
Tomo Yamahira - One of the best experts on this subject based on the ideXlab platform.
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Ultrastructure of the Parathyroid Gland of the young golden hamster after short-term treatment with ethanol
Histology and Histopathology, 1998Co-Authors: Huayue Chen, Shoichi Emura, Hideo Isono, Daisuke Hayakawa, A. Tamada, Marjan Jamali, Tomo Yamahira, Kishiko Yoshida-terasawa, Shizuko ShoumuraAbstract:We studied the ultrastructure of the Parathyroid Gland of young golden hamsters after short-term treatment with ethanol (1.5 gkg bw or 6.0 gkg bw). We did not find any ultrastructural changes of the Parathyroid Gland after administration of 1.5 g/kg ethanol. In the hamsters, 3 hours after administration of 6.0 g!kg ethanol, the mean serum calcium concentration was significantly low as compared to that of the control animals. In the Parathyroid Gland 1 hour after administration of 6.0 glkg ethanol, the Golgi complexes associated with a few prosecretory granules and the volume density occupied by the Golgi complexes decreased compared with that of the control animals. In the Parathyroid Glands 3 hours after administration of 6.0 g/kg ethanol, the Golgi complexes decreased as compared with those of the control animals, while the large vacuolar bodies increased. These findings suggest that the cellular activity of the Parathyroid Gland is suppressed after short-term treatment with ethanol. Intracellular lumen was found in the Parathyroid chief cells 3 hours after administration of 6.0 &kg ethanol, and the significance of this structure is discussed.
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Effects of short-term treatment with ethanol on the ultrastructure of the adult golden hamster Parathyroid Gland
Medical Electron Microscopy, 1997Co-Authors: Huayue Chen, Shoichi Emura, Hideo Isono, Daisuke Hayakawa, A. Tamada, Marjan Jamali, Tomo Yamahira, Kishiko Terasawa, Shizuko ShoumuraAbstract:Several previous studies have indicated that ingestion of ethanol can induce hypocalcemia or osteoporosis. However, few data are available concerning the effects of ethanol on the Parathyroid Gland. To clarify the mechanism of ethanol-induced hypocalcemia, we studied the ultrastructure to the Parathyroid Gland in golden hamsters after shortterm treatment with ethanol. Ethanol was administered by gavage via an intragastric tube at 6g/kg of 50% ethanol in distilled water. The mean serum calcium concentration was significantly low at 3 and 5h after administration. The Golgi complexes of the Parathyroid chief cells significantly decreased 1 and 3h after administration. The lipid droplets and the large vacuolar bodies significantly increased 5h after administration. These findings suggest that the cellular activity of the Parathyroid Gland is suppressed after shortterm treatment with ethanol.
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Effects of melatonin on the ultrastructure of the golden hamster Parathyroid Gland.
Histology and Histopathology, 1991Co-Authors: Huayue Chen, Shizuko Shoumura, Shoichi Emura, Tomo Yamahira, M. Utsumi, Hideo IsonoAbstract:: Ultrastructural changes of the Parathyroid Glands of melatonin-treated golden hamsters were studied. Many chief cells in the Parathyroid Glands after 1 hour of administration of melatonin contained poorly-developed Golgi complexes associated with a few prosecretory granules and numerous lipid droplets as compared with those of the control animals. The morphology of the Parathyroid Glands after 5 hours of administration resembled that of the control animals. Many chief cells in the Parathyroid Glands after 24 hours of administration had well-developed Golgi complexes and cisternae of the granular endoplasmic reticulum, numerous prosecretory granules, a few lipid droplets and many secretory granules in the peripheral cytoplasm as compared with those of the control animals. The ultrastructure of the Parathyroid Glands after 48 hours of administration was almost similar to that of the control animals. It is considered that melatonin affects the secretory activity of the Parathyroid Gland.
Shoichi Emura - One of the best experts on this subject based on the ideXlab platform.
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Nerve fibres in the Parathyroid Gland of the golden hamster (Mesocricetus auratus): immunohistochemical and ultrastructural investigations.
Anatomia Histologia Embryologia, 2005Co-Authors: Huayue Chen, Shizuko Shoumura, Shoichi EmuraAbstract:Summary We investigated the morphology and the distribution of the nerve fibres in golden hamster (Mesocricetus auratus) Parathyroid Glands using antibodies to calcitonin gene-related peptide (CGRP) and substance P, and electron microscopy. CGRP-immunoreactive nerve fibres were densely distributed in the interstitial tissues and the capsules of the hamster Parathyroid Glands. Some nerve fibres were detected in close proximity of the Parathyroid chief cells. The distribution pattern for substance P-immunoreactive nerve fibres was roughly the same as for CGRP-immunoreactive fibres. Ultrastructurally, we found numerous nerve fibres joining the blood vessels. Axon bundles were located adjacent to the smooth muscle cells of the arterioles. The axons formed structurally specialized neuromuscular junctions with the vascular smooth muscle cells. Some axons were in close vicinity to the Parathyroid chief cells. These findings indicate that the hamster Parathyroid Gland contain CGRP and substance P, which may regulate the blood flow and the secretory activity of the Gland.
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Morphological study of the Parathyroid Gland and thyroid C cell in senescence-accelerated mouse (SAMP6), a murine model for senile osteoporosis
Tissue & Cell, 2004Co-Authors: Huayue Chen, Shoichi Emura, Shizuko ShoumuraAbstract:Abstract SAMP6, a substrain of senescence-accelerated mouse, was developed as an animal model for senile osteoporosis. We investigated the morphology of the Parathyroid Gland and thyroid C cell, together with the serum Parathyroid hormone (PTH) and calcitonin (CT) in SAMP6 and age-matched normal mice SAMR1. We did not find any significant differences between SAMR1 and SAMP6 at 1 month of age with regard to the serum PTH level and the morphology of the Parathyroid Glands. As compared with SAMR1, the serum PTH level was significantly higher in SAMP6 at 2, 5 and 12 months of age. In the Parathyroid chief cells of SAMP6 at 2, 5 and 12 months of age, the Golgi complexes and the cisternae of the granular endoplasmic reticulum were well developed. Numerous secretory granules were located near the plasma membranes and mitoses were sometimes observed. There was no marked difference between SAMR1 and SAMP6 regarding the morphology of the thyroid C cells and the serum CT level. These findings suggest that the secretory activity of the Parathyroid Gland is stimulated in SAMP6 at 2, 5 and 12 months of age. The Parathyroid follicle was sometimes found in SAMP6, and the significance of this structure was also discussed.
-
Ultrastructure of the Parathyroid Gland of the young golden hamster after short-term treatment with ethanol
Histology and Histopathology, 1998Co-Authors: Huayue Chen, Shoichi Emura, Hideo Isono, Daisuke Hayakawa, A. Tamada, Marjan Jamali, Tomo Yamahira, Kishiko Yoshida-terasawa, Shizuko ShoumuraAbstract:We studied the ultrastructure of the Parathyroid Gland of young golden hamsters after short-term treatment with ethanol (1.5 gkg bw or 6.0 gkg bw). We did not find any ultrastructural changes of the Parathyroid Gland after administration of 1.5 g/kg ethanol. In the hamsters, 3 hours after administration of 6.0 g!kg ethanol, the mean serum calcium concentration was significantly low as compared to that of the control animals. In the Parathyroid Gland 1 hour after administration of 6.0 glkg ethanol, the Golgi complexes associated with a few prosecretory granules and the volume density occupied by the Golgi complexes decreased compared with that of the control animals. In the Parathyroid Glands 3 hours after administration of 6.0 g/kg ethanol, the Golgi complexes decreased as compared with those of the control animals, while the large vacuolar bodies increased. These findings suggest that the cellular activity of the Parathyroid Gland is suppressed after short-term treatment with ethanol. Intracellular lumen was found in the Parathyroid chief cells 3 hours after administration of 6.0 &kg ethanol, and the significance of this structure is discussed.
-
Effects of short-term treatment with ethanol on the ultrastructure of the adult golden hamster Parathyroid Gland
Medical Electron Microscopy, 1997Co-Authors: Huayue Chen, Shoichi Emura, Hideo Isono, Daisuke Hayakawa, A. Tamada, Marjan Jamali, Tomo Yamahira, Kishiko Terasawa, Shizuko ShoumuraAbstract:Several previous studies have indicated that ingestion of ethanol can induce hypocalcemia or osteoporosis. However, few data are available concerning the effects of ethanol on the Parathyroid Gland. To clarify the mechanism of ethanol-induced hypocalcemia, we studied the ultrastructure to the Parathyroid Gland in golden hamsters after shortterm treatment with ethanol. Ethanol was administered by gavage via an intragastric tube at 6g/kg of 50% ethanol in distilled water. The mean serum calcium concentration was significantly low at 3 and 5h after administration. The Golgi complexes of the Parathyroid chief cells significantly decreased 1 and 3h after administration. The lipid droplets and the large vacuolar bodies significantly increased 5h after administration. These findings suggest that the cellular activity of the Parathyroid Gland is suppressed after shortterm treatment with ethanol.
-
The Parathyroid Gland under normal and experimental conditions
Japanese Journal of anatomy, 1993Co-Authors: Shizuko Shoumura, Shoichi Emura, Hideo IsonoAbstract:: Since Sandstrom reported the first detailed description of the Parathyroid Glands of human beings in 1880, and Lever first described the ultrastructure of the Parathyroid chief cells of rat in 1957, a large number of light and electron microscopic studies have been done on the Parathyroid Glands of numerous animal species under normal and experimental conditions. This review deals with the comparative morphology of the Parathyroid Glands in amphibians, reptiles, birds and mammals under normal conditions, and the problem concerning the effects of various experimental conditions on the Parathyroid Glands in mice, rabbits and hamsters. The Parathyroid Glands were recognized in all vertebrate animals higher than fish, and arose from the third and fourth branchial pouches. Several animals, such as the newt, lizard, gecko, mouse, rat, hamster and gerbil, had only two Parathyroid Glands, but most animals had four. In mammals, most of the Parathyroid Glands were closely associated with the thyroid Gland, but in amphibians, reptiles and birds, the Glands separated from the thyroid Gland. In some mammals, the parenchymal cells of the Parathyroid Gland were classified under a light microscope into two main types of cells: chief cells and oxyphil cells. Examinations under an electron microscope also showed the chief cells having many cell organelles and the oxyphil cells filled with numerous mitochondria in the Parathyroid Glands of human beings, monkeys, cows, horses, bats and turtles. In addition, the chief cells in most animals were classified at the light microscopic level into light cells and dark cells, moreover the chief cells were also electron microscopically divided into a light and dark type showing different functional phases of a single cell type when osmium or glutaraldehyde fixative was used. However, it is widely accepted today that differences in cytoplasmic density of the chief cells are due to artifacts produced in the process of tissue preparation. The parenchymal cells of the Parathyroid Gland of the newt were divided into the basal cells (supporting cells) and the suprabasal cells (chief cells). In the Parathyroid Gland of the frog and toad, blood vessels and connective tissues were not present. In the Parathyroid Gland of the rabbit and hamster, the water-clear cell was observed. In the electron microscopic radioautograph of the Parathyroid Gland treated with 3H-leucine, most of the silver grains were seen over cisternae of the granular endoplasmic reticulum at 15 minutes, over the Golgi complexes at 30 minutes, and over secretory granules at 60 minutes.(ABSTRACT TRUNCATED AT 400 WORDS)
